
Prof.dr.ir. Peter J.M. Weijs
Lector en Bijzonder Hoogleraar Voeding en Beweging
- Group:2EAT, IMPACT, Lectoraat Voeding & Bewegen
Prof.dr.ir. Peter J.M. Weijs
Lector en Bijzonder Hoogleraar Voeding en Beweging

Peter Weijs is lector en bijzonder hoogleraar Voeding en Beweging. Peter begon in 1994 als docent Voeding bij de HvA. In 2024 is hij 30 jaar verbonden aan de opleiding Voeding & Dietetiek en bestaat het lectoraat 15 jaar.
Gezonde voeding en voldoende beweging vormen een belangrijke rol bij het gezond opgroeien en bij het gezond ouder worden. Zowel bij het voorkomen van ziekte als bij het herstel van ziekte. Het lectoraat/leerstoel Voeding en Beweging richt zich op het optimaliseren en behouden van een gezonde leefstijl bij diverse kwetsbare doelgroepen. Hiervoor worden voeding & beweging interventies ontwikkeld en getest voor het behoud en herstel van dagelijks functioneren en gezondheid. Dit op basis van expertise op het gebied van overgewicht & obesitas, sarcopenie, sarcopene obesitas, het meten van lichaamssamenstelling en energieverbruik, eiwitbehoefte en eiwitkwaliteit.
In 1986 behaalde Peter zijn MSc bij Humane Voeding aan de Wageningen Universiteit, op basis van onderzoek naar energiehuishouding en eiwitmetabolisme. In 1988 werkte hij aan de University of Texas Medical Branch. In 1993 behaalde hij zijn PhD aan de Wageningen Universiteit op basis van onderzoek naar bepalende factoren voor eiwitbehoefte. In 1993-1994 werkte Peter als European Commission Marie Curie Fellow aan het Rowett Research Institute in Aberdeen. In 1994 kwam Peter als docent werken bij de opleiding Voeding en Dietetiek van de HvA. Hij was o.a. 10 jaar afstudeercoordinator. Vanaf 2004 t/m 2023 werkte hij bij Dietetiek & Voedingswetenschappen van het Amsterdam UMC, alliantie Vumc & AMC. In 2006 richtte hij het Voedingslab (zie ANAC) op. In 2009 werd hij lector en in 2018 hoogleraar.
Peter is lid van de directie van het Center of Expertise Urban Vitality en themaleider van het thema Mensen in Beweging. De onderzoeksgroep Mensen in Beweging is ontstaan uit het SIA-SPRONG project Mensen in Beweging, waarin gezocht wordt naar optimale combinaties van voeding, beweging en technologie om te komen tot duurzame gedragsbeïnvloeding en behoud van gezondheid en vitaliteit. Internationaal is hij actief binnen het Sarcopenic Obesity Global Leadership Initiative (SOGLI).
Peter geeft leiding aan zowel een lectoraat met een omvang van 12 fte, waaronder 6 postdocs en 16 promovendi, het thema MiB als de bijzondere leerstoel bij de VU.
Bekijk de publicaties van Peter Weijs of bezoek zijn volledige research profiel.
2011
Weijs, Peter J M
Hypermetabolism, is it real? The example of amyotrophic lateral sclerosis Diversen
2011, ISSN: 1878-3570.
@misc{pmid22027048,
title = {Hypermetabolism, is it real? The example of amyotrophic lateral sclerosis},
author = {Peter J M Weijs},
doi = {10.1016/j.jada.2011.08.011},
issn = {1878-3570},
year = {2011},
date = {2011-11-01},
journal = {J Am Diet Assoc},
volume = {111},
number = {11},
pages = {1670--1673},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
Wierdsma, Nicolette J; Peters, Job H C; Weijs, Peter J M; Keur, Martjin B; Girbes, Armand R J; Bodegraven, Ad A; Beishuizen, Albertus
Malabsorption and nutritional balance in the ICU: fecal weight
as a biomarker: a prospective observational pilot study Tijdschriftartikel
In: Crit. Care, vol. 15, nr. 6, pp. R264, 2011.
@article{Wierdsma2011-be,
title = {Malabsorption and nutritional balance in the ICU: fecal weight
as a biomarker: a prospective observational pilot study},
author = {Nicolette J Wierdsma and Job H C Peters and Peter J M Weijs and Martjin B Keur and Armand R J Girbes and Ad A Bodegraven and Albertus Beishuizen},
year = {2011},
date = {2011-11-01},
journal = {Crit. Care},
volume = {15},
number = {6},
pages = {R264},
publisher = {Springer Nature},
abstract = {INTRODUCTION: Malabsorption, which is frequently underdiagnosed
in critically ill patients, is clinically relevant with regard
to nutritional balance and nutritional management. We aimed to
validate the diagnostic accuracy of fecal weight as a biomarker
for fecal loss and additionally to assess fecal macronutrient
contents and intestinal absorption capacity in ICU patients.
METHODS: This was an observational pilot study in a tertiary
mixed medical-surgical ICU in hemodynamically stable adult ICU
patients, without clinically evident gastrointestinal
malfunction. Fecal weight (grams/day), fecal energy (by bomb
calorimetry in kcal/day), and macronutrient content (fat,
protein, and carbohydrate in grams/day) were measured.
Diagnostic accuracy expressed in terms of test sensitivity,
specificity, positive (PPV) and negative predictive value (NPV),
and receiver operator curves (ROCs) were calculated for fecal
weight as a marker for energy malabsorption. Malabsorption was a
priori defined as 350 g/day (that is, diarrhea) was linked to
the optimal ROC (0.879), showing a sensitivity and PPV of 80%,
respectively. Specificity and NPV were both 96%. Fecal weight
(grams/day) and intestinal energy-absorption capacity were inversely correlated (r = -0.69; P 350 g feces/day had a
significantly more-negative energy balance compared with
patients with 350 g/day in ICU patients is a biomarker
applicable in daily practice, which can act as a surrogate for
fecal energy loss and intestinal energy absorption. Daily
measurement of fecal weight is a feasible means of monitoring
the nutritional status of critically ill patients and, in those
identified as having malabsorption, can monitor responses to
changes in dietary management.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
in critically ill patients, is clinically relevant with regard
to nutritional balance and nutritional management. We aimed to
validate the diagnostic accuracy of fecal weight as a biomarker
for fecal loss and additionally to assess fecal macronutrient
contents and intestinal absorption capacity in ICU patients.
METHODS: This was an observational pilot study in a tertiary
mixed medical-surgical ICU in hemodynamically stable adult ICU
patients, without clinically evident gastrointestinal
malfunction. Fecal weight (grams/day), fecal energy (by bomb
calorimetry in kcal/day), and macronutrient content (fat,
protein, and carbohydrate in grams/day) were measured.
Diagnostic accuracy expressed in terms of test sensitivity,
specificity, positive (PPV) and negative predictive value (NPV),
and receiver operator curves (ROCs) were calculated for fecal
weight as a marker for energy malabsorption. Malabsorption was a
priori defined as 350 g/day (that is, diarrhea) was linked to
the optimal ROC (0.879), showing a sensitivity and PPV of 80%,
respectively. Specificity and NPV were both 96%. Fecal weight
(grams/day) and intestinal energy-absorption capacity were inversely correlated (r = -0.69; P 350 g feces/day had a
significantly more-negative energy balance compared with
patients with 350 g/day in ICU patients is a biomarker
applicable in daily practice, which can act as a surrogate for
fecal energy loss and intestinal energy absorption. Daily
measurement of fecal weight is a feasible means of monitoring
the nutritional status of critically ill patients and, in those
identified as having malabsorption, can monitor responses to
changes in dietary management.
Weijs, Peter J M
Hypermetabolism, is it real? The example of amyotrophic lateral
sclerosis Tijdschriftartikel
In: J. Am. Diet. Assoc., vol. 111, nr. 11, pp. 1670–1673, 2011.
@article{Weijs2011-um,
title = {Hypermetabolism, is it real? The example of amyotrophic lateral
sclerosis},
author = {Peter J M Weijs},
year = {2011},
date = {2011-11-01},
journal = {J. Am. Diet. Assoc.},
volume = {111},
number = {11},
pages = {1670–1673},
publisher = {Elsevier BV},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Weijs, Peter J M; Kool, Laura M; Baar, Nicolien M; Zee, Saskia C
High beverage sugar as well as high animal protein intake at
infancy may increase overweight risk at 8 years: a prospective
longitudinal pilot study Tijdschriftartikel
In: Nutr. J., vol. 10, nr. 1, pp. 95, 2011.
@article{Weijs2011-db,
title = {High beverage sugar as well as high animal protein intake at
infancy may increase overweight risk at 8 years: a prospective
longitudinal pilot study},
author = {Peter J M Weijs and Laura M Kool and Nicolien M Baar and Saskia C Zee},
year = {2011},
date = {2011-09-01},
journal = {Nutr. J.},
volume = {10},
number = {1},
pages = {95},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: Combined effects of early exposure to beverage sugar
and animal protein and later life overweight risk have not been
studied. METHODS: A prospective longitudinal study was initiated
in 2001 with 226 infants between 4 and 13 months of age. Dietary
intake was assessed with a 2 day food record. Also information
on infant body weight and socio-economic status was obtained at
baseline. At 8 year follow-up in 2009, children were surveyed
again. Main outcome measure was overweight at 8 years as defined by BMIsds > = +1.0. Also maternal BMI, present dietary intake
and physical activity, were obtained by questionnaire and 2-day
food record. RESULTS: At the 8 year follow up, 120 children
(53%) were surveyed again. Of those, questionnaires and food
records were completed for 63 children, for the other 57
children only weight and height at 8 years was available; 20 out
of 120 children (17%) were self-reported overweight at 8 years
of age. Unadjusted odds ratios (ORs; 95% CI) for overweight at
8 years were 1.10 (1.02, 1.18) for beverage sugar intake per one
percent of energy intake and 4.06 (1.50, 11.00) for the highest
tertile of animal protein intake at infancy compared to the
lowest two tertiles. After adjustment for sex, age, infant
weight, breastfed at intake assessment, and socio-economic
status, odds ratios were 1.13 (1.03, 1.24) for beverage sugar,
and 9.67 (2.56, 36.53) for highest tertile of animal protein intake. In the subgroup with completed questionnaire (n = 63)
ORs were also adjusted for current maternal overweight, more
than 2 months full breastfeeding, physical activity, and energy
intake, but ORs remained significantly associated with
overweight at 8 years. CONCLUSIONS: A high intake of sugar
containing beverages as well as animal protein in the first year
of life may increase the risk of overweight at 8 years. The
results of this pilot investigation should be confirmed in a
larger cohort.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
and animal protein and later life overweight risk have not been
studied. METHODS: A prospective longitudinal study was initiated
in 2001 with 226 infants between 4 and 13 months of age. Dietary
intake was assessed with a 2 day food record. Also information
on infant body weight and socio-economic status was obtained at
baseline. At 8 year follow-up in 2009, children were surveyed
again. Main outcome measure was overweight at 8 years as defined by BMIsds > = +1.0. Also maternal BMI, present dietary intake
and physical activity, were obtained by questionnaire and 2-day
food record. RESULTS: At the 8 year follow up, 120 children
(53%) were surveyed again. Of those, questionnaires and food
records were completed for 63 children, for the other 57
children only weight and height at 8 years was available; 20 out
of 120 children (17%) were self-reported overweight at 8 years
of age. Unadjusted odds ratios (ORs; 95% CI) for overweight at
8 years were 1.10 (1.02, 1.18) for beverage sugar intake per one
percent of energy intake and 4.06 (1.50, 11.00) for the highest
tertile of animal protein intake at infancy compared to the
lowest two tertiles. After adjustment for sex, age, infant
weight, breastfed at intake assessment, and socio-economic
status, odds ratios were 1.13 (1.03, 1.24) for beverage sugar,
and 9.67 (2.56, 36.53) for highest tertile of animal protein intake. In the subgroup with completed questionnaire (n = 63)
ORs were also adjusted for current maternal overweight, more
than 2 months full breastfeeding, physical activity, and energy
intake, but ORs remained significantly associated with
overweight at 8 years. CONCLUSIONS: A high intake of sugar
containing beverages as well as animal protein in the first year
of life may increase the risk of overweight at 8 years. The
results of this pilot investigation should be confirmed in a
larger cohort.
Leistra, Eva; Willeboordse, Floor; van Bokhorst-de van der Schueren, Marian A E; Visser, Marjolein; Weijs, Peter J M; den Oord, Annelie Haans-van; Oostenbrink, Jan; Evers, Anja M; Kruizenga, Hinke M
Predictors for achieving protein and energy requirements in undernourished hospital patients Tijdschriftartikel
In: Clin Nutr, vol. 30, nr. 4, pp. 484–489, 2011, ISSN: 1532-1983.
@article{pmid21376433,
title = {Predictors for achieving protein and energy requirements in undernourished hospital patients},
author = {Eva Leistra and Floor Willeboordse and Marian A E van Bokhorst-de van der Schueren and Marjolein Visser and Peter J M Weijs and Annelie Haans-van den Oord and Jan Oostenbrink and Anja M Evers and Hinke M Kruizenga},
doi = {10.1016/j.clnu.2011.01.008},
issn = {1532-1983},
year = {2011},
date = {2011-08-01},
journal = {Clin Nutr},
volume = {30},
number = {4},
pages = {484--489},
abstract = {BACKGROUND & AIMS: Providing sufficient protein an energy is considered crucial in the treatment of undernutrition. Still, the majority of undernourished hospital patients have a suboptimal protein and energy intake. The aim of this study was to investigate predictors for achieving protein and energy requirements on the fourth day of admission in undernourished hospitalized patients.nnMETHODS: 830 adult undernourished patients (SNAQ ≥ 3) were retrospectively included. Intake requirements were defined as ≥1.2 g protein per kg bodyweight and ≥100% of the energy requirement based on calculated resting energy expenditure according to Harris & Benedict + 30%. Logistic regression analyses were performed to investigate predictors for achieving the requirements.nnRESULTS: Protein and energy intake had been recorded for 610 patients, of whom 25.6% had sufficient protein and energy intake. Protein requirements were less commonly met than energy requirements. Complete case analyses (n = 575) showed that negative predictors for achieving the protein and energy requirements were: nausea (OR = 0.18; 95%CI = 0.06-0.53), cancer (0.57; 0.35-0.93), acute infections (0.63; 0.37-1.01) and higher BMI (0.84; 0.79-0.89). Positive predictors were: a higher age (1.01; 1.00-1.03), chronic lung disease (3.76; 2.33-6.07) and receiving tube feeding (3.89; 1.56-9.73).nnCONCLUSION: Only one in four undernourished hospital patients meets the predefined protein and energy requirements on the fourth day of admission. Nausea, cancer, acute infections, BMI, age, chronic lung disease and tube feeding were identified as predictors for achieving protein and energy intake.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Leistra, Eva; Willeboordse, Floor; Schueren, Marian A E; Visser, Marjolein; Weijs, Peter J M; den Oord, Annelie Haans-van; Oostenbrink, Jan; Evers, Anja M; Kruizenga, Hinke M
Predictors for achieving protein and energy requirements in
undernourished hospital patients Tijdschriftartikel
In: Clin. Nutr., vol. 30, nr. 4, pp. 484–489, 2011.
@article{Leistra2011-tp,
title = {Predictors for achieving protein and energy requirements in
undernourished hospital patients},
author = {Eva Leistra and Floor Willeboordse and Marian A E Schueren and Marjolein Visser and Peter J M Weijs and Annelie Haans-van den Oord and Jan Oostenbrink and Anja M Evers and Hinke M Kruizenga},
year = {2011},
date = {2011-08-01},
journal = {Clin. Nutr.},
volume = {30},
number = {4},
pages = {484–489},
publisher = {Elsevier BV},
abstract = {BACKGROUND & AIMS: Providing sufficient protein an energy is
considered crucial in the treatment of undernutrition. Still,
the majority of undernourished hospital patients have a
suboptimal protein and energy intake. The aim of this study was
to investigate predictors for achieving protein and energy
requirements on the fourth day of admission in undernourished
hospitalized patients. METHODS: 830 adult undernourished
patients (SNAQ $geq$ 3) were retrospectively included. Intake
requirements were defined as $geq$1.2 g protein per kg
bodyweight and $geq$100% of the energy requirement based on
calculated resting energy expenditure according to Harris &
Benedict + 30%. Logistic regression analyses were performed to
investigate predictors for achieving the requirements. RESULTS:
Protein and energy intake had been recorded for 610 patients, of
whom 25.6% had sufficient protein and energy intake. Protein
requirements were less commonly met than energy requirements. Complete case analyses (n = 575) showed that negative predictors
for achieving the protein and energy requirements were: nausea (OR = 0.18; 95%CI = 0.06-0.53), cancer (0.57; 0.35-0.93), acute
infections (0.63; 0.37-1.01) and higher BMI (0.84; 0.79-0.89).
Positive predictors were: a higher age (1.01; 1.00-1.03),
chronic lung disease (3.76; 2.33-6.07) and receiving tube
feeding (3.89; 1.56-9.73). CONCLUSION: Only one in four
undernourished hospital patients meets the predefined protein
and energy requirements on the fourth day of admission. Nausea,
cancer, acute infections, BMI, age, chronic lung disease and
tube feeding were identified as predictors for achieving protein
and energy intake.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
considered crucial in the treatment of undernutrition. Still,
the majority of undernourished hospital patients have a
suboptimal protein and energy intake. The aim of this study was
to investigate predictors for achieving protein and energy
requirements on the fourth day of admission in undernourished
hospitalized patients. METHODS: 830 adult undernourished
patients (SNAQ $geq$ 3) were retrospectively included. Intake
requirements were defined as $geq$1.2 g protein per kg
bodyweight and $geq$100% of the energy requirement based on
calculated resting energy expenditure according to Harris &
Benedict + 30%. Logistic regression analyses were performed to
investigate predictors for achieving the requirements. RESULTS:
Protein and energy intake had been recorded for 610 patients, of
whom 25.6% had sufficient protein and energy intake. Protein
requirements were less commonly met than energy requirements. Complete case analyses (n = 575) showed that negative predictors
for achieving the protein and energy requirements were: nausea (OR = 0.18; 95%CI = 0.06-0.53), cancer (0.57; 0.35-0.93), acute
infections (0.63; 0.37-1.01) and higher BMI (0.84; 0.79-0.89).
Positive predictors were: a higher age (1.01; 1.00-1.03),
chronic lung disease (3.76; 2.33-6.07) and receiving tube
feeding (3.89; 1.56-9.73). CONCLUSION: Only one in four
undernourished hospital patients meets the predefined protein
and energy requirements on the fourth day of admission. Nausea,
cancer, acute infections, BMI, age, chronic lung disease and
tube feeding were identified as predictors for achieving protein
and energy intake.
2010
Weijs, Peter J M; Vansant, Greet A A M
Validity of predictive equations for resting energy expenditure
in Belgian normal weight to morbid obese women Tijdschriftartikel
In: Clin. Nutr., vol. 29, nr. 3, pp. 347–351, 2010.
@article{Weijs2010-gh,
title = {Validity of predictive equations for resting energy expenditure
in Belgian normal weight to morbid obese women},
author = {Peter J M Weijs and Greet A A M Vansant},
year = {2010},
date = {2010-06-01},
journal = {Clin. Nutr.},
volume = {29},
number = {3},
pages = {347–351},
publisher = {Elsevier BV},
abstract = {BACKGROUND & AIMS: Individual energy requirements of overweight
and obese adults can often not be measured by indirect
calorimetry, mainly due to the time-consuming procedure and the
high costs. To analyze which resting energy expenditure (REE)
predictive equation is the best alternative for indirect
calorimetry in Belgian normal weight to morbid obese women.
METHODS: Predictive equations were included when based on
weight, height, gender, age, fat free mass and fat mass. REE was
measured with indirect calorimetry. Accuracy of equations was
evaluated by the percentage of subjects predicted within 10% of
REE measured, the root mean squared prediction error (RMSE) and
the mean percentage difference (bias) between predicted and
measured REE. RESULTS: Twenty-seven predictive equations (of
which 9 based on FFM) were included. Validation was based on 536
F (18-71 year). Most accurate and precise for the Belgian women
were the Huang, Siervo, Muller (FFM), Harris-Benedict (HB), and
the Mifflin equation with 71%, 71%, 70%, 69%, and 68%
accurate predictions, respectively; bias -1.7, -0.5, +1.1, +2.2,
and -1.8%, RMSE 168, 170, 163, 167, and 173kcal/d. The
equations of HB and Mifflin are most widely used in clinical
practice and both provide accurate predictions across a wide
range of BMI groups. In an already overweight group the
underpredicting Mifflin equation might be preferred. Above BMI
45kg/m(2), the Siervo equation performed best, while the
FAO/WHO/UNU or Schofield equation should not be used in this
extremely obese group. CONCLUSIONS: In Belgian women, the
original Harris-Benedict or the Mifflin equation is a reliable
tool to predict REE across a wide variety of body weight (BMI
18.5-50). Estimations for the BMI range between 30 and
40kg/m(2), however, should be improved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
and obese adults can often not be measured by indirect
calorimetry, mainly due to the time-consuming procedure and the
high costs. To analyze which resting energy expenditure (REE)
predictive equation is the best alternative for indirect
calorimetry in Belgian normal weight to morbid obese women.
METHODS: Predictive equations were included when based on
weight, height, gender, age, fat free mass and fat mass. REE was
measured with indirect calorimetry. Accuracy of equations was
evaluated by the percentage of subjects predicted within 10% of
REE measured, the root mean squared prediction error (RMSE) and
the mean percentage difference (bias) between predicted and
measured REE. RESULTS: Twenty-seven predictive equations (of
which 9 based on FFM) were included. Validation was based on 536
F (18-71 year). Most accurate and precise for the Belgian women
were the Huang, Siervo, Muller (FFM), Harris-Benedict (HB), and
the Mifflin equation with 71%, 71%, 70%, 69%, and 68%
accurate predictions, respectively; bias -1.7, -0.5, +1.1, +2.2,
and -1.8%, RMSE 168, 170, 163, 167, and 173kcal/d. The
equations of HB and Mifflin are most widely used in clinical
practice and both provide accurate predictions across a wide
range of BMI groups. In an already overweight group the
underpredicting Mifflin equation might be preferred. Above BMI
45kg/m(2), the Siervo equation performed best, while the
FAO/WHO/UNU or Schofield equation should not be used in this
extremely obese group. CONCLUSIONS: In Belgian women, the
original Harris-Benedict or the Mifflin equation is a reliable
tool to predict REE across a wide variety of body weight (BMI
18.5-50). Estimations for the BMI range between 30 and
40kg/m(2), however, should be improved.
Hofsteenge, Geesje H; Chinapaw, Mai J M; de Waal, Henriette A Delemarre-van; Weijs, Peter J M
Validation of predictive equations for resting energy expenditure in obese adolescents Tijdschriftartikel
In: Am J Clin Nutr, vol. 91, nr. 5, pp. 1244–1254, 2010, ISSN: 1938-3207.
@article{pmid20237141,
title = {Validation of predictive equations for resting energy expenditure in obese adolescents},
author = {Geesje H Hofsteenge and Mai J M Chinapaw and Henriette A Delemarre-van de Waal and Peter J M Weijs},
doi = {10.3945/ajcn.2009.28330},
issn = {1938-3207},
year = {2010},
date = {2010-05-01},
journal = {Am J Clin Nutr},
volume = {91},
number = {5},
pages = {1244--1254},
abstract = {BACKGROUND: When the resting energy expenditure (REE) of overweight and obese adolescents cannot be measured by indirect calorimetry, it has to be predicted with an equation.nnOBJECTIVE: The aim of this study was to examine the validity of published equations for REE compared with indirect calorimetry in overweight and obese adolescents.nnDESIGN: Predictive equations based on weight, height, sex, age, fat-free mass (FFM), and fat mass were compared with measured REE. REE was measured by indirect calorimetry, and body composition was measured by dual-energy X-ray absorptiometry. The accuracy of the REE equations was evaluated on the basis of the percentage of adolescents predicted within 10% of REE measured, the mean percentage difference between predicted and measured values (bias), and the root mean squared prediction error (RMSE).nnRESULTS: Forty-three predictive equations (of which 12 were based on FFM) were included. Validation was based on 70 girls and 51 boys with a mean age of 14.5 y and a mean (+/-SD) body mass index SD score of 2.93 +/- 0.45. The percentage of adolescents with accurate predictions ranged from 74% to 12% depending on the equation used. The most accurate and precise equation for these adolescents was the Molnar equation (accurate predictions: 74%; bias: -1.2%; RMSE: 174 kcal/d). The often-used Schofield-weight equation for age 10-18 y was not accurate (accurate predictions: 50%; bias: +10.7%; RMSE: 276 kcal/d).nnCONCLUSIONS: Indirect calorimetry remains the method of choice for REE in overweight and obese adolescents. However, the sex-specific Molnar REE prediction equation appears to be the most accurate for overweight and obese adolescents aged 12-18 y. This trial was registered at www.trialregister.nl with the Netherlands Trial Register as ISRCTN27626398.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hofsteenge, Geesje H; Chinapaw, Mai J M; de Waal, Henriette A Delemarre-van; Weijs, Peter J M
Validation of predictive equations for resting energy
expenditure in obese adolescents Tijdschriftartikel
In: Am. J. Clin. Nutr., vol. 91, nr. 5, pp. 1244–1254, 2010.
@article{Hofsteenge2010-lj,
title = {Validation of predictive equations for resting energy
expenditure in obese adolescents},
author = {Geesje H Hofsteenge and Mai J M Chinapaw and Henriette A Delemarre-van de Waal and Peter J M Weijs},
year = {2010},
date = {2010-05-01},
journal = {Am. J. Clin. Nutr.},
volume = {91},
number = {5},
pages = {1244–1254},
publisher = {Elsevier BV},
abstract = {BACKGROUND: When the resting energy expenditure (REE) of
overweight and obese adolescents cannot be measured by indirect
calorimetry, it has to be predicted with an equation. OBJECTIVE:
The aim of this study was to examine the validity of published
equations for REE compared with indirect calorimetry in
overweight and obese adolescents. DESIGN: Predictive equations
based on weight, height, sex, age, fat-free mass (FFM), and fat
mass were compared with measured REE. REE was measured by
indirect calorimetry, and body composition was measured by
dual-energy X-ray absorptiometry. The accuracy of the REE
equations was evaluated on the basis of the percentage of
adolescents predicted within 10% of REE measured, the mean
percentage difference between predicted and measured values
(bias), and the root mean squared prediction error (RMSE).
RESULTS: Forty-three predictive equations (of which 12 were
based on FFM) were included. Validation was based on 70 girls
and 51 boys with a mean age of 14.5 y and a mean (+/-SD) body
mass index SD score of 2.93 +/- 0.45. The percentage of
adolescents with accurate predictions ranged from 74% to 12%
depending on the equation used. The most accurate and precise
equation for these adolescents was the Molnar equation (accurate
predictions: 74%; bias: -1.2%; RMSE: 174 kcal/d). The
often-used Schofield-weight equation for age 10-18 y was not
accurate (accurate predictions: 50%; bias: +10.7%; RMSE: 276
kcal/d). CONCLUSIONS: Indirect calorimetry remains the method of
choice for REE in overweight and obese adolescents. However, the
sex-specific Molnar REE prediction equation appears to be the
most accurate for overweight and obese adolescents aged 12-18 y.
This trial was registered at www.trialregister.nl with the
Netherlands Trial Register as ISRCTN27626398.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
overweight and obese adolescents cannot be measured by indirect
calorimetry, it has to be predicted with an equation. OBJECTIVE:
The aim of this study was to examine the validity of published
equations for REE compared with indirect calorimetry in
overweight and obese adolescents. DESIGN: Predictive equations
based on weight, height, sex, age, fat-free mass (FFM), and fat
mass were compared with measured REE. REE was measured by
indirect calorimetry, and body composition was measured by
dual-energy X-ray absorptiometry. The accuracy of the REE
equations was evaluated on the basis of the percentage of
adolescents predicted within 10% of REE measured, the mean
percentage difference between predicted and measured values
(bias), and the root mean squared prediction error (RMSE).
RESULTS: Forty-three predictive equations (of which 12 were
based on FFM) were included. Validation was based on 70 girls
and 51 boys with a mean age of 14.5 y and a mean (+/-SD) body
mass index SD score of 2.93 +/- 0.45. The percentage of
adolescents with accurate predictions ranged from 74% to 12%
depending on the equation used. The most accurate and precise
equation for these adolescents was the Molnar equation (accurate
predictions: 74%; bias: -1.2%; RMSE: 174 kcal/d). The
often-used Schofield-weight equation for age 10-18 y was not
accurate (accurate predictions: 50%; bias: +10.7%; RMSE: 276
kcal/d). CONCLUSIONS: Indirect calorimetry remains the method of
choice for REE in overweight and obese adolescents. However, the
sex-specific Molnar REE prediction equation appears to be the
most accurate for overweight and obese adolescents aged 12-18 y.
This trial was registered at www.trialregister.nl with the
Netherlands Trial Register as ISRCTN27626398.
Leibbrandt, Anke J; Jong, Jessica C Kiefte-de; Hogenelst, Marloes H E; Snoek, Frank J; Weijs, Peter J M
Effects of the PRo-active Interdisciplinary Self-MAnagement
(PRISMA, Dutch DESMOND) program on dietary intake in type 2
diabetes outpatients: a pilot study Tijdschriftartikel
In: Clin. Nutr., vol. 29, nr. 2, pp. 199–205, 2010.
@article{Leibbrandt2010-fj,
title = {Effects of the PRo-active Interdisciplinary Self-MAnagement
(PRISMA, Dutch DESMOND) program on dietary intake in type 2
diabetes outpatients: a pilot study},
author = {Anke J Leibbrandt and Jessica C Kiefte-de Jong and Marloes H E Hogenelst and Frank J Snoek and Peter J M Weijs},
year = {2010},
date = {2010-04-01},
journal = {Clin. Nutr.},
volume = {29},
number = {2},
pages = {199–205},
publisher = {Elsevier BV},
abstract = {BACKGROUND & AIMS: To investigate the effect on dietary intake
of the PRo-active Interdisciplinary Self-MAnagement (PRISMA)
program, developed analogous to DESMOND, in overweight type 2
diabetes patients. METHODS: All type 2 diabetes patients
referred to the Diabetes Outpatient Clinic of the VU University
Medical Center Amsterdam with a BMI >25kg/m(2), were eligible
for inclusion to the PRISMA program. At baseline and after 3, 6
and 12 months of follow-up, macronutrient intake,
anthropometric, biomedical and psychosocial measures were
evaluated by using Generalized Estimation Equations. RESULTS:
Included into the study were 38 patients, of which 22 completed
a 1-year follow-up. After 6 months energy and macronutrient
intake were significantly decreased. Reductions after 12 months
were still significant for protein, unsaturated fat and dietary
fiber and borderline significant for energy and saturated fat
intake. Patients positively evaluated the program, and most
patients held the view that they had learned something from
PRISMA. CONCLUSIONS: The PRISMA program reduced energy and
macronutrient intake up to 6 months. After 6 months, attention
should be paid to patients' food product choices. Follow-up
counselling might further improve long-term outcome. This pilot
study shows that the PRISMA program is promising in decreasing
dietary intake in newly diagnosed and established overweight
type 2 diabetes patients in secondary care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
of the PRo-active Interdisciplinary Self-MAnagement (PRISMA)
program, developed analogous to DESMOND, in overweight type 2
diabetes patients. METHODS: All type 2 diabetes patients
referred to the Diabetes Outpatient Clinic of the VU University
Medical Center Amsterdam with a BMI >25kg/m(2), were eligible
for inclusion to the PRISMA program. At baseline and after 3, 6
and 12 months of follow-up, macronutrient intake,
anthropometric, biomedical and psychosocial measures were
evaluated by using Generalized Estimation Equations. RESULTS:
Included into the study were 38 patients, of which 22 completed
a 1-year follow-up. After 6 months energy and macronutrient
intake were significantly decreased. Reductions after 12 months
were still significant for protein, unsaturated fat and dietary
fiber and borderline significant for energy and saturated fat
intake. Patients positively evaluated the program, and most
patients held the view that they had learned something from
PRISMA. CONCLUSIONS: The PRISMA program reduced energy and
macronutrient intake up to 6 months. After 6 months, attention
should be paid to patients' food product choices. Follow-up
counselling might further improve long-term outcome. This pilot
study shows that the PRISMA program is promising in decreasing
dietary intake in newly diagnosed and established overweight
type 2 diabetes patients in secondary care.
2009
Schijndel, R J M Strack; Groot, S D W; Driessen, R H; Ligthart-Melis, G; Girbes, A R J; Beishuizen, A; Weijs, Peter J M
Computer-aided support improves early and adequate delivery of
nutrients in the ICU Tijdschriftartikel
In: Neth. J. Med., vol. 67, nr. 11, pp. 388–393, 2009.
@article{Van_Schijndel2009-mt,
title = {Computer-aided support improves early and adequate delivery of
nutrients in the ICU},
author = {R J M Strack Schijndel and S D W Groot and R H Driessen and G Ligthart-Melis and A R J Girbes and A Beishuizen and Peter J M Weijs},
year = {2009},
date = {2009-12-01},
journal = {Neth. J. Med.},
volume = {67},
number = {11},
pages = {388–393},
abstract = {BACKGROUND: In 2007 a national guideline on perioperative
nutrition was issued in the Netherlands. As external indicator
for adequacy of nutritional therapy, the percentage of
malnourished patients who reach at least 1.2 grams of protein on
day 4 after admission was chosen by the Netherlands Health Care
Inspectorate. METHODS: We developed an algorithm that allows
users to ask for advice on which artificial nutritional formula
to prescribe and at which rate, assuring provision of adequate
amounts of both protein and energy. Feedback on nutritional
therapy is given to the users on a daily basis, and to the
management per quarter. Both the advice and the feedback have
been integrated in our data management system. The advice module
is also available on-line. RESULTS: In the baseline situation
over the first four quarters (2006) an average of 30.2% of
patients who had a full day 4 in our unit reached the protein
indicator. In the last six quarters post-implementation, the
average percentage reached was 56.5% with values consistently
over 50%. Changes were statistically significant at third
quarter of 2007 (p<0.05) and thereafter (p<0.001). Results for
day 7 of admission were unaffected, which indicates that targets
were reached earlier during hospital stay. CONCLUSION: Our study
shows that integration of nutritional advice and automatically
generated feedback to users in a data management system
consistently improves delivery of (early) nutrition.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
nutrition was issued in the Netherlands. As external indicator
for adequacy of nutritional therapy, the percentage of
malnourished patients who reach at least 1.2 grams of protein on
day 4 after admission was chosen by the Netherlands Health Care
Inspectorate. METHODS: We developed an algorithm that allows
users to ask for advice on which artificial nutritional formula
to prescribe and at which rate, assuring provision of adequate
amounts of both protein and energy. Feedback on nutritional
therapy is given to the users on a daily basis, and to the
management per quarter. Both the advice and the feedback have
been integrated in our data management system. The advice module
is also available on-line. RESULTS: In the baseline situation
over the first four quarters (2006) an average of 30.2% of
patients who had a full day 4 in our unit reached the protein
indicator. In the last six quarters post-implementation, the
average percentage reached was 56.5% with values consistently
over 50%. Changes were statistically significant at third
quarter of 2007 (p<0.05) and thereafter (p<0.001). Results for
day 7 of admission were unaffected, which indicates that targets
were reached earlier during hospital stay. CONCLUSION: Our study
shows that integration of nutritional advice and automatically
generated feedback to users in a data management system
consistently improves delivery of (early) nutrition.
Sikkes, M Ellen; Kooistra, Menno P; Weijs, Peter J M
Improved nutrition after conversion to nocturnal home hemodialysis Tijdschriftartikel
In: J Ren Nutr, vol. 19, nr. 6, pp. 494–499, 2009, ISSN: 1532-8503.
@article{pmid19616453,
title = {Improved nutrition after conversion to nocturnal home hemodialysis},
author = {M Ellen Sikkes and Menno P Kooistra and Peter J M Weijs},
doi = {10.1053/j.jrn.2009.05.006},
issn = {1532-8503},
year = {2009},
date = {2009-11-01},
journal = {J Ren Nutr},
volume = {19},
number = {6},
pages = {494--499},
abstract = {BACKGROUND: Protein-energy malnutrition is a frequently observed problem in hemodialysis patients. Nocturnal home hemodialysis (NHHD; 6 x 8hours during the night) seems to improve patient outcomes, including nutritional state.nnMETHODS: In a single-center, prospective, nonrandomized study, the effects of NHHD on various aspects of nutrition in 14 hemodialysis patients during 1 to 2 years were investigated, using dietary records, appetite questionnaires, laboratory tests, and patient data.nnRESULTS: Appetite, body weight, and energy and protein intakes improved. Patients could drink more. Serum phosphate, calcium, and potassium intake increased. Laboratory results remained excellent, without phosphate-binding agents or potassium-binding resins. However, fat intake also increased, with a risk for overweight status.nnCONCLUSIONS: Nocturnal home hemodialysis has a positive effect on nutritional state.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sikkes, M Ellen; Kooistra, Menno P; Weijs, Peter J M
Improved nutrition after conversion to nocturnal home
hemodialysis Tijdschriftartikel
In: J. Ren. Nutr., vol. 19, nr. 6, pp. 494–499, 2009.
@article{Sikkes2009-vp,
title = {Improved nutrition after conversion to nocturnal home
hemodialysis},
author = {M Ellen Sikkes and Menno P Kooistra and Peter J M Weijs},
year = {2009},
date = {2009-11-01},
journal = {J. Ren. Nutr.},
volume = {19},
number = {6},
pages = {494–499},
publisher = {Elsevier BV},
abstract = {BACKGROUND: Protein-energy malnutrition is a frequently observed
problem in hemodialysis patients. Nocturnal home hemodialysis
(NHHD; 6 x 8hours during the night) seems to improve patient
outcomes, including nutritional state. METHODS: In a
single-center, prospective, nonrandomized study, the effects of
NHHD on various aspects of nutrition in 14 hemodialysis patients
during 1 to 2 years were investigated, using dietary records,
appetite questionnaires, laboratory tests, and patient data.
RESULTS: Appetite, body weight, and energy and protein intakes
improved. Patients could drink more. Serum phosphate, calcium,
and potassium intake increased. Laboratory results remained
excellent, without phosphate-binding agents or potassium-binding
resins. However, fat intake also increased, with a risk for
overweight status. CONCLUSIONS: Nocturnal home hemodialysis has
a positive effect on nutritional state.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
problem in hemodialysis patients. Nocturnal home hemodialysis
(NHHD; 6 x 8hours during the night) seems to improve patient
outcomes, including nutritional state. METHODS: In a
single-center, prospective, nonrandomized study, the effects of
NHHD on various aspects of nutrition in 14 hemodialysis patients
during 1 to 2 years were investigated, using dietary records,
appetite questionnaires, laboratory tests, and patient data.
RESULTS: Appetite, body weight, and energy and protein intakes
improved. Patients could drink more. Serum phosphate, calcium,
and potassium intake increased. Laboratory results remained
excellent, without phosphate-binding agents or potassium-binding
resins. However, fat intake also increased, with a risk for
overweight status. CONCLUSIONS: Nocturnal home hemodialysis has
a positive effect on nutritional state.
Leistra, Eva; Neelemaat, Floor; Evers, Anja M; van Zandvoort, Myriam H W M; Weijs, Peter J M; van Bokhorst-de van der Schueren, Marian A E; Visser, Marjolein; Kruizenga, Hinke M
Prevalence of undernutrition in Dutch hospital outpatients Tijdschriftartikel
In: Eur J Intern Med, vol. 20, nr. 5, pp. 509–513, 2009, ISSN: 1879-0828.
@article{pmid19712855,
title = {Prevalence of undernutrition in Dutch hospital outpatients},
author = {Eva Leistra and Floor Neelemaat and Anja M Evers and Myriam H W M van Zandvoort and Peter J M Weijs and Marian A E van Bokhorst-de van der Schueren and Marjolein Visser and Hinke M Kruizenga},
doi = {10.1016/j.ejim.2009.03.011},
issn = {1879-0828},
year = {2009},
date = {2009-09-01},
journal = {Eur J Intern Med},
volume = {20},
number = {5},
pages = {509--513},
abstract = {BACKGROUND: The prevalence of undernutrition in hospital inpatients is high. Earlier detection and treatment in the hospital outpatient clinic may help to reduce these numbers. The purpose of this study was to assess the prevalence of undernutrition in hospital outpatients in the Netherlands, to determine high risk departments, and to determine the percentage of patients receiving dietetic treatment.nnMETHODS: This cross-sectional multicenter study was conducted in nine hospitals. Patients who visited the outpatient clinic on one of the screening days in the period March-May 2008 received a short questionnaire and were weighed. Patients were classified as severely undernourished, moderately undernourished or not undernourished.nnRESULTS: 2288 patients were included in the study, of which 5% were severely undernourished and 2% were moderately undernourished. The prevalence of severe undernutrition was highest in the outpatient departments of oral maxillofacial surgery (17%), oncology (10%), rehabilitation (8%), gastroenterology (7%) and pulmonology (7%). Only 17% of all severely undernourished and 4% of all moderately undernourished patients reported to receive dietetic treatment.nnCONCLUSION: The prevalence of undernutrition in hospital outpatients is generally low but largely undertreated. Future screening should focus on high risk departments.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Leistra, Eva; Neelemaat, Floor; Evers, Anja M; Zandvoort, Myriam H W M; Weijs, Peter J M; Schueren, Marian A E; Visser, Marjolein; Kruizenga, Hinke M
Prevalence of undernutrition in Dutch hospital outpatients Tijdschriftartikel
In: Eur. J. Intern. Med., vol. 20, nr. 5, pp. 509–513, 2009.
@article{Leistra2009-ol,
title = {Prevalence of undernutrition in Dutch hospital outpatients},
author = {Eva Leistra and Floor Neelemaat and Anja M Evers and Myriam H W M Zandvoort and Peter J M Weijs and Marian A E Schueren and Marjolein Visser and Hinke M Kruizenga},
year = {2009},
date = {2009-09-01},
journal = {Eur. J. Intern. Med.},
volume = {20},
number = {5},
pages = {509–513},
publisher = {Elsevier BV},
abstract = {BACKGROUND: The prevalence of undernutrition in hospital
inpatients is high. Earlier detection and treatment in the
hospital outpatient clinic may help to reduce these numbers. The
purpose of this study was to assess the prevalence of
undernutrition in hospital outpatients in the Netherlands, to
determine high risk departments, and to determine the percentage
of patients receiving dietetic treatment. METHODS: This
cross-sectional multicenter study was conducted in nine
hospitals. Patients who visited the outpatient clinic on one of
the screening days in the period March-May 2008 received a short
questionnaire and were weighed. Patients were classified as
severely undernourished, moderately undernourished or not
undernourished. RESULTS: 2288 patients were included in the
study, of which 5% were severely undernourished and 2% were
moderately undernourished. The prevalence of severe
undernutrition was highest in the outpatient departments of oral
maxillofacial surgery (17%), oncology (10%), rehabilitation
(8%), gastroenterology (7%) and pulmonology (7%). Only 17%
of all severely undernourished and 4% of all moderately
undernourished patients reported to receive dietetic treatment.
CONCLUSION: The prevalence of undernutrition in hospital
outpatients is generally low but largely undertreated. Future
screening should focus on high risk departments.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
inpatients is high. Earlier detection and treatment in the
hospital outpatient clinic may help to reduce these numbers. The
purpose of this study was to assess the prevalence of
undernutrition in hospital outpatients in the Netherlands, to
determine high risk departments, and to determine the percentage
of patients receiving dietetic treatment. METHODS: This
cross-sectional multicenter study was conducted in nine
hospitals. Patients who visited the outpatient clinic on one of
the screening days in the period March-May 2008 received a short
questionnaire and were weighed. Patients were classified as
severely undernourished, moderately undernourished or not
undernourished. RESULTS: 2288 patients were included in the
study, of which 5% were severely undernourished and 2% were
moderately undernourished. The prevalence of severe
undernutrition was highest in the outpatient departments of oral
maxillofacial surgery (17%), oncology (10%), rehabilitation
(8%), gastroenterology (7%) and pulmonology (7%). Only 17%
of all severely undernourished and 4% of all moderately
undernourished patients reported to receive dietetic treatment.
CONCLUSION: The prevalence of undernutrition in hospital
outpatients is generally low but largely undertreated. Future
screening should focus on high risk departments.
van Schijndel, Rob J M Strack; Weijs, Peter J M; Koopmans, Rixt H; Sauerwein, Hans P; Beishuizen, Albertus; Girbes, Armand R J
Optimal nutrition during the period of mechanical ventilation
decreases mortality in critically ill, long-term acute female
patients: a prospective observational cohort study Tijdschriftartikel
In: Crit. Care, vol. 13, nr. 4, pp. R132, 2009.
@article{Strack_van_Schijndel2009-tv,
title = {Optimal nutrition during the period of mechanical ventilation
decreases mortality in critically ill, long-term acute female
patients: a prospective observational cohort study},
author = {Rob J M Strack van Schijndel and Peter J M Weijs and Rixt H Koopmans and Hans P Sauerwein and Albertus Beishuizen and Armand R J Girbes},
year = {2009},
date = {2009-08-01},
journal = {Crit. Care},
volume = {13},
number = {4},
pages = {R132},
publisher = {Springer Nature},
abstract = {INTRODUCTION: Optimal nutrition for intensive care patients has
been proposed to be the provision of energy as determined by
indirect calorimetry, and protein provision of at least 1.2 g/kg
pre-admission weight per day. The evidence supporting these
nutritional goals is based on surrogate outcomes and is not yet
substantiated by patient oriented, clinically meaningful
endpoints. In the present study we evaluated the effects of
achieving optimal nutrition in ICU patients during their period
of mechanical ventilation on mortality. METHODS: This was a
prospective observational cohort study in a mixed
medical-surgical, 28-bed ICU in an academic hospital. 243
sequential mixed medical-surgical patients were enrolled on day
3-5 after admission if they had an expected stay of at least
another 5-7 days. They underwent indirect calorimetry as part of
routine care. Nutrition was guided by the result of indirect
calorimetry and we aimed to provide at least 1.2 g of
protein/kg/day. Cumulative balances were calculated for the
period of mechanical ventilation. Outcome parameters were ICU,
28-day and hospital mortality. RESULTS: In women, when corrected
for weight, height, Apache II score, diagnosis category, and
hyperglycaemic index, patients who reached their nutritional
goals compared to those who did not, showed a hazard ratio (HR) of 0.199 for ICU mortality (CI 0.048-0.831; P = 0.027), a HR of 0.079 for 28 day mortality (CI 0.013-0.467; P = 0.005) and a HR of 0.328 for hospital mortality (CI 0.113-0.952; P = 0.04).
Achievement of energy goals whilst not reaching protein goals,
did not affect ICU mortality; the HR for 28 day mortality was 0.120 (CI 0.027-0.528; P = 0.005) and 0.318 for hospital mortality (CI 0.107-0.945; P = 0.039). No difference in outcome
related to optimal feeding was found for men. CONCLUSIONS:
Optimal nutritional therapy improves ICU, 28-day and hospital
survival in female ICU patients. Female patients reaching both
energy and protein goals have better outcomes than those
reaching only the energy goal. In the present study men did not
benefit from optimal nutrition.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
been proposed to be the provision of energy as determined by
indirect calorimetry, and protein provision of at least 1.2 g/kg
pre-admission weight per day. The evidence supporting these
nutritional goals is based on surrogate outcomes and is not yet
substantiated by patient oriented, clinically meaningful
endpoints. In the present study we evaluated the effects of
achieving optimal nutrition in ICU patients during their period
of mechanical ventilation on mortality. METHODS: This was a
prospective observational cohort study in a mixed
medical-surgical, 28-bed ICU in an academic hospital. 243
sequential mixed medical-surgical patients were enrolled on day
3-5 after admission if they had an expected stay of at least
another 5-7 days. They underwent indirect calorimetry as part of
routine care. Nutrition was guided by the result of indirect
calorimetry and we aimed to provide at least 1.2 g of
protein/kg/day. Cumulative balances were calculated for the
period of mechanical ventilation. Outcome parameters were ICU,
28-day and hospital mortality. RESULTS: In women, when corrected
for weight, height, Apache II score, diagnosis category, and
hyperglycaemic index, patients who reached their nutritional
goals compared to those who did not, showed a hazard ratio (HR) of 0.199 for ICU mortality (CI 0.048-0.831; P = 0.027), a HR of 0.079 for 28 day mortality (CI 0.013-0.467; P = 0.005) and a HR of 0.328 for hospital mortality (CI 0.113-0.952; P = 0.04).
Achievement of energy goals whilst not reaching protein goals,
did not affect ICU mortality; the HR for 28 day mortality was 0.120 (CI 0.027-0.528; P = 0.005) and 0.318 for hospital mortality (CI 0.107-0.945; P = 0.039). No difference in outcome
related to optimal feeding was found for men. CONCLUSIONS:
Optimal nutritional therapy improves ICU, 28-day and hospital
survival in female ICU patients. Female patients reaching both
energy and protein goals have better outcomes than those
reaching only the energy goal. In the present study men did not
benefit from optimal nutrition.
2008
Hofsteenge, Geesje H; Chinapaw, Marijke J M; Weijs, Peter J M; Tulder, Maurits W; de Waal, Henriette A Delemarre-van
Go4it; study design of a randomised controlled trial and
economic evaluation of a multidisciplinary group intervention
for obese adolescents for prevention of diabetes mellitus type 2 Tijdschriftartikel
In: BMC Public Health, vol. 8, nr. 1, pp. 410, 2008.
@article{Hofsteenge2008-jk,
title = {Go4it; study design of a randomised controlled trial and
economic evaluation of a multidisciplinary group intervention
for obese adolescents for prevention of diabetes mellitus type 2},
author = {Geesje H Hofsteenge and Marijke J M Chinapaw and Peter J M Weijs and Maurits W Tulder and Henriette A Delemarre-van de Waal},
year = {2008},
date = {2008-12-01},
journal = {BMC Public Health},
volume = {8},
number = {1},
pages = {410},
publisher = {Springer Science and Business Media LLC},
abstract = {BACKGROUND: In the Netherlands, the first adolescents with
diabetes mellitus type 2 as a result of obesity have recently
been diagnosed. Therefore, it is very important that programs
aiming at the prevention of type 2 diabetes of obese adolescents
are developed and evaluated. METHODS: Go4it is a
multidisciplinary group treatment that focuses on: 1) increasing
awareness of the current dietary and physical activity behaviour
(i.e. energy balance behaviour), 2) improving diet, 3)
decreasing sedentary behaviour, 4) increasing levels of physical
activity, and 5) coping with difficult situations. Go4it
consists of 7 sessions with an interval of 2-3 weeks.The
effectiveness of the multidisciplinary group treatment compared
with usual care (i.e. referral to a dietician) was evaluated in
a randomised controlled trial. We examined effects on BMI(sds),
body composition, energy expenditure, glucose tolerance and
insulin resistance (primary outcome measure), as well as dietary
and physical activity behaviour and quality of life. An economic
evaluation from a societal perspective was conducted alongside
the randomised trial to evaluate the cost-effectiveness of the
multidisciplinary treatment program vs. usual care. DISCUSSION:
In this paper we described a multidisciplinary treatment program
(Go4it) for obese adolescents and the design of a randomised
controlled trial and economic evaluation to evaluate its
effectiveness and cost-effectiveness. TRIAL REGISTRATION:
Netherlands Trial Register (ISRCTN27626398).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
diabetes mellitus type 2 as a result of obesity have recently
been diagnosed. Therefore, it is very important that programs
aiming at the prevention of type 2 diabetes of obese adolescents
are developed and evaluated. METHODS: Go4it is a
multidisciplinary group treatment that focuses on: 1) increasing
awareness of the current dietary and physical activity behaviour
(i.e. energy balance behaviour), 2) improving diet, 3)
decreasing sedentary behaviour, 4) increasing levels of physical
activity, and 5) coping with difficult situations. Go4it
consists of 7 sessions with an interval of 2-3 weeks.The
effectiveness of the multidisciplinary group treatment compared
with usual care (i.e. referral to a dietician) was evaluated in
a randomised controlled trial. We examined effects on BMI(sds),
body composition, energy expenditure, glucose tolerance and
insulin resistance (primary outcome measure), as well as dietary
and physical activity behaviour and quality of life. An economic
evaluation from a societal perspective was conducted alongside
the randomised trial to evaluate the cost-effectiveness of the
multidisciplinary treatment program vs. usual care. DISCUSSION:
In this paper we described a multidisciplinary treatment program
(Go4it) for obese adolescents and the design of a randomised
controlled trial and economic evaluation to evaluate its
effectiveness and cost-effectiveness. TRIAL REGISTRATION:
Netherlands Trial Register (ISRCTN27626398).
Weijs, Peter J M
Validity of predictive equations for resting energy expenditure
in US and Dutch overweight and obese class I and II adults
aged 18-65 y Tijdschriftartikel
In: Am. J. Clin. Nutr., vol. 88, nr. 4, pp. 959–970, 2008.
@article{Weijs2008-pb,
title = {Validity of predictive equations for resting energy expenditure
in US and Dutch overweight and obese class I and II adults
aged 18-65 y},
author = {Peter J M Weijs},
year = {2008},
date = {2008-10-01},
journal = {Am. J. Clin. Nutr.},
volume = {88},
number = {4},
pages = {959–970},
abstract = {BACKGROUND: Individual energy requirements of overweight and
obese adults can often not be measured by indirect calorimetry.
OBJECTIVE: The objective was to analyze which resting energy
expenditure (REE) predictive equation was the best alternative to
indirect calorimetry in US and Dutch adults aged 18-65 y with a
body mass index (in kg/m(2)) of 25 to 40. DESIGN: Predictive
equations based on weight, height, sex, age, fat-free mass, and
fat mass were tested. REE in Dutch adults was measured with
indirect calorimetry, and published data from the Institute of
Medicine were used for US adults. The accuracy of the equations
was evaluated on the basis of the percentage of subjects
predicted within 10% of the REE measured, the root mean squared
prediction error (RMSE), and the mean percentage difference
(bias) between predicted and measured REE. RESULTS: Twenty-seven
predictive equations (9 of which were based on FFM) were
included. Validation was based on 180 women and 158 men from the
United States and on 154 women and 54 men from the Netherlands
aged <65 y with a body mass index (in kg/m(2)) of 25 to 40. Most
accurate and precise for the US adults was the Mifflin equation
(prediction accuracy: 79%; bias: -1.0%; RMSE: 136 kcal/d), for
overweight Dutch adults was the FAO/WHO/UNU weight equation
(prediction accuracy: 68%; bias: -2.5%; RMSE: 178), and for
obese Dutch adults was the Lazzer equation (prediction accuracy:
69%; bias: -3.0%; RMSE: 215 kcal/d). CONCLUSIONS: For US adults
aged 18-65 y with a body mass index of 25 to 40, the REE can best
be estimated with the Mifflin equation. For overweight and obese
Dutch adults, there appears to be no accurate equation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
obese adults can often not be measured by indirect calorimetry.
OBJECTIVE: The objective was to analyze which resting energy
expenditure (REE) predictive equation was the best alternative to
indirect calorimetry in US and Dutch adults aged 18-65 y with a
body mass index (in kg/m(2)) of 25 to 40. DESIGN: Predictive
equations based on weight, height, sex, age, fat-free mass, and
fat mass were tested. REE in Dutch adults was measured with
indirect calorimetry, and published data from the Institute of
Medicine were used for US adults. The accuracy of the equations
was evaluated on the basis of the percentage of subjects
predicted within 10% of the REE measured, the root mean squared
prediction error (RMSE), and the mean percentage difference
(bias) between predicted and measured REE. RESULTS: Twenty-seven
predictive equations (9 of which were based on FFM) were
included. Validation was based on 180 women and 158 men from the
United States and on 154 women and 54 men from the Netherlands
aged <65 y with a body mass index (in kg/m(2)) of 25 to 40. Most
accurate and precise for the US adults was the Mifflin equation
(prediction accuracy: 79%; bias: -1.0%; RMSE: 136 kcal/d), for
overweight Dutch adults was the FAO/WHO/UNU weight equation
(prediction accuracy: 68%; bias: -2.5%; RMSE: 178), and for
obese Dutch adults was the Lazzer equation (prediction accuracy:
69%; bias: -3.0%; RMSE: 215 kcal/d). CONCLUSIONS: For US adults
aged 18-65 y with a body mass index of 25 to 40, the REE can best
be estimated with the Mifflin equation. For overweight and obese
Dutch adults, there appears to be no accurate equation.
Hofsteenge, G H; Weijs, Peter J M; Paw, M J M Chin A; de Waal, H A Delemarre-van
First favourable results of the group education programme Go4it
for overweight and obese adolescents Tijdschriftartikel
In: Ned. Tijdschr. Geneeskd., vol. 152, nr. 29, pp. 1628–1633, 2008.
@article{Hofsteenge2008-wy,
title = {First favourable results of the group education programme Go4it
for overweight and obese adolescents},
author = {G H Hofsteenge and Peter J M Weijs and M J M Chin A Paw and H A Delemarre-van de Waal},
year = {2008},
date = {2008-07-01},
journal = {Ned. Tijdschr. Geneeskd.},
volume = {152},
number = {29},
pages = {1628–1633},
abstract = {OBJECTIVE: To evaluate the effect of Go4it, a multidisciplinary
group education programme for adolescents with overweight or
obesity. DESIGN: Uncontrolled intervention study. METHOD: At the
obesity outpatient clinic of the Transmural Research and
Treatment Centre for Overweight and Obese Children of the VU
University Medical Center, Amsterdam, The Netherlands, a group
education programme was developed for adolescents (age 12-18
year) who are overweight or obese. Obese adolescents who were
referred to the obesity outpatient clinic were asked to
participate. During 7 sessions (one session every two weeks) the
adolescents were educated on the health consequences of obesity,
diet, physical activity, energy balance, improving self-esteem
and how to handle bullying and other difficult situations. All
sessions were held in groups of 8-10 adolescents. In addition,
two sessions were organised for the parents concerning the health
consequences of obesity, diet, and physical activity. Body weight
and height, glucose tolerance (by an oral glucose tolerance test;
OGTT), and insulin resistance were measured at enrolment into the
Go4it programme and 6 months later. RESULTS: In total, 93
adolescents (39 boys, 54 girls) were included with a mean age of
3.9 (SD: 1.7) years. Of those, 69 adolescents (74%) attended at
least 6 out of 7 sessions of the education programme.
Stabilisation or reduction in obesity levels following completion
of Go4it was achieved in 51 (74%) of these participants. 50
adolescents had a second OGTT. The BMI standard deviation score (BMI-sds) decreased by 4.3% for boys (p = 0.020) and 3.3% for girls (p = 0.017). Among girls, fasting blood glucose levels
decreased by an average of 0.37 mmol/l (95% CI: 0.14-0.60) and
insulin concentrations decreased by an average of 299 pmol/l
(95% CI: 71-528). CONCLUSION: Participation in the Go4it
education programme is accompanied by a stabilisation or
reduction in the level of obesity and has favourable effects on
glucose and insulin metabolism.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
group education programme for adolescents with overweight or
obesity. DESIGN: Uncontrolled intervention study. METHOD: At the
obesity outpatient clinic of the Transmural Research and
Treatment Centre for Overweight and Obese Children of the VU
University Medical Center, Amsterdam, The Netherlands, a group
education programme was developed for adolescents (age 12-18
year) who are overweight or obese. Obese adolescents who were
referred to the obesity outpatient clinic were asked to
participate. During 7 sessions (one session every two weeks) the
adolescents were educated on the health consequences of obesity,
diet, physical activity, energy balance, improving self-esteem
and how to handle bullying and other difficult situations. All
sessions were held in groups of 8-10 adolescents. In addition,
two sessions were organised for the parents concerning the health
consequences of obesity, diet, and physical activity. Body weight
and height, glucose tolerance (by an oral glucose tolerance test;
OGTT), and insulin resistance were measured at enrolment into the
Go4it programme and 6 months later. RESULTS: In total, 93
adolescents (39 boys, 54 girls) were included with a mean age of
3.9 (SD: 1.7) years. Of those, 69 adolescents (74%) attended at
least 6 out of 7 sessions of the education programme.
Stabilisation or reduction in obesity levels following completion
of Go4it was achieved in 51 (74%) of these participants. 50
adolescents had a second OGTT. The BMI standard deviation score (BMI-sds) decreased by 4.3% for boys (p = 0.020) and 3.3% for girls (p = 0.017). Among girls, fasting blood glucose levels
decreased by an average of 0.37 mmol/l (95% CI: 0.14-0.60) and
insulin concentrations decreased by an average of 299 pmol/l
(95% CI: 71-528). CONCLUSION: Participation in the Go4it
education programme is accompanied by a stabilisation or
reduction in the level of obesity and has favourable effects on
glucose and insulin metabolism.
Weijs, Peter J M; Kruizenga, Hinke M; Dijk, Aimee E; Meij, Barbara S; Langius, Jacqueline A E; Knol, Dirk L; van Schijndel, Robert J M Strack; Schueren, Marian A E
Validation of predictive equations for resting energy
expenditure in adult outpatients and inpatients Tijdschriftartikel
In: Clin. Nutr., vol. 27, nr. 1, pp. 150–157, 2008.
@article{Weijs2008-lw,
title = {Validation of predictive equations for resting energy
expenditure in adult outpatients and inpatients},
author = {Peter J M Weijs and Hinke M Kruizenga and Aimee E Dijk and Barbara S Meij and Jacqueline A E Langius and Dirk L Knol and Robert J M Strack van Schijndel and Marian A E Schueren},
year = {2008},
date = {2008-02-01},
journal = {Clin. Nutr.},
volume = {27},
number = {1},
pages = {150–157},
publisher = {Elsevier BV},
abstract = {BACKGROUND & AIMS: When individual energy requirements of adult
patients cannot be measured by indirect calorimetry, they have
to be predicted with an equation. The aim of this study was to
analyze which resting energy expenditure (REE) predictive
equation was the best alternative to indirect calorimetry in
adult patients. METHODS: Predictive equations were included when
based on weight, height, gender and/or age. REE was measured
with indirect calorimetry. The mean squared prediction error was
used to evaluate how well the equations fitted the REE
measurement. RESULTS: Eighteen predictive equations were
included. Indirect calorimetry data were available for 48
outpatients and 45 inpatients. Also a subgroup of 42 underweight
patients (BMI<18.5) was analyzed. The mean squared prediction
error was 233-426 kcal/d and the percentage of patients with
acceptable prediction was 28-52% for adult patients depending
on the equation used. The FAO/WHO/UNU (1985) equation including
both weight and height had the smallest prediction error in
adult patients (233 kcal/d), outpatients (182 kcal/d),
inpatients (277 kcal/d) as well as underweight patients (219
kcal/d). CONCLUSIONS: The REE of adult outpatients, inpatients
and underweight patients can best be estimated with the
FAO/WHO/UNU equation including weight and height, when indirect
calorimetry is not available.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
patients cannot be measured by indirect calorimetry, they have
to be predicted with an equation. The aim of this study was to
analyze which resting energy expenditure (REE) predictive
equation was the best alternative to indirect calorimetry in
adult patients. METHODS: Predictive equations were included when
based on weight, height, gender and/or age. REE was measured
with indirect calorimetry. The mean squared prediction error was
used to evaluate how well the equations fitted the REE
measurement. RESULTS: Eighteen predictive equations were
included. Indirect calorimetry data were available for 48
outpatients and 45 inpatients. Also a subgroup of 42 underweight
patients (BMI<18.5) was analyzed. The mean squared prediction
error was 233-426 kcal/d and the percentage of patients with
acceptable prediction was 28-52% for adult patients depending
on the equation used. The FAO/WHO/UNU (1985) equation including
both weight and height had the smallest prediction error in
adult patients (233 kcal/d), outpatients (182 kcal/d),
inpatients (277 kcal/d) as well as underweight patients (219
kcal/d). CONCLUSIONS: The REE of adult outpatients, inpatients
and underweight patients can best be estimated with the
FAO/WHO/UNU equation including weight and height, when indirect
calorimetry is not available.
2006
van Schijndel, R J M Strack; Wierdsma, N J; Heijningen, E M B; Weijs, Peter J M; Groot, S D W; Girbes, A R J
Fecal energy losses in enterally fed intensive care patients: an
explorative study using bomb calorimetry Tijdschriftartikel
In: Clin. Nutr., vol. 25, nr. 5, pp. 758–764, 2006.
@article{Strack_van_Schijndel2006-ad,
title = {Fecal energy losses in enterally fed intensive care patients: an
explorative study using bomb calorimetry},
author = {R J M Strack van Schijndel and N J Wierdsma and E M B Heijningen and Peter J M Weijs and S D W Groot and A R J Girbes},
year = {2006},
date = {2006-10-01},
journal = {Clin. Nutr.},
volume = {25},
number = {5},
pages = {758–764},
publisher = {Elsevier BV},
abstract = {BACKGROUND & AIMS: Early enteral nutrition and tailored supply
of nutrients have become standard in most of the intensive care
units (ICU). So far little attention has been given to losses of
energy in the stools. The purpose of this explorative study was
to evaluate the energy losses of patients with loose stools,
necessitating the use of a feces-collector device in a tertiary
academic ICU. METHODS: In a group of 13 fully enterally fed and
mechanically ventilated patients with loose stools, the daily
energy loss in feces was determined, using bomb calorimetry.
Malabsorption was defined as an absorption capacity of 85% or
less. Energy expenditure was determined with indirect
calorimetry. RESULTS: Six out of 13 (46%) patients fulfilled
the criterion of malabsorption. The mean total energetic
absorption capacity was 84.6+/-13.3%. The mean capacity of
absorption of fat was 89.7+/-16.3%. The caloric value of energy
loss had a mean of 301+/-259 kcal/day. Fecal fat loss proved not
to be a good indicator of total fecal energy loss. A total of
4/13 patients (31%) had a net negative energy balance of over
500 kcal/day. A daily feces production of 250 g or more was a
good predictor of malabsorption. Energy loss could accurately be
predicted by using a factor 4.87 for the combined energetic
value of protein and carbohydrates, if dry weight and fecal fat
content are known. CONCLUSIONS: In this clinical study on ICU
patients with loose stools, malabsorption proved to be a
frequently occurring and so far unrecognized problem,
contributing strongly to negative energy balances in 1/3 of the
patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
of nutrients have become standard in most of the intensive care
units (ICU). So far little attention has been given to losses of
energy in the stools. The purpose of this explorative study was
to evaluate the energy losses of patients with loose stools,
necessitating the use of a feces-collector device in a tertiary
academic ICU. METHODS: In a group of 13 fully enterally fed and
mechanically ventilated patients with loose stools, the daily
energy loss in feces was determined, using bomb calorimetry.
Malabsorption was defined as an absorption capacity of 85% or
less. Energy expenditure was determined with indirect
calorimetry. RESULTS: Six out of 13 (46%) patients fulfilled
the criterion of malabsorption. The mean total energetic
absorption capacity was 84.6+/-13.3%. The mean capacity of
absorption of fat was 89.7+/-16.3%. The caloric value of energy
loss had a mean of 301+/-259 kcal/day. Fecal fat loss proved not
to be a good indicator of total fecal energy loss. A total of
4/13 patients (31%) had a net negative energy balance of over
500 kcal/day. A daily feces production of 250 g or more was a
good predictor of malabsorption. Energy loss could accurately be
predicted by using a factor 4.87 for the combined energetic
value of protein and carbohydrates, if dry weight and fecal fat
content are known. CONCLUSIONS: In this clinical study on ICU
patients with loose stools, malabsorption proved to be a
frequently occurring and so far unrecognized problem,
contributing strongly to negative energy balances in 1/3 of the
patients.
Weijs, Peter J M; Bakker, M I; Korver, K R; Ghanaviztchi, K Goor; Wijnen, J H
Dioxin and dioxin-like PCB exposure of non-breastfed Dutch
infants Tijdschriftartikel
In: Chemosphere, vol. 64, nr. 9, pp. 1521–1525, 2006.
@article{Weijs2006-rd,
title = {Dioxin and dioxin-like PCB exposure of non-breastfed Dutch
infants},
author = {Peter J M Weijs and M I Bakker and K R Korver and K Goor Ghanaviztchi and J H Wijnen},
year = {2006},
date = {2006-08-01},
journal = {Chemosphere},
volume = {64},
number = {9},
pages = {1521–1525},
publisher = {Elsevier BV},
abstract = {The exposure of humans to PCDD/Fs (polychlorinated
dibenzo-p-dioxins and dibenzofurans) and dioxin-like PCBs
(dl-PCBs, i.e. polychlorinated non-ortho and mono-ortho
biphenyls) occurs predominantly via the intake of food. Young
children have a relatively high intake of these substances, due
to their high food consumption per kilogram body weight. As the
exposure of non-breastfed infants to these compounds has not
been assessed before in The Netherlands, we studied the dietary
intake of 17 PCDD/Fs and 11 dioxin-like PCBs in 188 Dutch
non-breastfed infants between 4 and 13 months. The food intake
of the infants was assessed by a 2-d food record. From these
data PCDD/F and dioxin-like PCB intake was calculated using
PCDD/F and dioxin-like PCB concentrations of food products
sampled in 1998/1999 in The Netherlands. The long-term PCDD/F
and dioxin-like PCB exposure of the infants was calculated using
the statistical exposure model (STEM). For infants of 5 months
the chronic exposure to PCDD/F and dioxin-like PCB was 1.1pg
WHO-TEQ (toxic equivalents) per kilogram body weight (bw) per
day (95th percentile: 1.7pg WHO-TEQ/kg bwxd), which mainly
originated from infant formula and vegetables and increased to
2.3pg WHO-TEQ/kg bwxd (95th percentile 3.7pg WHO-TEQ/kg bwxd)
for infants just over 1 year old eating the same food as their
parents. The percentage of formula-fed infants with an exposure
exceeding the TDI of 2pg WHO-TEQ/kg bwxd was 5% at 5 months,
49% at 9 months and 64% at 12 months.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
dibenzo-p-dioxins and dibenzofurans) and dioxin-like PCBs
(dl-PCBs, i.e. polychlorinated non-ortho and mono-ortho
biphenyls) occurs predominantly via the intake of food. Young
children have a relatively high intake of these substances, due
to their high food consumption per kilogram body weight. As the
exposure of non-breastfed infants to these compounds has not
been assessed before in The Netherlands, we studied the dietary
intake of 17 PCDD/Fs and 11 dioxin-like PCBs in 188 Dutch
non-breastfed infants between 4 and 13 months. The food intake
of the infants was assessed by a 2-d food record. From these
data PCDD/F and dioxin-like PCB intake was calculated using
PCDD/F and dioxin-like PCB concentrations of food products
sampled in 1998/1999 in The Netherlands. The long-term PCDD/F
and dioxin-like PCB exposure of the infants was calculated using
the statistical exposure model (STEM). For infants of 5 months
the chronic exposure to PCDD/F and dioxin-like PCB was 1.1pg
WHO-TEQ (toxic equivalents) per kilogram body weight (bw) per
day (95th percentile: 1.7pg WHO-TEQ/kg bwxd), which mainly
originated from infant formula and vegetables and increased to
2.3pg WHO-TEQ/kg bwxd (95th percentile 3.7pg WHO-TEQ/kg bwxd)
for infants just over 1 year old eating the same food as their
parents. The percentage of formula-fed infants with an exposure
exceeding the TDI of 2pg WHO-TEQ/kg bwxd was 5% at 5 months,
49% at 9 months and 64% at 12 months.
1996
Weijs, Peter J M; Calder, A G; Milne, E; Lobley, G E
Conversion of [15N]ammonia into urea and amino acids in humans
and the effect of nutritional status Tijdschriftartikel
In: Br. J. Nutr., vol. 76, nr. 4, pp. 491–499, 1996.
@article{Weijs1996-qz,
title = {Conversion of [15N]ammonia into urea and amino acids in humans
and the effect of nutritional status},
author = {Peter J M Weijs and A G Calder and E Milne and G E Lobley},
year = {1996},
date = {1996-10-01},
journal = {Br. J. Nutr.},
volume = {76},
number = {4},
pages = {491–499},
abstract = {Hepatic NH3 detoxification by ureagenesis requires an input of
aspartate-N, originating either from amino acid-N or NH3-N. The
relative importance of these two routes may depend on the
nutritional state. To test this, four volunteers were given a
liquid diet for 2 d and then on day 3 were either fed every 20
min or fasted. Doses of 15NH4Cl were taken orally every 20 min
for 6 h (total 1.5 g) and blood was sampled hourly. Urea-N
elimination under fasted conditions was only 0.75 of that for the
fed state. Considering the increase in body urea pool during
feeding, ureagenesis during fasting was probably closer to 0.6 of
that during feeding. Since the [14N15N]urea enrichment was not
different between the fed and fasted states, the proportion of
the 15NH3 dose converted to urea during fasting was also 0.6 of
that during the fed condition. No change in [14N15N]urea and
[amide-15N]glutamine enrichment suggested that NH3 enrichment was
also not affected by nutritional state. Enrichment of
[15N15N]urea was approximately 0.05 that of [14N15N]urea which
indicates that 15NH3 can also enter the aspartate route, the
importance of which is yet unknown. Both [15N15N]urea and
[amino-15N]glutamine enrichment in the fasted state were
approximately 1.7 times that in the fed state, indicating
increased labelling of precursors and/or increased NH3 flux
through the aspartate route. Glutamate, valine, leucine and
isoleucine showed comparable increases in enrichment during
fasting. Arginine enrichment was unaltered by nutritional state,
but was lower than [14N15N]urea, indicating incomplete
equilibration with the arginine pool in periportal hepatocytes.
The present study indicates that hepatic NH3 detoxification may
use the aspartate route, gaining importance in the fasted state.
The majority of urea was supplied with only one N atom from NH3,
thus provision of the other may have consequences for alternative
substrates, in particular amino acids.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
aspartate-N, originating either from amino acid-N or NH3-N. The
relative importance of these two routes may depend on the
nutritional state. To test this, four volunteers were given a
liquid diet for 2 d and then on day 3 were either fed every 20
min or fasted. Doses of 15NH4Cl were taken orally every 20 min
for 6 h (total 1.5 g) and blood was sampled hourly. Urea-N
elimination under fasted conditions was only 0.75 of that for the
fed state. Considering the increase in body urea pool during
feeding, ureagenesis during fasting was probably closer to 0.6 of
that during feeding. Since the [14N15N]urea enrichment was not
different between the fed and fasted states, the proportion of
the 15NH3 dose converted to urea during fasting was also 0.6 of
that during the fed condition. No change in [14N15N]urea and
[amide-15N]glutamine enrichment suggested that NH3 enrichment was
also not affected by nutritional state. Enrichment of
[15N15N]urea was approximately 0.05 that of [14N15N]urea which
indicates that 15NH3 can also enter the aspartate route, the
importance of which is yet unknown. Both [15N15N]urea and
[amino-15N]glutamine enrichment in the fasted state were
approximately 1.7 times that in the fed state, indicating
increased labelling of precursors and/or increased NH3 flux
through the aspartate route. Glutamate, valine, leucine and
isoleucine showed comparable increases in enrichment during
fasting. Arginine enrichment was unaltered by nutritional state,
but was lower than [14N15N]urea, indicating incomplete
equilibration with the arginine pool in periportal hepatocytes.
The present study indicates that hepatic NH3 detoxification may
use the aspartate route, gaining importance in the fasted state.
The majority of urea was supplied with only one N atom from NH3,
thus provision of the other may have consequences for alternative
substrates, in particular amino acids.
1995
Weijs, Peter J M; Schreurs, V V; Grooten, H N
Meal feeding and leucine utilization in pregnant rats Tijdschriftartikel
In: Br. J. Nutr., vol. 73, nr. 2, pp. 253–258, 1995.
@article{Weijs1995-uj,
title = {Meal feeding and leucine utilization in pregnant rats},
author = {Peter J M Weijs and V V Schreurs and H N Grooten},
year = {1995},
date = {1995-02-01},
journal = {Br. J. Nutr.},
volume = {73},
number = {2},
pages = {253–258},
abstract = {During pregnancy a higher amino acid requirement may be expected,
but the increase in food intake does not match the increased
growth rate during pregnancy. It is hypothesized that amino acid
utilization can be increased during both fasting and feeding in
order to account for the increased requirement. Therefore mature
female rats (20 weeks old) were investigated before and at day 18
of pregnancy. Rats were fed on a high-protein (HP) diet (210 g
casein/kg diet) for 3 weeks and fasted overnight. Rats were then
subjected to an 8 h constant infusion of L-[1-14C]leucine with
continuous measurement of expired 14CO2 (as a percentage of the
infused dose). After 3 h infusion a 5 g HP or low-protein (LP; 75
g casein/kg diet) meal was offered for 30 min. Pregnant rats had
a significantly lower percentage leucine oxidation in the fasted
state (12.5 (SE 0.7) v. 15.9 (SE 1.1)%; P < 0.05), which
suggests improved reutilization of leucine. Meal ingestion
resulted in a fast increase in 14CO2 expiration. After the LP
meal the level of 14CO2 expiration decreased again after the
acute response (0-1.5 h), but this was not the case after the HP
meal. After the HP meal (average 1.5-5 h), no difference was
observed between pregnant and non-pregnant status (36.8 (SE 1.6)
v. 35.0 (SE 2.5)%). After the LP meal (average 1.5-5 h),
however, the percentage leucine oxidation tended to be lower in
pregnant rats but this difference did not reach statistical
significance (19.7 (SE 1.1) v. 25.8 (SE 2.8)%).(ABSTRACT
TRUNCATED AT 250 WORDS)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
but the increase in food intake does not match the increased
growth rate during pregnancy. It is hypothesized that amino acid
utilization can be increased during both fasting and feeding in
order to account for the increased requirement. Therefore mature
female rats (20 weeks old) were investigated before and at day 18
of pregnancy. Rats were fed on a high-protein (HP) diet (210 g
casein/kg diet) for 3 weeks and fasted overnight. Rats were then
subjected to an 8 h constant infusion of L-[1-14C]leucine with
continuous measurement of expired 14CO2 (as a percentage of the
infused dose). After 3 h infusion a 5 g HP or low-protein (LP; 75
g casein/kg diet) meal was offered for 30 min. Pregnant rats had
a significantly lower percentage leucine oxidation in the fasted
state (12.5 (SE 0.7) v. 15.9 (SE 1.1)%; P < 0.05), which
suggests improved reutilization of leucine. Meal ingestion
resulted in a fast increase in 14CO2 expiration. After the LP
meal the level of 14CO2 expiration decreased again after the
acute response (0-1.5 h), but this was not the case after the HP
meal. After the HP meal (average 1.5-5 h), no difference was
observed between pregnant and non-pregnant status (36.8 (SE 1.6)
v. 35.0 (SE 2.5)%). After the LP meal (average 1.5-5 h),
however, the percentage leucine oxidation tended to be lower in
pregnant rats but this difference did not reach statistical
significance (19.7 (SE 1.1) v. 25.8 (SE 2.8)%).(ABSTRACT
TRUNCATED AT 250 WORDS)
1993
Weijs, Peter J M; Schreurs, V V; Koopmanschap, R E; Grooten, H N; Schoonman, A T; Boekholt, H A
Effects of acute and chronic level of protein supply on metabolic
leucine utilization in growing and mature rats Tijdschriftartikel
In: Br. J. Nutr., vol. 70, nr. 1, pp. 117–125, 1993.
@article{Weijs1993-tc,
title = {Effects of acute and chronic level of protein supply on metabolic
leucine utilization in growing and mature rats},
author = {Peter J M Weijs and V V Schreurs and R E Koopmanschap and H N Grooten and A T Schoonman and H A Boekholt},
year = {1993},
date = {1993-07-01},
journal = {Br. J. Nutr.},
volume = {70},
number = {1},
pages = {117–125},
abstract = {Effects of acute (meal) and chronic (diet) level of protein
supply on metabolic leucine utilization were investigated in
growing (10 weeks) and mature (> 1 year) rats. Rats were
conditioned on a high-protein (HP) diet (210 g casein/kg feed) or
a low-protein (LP) diet (75 g casein/kg feed) from 7 weeks of
age. Overnight-fasted rats were offered a HP or LP meal during a
8 h 14CO2 breath test with a constant infusion of either
L-[1-14C]leucine (carboxyl, CL) or L-[U-14C]leucine (universal,
UL). Before the meal 14CO2 output was lower for overnight-fasted
rats fed on LP than on HP (P < 0.001), and also lower for growing
than for mature rats (P < 0.001). Meal ingestion resulted in a
rapid increase in 14CO2 output. From 2 h after the start of the
meal the effect of acute protein supply on 14CO2 output was
significant (P < 0.001), while the effect of chronic protein
supply disappeared for CL. After the meal 14CO2 output was
transiently lower for growing than for mature rats (P < 0.05),
especially after the LP meal. The difference in 14CO2 output
between CL and UL increased transiently after the meal,
indicating an increase in decarboxylation relative to total
oxidation of leucine.(ABSTRACT TRUNCATED AT 250 WORDS)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
supply on metabolic leucine utilization were investigated in
growing (10 weeks) and mature (> 1 year) rats. Rats were
conditioned on a high-protein (HP) diet (210 g casein/kg feed) or
a low-protein (LP) diet (75 g casein/kg feed) from 7 weeks of
age. Overnight-fasted rats were offered a HP or LP meal during a
8 h 14CO2 breath test with a constant infusion of either
L-[1-14C]leucine (carboxyl, CL) or L-[U-14C]leucine (universal,
UL). Before the meal 14CO2 output was lower for overnight-fasted
rats fed on LP than on HP (P < 0.001), and also lower for growing
than for mature rats (P < 0.001). Meal ingestion resulted in a
rapid increase in 14CO2 output. From 2 h after the start of the
meal the effect of acute protein supply on 14CO2 output was
significant (P < 0.001), while the effect of chronic protein
supply disappeared for CL. After the meal 14CO2 output was
transiently lower for growing than for mature rats (P < 0.05),
especially after the LP meal. The difference in 14CO2 output
between CL and UL increased transiently after the meal,
indicating an increase in decarboxylation relative to total
oxidation of leucine.(ABSTRACT TRUNCATED AT 250 WORDS)
1991
Weijs, Peter J M; H, Leuken; RA, Groot; Fuggle, J C; Reiter, S; Wiech, G; Buschow, K H
X-ray-emission studies of chemical bonding in transition-metal
silicides Tijdschriftartikel
In: Phys. Rev. B Condens. Matter, vol. 44, nr. 15, pp. 8195–8203, 1991.
@article{Weijs1991-bj,
title = {X-ray-emission studies of chemical bonding in transition-metal
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author = {Peter J M Weijs and Leuken H and Groot RA and J C Fuggle and S Reiter and G Wiech and K H Buschow},
year = {1991},
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journal = {Phys. Rev. B Condens. Matter},
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JF, Acker; Weijs, Peter J M; Fuggle, J C; Horn, K; Haak, H; Buschow, K H
Photoemission investigation of the electronic structure of
Fe-Pd and Fe-Pt alloys Tijdschriftartikel
In: Phys. Rev. B Condens. Matter, vol. 43, nr. 11, pp. 8903–8910, 1991.
@article{Van_Acker_JF1991-vc,
title = {Photoemission investigation of the electronic structure of
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year = {1991},
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1990
Weijs, Peter J M; Czyzyk, M T; JF, Acker; Speier, W; Goedkoop, J B; H, Leuken; Hendrix, H J; RA, Groot; G, Laan; Buschow, K H; Wiech, G; Fuggle, J C
Core-hole effects in the x-ray-absorption spectra of
transition-metal silicides Tijdschriftartikel
In: Phys. Rev. B Condens. Matter, vol. 41, nr. 17, pp. 11899–11910, 1990.
@article{Weijs1990-xn,
title = {Core-hole effects in the x-ray-absorption spectra of
transition-metal silicides},
author = {Peter J M Weijs and M T Czyzyk and Acker JF and W Speier and J B Goedkoop and Leuken H and H J Hendrix and Groot RA and Laan G and K H Buschow and G Wiech and J C Fuggle},
year = {1990},
date = {1990-06-01},
journal = {Phys. Rev. B Condens. Matter},
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1988
Kuiper, P; Kruizinga, G; Ghijsen, J; Grioni, M; Weijs, Peter J M; FM, Groot; Sawatzky, G A; Verweij, H; Feiner, L F; Petersen, H
X-ray absorption study of the O 2p hole concentration
dependence on O stoichiometry in YBa2Cu3Ox Tijdschriftartikel
In: Phys. Rev. B Condens. Matter, vol. 38, nr. 10, pp. 6483–6489, 1988.
@article{Kuiper1988-kx,
title = {X-ray absorption study of the O 2p hole concentration
dependence on O stoichiometry in YBa2Cu3Ox},
author = {P Kuiper and G Kruizinga and J Ghijsen and M Grioni and Peter J M Weijs and Groot FM and G A Sawatzky and H Verweij and L F Feiner and H Petersen},
year = {1988},
date = {1988-10-01},
journal = {Phys. Rev. B Condens. Matter},
volume = {38},
number = {10},
pages = {6483–6489},
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Fuggle, J C; Weijs, Peter J M; Schoorl, R; Sawatzky, G A; Fink, J; Nücker, N; Durham, P J; Temmerman, W M
Valence bands and electron correlation in the high-Tc
superconductors Tijdschriftartikel
In: Phys. Rev. B Condens. Matter, vol. 37, nr. 1, pp. 123–126, 1988.
@article{Fuggle1988-dg,
title = {Valence bands and electron correlation in the high-Tc
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author = {J C Fuggle and Peter J M Weijs and R Schoorl and G A Sawatzky and J Fink and N Nücker and P J Durham and W M Temmerman},
year = {1988},
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journal = {Phys. Rev. B Condens. Matter},
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