Publicaties

@article{pmid41916635,

title = {Feasibility and effectiveness of a multicomponent and multilevel personalised lifestyle intervention for adults with intellectual disabilities: protocol for a feasibility and multiple baseline one-arm effectiveness study.},

author = {Bas Valentin and Josje D Schoufour and Annelies Overwijk and Kirsten A Lamberts and Tim Pelle and Rianne H A Steenbergen and Peter J M Weijs and Aly Waninge and Alyt Oppewal},

doi = {10.1136/bmjopen-2025-114209},

issn = {2044-6055},

year  = {2026},

date = {2026-03-30},

journal = {BMJ Open},

volume = {16},

number = {3},

pages = {e114209},

abstract = {INTRODUCTION: The LIFE-ID (lifestyle interventions for adults with intellectual disabilities) intervention, a multicomponent and multilevel lifestyle programme, was developed to improve the lifestyle of adults with ID and the support provided by their interpersonal and organisational environment. This paper describes the protocol of a multiple baseline one-arm feasibility and effectiveness study of the LIFE-ID intervention. METHOD AND ANALYSIS: To evaluate the effectiveness of the LIFE-ID intervention for adults with ID, alongside an embedded assessment of feasibility, we employ a one-arm multiple-baseline trial in the Netherlands, in collaboration with healthcare organisations providing support to adults with ID. The LIFE-ID intervention intervenes at intrapersonal, interpersonal and organisational levels and uses a tailored approach to improve both physical activity and dietary quality in adults with ID. To support healthcare professionals in selecting interventions, the lifestyle support tool was developed, including existing, effective, and ID-specific nutrition and physical activity interventions. The lifestyle support tool takes into account intrapersonal, interpersonal and organisational characteristics and considers the participants' wishes and needs related to their personal lifestyle goals. An embedded feasibility evaluation of the LIFE-ID intervention is conducted with the first 15 participants in the study and their involved healthcare professionals. Information on dose delivered, dose received, acceptability and fidelity of the intervention performance compared with the description is retrieved through biweekly reflection forms obtained from direct support professionals. Group interviews are conducted to collect feedback on the experiences with the LIFE-ID intervention discussing the following topics: acceptance and suitability of the intervention, and barriers and facilitators during execution. Outcomes related to the lifestyle support tool include usability, usefulness and ease of use. To evaluate the effectiveness of the 6-month LIFE-ID intervention, 80 adults (≥18 years) with ID are included (including 15 participants from the feasibility evaluation). The primary outcome is physical activity. Secondary outcomes on the intrapersonal level include dietary quality, physical fitness, body composition, calf circumference, blood pressure, heart rate, frailty, anxiety, depression, behavioural problems and goal attainment. On the interpersonal level, outcomes include attitude of professionals towards support in healthy exercise and nutrition. On the organisational level, outcomes are barriers and facilitators associated with creating a healthy living environment, and determinants that affect the implementation of the LIFE-ID intervention. ETHICS AND DISSEMINATION: The study protocol is approved by the Medical Ethics Review Board of the University Medical Center Groningen (METc 2023-520). Written consent is obtained from all participants who are capable to provide consent, and from legal representatives when they are not. Study findings will be disseminated through peer-reviewed publications, conference presentations and accessible summaries for participants, families and healthcare organisations. TRIAL REGISTRATION NUMBER: The study has been registered in the Overview of Medical Research in the Netherlands (OMON; NL85438), which is linked to the International Clinical Trial Registry Platform (ICTRP).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41449692,

title = {Plant-based protein for older adults with obesity.},

author = {Sophie L Oppenraaij and Susanne Wildemast and Esmee M Reijnierse and Josje D Schoufour and Sjors Verlaan and Peter J M Weijs},

doi = {10.1017/S0029665125102085},

issn = {1475-2719},

year  = {2025},

date = {2025-12-26},

journal = {Proc Nutr Soc},

pages = {1–6},

abstract = {The global syndemic of obesity, undernutrition and climate change - three interconnected challenges - threatens both human and planetary health. This review focuses on one critical intersection: older populations living with overweight and obesity in the context of sustainable nutrition. Obesity and sarcopenia, particularly the co-occurrence called sarcopenic obesity, are often overlooked until the onset or exacerbation of other diseases necessitates secondary care. Preventing sarcopenic obesity requires reducing excess fat mass while preserving muscle mass and function. This involves lowering total energy intake while ensuring adequate protein intake in terms of quantity, quality and distribution, combined with physical activity, particularly resistance exercise. Short-term studies show that both the source and dose of dietary protein significantly influence muscle protein synthesis rates. Longer-term studies examining the impact of plant-based diets on muscle health in older adults with or without overweight or obesity remain limited. Animal protein have shown a modest advantage over most plant-based protein in supporting muscle mass. Qualitative studies suggest that emphasising both the health benefits and palatability of plant-based protein sources is key to promoting dietary changes in older adults. In older adults with obesity, it is challenging to combine energy restriction with higher protein intake, especially when protein sources are plant-based. To prevent and treat sarcopenic obesity in older adults and support planetary health, a shift toward more plant-based protein sources is required, while ensuring sufficient protein quantity and quality to preserve muscle health during weight loss.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41397687,

title = {Tailoring mHealth for Healthy Aging: Focus Group Study With Retirement-Age Adults.},

author = {Paula Collazo-Castiñeira and Rocío Rodríguez-Rey and Alfonso J Cruz-Jentoft and Somaya Ben Allouch and Doris Eglseer and Josje Schoufour and Eva Topinková and Peter J M Weijs and Yves Boirie and Macarena Sánchez-Izquierdo},

doi = {10.2196/70051},

issn = {2291-5222},

year  = {2025},

date = {2025-12-15},

journal = {JMIR Mhealth Uhealth},

volume = {13},

pages = {e70051},

abstract = {BACKGROUND: The adoption of mobile health (mHealth) technologies among older adults remains significantly lower than in younger populations, despite their potential to promote healthier lifestyles and mitigate age-related health risks. OBJECTIVE: This study aims to explore the perspectives of retirement-age adults on mHealth interventions, identifying factors that influence their adoption, such as persuasive elements in the app design and psychological techniques. METHODS: A qualitative focus group study was conducted with 19 Spanish participants recruited from urban community settings in Madrid, Spain (mean age 61.5 years; 15/19, 79% women). Participants discussed their attitudes, barriers, and preferences for mHealth tools. Focus groups were recorded, transcribed, and coded using an iterative process to ensure rigorous data analysis. An abductive approach was followed, using the persuasive design principles framework and the behavior change techniques' taxonomy, and representing any theme outside those frameworks. RESULTS: Participants expressed generally positive attitudes toward mHealth tools, favoring intuitive, user-friendly designs that are minimally time-demanding. However, significant barriers also emerged, such as low digital literacy and concerns about technology dependence. Key design preferences (persuasive design principles) and psychological techniques (behavior change techniques) were deemed beneficial, with preferred features such as tailored and meaningful goal-setting, self-monitoring, positive feedback (eg, congratulating messages after achieving a goal; social rewards), and a moderated use of notifications and prompts. Participants also stressed the importance of age-appropriate recommendations (eg, suggested diets for their age and characteristics) and design (eg, accessible, easy-to-use interfaces and human-like communication). Additionally, some preferences appeared to be culturally grounded (eg, rejection of anglicisms and the desire for locally relevant content, such as suggested activities specific to Madrid). Social support mechanisms, such as group activities and peer interactions through mHealth, were seen as critical for fostering motivation and engagement. CONCLUSIONS: mHealth interventions for this population should offer accessible and easy-to-use interfaces along with initial tutorials, facilitating an easy onboarding to overcome low digital literacy, thereby enhancing both usability and initial adoption. Furthermore, by providing meaningful, tailored content (eg, personalized diets and goals) and social features that foster peer connection (eg, user chats or organized activities), these tools may better support sustained engagement over time.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wagenaar2024-rdb,

title = {Effect of a multidisciplinary lifestyle intervention on body 

 composition in people with osteoarthritis: Secondary analysis of 

 the ``Plants for Joints'' randomized controlled trial},

author = {C A Wagenaar and W Walrabenstein and C S Jonge and M Bisschops and M Leeden and M Esch and P J M Weijs and M A Troelstra and M A Korteweg and A J Nederveen and D Schaardenburg},

year  = {2024},

date = {2024-12-01},

journal = {Osteoarthr. Cartil. Open},

volume = {6},

number = {4},

pages = {100524},

publisher = {Elsevier BV},

abstract = {Objective: The Plants for Joints (PFJ) intervention 

 significantly improved pain, stiffness, and physical function, 

 and metabolic outcomes, in people with metabolic 

 syndrome-associated osteoarthritis (MSOA). This secondary 

 analysis investigated its effects on body composition. Method: 

 In the randomized PFJ study, people with MSOA followed a 16-week 

 intervention based on a whole-food plant-based diet, physical 

 activity, and stress management, or usual care. For this 

 secondary analysis, fat mass, muscle mass, and bone mineral 

 density were measured using dual-energy X-ray absorptiometry (DEXA) for all participants. Additionally, in a subgroup (n = 

 32), hepatocellular lipid (HCL) content and composition of 

 visceral adipose tissue (VAT) were measured using magnetic 

 resonance spectroscopy (MRS). An intention-to-treat analysis 

 with a linear-mixed model adjusted for baseline values was used 

 to analyse between-group differences. Results: Of 66 people 

 randomized, 64 (97%) completed the study. The PFJ group 

 experienced significant weight loss (-5.2 kg; 95% CI -6.9, 

 -3.6) compared to controls, primarily from fat mass reduction 

 (-3.9 kg; 95% CI -5.3 to -2.5). No significant differences 

 were found in lean mass, muscle strength, or bone mineral 

 density between groups. In the subgroup who underwent MRI scans, 

 the PFJ group had a greater reduction in HCL (-6.5%; 95% CI 

 -9.9, 3.0) compared to controls, with no observed differences in 

 VAT composition. Conclusion: The PFJ multidisciplinary 

 intervention positively impacted clinical and metabolic 

 outcomes, and appears to significantly reduce body fat, 

 including liver fat, while preserving muscle mass and strength.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wagenaar2024-rd,

title = {Effect of a multidisciplinary lifestyle intervention on body 

 composition in people with osteoarthritis: Secondary analysis of 

 the ``Plants for Joints'' randomized controlled trial},

author = {C A Wagenaar and W Walrabenstein and C S Jonge and M Bisschops and M Leeden and M Esch and P J M Weijs and M A Troelstra and M A Korteweg and A J Nederveen and D Schaardenburg},

year  = {2024},

date = {2024-12-01},

journal = {Osteoarthr. Cartil. Open},

volume = {6},

number = {4},

pages = {100524},

publisher = {Elsevier BV},

abstract = {Objective: The Plants for Joints (PFJ) intervention 

 significantly improved pain, stiffness, and physical function, 

 and metabolic outcomes, in people with metabolic 

 syndrome-associated osteoarthritis (MSOA). This secondary 

 analysis investigated its effects on body composition. Method: 

 In the randomized PFJ study, people with MSOA followed a 16-week 

 intervention based on a whole-food plant-based diet, physical 

 activity, and stress management, or usual care. For this 

 secondary analysis, fat mass, muscle mass, and bone mineral 

 density were measured using dual-energy X-ray absorptiometry (DEXA) for all participants. Additionally, in a subgroup (n = 

 32), hepatocellular lipid (HCL) content and composition of 

 visceral adipose tissue (VAT) were measured using magnetic 

 resonance spectroscopy (MRS). An intention-to-treat analysis 

 with a linear-mixed model adjusted for baseline values was used 

 to analyse between-group differences. Results: Of 66 people 

 randomized, 64 (97%) completed the study. The PFJ group 

 experienced significant weight loss (-5.2 kg; 95% CI -6.9, 

 -3.6) compared to controls, primarily from fat mass reduction 

 (-3.9 kg; 95% CI -5.3 to -2.5). No significant differences 

 were found in lean mass, muscle strength, or bone mineral 

 density between groups. In the subgroup who underwent MRI scans, 

 the PFJ group had a greater reduction in HCL (-6.5%; 95% CI 

 -9.9, 3.0) compared to controls, with no observed differences in 

 VAT composition. Conclusion: The PFJ multidisciplinary 

 intervention positively impacted clinical and metabolic 

 outcomes, and appears to significantly reduce body fat, 

 including liver fat, while preserving muscle mass and strength.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Weijs2024-ldb,

title = {Protein requirement in obesity},

author = {Peter J M Weijs},

year  = {2024},

date = {2024-11-01},

journal = {Curr. Opin. Clin. Nutr. Metab. Care},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {PURPOSE OF REVIEW: The combined obesity and ageing pandemic 

 require action to avoid a total health system infarct. Obesity 

 is largely challenged with caloric restriction and endurance 

 exercise, likely to be assisted by drugs. The older adults with 

 the highest obesity levels may face extreme loss of muscle mass 

 and increased risk of sarcopenic obesity.Within this context the 

 question of what is the protein requirement is extremely urgent. 

 RECENT FINDINGS: While the topic is essential, no trials have 

 directly assessed protein requirements for obesity. Therefore, 

 we will have to deal with more indirect evidence. Several 

 systematic reviews have appeared for obesity treatment involving 

 protein and a few randomized controlled trials during weight 

 loss are worth mentioning considering the amount of protein 

 needed, especially with increasing age. SUMMARY: Protein 

 requirements are hard to derive for obesity defined by BMI over 

 30 perse. During weight loss the rebuilding of the body is 

 likely to need at least 1.2 g/kg body weight/d with a maximum 

 weight of BMI 30, especially in the aged. Obesity might increase 

 protein requirements, however being obese with a healthy and 

 active lifestyle might result in normal protein requirements.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Weijs2024-ld,

title = {Protein requirement in obesity},

author = {Peter J M Weijs},

year  = {2024},

date = {2024-11-01},

journal = {Curr. Opin. Clin. Nutr. Metab. Care},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {PURPOSE OF REVIEW: The combined obesity and ageing pandemic 

 require action to avoid a total health system infarct. Obesity 

 is largely challenged with caloric restriction and endurance 

 exercise, likely to be assisted by drugs. The older adults with 

 the highest obesity levels may face extreme loss of muscle mass 

 and increased risk of sarcopenic obesity.Within this context the 

 question of what is the protein requirement is extremely urgent. 

 RECENT FINDINGS: While the topic is essential, no trials have 

 directly assessed protein requirements for obesity. Therefore, 

 we will have to deal with more indirect evidence. Several 

 systematic reviews have appeared for obesity treatment involving 

 protein and a few randomized controlled trials during weight 

 loss are worth mentioning considering the amount of protein 

 needed, especially with increasing age. SUMMARY: Protein 

 requirements are hard to derive for obesity defined by BMI over 

 30 perse. During weight loss the rebuilding of the body is 

 likely to need at least 1.2 g/kg body weight/d with a maximum 

 weight of BMI 30, especially in the aged. Obesity might increase 

 protein requirements, however being obese with a healthy and 

 active lifestyle might result in normal protein requirements.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Erck2024-bsb,

title = {Low muscle quality on a procedural computed tomography scan 

 assessed with deep learning as a practical useful predictor of 

 mortality in patients with severe aortic valve stenosis},

author = {Dennis Erck and Pim Moeskops and Josje D Schoufour and Peter J M Weijs and Wilma J M Scholte Op Reimer and Martijn S Mourik and R Nils Planken and Marije M Vis and Jan Baan and Ivana Išgum and José P Henriques and Bob D Vos and Ronak Delewi},

year  = {2024},

date = {2024-10-01},

journal = {Clin. Nutr. ESPEN},

volume = {63},

pages = {142–147},

publisher = {Elsevier BV},

abstract = {BACKGROUND & AIMS: Accurate diagnosis of sarcopenia requires 

 evaluation of muscle quality, which refers to the amount of fat 

 infiltration in muscle tissue. In this study, we aim to 

 investigate whether we can independently predict mortality risk 

 in transcatheter aortic valve implantation (TAVI) patients, 

 using automatic deep learning algorithms to assess muscle 

 quality on procedural computed tomography (CT) scans. METHODS: 

 This study included 1199 patients with severe aortic stenosis 

 who underwent transcatheter aortic valve implantation (TAVI) 

 between January 2010 and January 2020. A procedural CT scan was 

 performed as part of the preprocedural-TAVI evaluation, and the 

 scans were analyzed using deep-learning-based software to 

 automatically determine skeletal muscle density (SMD) and 

 intermuscular adipose tissue (IMAT). The association of SMD and 

 IMAT with all-cause mortality was analyzed using a Cox 

 regression model, adjusted for other known mortality predictors, 

 including muscle mass. RESULTS: The mean age of the participants 

 was 80 $±$ 7 years, 53% were female. The median observation 

 time was 1084 days, and the overall mortality rate was 39%. We 

 found that the lowest tertile of muscle quality, as determined 

 by SMD, was associated with an increased risk of mortality (HR 

 1.40 [95%CI: 1.15-1.70], p < 0.01). Similarly, low muscle 

 quality as defined by high IMAT in the lowest tertile was also 

 associated with increased mortality risk (HR 1.24 [95%CI: 1.01-1.52},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bauer2024-hwb,

title = {Adherence to resistance training and hypocaloric diet among 

 persons near retirement age - A secondary data analysis of three 

 randomized controlled trials},

author = {S Bauer and L Reiter and Peter J M Weijs and J D Schoufour and Y Boirie and E Topinková and R G Memelink and A M Verreijen and A Borenich and D Eglseer and SO-NUTS consortium},

year  = {2024},

date = {2024-10-01},

journal = {J. Nutr. Health Aging},

volume = {28},

number = {10},

pages = {100344},

publisher = {Elsevier BV},

abstract = {OBJECTIVES: Adherence to lifestyle interventions is crucial for 

 the treatment of obesity. However, there is little research 

 about adherence to lifestyle interventions in persons around 

 retirement age. The objectives of this study are (1) to identify 

 factors associated with the adherence to resistance training and 

 a hypocaloric diet and (2) to describe the association between 

 adherence and changes in body composition outcome parameters. 

 DESIGN: This secondary data analysis included three randomized 

 controlled trials. SETTING & PARTICIPANTS: The inclusion 

 criteria of the participants were an age of 55-75 years, a BMI 

 $geq$ 25 kg/m2 and receiving both a hypocaloric diet and 

 resistance training. All participants were residing in the 

 community. MEASUREMENTS: Adherence to hypocaloric diet was 

 measured through the mean dietary intake on the basis of a 3-day 

 dietary record. If the participant consumed at least 600 kcal 

 less than the individual caloric requirements, they were 

 considered adherent. Adherence to resistance training was 

 achieved if $geq$67% of the recommended training sessions were 

 attended over the course of the study periods. RESULTS: 232 

 participants were included, 47.0% female, mean age 64.0 

 ($±$5.5) years. 80.2% adhered to resistance training and 

 51.3% adhered to a hypocaloric diet. Older age (Beta 0.41; 95% CI 0.05, 0.78; p = 0.028) and male sex (Beta 7.7; 95% CI 3.6, 

 11; p < 0.001) were associated with higher resistance training 

 adherence. A higher BMI at baseline (Beta 6.4; 95% CI 3.6, 9.2; 

 p < 0.001) and male sex (Beta 65; 95% CI 41, 88; p < 0.001) 

 were associated with higher adherence to hypocaloric diet. 

 CONCLUSION: We identified several associated factors (sex, age 

 and BMI at baseline) that should be considered to promote 

 adherence in future lifestyle intervention studies in persons 

 around retirement age. We recommend including behavior change 

 techniques in lifestyle interventions and consider sex-specific 

 interventions to improve the adherence of women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Erck2024-bs,

title = {Low muscle quality on a procedural computed tomography scan 

 assessed with deep learning as a practical useful predictor of 

 mortality in patients with severe aortic valve stenosis},

author = {Dennis Erck and Pim Moeskops and Josje D Schoufour and Peter J M Weijs and Wilma J M Scholte Op Reimer and Martijn S Mourik and R Nils Planken and Marije M Vis and Jan Baan and Ivana Išgum and José P Henriques and Bob D Vos and Ronak Delewi},

year  = {2024},

date = {2024-10-01},

journal = {Clin. Nutr. ESPEN},

volume = {63},

pages = {142–147},

publisher = {Elsevier BV},

abstract = {BACKGROUND & AIMS: Accurate diagnosis of sarcopenia requires 

 evaluation of muscle quality, which refers to the amount of fat 

 infiltration in muscle tissue. In this study, we aim to 

 investigate whether we can independently predict mortality risk 

 in transcatheter aortic valve implantation (TAVI) patients, 

 using automatic deep learning algorithms to assess muscle 

 quality on procedural computed tomography (CT) scans. METHODS: 

 This study included 1199 patients with severe aortic stenosis 

 who underwent transcatheter aortic valve implantation (TAVI) 

 between January 2010 and January 2020. A procedural CT scan was 

 performed as part of the preprocedural-TAVI evaluation, and the 

 scans were analyzed using deep-learning-based software to 

 automatically determine skeletal muscle density (SMD) and 

 intermuscular adipose tissue (IMAT). The association of SMD and 

 IMAT with all-cause mortality was analyzed using a Cox 

 regression model, adjusted for other known mortality predictors, 

 including muscle mass. RESULTS: The mean age of the participants 

 was 80 $±$ 7 years, 53% were female. The median observation 

 time was 1084 days, and the overall mortality rate was 39%. We 

 found that the lowest tertile of muscle quality, as determined 

 by SMD, was associated with an increased risk of mortality (HR 

 1.40 [95%CI: 1.15-1.70], p < 0.01). Similarly, low muscle 

 quality as defined by high IMAT in the lowest tertile was also 

 associated with increased mortality risk (HR 1.24 [95%CI: 1.01-1.52},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bauer2024-hw,

title = {Adherence to resistance training and hypocaloric diet among 

 persons near retirement age - A secondary data analysis of three 

 randomized controlled trials},

author = {S Bauer and L Reiter and Peter J M Weijs and J D Schoufour and Y Boirie and E Topinková and R G Memelink and A M Verreijen and A Borenich and D Eglseer and SO-NUTS consortium},

year  = {2024},

date = {2024-10-01},

journal = {J. Nutr. Health Aging},

volume = {28},

number = {10},

pages = {100344},

publisher = {Elsevier BV},

abstract = {OBJECTIVES: Adherence to lifestyle interventions is crucial for 

 the treatment of obesity. However, there is little research 

 about adherence to lifestyle interventions in persons around 

 retirement age. The objectives of this study are (1) to identify 

 factors associated with the adherence to resistance training and 

 a hypocaloric diet and (2) to describe the association between 

 adherence and changes in body composition outcome parameters. 

 DESIGN: This secondary data analysis included three randomized 

 controlled trials. SETTING & PARTICIPANTS: The inclusion 

 criteria of the participants were an age of 55-75 years, a BMI 

 $geq$ 25 kg/m2 and receiving both a hypocaloric diet and 

 resistance training. All participants were residing in the 

 community. MEASUREMENTS: Adherence to hypocaloric diet was 

 measured through the mean dietary intake on the basis of a 3-day 

 dietary record. If the participant consumed at least 600 kcal 

 less than the individual caloric requirements, they were 

 considered adherent. Adherence to resistance training was 

 achieved if $geq$67% of the recommended training sessions were 

 attended over the course of the study periods. RESULTS: 232 

 participants were included, 47.0% female, mean age 64.0 

 ($±$5.5) years. 80.2% adhered to resistance training and 

 51.3% adhered to a hypocaloric diet. Older age (Beta 0.41; 95% CI 0.05, 0.78; p = 0.028) and male sex (Beta 7.7; 95% CI 3.6, 

 11; p < 0.001) were associated with higher resistance training 

 adherence. A higher BMI at baseline (Beta 6.4; 95% CI 3.6, 9.2; 

 p < 0.001) and male sex (Beta 65; 95% CI 41, 88; p < 0.001) 

 were associated with higher adherence to hypocaloric diet. 

 CONCLUSION: We identified several associated factors (sex, age 

 and BMI at baseline) that should be considered to promote 

 adherence in future lifestyle intervention studies in persons 

 around retirement age. We recommend including behavior change 

 techniques in lifestyle interventions and consider sex-specific 

 interventions to improve the adherence of women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38944828c,

title = {Low muscle quality on a procedural computed tomography scan assessed with deep learning as a practical useful predictor of mortality in patients with severe aortic valve stenosis},

author = {Dennis van Erck and Pim Moeskops and Josje D Schoufour and Peter J M Weijs and Wilma J M Scholte Op Reimer and Martijn S van Mourik and R Nils Planken and Marije M Vis and Jan Baan and Ivana Išgum and José P Henriques and Bob D de Vos and Ronak Delewi},

doi = {10.1016/j.clnesp.2024.06.013},

issn = {2405-4577},

year  = {2024},

date = {2024-10-01},

journal = {Clin Nutr ESPEN},

volume = {63},

pages = {142--147},

abstract = {BACKGROUND & AIMS: Accurate diagnosis of sarcopenia requires evaluation of muscle quality, which refers to the amount of fat infiltration in muscle tissue. In this study, we aim to investigate whether we can independently predict mortality risk in transcatheter aortic valve implantation (TAVI) patients, using automatic deep learning algorithms to assess muscle quality on procedural computed tomography (CT) scans.nnMETHODS: This study included 1199 patients with severe aortic stenosis who underwent transcatheter aortic valve implantation (TAVI) between January 2010 and January 2020. A procedural CT scan was performed as part of the preprocedural-TAVI evaluation, and the scans were analyzed using deep-learning-based software to automatically determine skeletal muscle density (SMD) and intermuscular adipose tissue (IMAT). The association of SMD and IMAT with all-cause mortality was analyzed using a Cox regression model, adjusted for other known mortality predictors, including muscle mass.nnRESULTS: The mean age of the participants was 80 ± 7 years, 53% were female. The median observation time was 1084 days, and the overall mortality rate was 39%. We found that the lowest tertile of muscle quality, as determined by SMD, was associated with an increased risk of mortality (HR 1.40 [95%CI: 1.15-1.70], p < 0.01). Similarly, low muscle quality as defined by high IMAT in the lowest tertile was also associated with increased mortality risk (HR 1.24 [95%CI: 1.01-1.52], p = 0.04).nnCONCLUSIONS: Our findings suggest that deep learning-assessed low muscle quality, as indicated by fat infiltration in muscle tissue, is a practical, useful and independent predictor of mortality after TAVI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39191118c,

title = {Adherence to resistance training and hypocaloric diet among persons near retirement age - A secondary data analysis of three randomized controlled trials},

author = {S Bauer and L Reiter and P J M Weijs and J D Schoufour and Y Boirie and E Topinková and R G Memelink and A M Verreijen and A Borenich and D Eglseer and },

doi = {10.1016/j.jnha.2024.100344},

issn = {1760-4788},

year  = {2024},

date = {2024-10-01},

journal = {J Nutr Health Aging},

volume = {28},

number = {10},

pages = {100344},

abstract = {OBJECTIVES: Adherence to lifestyle interventions is crucial for the treatment of obesity. However, there is little research about adherence to lifestyle interventions in persons around retirement age. The objectives of this study are (1) to identify factors associated with the adherence to resistance training and a hypocaloric diet and (2) to describe the association between adherence and changes in body composition outcome parameters.nnDESIGN: This secondary data analysis included three randomized controlled trials.nnSETTING & PARTICIPANTS: The inclusion criteria of the participants were an age of 55-75 years, a BMI ≥ 25 kg/m and receiving both a hypocaloric diet and resistance training. All participants were residing in the community.nnMEASUREMENTS: Adherence to hypocaloric diet was measured through the mean dietary intake on the basis of a 3-day dietary record. If the participant consumed at least 600 kcal less than the individual caloric requirements, they were considered adherent. Adherence to resistance training was achieved if ≥67% of the recommended training sessions were attended over the course of the study periods.nnRESULTS: 232 participants were included, 47.0% female, mean age 64.0 (±5.5) years. 80.2% adhered to resistance training and 51.3% adhered to a hypocaloric diet. Older age (Beta 0.41; 95% CI 0.05, 0.78; p = 0.028) and male sex (Beta 7.7; 95% CI 3.6, 11; p < 0.001) were associated with higher resistance training adherence. A higher BMI at baseline (Beta 6.4; 95% CI 3.6, 9.2; p < 0.001) and male sex (Beta 65; 95% CI 41, 88; p < 0.001) were associated with higher adherence to hypocaloric diet.nnCONCLUSION: We identified several associated factors (sex, age and BMI at baseline) that should be considered to promote adherence in future lifestyle intervention studies in persons around retirement age. We recommend including behavior change techniques in lifestyle interventions and consider sex-specific interventions to improve the adherence of women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38944828,

title = {Low muscle quality on a procedural computed tomography scan assessed with deep learning as a practical useful predictor of mortality in patients with severe aortic valve stenosis},

author = {Dennis van Erck and Pim Moeskops and Josje D Schoufour and Peter J M Weijs and Wilma J M Scholte Op Reimer and Martijn S van Mourik and R Nils Planken and Marije M Vis and Jan Baan and Ivana Išgum and José P Henriques and Bob D de Vos and Ronak Delewi},

doi = {10.1016/j.clnesp.2024.06.013},

issn = {2405-4577},

year  = {2024},

date = {2024-10-01},

journal = {Clin Nutr ESPEN},

volume = {63},

pages = {142--147},

abstract = {BACKGROUND & AIMS: Accurate diagnosis of sarcopenia requires evaluation of muscle quality, which refers to the amount of fat infiltration in muscle tissue. In this study, we aim to investigate whether we can independently predict mortality risk in transcatheter aortic valve implantation (TAVI) patients, using automatic deep learning algorithms to assess muscle quality on procedural computed tomography (CT) scans.nnMETHODS: This study included 1199 patients with severe aortic stenosis who underwent transcatheter aortic valve implantation (TAVI) between January 2010 and January 2020. A procedural CT scan was performed as part of the preprocedural-TAVI evaluation, and the scans were analyzed using deep-learning-based software to automatically determine skeletal muscle density (SMD) and intermuscular adipose tissue (IMAT). The association of SMD and IMAT with all-cause mortality was analyzed using a Cox regression model, adjusted for other known mortality predictors, including muscle mass.nnRESULTS: The mean age of the participants was 80 ± 7 years, 53% were female. The median observation time was 1084 days, and the overall mortality rate was 39%. We found that the lowest tertile of muscle quality, as determined by SMD, was associated with an increased risk of mortality (HR 1.40 [95%CI: 1.15-1.70], p < 0.01). Similarly, low muscle quality as defined by high IMAT in the lowest tertile was also associated with increased mortality risk (HR 1.24 [95%CI: 1.01-1.52], p = 0.04).nnCONCLUSIONS: Our findings suggest that deep learning-assessed low muscle quality, as indicated by fat infiltration in muscle tissue, is a practical, useful and independent predictor of mortality after TAVI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rashid2024-ahb,

title = {Dietary patterns by level of maternal education and their 

 contribution to BMI, fat mass index, and fat-free mass index at 

 age 5 and the longitudinal association with BMI at age 10},

author = {Viyan Rashid and Mary Nicolaou and Arnoud P Verhoeff and Peter J M Weijs and Martinette T Streppel},

year  = {2024},

date = {2024-09-01},

journal = {Nutrients},

volume = {16},

number = {19},

abstract = {BACKGROUND: Our aim was to identify dietary patterns by the level 

 of maternal education that contribute to BMI, fat mass index 

 (FMI), and fat-free mass index (FFMI) in children at age 5 and to 

 assess if these dietary patterns are related to BMI at age 10. 

 METHODS: Per group (low/middle/high level), Reduced Rank 

 Regression (RRR) was used to derive dietary patterns for the 

 response variables BMI z-score, FMI, and FFMI in 1728 children at 

 age 5 in the Amsterdam Born Children and their Development (ABCD) 

 cohort. Regression analyses were then used to determine the 

 association with BMI at age 10. RESULTS: In each group, pattern 1 

 was characterized by its own cluster of food groups. Low: 

 water/tea, savory snacks, sugar, low-fat meat, and fruits; 

 middle: water/tea, low-fat cheese, fish, low-fat dairy, fruit 

 drink, low-fat meat, and eggs; and high: low-fat cheese, fruits, 

 whole-grain breakfast products, and low-fat and processed meat. 

 Additionally, in each group, pattern 1 was positively associated 

 with BMI z-scores at age 10 (low: β $łeq$ 0.43 [95% CI 

 $łeq$ 0.21; 0.66], p < 0.001, middle: β $łeq$ 0.23 [0.09; 

 0.36], p $łeq$ 0.001, and high: β $łeq$ 0.24 [0.18; 

 0.30], p < 0.001). CONCLUSIONS: The dietary patterns stratified 

 by the level of maternal education are characterized by different 

 food groups. But in all the groups, pattern 1 is positively 

 associated with BMI at age 10.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rashid2024-ah,

title = {Dietary patterns by level of maternal education and their 

 contribution to BMI, fat mass index, and fat-free mass index at 

 age 5 and the longitudinal association with BMI at age 10},

author = {Viyan Rashid and Mary Nicolaou and Arnoud P Verhoeff and Peter J M Weijs and Martinette T Streppel},

year  = {2024},

date = {2024-09-01},

journal = {Nutrients},

volume = {16},

number = {19},

abstract = {BACKGROUND: Our aim was to identify dietary patterns by the level 

 of maternal education that contribute to BMI, fat mass index 

 (FMI), and fat-free mass index (FFMI) in children at age 5 and to 

 assess if these dietary patterns are related to BMI at age 10. 

 METHODS: Per group (low/middle/high level), Reduced Rank 

 Regression (RRR) was used to derive dietary patterns for the 

 response variables BMI z-score, FMI, and FFMI in 1728 children at 

 age 5 in the Amsterdam Born Children and their Development (ABCD) 

 cohort. Regression analyses were then used to determine the 

 association with BMI at age 10. RESULTS: In each group, pattern 1 

 was characterized by its own cluster of food groups. Low: 

 water/tea, savory snacks, sugar, low-fat meat, and fruits; 

 middle: water/tea, low-fat cheese, fish, low-fat dairy, fruit 

 drink, low-fat meat, and eggs; and high: low-fat cheese, fruits, 

 whole-grain breakfast products, and low-fat and processed meat. 

 Additionally, in each group, pattern 1 was positively associated 

 with BMI z-scores at age 10 (low: β $łeq$ 0.43 [95% CI 

 $łeq$ 0.21; 0.66], p < 0.001, middle: β $łeq$ 0.23 [0.09; 

 0.36], p $łeq$ 0.001, and high: β $łeq$ 0.24 [0.18; 

 0.30], p < 0.001). CONCLUSIONS: The dietary patterns stratified 

 by the level of maternal education are characterized by different 

 food groups. But in all the groups, pattern 1 is positively 

 associated with BMI at age 10.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Collazo-Castineira2024-pzb,

title = {Analysis of behavioral change techniques used in exercise and 

 nutritional interventions targeting adults around retirement age 

 with sarcopenic obesity in a systematic review},

author = {Paula Collazo-Castiñeira and Macarena Sánchez-Izquierdo and Lea Joanne Reiter and Silvia Bauer and Alfonso J Cruz-Jentoft and Josje D Schoufour and Peter J M Weijs and Doris Eglseer},

year  = {2024},

date = {2024-08-01},

journal = {Arch. Gerontol. Geriatr.},

volume = {123},

number = {105437},

pages = {105437},

publisher = {Elsevier BV},

abstract = {BACKGROUND: Sarcopenic obesity significantly burdens health and 

 autonomy. Strategies to intervene in or prevent sarcopenic 

 obesity generally focus on losing body fat and building or 

 maintaining muscle mass and function. For a lifestyle 

 intervention, it is important to consider psychological aspects 

 such as behavioral change techniques (BCTs) to elicit a 

 long-lasting behavioral change. PURPOSE: The study was carried 

 out to analyze BCTs used in exercise and nutritional 

 interventions targeting community-dwelling adults around 

 retirement age with sarcopenic obesity. METHODS: We conducted an 

 analysis of articles cited in an existing systematic review on 

 the effectiveness of exercise and nutritional interventions on 

 physiological outcomes in community-dwelling adults around 

 retirement age with sarcopenic obesity. We identified BCTs used 

 in these studies by applying a standardized taxonomy. RESULTS: 

 Only nine BCTs were identified. Most BCTs were not used 

 intentionally (82 %), and those used derived from the 

 implementation of lifestyle components, such as exercise classes 

 (``instructions on how to perform a behavior,'' ``demonstration 

 of the behavior,'' ``behavioral practice/rehearsal,'' and ``body 

 changes''). Only two studies used BCTs intentionally to 

 reinforce adherence in their interventions. CONCLUSIONS: Few 

 studies integrated BCTs in lifestyle interventions for 

 community-dwelling persons around retirement age with sarcopenic 

 obesity. Future studies on interventions to counteract 

 sarcopenic obesity should include well-established BCTs to 

 foster adherence and, therefore, their effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bels2024-qcb,

title = {Effect of high versus standard protein provision on functional 

 recovery in people with critical illness (PRECISe): an 

 investigator-initiated, double-blinded, multicentre, 

 parallel-group, randomised controlled trial in Belgium and the 

 Netherlands},

author = {Julia L M Bels and Steven Thiessen and Rob J J Gassel and Albertus Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H Zanten and Laura Bormans-Russell and Bas C T Bussel and Marlies M J Dictus and Tom Fivez and Ingeborg Harks and Iwan C C Horst and Joop Jonckheer and Hugues Marechal and Paul B Massion and Ingrid Meex and Michelle C Paulus and Martin Rinket and Susanne Santen and Katrien Tartaglia and Adam M Deane and Frieda Demuydt and Zudin Puthucheary and Lilian C M Vloet and Peter J M Weijs and Sander M J Kuijk and Marcel C G Poll and Dieter Mesotten and PRECISe team},

year  = {2024},

date = {2024-08-01},

journal = {Lancet},

volume = {404},

number = {10453},

pages = {659–669},

publisher = {Elsevier BV},

abstract = {BACKGROUND: Increased protein provision might ameliorate muscle 

 wasting and improve long-term outcomes in critically ill 

 patients. The aim of the PRECISe trial was to assess whether 

 higher enteral protein provision (ie, 2·0 g/kg per day) would 

 improve health-related quality of life and functional outcomes 

 in critically ill patients who were mechanically ventilated 

 compared with standard enteral protein provision (ie, 1·3 g/kg 

 per day). METHODS: The PRECISe trial was an 

 investigator-initiated, double-blinded, multicentre, 

 parallel-group, randomised controlled trial in five Dutch 

 hospitals and five Belgian hospitals. Inclusion criteria were 

 initiation of invasive mechanical ventilation within 24 h of 

 intensive care unit (ICU) admission and an expected duration of 

 invasive ventilation of 3 days or longer. Exclusion criteria 

 were contraindications for enteral nutrition, moribund 

 condition, BMI less than 18 kg/m2, kidney failure with a no 

 dialysis code, or hepatic encephalopathy. Patients were randomly 

 assigned to one of four randomisation labels, corresponding with 

 two study groups (ie, standard or high protein; two labels per 

 group) in a 1:1:1:1 ratio through an interactive web-response 

 system. Randomisation was done via random permuted-block 

 randomisation in varying block sizes of eight and 12, stratified 

 by centre. Participants, care providers, investigators, outcome 

 assessors, data analysts, and the independent data safety 

 monitoring board were all blinded to group allocation. Patients 

 received isocaloric enteral feeds that contained 1·3 kcal/mL and 

 0·06 g of protein/mL (ie, standard protein) or 1·3 kcal/mL and 

 0·10 g of protein/mL (ie, high protein). The study-nutrition 

 intervention was limited to the time period during the patient's 

 ICU stay in which they required enteral feeding, with a maximum 

 of 90 days. The primary outcome was EuroQoL 5-Dimension 5-level 

 (EQ-5D-5L) health utility score at 30 days, 90 days, and 180 

 days after randomisation, adjusted for baseline EQ-5D-5L health 

 utility score. This trial was registered with ClinicalTrials.gov 

 (NCT04633421) and is closed to new participants. FINDINGS: 

 Between Nov 19, 2020, and April 14, 2023, 935 patients were 

 randomly assigned. 335 (35·8%) of 935 patients were female and 

 600 (64·2%) were male. 465 (49·7%) of 935 were assigned to the 

 standard protein group and 470 (50·3%) were assigned to the 

 high protein group. 430 (92·5%) of 465 patients in the standard 

 protein group and 419 (89·1%) of 470 patients in the high 

 protein group were assessed for the primary outcome. The primary 

 outcome, EQ-5D-5L health utility score during 180 days after 

 randomisation (assessed at 30 days, 90 days, and 180 days), was 

 lower in patients allocated to the high protein group than in 

 those allocated to the standard protein group, with a mean difference of -0·05 (95% CI -0·10 to -0·01; p=0·031). Regarding 

 safety outcomes, the probability of mortality during the entire 

 follow-up was 0·38 (SE 0·02) in the standard protein group and 

 0·42 (0·02) in the high protein group (hazard ratio 1·14, 95% CI 0·92 to 1·40; p=0·22). There was a higher incidence of 

 symptoms of gastrointestinal intolerance in patients in the high protein group (odds ratio 1·76, 95% CI 1·06 to 2·92; p=0·030). 

 Incidence of other adverse events did not differ between groups. 

 INTERPRETATION: High enteral protein provision compared with 

 standard enteral protein provision resulted in worse 

 health-related quality of life in critically ill patients and 

 did not improve functional outcomes during 180 days after ICU 

 admission. FUNDING: Netherlands Organisation for Healthcare 

 Research and Development and Belgian Health Care Knowledge 

 Centre.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Collazo-Castineira2024-pz,

title = {Analysis of behavioral change techniques used in exercise and 

 nutritional interventions targeting adults around retirement age 

 with sarcopenic obesity in a systematic review},

author = {Paula Collazo-Castiñeira and Macarena Sánchez-Izquierdo and Lea Joanne Reiter and Silvia Bauer and Alfonso J Cruz-Jentoft and Josje D Schoufour and Peter J M Weijs and Doris Eglseer},

year  = {2024},

date = {2024-08-01},

journal = {Arch. Gerontol. Geriatr.},

volume = {123},

number = {105437},

pages = {105437},

publisher = {Elsevier BV},

abstract = {BACKGROUND: Sarcopenic obesity significantly burdens health and 

 autonomy. Strategies to intervene in or prevent sarcopenic 

 obesity generally focus on losing body fat and building or 

 maintaining muscle mass and function. For a lifestyle 

 intervention, it is important to consider psychological aspects 

 such as behavioral change techniques (BCTs) to elicit a 

 long-lasting behavioral change. PURPOSE: The study was carried 

 out to analyze BCTs used in exercise and nutritional 

 interventions targeting community-dwelling adults around 

 retirement age with sarcopenic obesity. METHODS: We conducted an 

 analysis of articles cited in an existing systematic review on 

 the effectiveness of exercise and nutritional interventions on 

 physiological outcomes in community-dwelling adults around 

 retirement age with sarcopenic obesity. We identified BCTs used 

 in these studies by applying a standardized taxonomy. RESULTS: 

 Only nine BCTs were identified. Most BCTs were not used 

 intentionally (82 %), and those used derived from the 

 implementation of lifestyle components, such as exercise classes 

 (``instructions on how to perform a behavior,'' ``demonstration 

 of the behavior,'' ``behavioral practice/rehearsal,'' and ``body 

 changes''). Only two studies used BCTs intentionally to 

 reinforce adherence in their interventions. CONCLUSIONS: Few 

 studies integrated BCTs in lifestyle interventions for 

 community-dwelling persons around retirement age with sarcopenic 

 obesity. Future studies on interventions to counteract 

 sarcopenic obesity should include well-established BCTs to 

 foster adherence and, therefore, their effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bels2024-qc,

title = {Effect of high versus standard protein provision on functional 

 recovery in people with critical illness (PRECISe): an 

 investigator-initiated, double-blinded, multicentre, 

 parallel-group, randomised controlled trial in Belgium and the 

 Netherlands},

author = {Julia L M Bels and Steven Thiessen and Rob J J Gassel and Albertus Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H Zanten and Laura Bormans-Russell and Bas C T Bussel and Marlies M J Dictus and Tom Fivez and Ingeborg Harks and Iwan C C Horst and Joop Jonckheer and Hugues Marechal and Paul B Massion and Ingrid Meex and Michelle C Paulus and Martin Rinket and Susanne Santen and Katrien Tartaglia and Adam M Deane and Frieda Demuydt and Zudin Puthucheary and Lilian C M Vloet and Peter J M Weijs and Sander M J Kuijk and Marcel C G Poll and Dieter Mesotten and PRECISe team},

year  = {2024},

date = {2024-08-01},

journal = {Lancet},

volume = {404},

number = {10453},

pages = {659–669},

publisher = {Elsevier BV},

abstract = {BACKGROUND: Increased protein provision might ameliorate muscle 

 wasting and improve long-term outcomes in critically ill 

 patients. The aim of the PRECISe trial was to assess whether 

 higher enteral protein provision (ie, 2·0 g/kg per day) would 

 improve health-related quality of life and functional outcomes 

 in critically ill patients who were mechanically ventilated 

 compared with standard enteral protein provision (ie, 1·3 g/kg 

 per day). METHODS: The PRECISe trial was an 

 investigator-initiated, double-blinded, multicentre, 

 parallel-group, randomised controlled trial in five Dutch 

 hospitals and five Belgian hospitals. Inclusion criteria were 

 initiation of invasive mechanical ventilation within 24 h of 

 intensive care unit (ICU) admission and an expected duration of 

 invasive ventilation of 3 days or longer. Exclusion criteria 

 were contraindications for enteral nutrition, moribund 

 condition, BMI less than 18 kg/m2, kidney failure with a no 

 dialysis code, or hepatic encephalopathy. Patients were randomly 

 assigned to one of four randomisation labels, corresponding with 

 two study groups (ie, standard or high protein; two labels per 

 group) in a 1:1:1:1 ratio through an interactive web-response 

 system. Randomisation was done via random permuted-block 

 randomisation in varying block sizes of eight and 12, stratified 

 by centre. Participants, care providers, investigators, outcome 

 assessors, data analysts, and the independent data safety 

 monitoring board were all blinded to group allocation. Patients 

 received isocaloric enteral feeds that contained 1·3 kcal/mL and 

 0·06 g of protein/mL (ie, standard protein) or 1·3 kcal/mL and 

 0·10 g of protein/mL (ie, high protein). The study-nutrition 

 intervention was limited to the time period during the patient's 

 ICU stay in which they required enteral feeding, with a maximum 

 of 90 days. The primary outcome was EuroQoL 5-Dimension 5-level 

 (EQ-5D-5L) health utility score at 30 days, 90 days, and 180 

 days after randomisation, adjusted for baseline EQ-5D-5L health 

 utility score. This trial was registered with ClinicalTrials.gov 

 (NCT04633421) and is closed to new participants. FINDINGS: 

 Between Nov 19, 2020, and April 14, 2023, 935 patients were 

 randomly assigned. 335 (35·8%) of 935 patients were female and 

 600 (64·2%) were male. 465 (49·7%) of 935 were assigned to the 

 standard protein group and 470 (50·3%) were assigned to the 

 high protein group. 430 (92·5%) of 465 patients in the standard 

 protein group and 419 (89·1%) of 470 patients in the high 

 protein group were assessed for the primary outcome. The primary 

 outcome, EQ-5D-5L health utility score during 180 days after 

 randomisation (assessed at 30 days, 90 days, and 180 days), was 

 lower in patients allocated to the high protein group than in 

 those allocated to the standard protein group, with a mean difference of -0·05 (95% CI -0·10 to -0·01; p=0·031). Regarding 

 safety outcomes, the probability of mortality during the entire 

 follow-up was 0·38 (SE 0·02) in the standard protein group and 

 0·42 (0·02) in the high protein group (hazard ratio 1·14, 95% CI 0·92 to 1·40; p=0·22). There was a higher incidence of 

 symptoms of gastrointestinal intolerance in patients in the high protein group (odds ratio 1·76, 95% CI 1·06 to 2·92; p=0·030). 

 Incidence of other adverse events did not differ between groups. 

 INTERPRETATION: High enteral protein provision compared with 

 standard enteral protein provision resulted in worse 

 health-related quality of life in critically ill patients and 

 did not improve functional outcomes during 180 days after ICU 

 admission. FUNDING: Netherlands Organisation for Healthcare 

 Research and Development and Belgian Health Care Knowledge 

 Centre.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38653002c,

title = {Analysis of behavioral change techniques used in exercise and nutritional interventions targeting adults around retirement age with sarcopenic obesity in a systematic review},

author = {Paula Collazo-Castiñeira and Macarena Sánchez-Izquierdo and Lea Joanne Reiter and Silvia Bauer and Alfonso J Cruz-Jentoft and Josje D Schoufour and Peter J M Weijs and Doris Eglseer},

doi = {10.1016/j.archger.2024.105437},

issn = {1872-6976},

year  = {2024},

date = {2024-08-01},

journal = {Arch Gerontol Geriatr},

volume = {123},

pages = {105437},

abstract = {BACKGROUND: Sarcopenic obesity significantly burdens health and autonomy. Strategies to intervene in or prevent sarcopenic obesity generally focus on losing body fat and building or maintaining muscle mass and function. For a lifestyle intervention, it is important to consider psychological aspects such as behavioral change techniques (BCTs) to elicit a long-lasting behavioral change.nnPURPOSE: The study was carried out to analyze BCTs used in exercise and nutritional interventions targeting community-dwelling adults around retirement age with sarcopenic obesity.nnMETHODS: We conducted an analysis of articles cited in an existing systematic review on the effectiveness of exercise and nutritional interventions on physiological outcomes in community-dwelling adults around retirement age with sarcopenic obesity. We identified BCTs used in these studies by applying a standardized taxonomy.nnRESULTS: Only nine BCTs were identified. Most BCTs were not used intentionally (82 %), and those used derived from the implementation of lifestyle components, such as exercise classes ("instructions on how to perform a behavior," "demonstration of the behavior," "behavioral practice/rehearsal," and "body changes"). Only two studies used BCTs intentionally to reinforce adherence in their interventions.nnCONCLUSIONS: Few studies integrated BCTs in lifestyle interventions for community-dwelling persons around retirement age with sarcopenic obesity. Future studies on interventions to counteract sarcopenic obesity should include well-established BCTs to foster adherence and, therefore, their effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39191118,

title = {Adherence to resistance training and hypocaloric diet among persons near retirement age - A secondary data analysis of three randomized controlled trials},

author = {S Bauer and L Reiter and P J M Weijs and J D Schoufour and Y Boirie and E Topinková and R G Memelink and A M Verreijen and A Borenich and D Eglseer and },

doi = {10.1016/j.jnha.2024.100344},

issn = {1760-4788},

year  = {2024},

date = {2024-08-01},

journal = {J Nutr Health Aging},

volume = {28},

number = {10},

pages = {100344},

abstract = {OBJECTIVES: Adherence to lifestyle interventions is crucial for the treatment of obesity. However, there is little research about adherence to lifestyle interventions in persons around retirement age. The objectives of this study are (1) to identify factors associated with the adherence to resistance training and a hypocaloric diet and (2) to describe the association between adherence and changes in body composition outcome parameters.nnDESIGN: This secondary data analysis included three randomized controlled trials.nnSETTING & PARTICIPANTS: The inclusion criteria of the participants were an age of 55-75 years, a BMI ≥ 25 kg/m and receiving both a hypocaloric diet and resistance training. All participants were residing in the community.nnMEASUREMENTS: Adherence to hypocaloric diet was measured through the mean dietary intake on the basis of a 3-day dietary record. If the participant consumed at least 600 kcal less than the individual caloric requirements, they were considered adherent. Adherence to resistance training was achieved if ≥67% of the recommended training sessions were attended over the course of the study periods.nnRESULTS: 232 participants were included, 47.0% female, mean age 64.0 (±5.5) years. 80.2% adhered to resistance training and 51.3% adhered to a hypocaloric diet. Older age (Beta 0.41; 95% CI 0.05, 0.78; p = 0.028) and male sex (Beta 7.7; 95% CI 3.6, 11; p < 0.001) were associated with higher resistance training adherence. A higher BMI at baseline (Beta 6.4; 95% CI 3.6, 9.2; p < 0.001) and male sex (Beta 65; 95% CI 41, 88; p < 0.001) were associated with higher adherence to hypocaloric diet.nnCONCLUSION: We identified several associated factors (sex, age and BMI at baseline) that should be considered to promote adherence in future lifestyle intervention studies in persons around retirement age. We recommend including behavior change techniques in lifestyle interventions and consider sex-specific interventions to improve the adherence of women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38653002,

title = {Analysis of behavioral change techniques used in exercise and nutritional interventions targeting adults around retirement age with sarcopenic obesity in a systematic review},

author = {Paula Collazo-Castiñeira and Macarena Sánchez-Izquierdo and Lea Joanne Reiter and Silvia Bauer and Alfonso J Cruz-Jentoft and Josje D Schoufour and Peter J M Weijs and Doris Eglseer},

doi = {10.1016/j.archger.2024.105437},

issn = {1872-6976},

year  = {2024},

date = {2024-08-01},

journal = {Arch Gerontol Geriatr},

volume = {123},

pages = {105437},

abstract = {BACKGROUND: Sarcopenic obesity significantly burdens health and autonomy. Strategies to intervene in or prevent sarcopenic obesity generally focus on losing body fat and building or maintaining muscle mass and function. For a lifestyle intervention, it is important to consider psychological aspects such as behavioral change techniques (BCTs) to elicit a long-lasting behavioral change.nnPURPOSE: The study was carried out to analyze BCTs used in exercise and nutritional interventions targeting community-dwelling adults around retirement age with sarcopenic obesity.nnMETHODS: We conducted an analysis of articles cited in an existing systematic review on the effectiveness of exercise and nutritional interventions on physiological outcomes in community-dwelling adults around retirement age with sarcopenic obesity. We identified BCTs used in these studies by applying a standardized taxonomy.nnRESULTS: Only nine BCTs were identified. Most BCTs were not used intentionally (82 %), and those used derived from the implementation of lifestyle components, such as exercise classes ("instructions on how to perform a behavior," "demonstration of the behavior," "behavioral practice/rehearsal," and "body changes"). Only two studies used BCTs intentionally to reinforce adherence in their interventions.nnCONCLUSIONS: Few studies integrated BCTs in lifestyle interventions for community-dwelling persons around retirement age with sarcopenic obesity. Future studies on interventions to counteract sarcopenic obesity should include well-established BCTs to foster adherence and, therefore, their effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39153816,

title = {Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands},

author = {Julia L M Bels and Steven Thiessen and Rob J J van Gassel and Albertus Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H van Zanten and Laura Bormans-Russell and Bas C T van Bussel and Marlies M J Dictus and Tom Fivez and Ingeborg Harks and Iwan C C van der Horst and Joop Jonckheer and Hugues Marechal and Paul B Massion and Ingrid Meex and Michelle C Paulus and Martin Rinket and Susanne van Santen and Katrien Tartaglia and Adam M Deane and Frieda Demuydt and Zudin Puthucheary and Lilian C M Vloet and Peter J M Weijs and Sander M J van Kuijk and Marcel C G van de Poll and Dieter Mesotten and },

doi = {10.1016/S0140-6736(24)01304-7},

issn = {1474-547X},

year  = {2024},

date = {2024-08-01},

journal = {Lancet},

volume = {404},

number = {10453},

pages = {659--669},

abstract = {BACKGROUND: Increased protein provision might ameliorate muscle wasting and improve long-term outcomes in critically ill patients. The aim of the PRECISe trial was to assess whether higher enteral protein provision (ie, 2·0 g/kg per day) would improve health-related quality of life and functional outcomes in critically ill patients who were mechanically ventilated compared with standard enteral protein provision (ie, 1·3 g/kg per day).nnMETHODS: The PRECISe trial was an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in five Dutch hospitals and five Belgian hospitals. Inclusion criteria were initiation of invasive mechanical ventilation within 24 h of intensive care unit (ICU) admission and an expected duration of invasive ventilation of 3 days or longer. Exclusion criteria were contraindications for enteral nutrition, moribund condition, BMI less than 18 kg/m, kidney failure with a no dialysis code, or hepatic encephalopathy. Patients were randomly assigned to one of four randomisation labels, corresponding with two study groups (ie, standard or high protein; two labels per group) in a 1:1:1:1 ratio through an interactive web-response system. Randomisation was done via random permuted-block randomisation in varying block sizes of eight and 12, stratified by centre. Participants, care providers, investigators, outcome assessors, data analysts, and the independent data safety monitoring board were all blinded to group allocation. Patients received isocaloric enteral feeds that contained 1·3 kcal/mL and 0·06 g of protein/mL (ie, standard protein) or 1·3 kcal/mL and 0·10 g of protein/mL (ie, high protein). The study-nutrition intervention was limited to the time period during the patient's ICU stay in which they required enteral feeding, with a maximum of 90 days. The primary outcome was EuroQoL 5-Dimension 5-level (EQ-5D-5L) health utility score at 30 days, 90 days, and 180 days after randomisation, adjusted for baseline EQ-5D-5L health utility score. This trial was registered with ClinicalTrials.gov (NCT04633421) and is closed to new participants.nnFINDINGS: Between Nov 19, 2020, and April 14, 2023, 935 patients were randomly assigned. 335 (35·8%) of 935 patients were female and 600 (64·2%) were male. 465 (49·7%) of 935 were assigned to the standard protein group and 470 (50·3%) were assigned to the high protein group. 430 (92·5%) of 465 patients in the standard protein group and 419 (89·1%) of 470 patients in the high protein group were assessed for the primary outcome. The primary outcome, EQ-5D-5L health utility score during 180 days after randomisation (assessed at 30 days, 90 days, and 180 days), was lower in patients allocated to the high protein group than in those allocated to the standard protein group, with a mean difference of -0·05 (95% CI -0·10 to -0·01; p=0·031). Regarding safety outcomes, the probability of mortality during the entire follow-up was 0·38 (SE 0·02) in the standard protein group and 0·42 (0·02) in the high protein group (hazard ratio 1·14, 95% CI 0·92 to 1·40; p=0·22). There was a higher incidence of symptoms of gastrointestinal intolerance in patients in the high protein group (odds ratio 1·76, 95% CI 1·06 to 2·92; p=0·030). Incidence of other adverse events did not differ between groups.nnINTERPRETATION: High enteral protein provision compared with standard enteral protein provision resulted in worse health-related quality of life in critically ill patients and did not improve functional outcomes during 180 days after ICU admission.nnFUNDING: Netherlands Organisation for Healthcare Research and Development and Belgian Health Care Knowledge Centre.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Memelink2024-rrb,

title = {The effect of a combined lifestyle intervention with and without 

 protein drink on inflammation in older adults with obesity and 

 type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J Bos Kuil and Suzan Wopereis and Johan Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

year  = {2024},

date = {2024-06-01},

journal = {Exp. Gerontol.},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one 

 of the pathways involved in type 2 diabetes (T2D). Currently, 

 there is limited evidence for ameliorating effects of combined 

 lifestyle interventions on CLIP in type 2 diabetes. We 

 investigated whether a 13-week combined lifestyle intervention, 

 using hypocaloric diet and resistance exercise plus 

 high-intensity interval training with or without consumption of a 

 protein drink, affected CLIP in older adults with T2D. METHODS: 

 In this post-hoc analysis of the PROBE study 114 adults ($geq$55 

 years) with obesity and type 2 (pre-)diabetes had measurements of 

 C-reactive protein (CRP), pro-inflammatory cytokines interleukin 

 (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte 

 chemoattractant protein (MCP)-1, anti-inflammatory cytokines 

 IL-10, IL-1 receptor antagonist (RA), and soluble 

 tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and 

 adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) 

 and soluble receptor for advanced glycation end products (sRAGE) 

 from fasting blood samples. A linear mixed model was used to 

 evaluate change in inflammatory biomarkers after lifestyle 

 intervention and effect of the protein drink. Linear regression 

 analysis was performed with parameters of body composition (by 

 dual-energy X-ray absorptiometry) and parameters of insulin 

 resistance (by oral glucose tolerance test). RESULTS: There were 

 no significant differences in CLIP responses between the protein 

 and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 

 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP 

 increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pinel2024-hkb,

title = {Identification of factors associated with sarcopenic obesity 

 development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and Peter J M Weijs and Y Boirie},

year  = {2024},

date = {2024-06-01},

journal = {Clin. Nutr.},

volume = {43},

number = {6},

pages = {1414–1424},

publisher = {Elsevier BV},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess 

 fat mass (obesity) and low skeletal muscle mass and function 

 (sarcopenia). The identification and classification of factors 

 related to SO would favor better prevention and diagnosis. The 

 present article aimed to (i) define a list of factors related 

 with SO based on literature analysis, (ii) identify clinical 

 conditions linked with SO development from literature search and 

 (iii) evaluate their relevance and the potential research gaps 

 by consulting an expert panel. From 4746 articles screened, 240 

 articles were selected for extraction of the factors associated 

 with SO. Factors were classified according to their frequency in 

 the literature. Clinical conditions were also recorded. Then, 

 they were evaluated by a panel of expert for evaluation of their 

 relevance in SO development. Experts also suggested additional 

 factors. Thirty-nine unique factors were extracted from the 

 papers and additional eleven factors suggested by a panel of 

 experts in the SO field. The frequency in the literature showed 

 insulin resistance, dyslipidemia, lack of exercise training, 

 inflammation and hypertension as the most frequent factors 

 associated with SO whereas experts ranked low spontaneous 

 physical activity, protein and energy intakes, low exercise 

 training and aging as the most important. Although literature 

 and expert panel presented some differences, this first list of 

 associated factors could help to identify patients at risk of 

 SO. Further work is needed to confirm the contribution of 

 factors associated with SO among the population overtime or in 

 randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Memelink2024-rr,

title = {The effect of a combined lifestyle intervention with and without 

 protein drink on inflammation in older adults with obesity and 

 type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J Bos Kuil and Suzan Wopereis and Johan Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

year  = {2024},

date = {2024-06-01},

journal = {Exp. Gerontol.},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one 

 of the pathways involved in type 2 diabetes (T2D). Currently, 

 there is limited evidence for ameliorating effects of combined 

 lifestyle interventions on CLIP in type 2 diabetes. We 

 investigated whether a 13-week combined lifestyle intervention, 

 using hypocaloric diet and resistance exercise plus 

 high-intensity interval training with or without consumption of a 

 protein drink, affected CLIP in older adults with T2D. METHODS: 

 In this post-hoc analysis of the PROBE study 114 adults ($geq$55 

 years) with obesity and type 2 (pre-)diabetes had measurements of 

 C-reactive protein (CRP), pro-inflammatory cytokines interleukin 

 (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte 

 chemoattractant protein (MCP)-1, anti-inflammatory cytokines 

 IL-10, IL-1 receptor antagonist (RA), and soluble 

 tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and 

 adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) 

 and soluble receptor for advanced glycation end products (sRAGE) 

 from fasting blood samples. A linear mixed model was used to 

 evaluate change in inflammatory biomarkers after lifestyle 

 intervention and effect of the protein drink. Linear regression 

 analysis was performed with parameters of body composition (by 

 dual-energy X-ray absorptiometry) and parameters of insulin 

 resistance (by oral glucose tolerance test). RESULTS: There were 

 no significant differences in CLIP responses between the protein 

 and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 

 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP 

 increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pinel2024-hk,

title = {Identification of factors associated with sarcopenic obesity 

 development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and Peter J M Weijs and Y Boirie},

year  = {2024},

date = {2024-06-01},

journal = {Clin. Nutr.},

volume = {43},

number = {6},

pages = {1414–1424},

publisher = {Elsevier BV},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess 

 fat mass (obesity) and low skeletal muscle mass and function 

 (sarcopenia). The identification and classification of factors 

 related to SO would favor better prevention and diagnosis. The 

 present article aimed to (i) define a list of factors related 

 with SO based on literature analysis, (ii) identify clinical 

 conditions linked with SO development from literature search and 

 (iii) evaluate their relevance and the potential research gaps 

 by consulting an expert panel. From 4746 articles screened, 240 

 articles were selected for extraction of the factors associated 

 with SO. Factors were classified according to their frequency in 

 the literature. Clinical conditions were also recorded. Then, 

 they were evaluated by a panel of expert for evaluation of their 

 relevance in SO development. Experts also suggested additional 

 factors. Thirty-nine unique factors were extracted from the 

 papers and additional eleven factors suggested by a panel of 

 experts in the SO field. The frequency in the literature showed 

 insulin resistance, dyslipidemia, lack of exercise training, 

 inflammation and hypertension as the most frequent factors 

 associated with SO whereas experts ranked low spontaneous 

 physical activity, protein and energy intakes, low exercise 

 training and aging as the most important. Although literature 

 and expert panel presented some differences, this first list of 

 associated factors could help to identify patients at risk of 

 SO. Further work is needed to confirm the contribution of 

 factors associated with SO among the population overtime or in 

 randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38527636c,

title = {The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J de Bos Kuil and Suzan Wopereis and Johan de Vogel-van den Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

doi = {10.1016/j.exger.2024.112410},

issn = {1873-6815},

year  = {2024},

date = {2024-06-01},

journal = {Exp Gerontol},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D.nnMETHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples. A linear mixed model was used to evaluate change in inflammatory biomarkers after lifestyle intervention and effect of the protein drink. Linear regression analysis was performed with parameters of body composition (by dual-energy X-ray absorptiometry) and parameters of insulin resistance (by oral glucose tolerance test).nnRESULTS: There were no significant differences in CLIP responses between the protein and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP increased by 12 % in participants with low to average CLIP (pre 1.91 ± 0.39 mg/L, post 2.13 ± 1.16 mg/L, p = 0.006) and decreased by 36 % in those with high CLIP (pre 5.14 mg/L ± 1.20, post 3.30 ± 2.29 mg/L, p < 0.001). Change in leptin and IL-1RA was positively associated with change in fat mass (β = 0.133, p < 0.001; β = 0.017, p < 0.001) and insulin resistance (β = 0.095, p = 0.024; β = 0.020, p = 0.001). Change in lean mass was not associated with any of the biomarkers.nnCONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38701709c,

title = {Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and P J M Weijs and Y Boirie},

doi = {10.1016/j.clnu.2024.04.033},

issn = {1532-1983},

year  = {2024},

date = {2024-06-01},

journal = {Clin Nutr},

volume = {43},

number = {6},

pages = {1414--1424},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38701709,

title = {Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and P J M Weijs and Y Boirie},

doi = {10.1016/j.clnu.2024.04.033},

issn = {1532-1983},

year  = {2024},

date = {2024-06-01},

journal = {Clin Nutr},

volume = {43},

number = {6},

pages = {1414--1424},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38527636,

title = {The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J de Bos Kuil and Suzan Wopereis and Johan de Vogel-van den Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

doi = {10.1016/j.exger.2024.112410},

issn = {1873-6815},

year  = {2024},

date = {2024-06-01},

journal = {Exp Gerontol},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D.nnMETHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples. A linear mixed model was used to evaluate change in inflammatory biomarkers after lifestyle intervention and effect of the protein drink. Linear regression analysis was performed with parameters of body composition (by dual-energy X-ray absorptiometry) and parameters of insulin resistance (by oral glucose tolerance test).nnRESULTS: There were no significant differences in CLIP responses between the protein and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP increased by 12 % in participants with low to average CLIP (pre 1.91 ± 0.39 mg/L, post 2.13 ± 1.16 mg/L, p = 0.006) and decreased by 36 % in those with high CLIP (pre 5.14 mg/L ± 1.20, post 3.30 ± 2.29 mg/L, p < 0.001). Change in leptin and IL-1RA was positively associated with change in fat mass (β = 0.133, p < 0.001; β = 0.017, p < 0.001) and insulin resistance (β = 0.095, p = 0.024; β = 0.020, p = 0.001). Change in lean mass was not associated with any of the biomarkers.nnCONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hoevenaars2024-adb,

title = {Lifestyle and health changes in wheelchair users with a chronic 

 disability after 12 weeks of using the WHEELS mHealth 

 application},

author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},

year  = {2024},

date = {2024-04-01},

journal = {Disabil. Rehabil. Assist. Technol.},

volume = {19},

number = {3},

pages = {648–657},

abstract = {PURPOSE: The aim of this study was to determine changes in 

 physical activity, nutrition, sleep behaviour and body 

 composition in wheelchair users with a chronic disability after 

 12 weeks of using the WHEELS mHealth application (app). METHODS: 

 A 12-week pre-post intervention study was performed, starting 

 with a 1-week control period. Physical activity and sleep 

 behaviour were continuously measured with a Fitbit charge 3. 

 Self-reported nutritional intake, body mass and waist 

 circumference were collected. Pre-post outcomes were compared 

 with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit 

 data were analysed with a mixed model or a panel linear model. 

 Effect sizes were determined and significance was accepted at p < 

 .05. RESULTS: Thirty participants completed the study. No 

 significant changes in physical activity (+1.5 $surd$steps) and 

 sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Ruijven2024-stb,

title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as 

 beneficially high protein provision in critically ill patients},

author = {Isabel M Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},

year  = {2024},

date = {2024-04-01},

journal = {Clin. Nutr.},

volume = {43},

number = {4},

pages = {1077–1078},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hoevenaars2024-ad,

title = {Lifestyle and health changes in wheelchair users with a chronic 

 disability after 12 weeks of using the WHEELS mHealth 

 application},

author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},

year  = {2024},

date = {2024-04-01},

journal = {Disabil. Rehabil. Assist. Technol.},

volume = {19},

number = {3},

pages = {648–657},

abstract = {PURPOSE: The aim of this study was to determine changes in 

 physical activity, nutrition, sleep behaviour and body 

 composition in wheelchair users with a chronic disability after 

 12 weeks of using the WHEELS mHealth application (app). METHODS: 

 A 12-week pre-post intervention study was performed, starting 

 with a 1-week control period. Physical activity and sleep 

 behaviour were continuously measured with a Fitbit charge 3. 

 Self-reported nutritional intake, body mass and waist 

 circumference were collected. Pre-post outcomes were compared 

 with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit 

 data were analysed with a mixed model or a panel linear model. 

 Effect sizes were determined and significance was accepted at p < 

 .05. RESULTS: Thirty participants completed the study. No 

 significant changes in physical activity (+1.5 $surd$steps) and 

 sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Ruijven2024-st,

title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as 

 beneficially high protein provision in critically ill patients},

author = {Isabel M Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},

year  = {2024},

date = {2024-04-01},

journal = {Clin. Nutr.},

volume = {43},

number = {4},

pages = {1077–1078},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36165036,

title = {Lifestyle and health changes in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application},

author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja de Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},

doi = {10.1080/17483107.2022.2115563},

issn = {1748-3115},

year  = {2024},

date = {2024-04-01},

journal = {Disabil Rehabil Assist Technol},

volume = {19},

number = {3},

pages = {648--657},

abstract = {PURPOSE: The aim of this study was to determine changes in physical activity, nutrition, sleep behaviour and body composition in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application (app).nnMETHODS: A 12-week pre-post intervention study was performed, starting with a 1-week control period. Physical activity and sleep behaviour were continuously measured with a Fitbit charge 3. Self-reported nutritional intake, body mass and waist circumference were collected. Pre-post outcomes were compared with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit data were analysed with a mixed model or a panel linear model. Effect sizes were determined and significance was accepted at  < .05.nnRESULTS: Thirty participants completed the study. No significant changes in physical activity (+1.5 √steps) and sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 kJ,  = 0.71), protein (-8.3 g,  = 0.61) and fat (-13.1 g,  = 0.87) intake, body mass (-2.2 kg,  = 0.61) and waist circumference (-3.3 cm,  = 0.80) were found.nnCONCLUSION: Positive changes were found in nutritional behaviour and body composition, but not in physical activity and sleep quality. The WHEELS app seems to partly support healthy lifestyle behaviour.Implications for RehabilitationHealthy lifestyle promotion is crucial, especially for wheelchair users as they tend to show poorer lifestyle behaviour despite an increased risk of obesity and comorbidity.The WHEELS lifestyle app seems to be a valuable tool to support healthy nutrition choices and weight loss and to improve body satisfaction, mental health and vitality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Benz2024-onb,

title = {Sarcopenia and sarcopenic obesity and mortality among older 

 people},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw. Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {Importance: Sarcopenia and obesity are 2 global concerns 

 associated with adverse health outcomes in older people. Evidence 

 on the population-based prevalence of the combination of 

 sarcopenia with obesity (sarcopenic obesity [SO]) and its 

 association with mortality are still limited. Objective: To 

 investigate the prevalence of sarcopenia and SO and their 

 association with all-cause mortality. Design, Setting, and 

 Participants: This large-scale, population-based cohort study 

 assessed participants from the Rotterdam Study from March 1, 

 2009, to June 1, 2014. Associations of sarcopenia and SO with 

 all-cause mortality were studied using Kaplan-Meier curves, Cox 

 proportional hazards regression, and accelerated failure time 

 models fitted for sex, age, and body mass index (BMI). Data 

 analysis was performed from January 1 to April 1, 2023. 

 Exposures: The prevalence of sarcopenia and SO, measured based on 

 handgrip strength and body composition (BC) (dual-energy x-ray 

 absorptiometry) as recommended by current consensus criteria, 

 with probable sarcopenia defined as having low handgrip strength 

 and confirmed sarcopenia and SO defined as altered BC (high fat 

 percentage and/or low appendicular skeletal muscle index) in 

 addition to low handgrip strength. Main Outcome and Measure: The 

 primary outcome was all-cause mortality, collected using linked 

 mortality data from general practitioners and the central 

 municipal records, until October 2022. Results: In the total 

 population of 5888 participants (mean [SD] age, 69.5 [9.1] years; 

 mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 

 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 

 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic 

 obesity with 1 altered component of BC was present in 295 

 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered 

 components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An 

 increased risk of all-cause mortality was observed in 

 participants with probable sarcopenia (hazard ratio [HR], 1.29; 

 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 

 1.53-2.43). Participants with SO plus 1 altered component of BC 

 (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC 

 (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality 

 than those without SO. Similar results for SO were obtained for 

 participants with a BMI of 27 or greater. Conclusions and 

 Relevance: In this study, sarcopenia and SO were found to be 

 prevalent phenotypes in older people and were associated with 

 all-cause mortality. Additional alterations of BC amplified this 

 risk independently of age, sex, and BMI. The use of low muscle 

 strength as a first step of both diagnoses may allow for early 

 identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Benz2024-on,

title = {Sarcopenia and sarcopenic obesity and mortality among older 

 people},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw. Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {Importance: Sarcopenia and obesity are 2 global concerns 

 associated with adverse health outcomes in older people. Evidence 

 on the population-based prevalence of the combination of 

 sarcopenia with obesity (sarcopenic obesity [SO]) and its 

 association with mortality are still limited. Objective: To 

 investigate the prevalence of sarcopenia and SO and their 

 association with all-cause mortality. Design, Setting, and 

 Participants: This large-scale, population-based cohort study 

 assessed participants from the Rotterdam Study from March 1, 

 2009, to June 1, 2014. Associations of sarcopenia and SO with 

 all-cause mortality were studied using Kaplan-Meier curves, Cox 

 proportional hazards regression, and accelerated failure time 

 models fitted for sex, age, and body mass index (BMI). Data 

 analysis was performed from January 1 to April 1, 2023. 

 Exposures: The prevalence of sarcopenia and SO, measured based on 

 handgrip strength and body composition (BC) (dual-energy x-ray 

 absorptiometry) as recommended by current consensus criteria, 

 with probable sarcopenia defined as having low handgrip strength 

 and confirmed sarcopenia and SO defined as altered BC (high fat 

 percentage and/or low appendicular skeletal muscle index) in 

 addition to low handgrip strength. Main Outcome and Measure: The 

 primary outcome was all-cause mortality, collected using linked 

 mortality data from general practitioners and the central 

 municipal records, until October 2022. Results: In the total 

 population of 5888 participants (mean [SD] age, 69.5 [9.1] years; 

 mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 

 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 

 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic 

 obesity with 1 altered component of BC was present in 295 

 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered 

 components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An 

 increased risk of all-cause mortality was observed in 

 participants with probable sarcopenia (hazard ratio [HR], 1.29; 

 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 

 1.53-2.43). Participants with SO plus 1 altered component of BC 

 (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC 

 (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality 

 than those without SO. Similar results for SO were obtained for 

 participants with a BMI of 27 or greater. Conclusions and 

 Relevance: In this study, sarcopenia and SO were found to be 

 prevalent phenotypes in older people and were associated with 

 all-cause mortality. Additional alterations of BC amplified this 

 risk independently of age, sex, and BMI. The use of low muscle 

 strength as a first step of both diagnoses may allow for early 

 identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38526491c,

title = {Sarcopenia and Sarcopenic Obesity and Mortality Among Older People},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

doi = {10.1001/jamanetworkopen.2024.3604},

issn = {2574-3805},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38526491,

title = {Sarcopenia and Sarcopenic Obesity and Mortality Among Older People},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

doi = {10.1001/jamanetworkopen.2024.3604},

issn = {2574-3805},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wagenaar2024-fub,

title = {Long-term effectiveness of a lifestyle intervention for 

 rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 

 'Plants for Joints' randomised clinical trial},

author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin Esch and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

pages = {e004025},

publisher = {BMJ},

abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for 

 Joints (PFJ) multidisciplinary lifestyle intervention reduced 

 signs and symptoms of rheumatoid arthritis (RA), or metabolic 

 syndrome-associated hip or knee osteoarthritis (MSOA) compared 

 with usual care. The current study investigated long-term 

 outcomes. METHODS: After completion of two 16-week trials in 

 people with (1) RA or (2) MSOA, control groups switched to the 

 active PFJ intervention. At the end of the intervention, all 

 participants were followed up in a 1-year observational 

 extension study. Primary outcomes were 28-joint Disease Activity 

 Score (DAS28) (RA) and Western Ontario and McMaster Universities 

 Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included 

 body composition, metabolic outcomes, medication changes and 

 intervention adherence. An intention-to-treat analysis with a 

 linear mixed model was used to analyse within-group changes. 

 RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 

 MSOA participants completed the extension study. The effects of 

 the PFJ intervention were replicated in the original control 

 groups and sustained within the RA group a year after 

 intervention completion (mean DAS28 -0.9 points; p<0.001), while 

 in the MSOA group mean WOMAC increased towards but remained well 

 under the starting value (-7.8 points, p<0.001). Improvements in 

 C-reactive protein, waist circumference (RA and MSOA); 

 low-density lipoprotein cholesterol (RA); and weight, 

 haemoglobin A1c, blood pressure (MSOA) were also sustained. 

 Participants had a net decrease of medication, and intervention 

 adherence was largely sustained. CONCLUSIONS: A year after the 

 PFJ lifestyle intervention, improvements of disease activity and 

 metabolic outcomes within RA and MSOA groups were largely 

 sustained and related to sustained adherence, with a net 

 decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800, 

 NL7801.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wagenaar2024-fu,

title = {Long-term effectiveness of a lifestyle intervention for 

 rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 

 'Plants for Joints' randomised clinical trial},

author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin Esch and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

pages = {e004025},

publisher = {BMJ},

abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for 

 Joints (PFJ) multidisciplinary lifestyle intervention reduced 

 signs and symptoms of rheumatoid arthritis (RA), or metabolic 

 syndrome-associated hip or knee osteoarthritis (MSOA) compared 

 with usual care. The current study investigated long-term 

 outcomes. METHODS: After completion of two 16-week trials in 

 people with (1) RA or (2) MSOA, control groups switched to the 

 active PFJ intervention. At the end of the intervention, all 

 participants were followed up in a 1-year observational 

 extension study. Primary outcomes were 28-joint Disease Activity 

 Score (DAS28) (RA) and Western Ontario and McMaster Universities 

 Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included 

 body composition, metabolic outcomes, medication changes and 

 intervention adherence. An intention-to-treat analysis with a 

 linear mixed model was used to analyse within-group changes. 

 RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 

 MSOA participants completed the extension study. The effects of 

 the PFJ intervention were replicated in the original control 

 groups and sustained within the RA group a year after 

 intervention completion (mean DAS28 -0.9 points; p<0.001), while 

 in the MSOA group mean WOMAC increased towards but remained well 

 under the starting value (-7.8 points, p<0.001). Improvements in 

 C-reactive protein, waist circumference (RA and MSOA); 

 low-density lipoprotein cholesterol (RA); and weight, 

 haemoglobin A1c, blood pressure (MSOA) were also sustained. 

 Participants had a net decrease of medication, and intervention 

 adherence was largely sustained. CONCLUSIONS: A year after the 

 PFJ lifestyle intervention, improvements of disease activity and 

 metabolic outcomes within RA and MSOA groups were largely 

 sustained and related to sustained adherence, with a net 

 decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800, 

 NL7801.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38413171,

title = {Long-term effectiveness of a lifestyle intervention for rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 'Plants for Joints' randomised clinical trial},

author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike van der Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin van der Esch and Henriët van Middendorp and Peter J M Weijs and Dirkjan van Schaardenburg},

doi = {10.1136/rmdopen-2023-004025},

issn = {2056-5933},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. The current study investigated long-term outcomes.nnMETHODS: After completion of two 16-week trials in people with (1) RA or (2) MSOA, control groups switched to the active PFJ intervention. At the end of the intervention, all participants were followed up in a 1-year observational extension study. Primary outcomes were 28-joint Disease Activity Score (DAS28) (RA) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included body composition, metabolic outcomes, medication changes and intervention adherence. An intention-to-treat analysis with a linear mixed model was used to analyse within-group changes.nnRESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 MSOA participants completed the extension study. The effects of the PFJ intervention were replicated in the original control groups and sustained within the RA group a year after intervention completion (mean DAS28 -0.9 points; p<0.001), while in the MSOA group mean WOMAC increased towards but remained well under the starting value (-7.8 points, p<0.001). Improvements in C-reactive protein, waist circumference (RA and MSOA); low-density lipoprotein cholesterol (RA); and weight, haemoglobin A1c, blood pressure (MSOA) were also sustained. Participants had a net decrease of medication, and intervention adherence was largely sustained.nnCONCLUSIONS: A year after the PFJ lifestyle intervention, improvements of disease activity and metabolic outcomes within RA and MSOA groups were largely sustained and related to sustained adherence, with a net decrease of medication.nnTRIAL REGISTRATION NUMBERS: NL7800, NL7801.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{De_Geus2024-ilb,

title = {The impact of combined nutrition and exercise interventions in 

 patients with chronic kidney disease},

author = {Manon Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},

year  = {2024},

date = {2024-01-01},

journal = {Nutrients},

volume = {16},

number = {3},

abstract = {Combined nutrition and exercise interventions potentially improve 

 protein-energy wasting/malnutrition-related outcomes in patients 

 with chronic kidney disease (CKD). The aim was to systematically 

 review the effect of combined interventions on nutritional 

 status, muscle strength, physical performance and QoL. MEDLINE, 

 Cochrane, Embase, Web of Science and Google Scholar were searched 

 for studies up to the date of July 2023. Methodological quality 

 was appraised with the Cochrane risk-of-bias tool. Ten randomized 

 controlled trials (nine publications) were included (334 

 patients). No differences were observed in body mass index, lean 

 body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{De_Geus2024-il,

title = {The impact of combined nutrition and exercise interventions in 

 patients with chronic kidney disease},

author = {Manon Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},

year  = {2024},

date = {2024-01-01},

journal = {Nutrients},

volume = {16},

number = {3},

abstract = {Combined nutrition and exercise interventions potentially improve 

 protein-energy wasting/malnutrition-related outcomes in patients 

 with chronic kidney disease (CKD). The aim was to systematically 

 review the effect of combined interventions on nutritional 

 status, muscle strength, physical performance and QoL. MEDLINE, 

 Cochrane, Embase, Web of Science and Google Scholar were searched 

 for studies up to the date of July 2023. Methodological quality 

 was appraised with the Cochrane risk-of-bias tool. Ten randomized 

 controlled trials (nine publications) were included (334 

 patients). No differences were observed in body mass index, lean 

 body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48},

keywords = {},

pubstate = {published},

tppubtype = {article}

}