Prof.dr.ir. Peter J.M. Weijs
Lector en Bijzonder Hoogleraar Voeding en Beweging
- Group:2EAT, IMPACT, Lectoraat Voeding & Bewegen
Prof.dr.ir. Peter J.M. Weijs
Lector en Bijzonder Hoogleraar Voeding en Beweging
Peter Weijs is lector en bijzonder hoogleraar Voeding en Beweging. Peter begon in 1994 als docent Voeding bij de HvA. In 2024 is hij 30 jaar verbonden aan de opleiding Voeding & Dietetiek en bestaat het lectoraat 15 jaar.
Gezonde voeding en voldoende beweging vormen een belangrijke rol bij het gezond opgroeien en bij het gezond ouder worden. Zowel bij het voorkomen van ziekte als bij het herstel van ziekte. Het lectoraat/leerstoel Voeding en Beweging richt zich op het optimaliseren en behouden van een gezonde leefstijl bij diverse kwetsbare doelgroepen. Hiervoor worden voeding & beweging interventies ontwikkeld en getest voor het behoud en herstel van dagelijks functioneren en gezondheid. Dit op basis van expertise op het gebied van overgewicht & obesitas, sarcopenie, sarcopene obesitas, het meten van lichaamssamenstelling en energieverbruik, eiwitbehoefte en eiwitkwaliteit.
In 1986 behaalde Peter zijn MSc bij Humane Voeding aan de Wageningen Universiteit, op basis van onderzoek naar energiehuishouding en eiwitmetabolisme. In 1988 werkte hij aan de University of Texas Medical Branch. In 1993 behaalde hij zijn PhD aan de Wageningen Universiteit op basis van onderzoek naar bepalende factoren voor eiwitbehoefte. In 1993-1994 werkte Peter als European Commission Marie Curie Fellow aan het Rowett Research Institute in Aberdeen. In 1994 kwam Peter als docent werken bij de opleiding Voeding en Dietetiek van de HvA. Hij was o.a. 10 jaar afstudeercoordinator. Vanaf 2004 t/m 2023 werkte hij bij Dietetiek & Voedingswetenschappen van het Amsterdam UMC, alliantie Vumc & AMC. In 2006 richtte hij het Voedingslab (zie ANAC) op. In 2009 werd hij lector en in 2018 hoogleraar.
Peter is lid van de directie van het Center of Expertise Urban Vitality en themaleider van het thema Mensen in Beweging. De onderzoeksgroep Mensen in Beweging is ontstaan uit het SIA-SPRONG project Mensen in Beweging, waarin gezocht wordt naar optimale combinaties van voeding, beweging en technologie om te komen tot duurzame gedragsbeïnvloeding en behoud van gezondheid en vitaliteit. Internationaal is hij actief binnen het Sarcopenic Obesity Global Leadership Initiative (SOGLI).
Peter geeft leiding aan zowel een lectoraat met een omvang van 12 fte, waaronder 6 postdocs en 16 promovendi, het thema MiB als de bijzondere leerstoel bij de VU.
Bekijk de publicaties van Peter Weijs of bezoek zijn volledige research profiel.
2024
Memelink, Robert G; Njemini, Rose; Kuil, Minse J J Bos; Wopereis, Suzan; Bosch, Johan; Schoufour, Josje D; Tieland, Michael; Weijs, Peter J M; Bautmans, Ivan
The effect of a combined lifestyle intervention with and without
protein drink on inflammation in older adults with obesity and
type 2 diabetes Tijdschriftartikel
In: Exp. Gerontol., vol. 190, pp. 112410, 2024.
@article{Memelink2024-rr,
title = {The effect of a combined lifestyle intervention with and without
protein drink on inflammation in older adults with obesity and
type 2 diabetes},
author = {Robert G Memelink and Rose Njemini and Minse J J Bos Kuil and Suzan Wopereis and Johan Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},
year = {2024},
date = {2024-06-01},
journal = {Exp. Gerontol.},
volume = {190},
pages = {112410},
abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one
of the pathways involved in type 2 diabetes (T2D). Currently,
there is limited evidence for ameliorating effects of combined
lifestyle interventions on CLIP in type 2 diabetes. We
investigated whether a 13-week combined lifestyle intervention,
using hypocaloric diet and resistance exercise plus
high-intensity interval training with or without consumption of a
protein drink, affected CLIP in older adults with T2D. METHODS:
In this post-hoc analysis of the PROBE study 114 adults ($geq$55
years) with obesity and type 2 (pre-)diabetes had measurements of
C-reactive protein (CRP), pro-inflammatory cytokines interleukin
(IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte
chemoattractant protein (MCP)-1, anti-inflammatory cytokines
IL-10, IL-1 receptor antagonist (RA), and soluble
tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and
adiponectin, and glycation biomarkers carboxymethyl-lysine (CML)
and soluble receptor for advanced glycation end products (sRAGE)
from fasting blood samples. A linear mixed model was used to
evaluate change in inflammatory biomarkers after lifestyle
intervention and effect of the protein drink. Linear regression
analysis was performed with parameters of body composition (by
dual-energy X-ray absorptiometry) and parameters of insulin
resistance (by oral glucose tolerance test). RESULTS: There were
no significant differences in CLIP responses between the protein
and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p <
0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP
increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one
of the pathways involved in type 2 diabetes (T2D). Currently,
there is limited evidence for ameliorating effects of combined
lifestyle interventions on CLIP in type 2 diabetes. We
investigated whether a 13-week combined lifestyle intervention,
using hypocaloric diet and resistance exercise plus
high-intensity interval training with or without consumption of a
protein drink, affected CLIP in older adults with T2D. METHODS:
In this post-hoc analysis of the PROBE study 114 adults ($geq$55
years) with obesity and type 2 (pre-)diabetes had measurements of
C-reactive protein (CRP), pro-inflammatory cytokines interleukin
(IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte
chemoattractant protein (MCP)-1, anti-inflammatory cytokines
IL-10, IL-1 receptor antagonist (RA), and soluble
tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and
adiponectin, and glycation biomarkers carboxymethyl-lysine (CML)
and soluble receptor for advanced glycation end products (sRAGE)
from fasting blood samples. A linear mixed model was used to
evaluate change in inflammatory biomarkers after lifestyle
intervention and effect of the protein drink. Linear regression
analysis was performed with parameters of body composition (by
dual-energy X-ray absorptiometry) and parameters of insulin
resistance (by oral glucose tolerance test). RESULTS: There were
no significant differences in CLIP responses between the protein
and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p <
0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP
increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/
of the pathways involved in type 2 diabetes (T2D). Currently,
there is limited evidence for ameliorating effects of combined
lifestyle interventions on CLIP in type 2 diabetes. We
investigated whether a 13-week combined lifestyle intervention,
using hypocaloric diet and resistance exercise plus
high-intensity interval training with or without consumption of a
protein drink, affected CLIP in older adults with T2D. METHODS:
In this post-hoc analysis of the PROBE study 114 adults ($geq$55
years) with obesity and type 2 (pre-)diabetes had measurements of
C-reactive protein (CRP), pro-inflammatory cytokines interleukin
(IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte
chemoattractant protein (MCP)-1, anti-inflammatory cytokines
IL-10, IL-1 receptor antagonist (RA), and soluble
tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and
adiponectin, and glycation biomarkers carboxymethyl-lysine (CML)
and soluble receptor for advanced glycation end products (sRAGE)
from fasting blood samples. A linear mixed model was used to
evaluate change in inflammatory biomarkers after lifestyle
intervention and effect of the protein drink. Linear regression
analysis was performed with parameters of body composition (by
dual-energy X-ray absorptiometry) and parameters of insulin
resistance (by oral glucose tolerance test). RESULTS: There were
no significant differences in CLIP responses between the protein
and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p <
0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP
increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/
Pinel, A; Guillet, C; Capel, F; Pouget, M; Antonio, M De; Pereira, B; Topinkova, E; Eglseer, D; Barazzoni, R; Cruz-Jentoft, A J; Schoufour, J D; Weijs, Peter J M; Boirie, Y
Identification of factors associated with sarcopenic obesity
development: Literature review and expert panel voting Tijdschriftartikel
In: Clin. Nutr., vol. 43, nr. 6, pp. 1414–1424, 2024.
@article{Pinel2024-hkb,
title = {Identification of factors associated with sarcopenic obesity
development: Literature review and expert panel voting},
author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and Peter J M Weijs and Y Boirie},
year = {2024},
date = {2024-06-01},
journal = {Clin. Nutr.},
volume = {43},
number = {6},
pages = {1414–1424},
publisher = {Elsevier BV},
abstract = {Sarcopenic obesity (SO) is defined as the combination of excess
fat mass (obesity) and low skeletal muscle mass and function
(sarcopenia). The identification and classification of factors
related to SO would favor better prevention and diagnosis. The
present article aimed to (i) define a list of factors related
with SO based on literature analysis, (ii) identify clinical
conditions linked with SO development from literature search and
(iii) evaluate their relevance and the potential research gaps
by consulting an expert panel. From 4746 articles screened, 240
articles were selected for extraction of the factors associated
with SO. Factors were classified according to their frequency in
the literature. Clinical conditions were also recorded. Then,
they were evaluated by a panel of expert for evaluation of their
relevance in SO development. Experts also suggested additional
factors. Thirty-nine unique factors were extracted from the
papers and additional eleven factors suggested by a panel of
experts in the SO field. The frequency in the literature showed
insulin resistance, dyslipidemia, lack of exercise training,
inflammation and hypertension as the most frequent factors
associated with SO whereas experts ranked low spontaneous
physical activity, protein and energy intakes, low exercise
training and aging as the most important. Although literature
and expert panel presented some differences, this first list of
associated factors could help to identify patients at risk of
SO. Further work is needed to confirm the contribution of
factors associated with SO among the population overtime or in
randomized controlled trials to demonstrate causality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sarcopenic obesity (SO) is defined as the combination of excess
fat mass (obesity) and low skeletal muscle mass and function
(sarcopenia). The identification and classification of factors
related to SO would favor better prevention and diagnosis. The
present article aimed to (i) define a list of factors related
with SO based on literature analysis, (ii) identify clinical
conditions linked with SO development from literature search and
(iii) evaluate their relevance and the potential research gaps
by consulting an expert panel. From 4746 articles screened, 240
articles were selected for extraction of the factors associated
with SO. Factors were classified according to their frequency in
the literature. Clinical conditions were also recorded. Then,
they were evaluated by a panel of expert for evaluation of their
relevance in SO development. Experts also suggested additional
factors. Thirty-nine unique factors were extracted from the
papers and additional eleven factors suggested by a panel of
experts in the SO field. The frequency in the literature showed
insulin resistance, dyslipidemia, lack of exercise training,
inflammation and hypertension as the most frequent factors
associated with SO whereas experts ranked low spontaneous
physical activity, protein and energy intakes, low exercise
training and aging as the most important. Although literature
and expert panel presented some differences, this first list of
associated factors could help to identify patients at risk of
SO. Further work is needed to confirm the contribution of
factors associated with SO among the population overtime or in
randomized controlled trials to demonstrate causality.
fat mass (obesity) and low skeletal muscle mass and function
(sarcopenia). The identification and classification of factors
related to SO would favor better prevention and diagnosis. The
present article aimed to (i) define a list of factors related
with SO based on literature analysis, (ii) identify clinical
conditions linked with SO development from literature search and
(iii) evaluate their relevance and the potential research gaps
by consulting an expert panel. From 4746 articles screened, 240
articles were selected for extraction of the factors associated
with SO. Factors were classified according to their frequency in
the literature. Clinical conditions were also recorded. Then,
they were evaluated by a panel of expert for evaluation of their
relevance in SO development. Experts also suggested additional
factors. Thirty-nine unique factors were extracted from the
papers and additional eleven factors suggested by a panel of
experts in the SO field. The frequency in the literature showed
insulin resistance, dyslipidemia, lack of exercise training,
inflammation and hypertension as the most frequent factors
associated with SO whereas experts ranked low spontaneous
physical activity, protein and energy intakes, low exercise
training and aging as the most important. Although literature
and expert panel presented some differences, this first list of
associated factors could help to identify patients at risk of
SO. Further work is needed to confirm the contribution of
factors associated with SO among the population overtime or in
randomized controlled trials to demonstrate causality.
Memelink, Robert G; Njemini, Rose; Kuil, Minse J J Bos; Wopereis, Suzan; Bosch, Johan; Schoufour, Josje D; Tieland, Michael; Weijs, Peter J M; Bautmans, Ivan
The effect of a combined lifestyle intervention with and without
protein drink on inflammation in older adults with obesity and
type 2 diabetes Tijdschriftartikel
In: Exp. Gerontol., vol. 190, pp. 112410, 2024.
@article{Memelink2024-rrb,
title = {The effect of a combined lifestyle intervention with and without
protein drink on inflammation in older adults with obesity and
type 2 diabetes},
author = {Robert G Memelink and Rose Njemini and Minse J J Bos Kuil and Suzan Wopereis and Johan Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},
year = {2024},
date = {2024-06-01},
journal = {Exp. Gerontol.},
volume = {190},
pages = {112410},
abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one
of the pathways involved in type 2 diabetes (T2D). Currently,
there is limited evidence for ameliorating effects of combined
lifestyle interventions on CLIP in type 2 diabetes. We
investigated whether a 13-week combined lifestyle intervention,
using hypocaloric diet and resistance exercise plus
high-intensity interval training with or without consumption of a
protein drink, affected CLIP in older adults with T2D. METHODS:
In this post-hoc analysis of the PROBE study 114 adults ($geq$55
years) with obesity and type 2 (pre-)diabetes had measurements of
C-reactive protein (CRP), pro-inflammatory cytokines interleukin
(IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte
chemoattractant protein (MCP)-1, anti-inflammatory cytokines
IL-10, IL-1 receptor antagonist (RA), and soluble
tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and
adiponectin, and glycation biomarkers carboxymethyl-lysine (CML)
and soluble receptor for advanced glycation end products (sRAGE)
from fasting blood samples. A linear mixed model was used to
evaluate change in inflammatory biomarkers after lifestyle
intervention and effect of the protein drink. Linear regression
analysis was performed with parameters of body composition (by
dual-energy X-ray absorptiometry) and parameters of insulin
resistance (by oral glucose tolerance test). RESULTS: There were
no significant differences in CLIP responses between the protein
and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p <
0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP
increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one
of the pathways involved in type 2 diabetes (T2D). Currently,
there is limited evidence for ameliorating effects of combined
lifestyle interventions on CLIP in type 2 diabetes. We
investigated whether a 13-week combined lifestyle intervention,
using hypocaloric diet and resistance exercise plus
high-intensity interval training with or without consumption of a
protein drink, affected CLIP in older adults with T2D. METHODS:
In this post-hoc analysis of the PROBE study 114 adults ($geq$55
years) with obesity and type 2 (pre-)diabetes had measurements of
C-reactive protein (CRP), pro-inflammatory cytokines interleukin
(IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte
chemoattractant protein (MCP)-1, anti-inflammatory cytokines
IL-10, IL-1 receptor antagonist (RA), and soluble
tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and
adiponectin, and glycation biomarkers carboxymethyl-lysine (CML)
and soluble receptor for advanced glycation end products (sRAGE)
from fasting blood samples. A linear mixed model was used to
evaluate change in inflammatory biomarkers after lifestyle
intervention and effect of the protein drink. Linear regression
analysis was performed with parameters of body composition (by
dual-energy X-ray absorptiometry) and parameters of insulin
resistance (by oral glucose tolerance test). RESULTS: There were
no significant differences in CLIP responses between the protein
and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p <
0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP
increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/
of the pathways involved in type 2 diabetes (T2D). Currently,
there is limited evidence for ameliorating effects of combined
lifestyle interventions on CLIP in type 2 diabetes. We
investigated whether a 13-week combined lifestyle intervention,
using hypocaloric diet and resistance exercise plus
high-intensity interval training with or without consumption of a
protein drink, affected CLIP in older adults with T2D. METHODS:
In this post-hoc analysis of the PROBE study 114 adults ($geq$55
years) with obesity and type 2 (pre-)diabetes had measurements of
C-reactive protein (CRP), pro-inflammatory cytokines interleukin
(IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte
chemoattractant protein (MCP)-1, anti-inflammatory cytokines
IL-10, IL-1 receptor antagonist (RA), and soluble
tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and
adiponectin, and glycation biomarkers carboxymethyl-lysine (CML)
and soluble receptor for advanced glycation end products (sRAGE)
from fasting blood samples. A linear mixed model was used to
evaluate change in inflammatory biomarkers after lifestyle
intervention and effect of the protein drink. Linear regression
analysis was performed with parameters of body composition (by
dual-energy X-ray absorptiometry) and parameters of insulin
resistance (by oral glucose tolerance test). RESULTS: There were
no significant differences in CLIP responses between the protein
and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p <
0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP
increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/
Pinel, A; Guillet, C; Capel, F; Pouget, M; Antonio, M De; Pereira, B; Topinkova, E; Eglseer, D; Barazzoni, R; Cruz-Jentoft, A J; Schoufour, J D; Weijs, P J M; Boirie, Y
Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting Tijdschriftartikel
In: Clin Nutr, vol. 43, nr. 6, pp. 1414–1424, 2024, ISSN: 1532-1983.
@article{pmid38701709,
title = {Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting},
author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and P J M Weijs and Y Boirie},
doi = {10.1016/j.clnu.2024.04.033},
issn = {1532-1983},
year = {2024},
date = {2024-06-01},
journal = {Clin Nutr},
volume = {43},
number = {6},
pages = {1414--1424},
abstract = {Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.
Pinel, A; Guillet, C; Capel, F; Pouget, M; Antonio, M De; Pereira, B; Topinkova, E; Eglseer, D; Barazzoni, R; Cruz-Jentoft, A J; Schoufour, J D; Weijs, P J M; Boirie, Y
Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting Tijdschriftartikel
In: Clin Nutr, vol. 43, nr. 6, pp. 1414–1424, 2024, ISSN: 1532-1983.
@article{pmid38701709c,
title = {Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting},
author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and P J M Weijs and Y Boirie},
doi = {10.1016/j.clnu.2024.04.033},
issn = {1532-1983},
year = {2024},
date = {2024-06-01},
journal = {Clin Nutr},
volume = {43},
number = {6},
pages = {1414--1424},
abstract = {Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.
van Ruijven, Isabel M; Brunsveld-Reinders, Anja H; Stapel, Sandra N; Weijs, Peter J M
2024, ISSN: 1532-1983.
@misc{pmid38049354,
title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as beneficially high protein provision in critically ill patients},
author = {Isabel M van Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},
doi = {10.1016/j.clnu.2023.11.035},
issn = {1532-1983},
year = {2024},
date = {2024-04-01},
journal = {Clin Nutr},
volume = {43},
number = {4},
pages = {1077--1078},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
Hoevenaars, Dirk; Holla, Jasmijn F M; de Groot, Sonja; Weijs, Peter J M; Kraaij, Wessel; Janssen, Thomas W J
Lifestyle and health changes in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application Tijdschriftartikel
In: Disabil Rehabil Assist Technol, vol. 19, nr. 3, pp. 648–657, 2024, ISSN: 1748-3115.
@article{pmid36165036,
title = {Lifestyle and health changes in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application},
author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja de Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},
doi = {10.1080/17483107.2022.2115563},
issn = {1748-3115},
year = {2024},
date = {2024-04-01},
journal = {Disabil Rehabil Assist Technol},
volume = {19},
number = {3},
pages = {648--657},
abstract = {PURPOSE: The aim of this study was to determine changes in physical activity, nutrition, sleep behaviour and body composition in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application (app).nnMETHODS: A 12-week pre-post intervention study was performed, starting with a 1-week control period. Physical activity and sleep behaviour were continuously measured with a Fitbit charge 3. Self-reported nutritional intake, body mass and waist circumference were collected. Pre-post outcomes were compared with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit data were analysed with a mixed model or a panel linear model. Effect sizes were determined and significance was accepted at < .05.nnRESULTS: Thirty participants completed the study. No significant changes in physical activity (+1.5 √steps) and sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 kJ, = 0.71), protein (-8.3 g, = 0.61) and fat (-13.1 g, = 0.87) intake, body mass (-2.2 kg, = 0.61) and waist circumference (-3.3 cm, = 0.80) were found.nnCONCLUSION: Positive changes were found in nutritional behaviour and body composition, but not in physical activity and sleep quality. The WHEELS app seems to partly support healthy lifestyle behaviour.Implications for RehabilitationHealthy lifestyle promotion is crucial, especially for wheelchair users as they tend to show poorer lifestyle behaviour despite an increased risk of obesity and comorbidity.The WHEELS lifestyle app seems to be a valuable tool to support healthy nutrition choices and weight loss and to improve body satisfaction, mental health and vitality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE: The aim of this study was to determine changes in physical activity, nutrition, sleep behaviour and body composition in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application (app).nnMETHODS: A 12-week pre-post intervention study was performed, starting with a 1-week control period. Physical activity and sleep behaviour were continuously measured with a Fitbit charge 3. Self-reported nutritional intake, body mass and waist circumference were collected. Pre-post outcomes were compared with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit data were analysed with a mixed model or a panel linear model. Effect sizes were determined and significance was accepted at < .05.nnRESULTS: Thirty participants completed the study. No significant changes in physical activity (+1.5 √steps) and sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 kJ, = 0.71), protein (-8.3 g, = 0.61) and fat (-13.1 g, = 0.87) intake, body mass (-2.2 kg, = 0.61) and waist circumference (-3.3 cm, = 0.80) were found.nnCONCLUSION: Positive changes were found in nutritional behaviour and body composition, but not in physical activity and sleep quality. The WHEELS app seems to partly support healthy lifestyle behaviour.Implications for RehabilitationHealthy lifestyle promotion is crucial, especially for wheelchair users as they tend to show poorer lifestyle behaviour despite an increased risk of obesity and comorbidity.The WHEELS lifestyle app seems to be a valuable tool to support healthy nutrition choices and weight loss and to improve body satisfaction, mental health and vitality.
Ruijven, Isabel M; Brunsveld-Reinders, Anja H; Stapel, Sandra N; Weijs, Peter J M
Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as
beneficially high protein provision in critically ill patients Tijdschriftartikel
In: Clin. Nutr., vol. 43, nr. 4, pp. 1077–1078, 2024.
@article{Van_Ruijven2024-st,
title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as
beneficially high protein provision in critically ill patients},
author = {Isabel M Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},
year = {2024},
date = {2024-04-01},
journal = {Clin. Nutr.},
volume = {43},
number = {4},
pages = {1077–1078},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hoevenaars, Dirk; Holla, Jasmijn F M; Groot, Sonja; Weijs, Peter J M; Kraaij, Wessel; Janssen, Thomas W J
Lifestyle and health changes in wheelchair users with a chronic
disability after 12 weeks of using the WHEELS mHealth
application Tijdschriftartikel
In: Disabil. Rehabil. Assist. Technol., vol. 19, nr. 3, pp. 648–657, 2024.
@article{Hoevenaars2024-ad,
title = {Lifestyle and health changes in wheelchair users with a chronic
disability after 12 weeks of using the WHEELS mHealth
application},
author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},
year = {2024},
date = {2024-04-01},
journal = {Disabil. Rehabil. Assist. Technol.},
volume = {19},
number = {3},
pages = {648–657},
abstract = {PURPOSE: The aim of this study was to determine changes in
physical activity, nutrition, sleep behaviour and body
composition in wheelchair users with a chronic disability after
12 weeks of using the WHEELS mHealth application (app). METHODS:
A 12-week pre-post intervention study was performed, starting
with a 1-week control period. Physical activity and sleep
behaviour were continuously measured with a Fitbit charge 3.
Self-reported nutritional intake, body mass and waist
circumference were collected. Pre-post outcomes were compared
with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit
data were analysed with a mixed model or a panel linear model.
Effect sizes were determined and significance was accepted at p <
.05. RESULTS: Thirty participants completed the study. No
significant changes in physical activity (+1.5 $surd$steps) and
sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE: The aim of this study was to determine changes in
physical activity, nutrition, sleep behaviour and body
composition in wheelchair users with a chronic disability after
12 weeks of using the WHEELS mHealth application (app). METHODS:
A 12-week pre-post intervention study was performed, starting
with a 1-week control period. Physical activity and sleep
behaviour were continuously measured with a Fitbit charge 3.
Self-reported nutritional intake, body mass and waist
circumference were collected. Pre-post outcomes were compared
with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit
data were analysed with a mixed model or a panel linear model.
Effect sizes were determined and significance was accepted at p <
.05. RESULTS: Thirty participants completed the study. No
significant changes in physical activity (+1.5 $surd$steps) and
sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k
physical activity, nutrition, sleep behaviour and body
composition in wheelchair users with a chronic disability after
12 weeks of using the WHEELS mHealth application (app). METHODS:
A 12-week pre-post intervention study was performed, starting
with a 1-week control period. Physical activity and sleep
behaviour were continuously measured with a Fitbit charge 3.
Self-reported nutritional intake, body mass and waist
circumference were collected. Pre-post outcomes were compared
with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit
data were analysed with a mixed model or a panel linear model.
Effect sizes were determined and significance was accepted at p <
.05. RESULTS: Thirty participants completed the study. No
significant changes in physical activity (+1.5 $surd$steps) and
sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k
Ruijven, Isabel M; Brunsveld-Reinders, Anja H; Stapel, Sandra N; Weijs, Peter J M
Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as
beneficially high protein provision in critically ill patients Tijdschriftartikel
In: Clin. Nutr., vol. 43, nr. 4, pp. 1077–1078, 2024.
@article{Van_Ruijven2024-stb,
title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as
beneficially high protein provision in critically ill patients},
author = {Isabel M Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},
year = {2024},
date = {2024-04-01},
journal = {Clin. Nutr.},
volume = {43},
number = {4},
pages = {1077–1078},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hoevenaars, Dirk; Holla, Jasmijn F M; Groot, Sonja; Weijs, Peter J M; Kraaij, Wessel; Janssen, Thomas W J
Lifestyle and health changes in wheelchair users with a chronic
disability after 12 weeks of using the WHEELS mHealth
application Tijdschriftartikel
In: Disabil. Rehabil. Assist. Technol., vol. 19, nr. 3, pp. 648–657, 2024.
@article{Hoevenaars2024-adb,
title = {Lifestyle and health changes in wheelchair users with a chronic
disability after 12 weeks of using the WHEELS mHealth
application},
author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},
year = {2024},
date = {2024-04-01},
journal = {Disabil. Rehabil. Assist. Technol.},
volume = {19},
number = {3},
pages = {648–657},
abstract = {PURPOSE: The aim of this study was to determine changes in
physical activity, nutrition, sleep behaviour and body
composition in wheelchair users with a chronic disability after
12 weeks of using the WHEELS mHealth application (app). METHODS:
A 12-week pre-post intervention study was performed, starting
with a 1-week control period. Physical activity and sleep
behaviour were continuously measured with a Fitbit charge 3.
Self-reported nutritional intake, body mass and waist
circumference were collected. Pre-post outcomes were compared
with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit
data were analysed with a mixed model or a panel linear model.
Effect sizes were determined and significance was accepted at p <
.05. RESULTS: Thirty participants completed the study. No
significant changes in physical activity (+1.5 $surd$steps) and
sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE: The aim of this study was to determine changes in
physical activity, nutrition, sleep behaviour and body
composition in wheelchair users with a chronic disability after
12 weeks of using the WHEELS mHealth application (app). METHODS:
A 12-week pre-post intervention study was performed, starting
with a 1-week control period. Physical activity and sleep
behaviour were continuously measured with a Fitbit charge 3.
Self-reported nutritional intake, body mass and waist
circumference were collected. Pre-post outcomes were compared
with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit
data were analysed with a mixed model or a panel linear model.
Effect sizes were determined and significance was accepted at p <
.05. RESULTS: Thirty participants completed the study. No
significant changes in physical activity (+1.5 $surd$steps) and
sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k
physical activity, nutrition, sleep behaviour and body
composition in wheelchair users with a chronic disability after
12 weeks of using the WHEELS mHealth application (app). METHODS:
A 12-week pre-post intervention study was performed, starting
with a 1-week control period. Physical activity and sleep
behaviour were continuously measured with a Fitbit charge 3.
Self-reported nutritional intake, body mass and waist
circumference were collected. Pre-post outcomes were compared
with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit
data were analysed with a mixed model or a panel linear model.
Effect sizes were determined and significance was accepted at p <
.05. RESULTS: Thirty participants completed the study. No
significant changes in physical activity (+1.5 $surd$steps) and
sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k
Benz, Elizabeth; Pinel, Alexandre; Guillet, Christelle; Capel, Frederic; Pereira, Bruno; Antonio, Marie De; Pouget, Melanie; Cruz-Jentoft, Alfonso J; Eglseer, Doris; Topinkova, Eva; Barazzoni, Rocco; Rivadeneira, Fernando; Ikram, M Arfan; Steur, Marinka; Voortman, Trudy; Schoufour, Josje D; Weijs, Peter J M; Boirie, Yves
Sarcopenia and Sarcopenic Obesity and Mortality Among Older People Tijdschriftartikel
In: JAMA Netw Open, vol. 7, nr. 3, pp. e243604, 2024, ISSN: 2574-3805.
@article{pmid38526491,
title = {Sarcopenia and Sarcopenic Obesity and Mortality Among Older People},
author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},
doi = {10.1001/jamanetworkopen.2024.3604},
issn = {2574-3805},
year = {2024},
date = {2024-03-01},
journal = {JAMA Netw Open},
volume = {7},
number = {3},
pages = {e243604},
abstract = {IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.
Benz, Elizabeth; Pinel, Alexandre; Guillet, Christelle; Capel, Frederic; Pereira, Bruno; Antonio, Marie De; Pouget, Melanie; Cruz-Jentoft, Alfonso J; Eglseer, Doris; Topinkova, Eva; Barazzoni, Rocco; Rivadeneira, Fernando; Ikram, M Arfan; Steur, Marinka; Voortman, Trudy; Schoufour, Josje D; Weijs, Peter J M; Boirie, Yves
Sarcopenia and Sarcopenic Obesity and Mortality Among Older People Tijdschriftartikel
In: JAMA Netw Open, vol. 7, nr. 3, pp. e243604, 2024, ISSN: 2574-3805.
@article{pmid38526491c,
title = {Sarcopenia and Sarcopenic Obesity and Mortality Among Older People},
author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},
doi = {10.1001/jamanetworkopen.2024.3604},
issn = {2574-3805},
year = {2024},
date = {2024-03-01},
journal = {JAMA Netw Open},
volume = {7},
number = {3},
pages = {e243604},
abstract = {IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.
Benz, Elizabeth; Pinel, Alexandre; Guillet, Christelle; Capel, Frederic; Pereira, Bruno; Antonio, Marie De; Pouget, Melanie; Cruz-Jentoft, Alfonso J; Eglseer, Doris; Topinkova, Eva; Barazzoni, Rocco; Rivadeneira, Fernando; Ikram, M Arfan; Steur, Marinka; Voortman, Trudy; Schoufour, Josje D; Weijs, Peter J M; Boirie, Yves
Sarcopenia and sarcopenic obesity and mortality among older
people Tijdschriftartikel
In: JAMA Netw. Open, vol. 7, nr. 3, pp. e243604, 2024.
@article{Benz2024-on,
title = {Sarcopenia and sarcopenic obesity and mortality among older
people},
author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},
year = {2024},
date = {2024-03-01},
journal = {JAMA Netw. Open},
volume = {7},
number = {3},
pages = {e243604},
abstract = {Importance: Sarcopenia and obesity are 2 global concerns
associated with adverse health outcomes in older people. Evidence
on the population-based prevalence of the combination of
sarcopenia with obesity (sarcopenic obesity [SO]) and its
association with mortality are still limited. Objective: To
investigate the prevalence of sarcopenia and SO and their
association with all-cause mortality. Design, Setting, and
Participants: This large-scale, population-based cohort study
assessed participants from the Rotterdam Study from March 1,
2009, to June 1, 2014. Associations of sarcopenia and SO with
all-cause mortality were studied using Kaplan-Meier curves, Cox
proportional hazards regression, and accelerated failure time
models fitted for sex, age, and body mass index (BMI). Data
analysis was performed from January 1 to April 1, 2023.
Exposures: The prevalence of sarcopenia and SO, measured based on
handgrip strength and body composition (BC) (dual-energy x-ray
absorptiometry) as recommended by current consensus criteria,
with probable sarcopenia defined as having low handgrip strength
and confirmed sarcopenia and SO defined as altered BC (high fat
percentage and/or low appendicular skeletal muscle index) in
addition to low handgrip strength. Main Outcome and Measure: The
primary outcome was all-cause mortality, collected using linked
mortality data from general practitioners and the central
municipal records, until October 2022. Results: In the total
population of 5888 participants (mean [SD] age, 69.5 [9.1] years;
mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%;
95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%;
95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic
obesity with 1 altered component of BC was present in 295
participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered
components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An
increased risk of all-cause mortality was observed in
participants with probable sarcopenia (hazard ratio [HR], 1.29;
95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI,
1.53-2.43). Participants with SO plus 1 altered component of BC
(HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC
(HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality
than those without SO. Similar results for SO were obtained for
participants with a BMI of 27 or greater. Conclusions and
Relevance: In this study, sarcopenia and SO were found to be
prevalent phenotypes in older people and were associated with
all-cause mortality. Additional alterations of BC amplified this
risk independently of age, sex, and BMI. The use of low muscle
strength as a first step of both diagnoses may allow for early
identification of individuals at risk for premature mortality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Importance: Sarcopenia and obesity are 2 global concerns
associated with adverse health outcomes in older people. Evidence
on the population-based prevalence of the combination of
sarcopenia with obesity (sarcopenic obesity [SO]) and its
association with mortality are still limited. Objective: To
investigate the prevalence of sarcopenia and SO and their
association with all-cause mortality. Design, Setting, and
Participants: This large-scale, population-based cohort study
assessed participants from the Rotterdam Study from March 1,
2009, to June 1, 2014. Associations of sarcopenia and SO with
all-cause mortality were studied using Kaplan-Meier curves, Cox
proportional hazards regression, and accelerated failure time
models fitted for sex, age, and body mass index (BMI). Data
analysis was performed from January 1 to April 1, 2023.
Exposures: The prevalence of sarcopenia and SO, measured based on
handgrip strength and body composition (BC) (dual-energy x-ray
absorptiometry) as recommended by current consensus criteria,
with probable sarcopenia defined as having low handgrip strength
and confirmed sarcopenia and SO defined as altered BC (high fat
percentage and/or low appendicular skeletal muscle index) in
addition to low handgrip strength. Main Outcome and Measure: The
primary outcome was all-cause mortality, collected using linked
mortality data from general practitioners and the central
municipal records, until October 2022. Results: In the total
population of 5888 participants (mean [SD] age, 69.5 [9.1] years;
mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%;
95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%;
95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic
obesity with 1 altered component of BC was present in 295
participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered
components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An
increased risk of all-cause mortality was observed in
participants with probable sarcopenia (hazard ratio [HR], 1.29;
95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI,
1.53-2.43). Participants with SO plus 1 altered component of BC
(HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC
(HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality
than those without SO. Similar results for SO were obtained for
participants with a BMI of 27 or greater. Conclusions and
Relevance: In this study, sarcopenia and SO were found to be
prevalent phenotypes in older people and were associated with
all-cause mortality. Additional alterations of BC amplified this
risk independently of age, sex, and BMI. The use of low muscle
strength as a first step of both diagnoses may allow for early
identification of individuals at risk for premature mortality.
associated with adverse health outcomes in older people. Evidence
on the population-based prevalence of the combination of
sarcopenia with obesity (sarcopenic obesity [SO]) and its
association with mortality are still limited. Objective: To
investigate the prevalence of sarcopenia and SO and their
association with all-cause mortality. Design, Setting, and
Participants: This large-scale, population-based cohort study
assessed participants from the Rotterdam Study from March 1,
2009, to June 1, 2014. Associations of sarcopenia and SO with
all-cause mortality were studied using Kaplan-Meier curves, Cox
proportional hazards regression, and accelerated failure time
models fitted for sex, age, and body mass index (BMI). Data
analysis was performed from January 1 to April 1, 2023.
Exposures: The prevalence of sarcopenia and SO, measured based on
handgrip strength and body composition (BC) (dual-energy x-ray
absorptiometry) as recommended by current consensus criteria,
with probable sarcopenia defined as having low handgrip strength
and confirmed sarcopenia and SO defined as altered BC (high fat
percentage and/or low appendicular skeletal muscle index) in
addition to low handgrip strength. Main Outcome and Measure: The
primary outcome was all-cause mortality, collected using linked
mortality data from general practitioners and the central
municipal records, until October 2022. Results: In the total
population of 5888 participants (mean [SD] age, 69.5 [9.1] years;
mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%;
95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%;
95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic
obesity with 1 altered component of BC was present in 295
participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered
components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An
increased risk of all-cause mortality was observed in
participants with probable sarcopenia (hazard ratio [HR], 1.29;
95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI,
1.53-2.43). Participants with SO plus 1 altered component of BC
(HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC
(HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality
than those without SO. Similar results for SO were obtained for
participants with a BMI of 27 or greater. Conclusions and
Relevance: In this study, sarcopenia and SO were found to be
prevalent phenotypes in older people and were associated with
all-cause mortality. Additional alterations of BC amplified this
risk independently of age, sex, and BMI. The use of low muscle
strength as a first step of both diagnoses may allow for early
identification of individuals at risk for premature mortality.
Benz, Elizabeth; Pinel, Alexandre; Guillet, Christelle; Capel, Frederic; Pereira, Bruno; Antonio, Marie De; Pouget, Melanie; Cruz-Jentoft, Alfonso J; Eglseer, Doris; Topinkova, Eva; Barazzoni, Rocco; Rivadeneira, Fernando; Ikram, M Arfan; Steur, Marinka; Voortman, Trudy; Schoufour, Josje D; Weijs, Peter J M; Boirie, Yves
Sarcopenia and sarcopenic obesity and mortality among older
people Tijdschriftartikel
In: JAMA Netw. Open, vol. 7, nr. 3, pp. e243604, 2024.
@article{Benz2024-onb,
title = {Sarcopenia and sarcopenic obesity and mortality among older
people},
author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},
year = {2024},
date = {2024-03-01},
journal = {JAMA Netw. Open},
volume = {7},
number = {3},
pages = {e243604},
abstract = {Importance: Sarcopenia and obesity are 2 global concerns
associated with adverse health outcomes in older people. Evidence
on the population-based prevalence of the combination of
sarcopenia with obesity (sarcopenic obesity [SO]) and its
association with mortality are still limited. Objective: To
investigate the prevalence of sarcopenia and SO and their
association with all-cause mortality. Design, Setting, and
Participants: This large-scale, population-based cohort study
assessed participants from the Rotterdam Study from March 1,
2009, to June 1, 2014. Associations of sarcopenia and SO with
all-cause mortality were studied using Kaplan-Meier curves, Cox
proportional hazards regression, and accelerated failure time
models fitted for sex, age, and body mass index (BMI). Data
analysis was performed from January 1 to April 1, 2023.
Exposures: The prevalence of sarcopenia and SO, measured based on
handgrip strength and body composition (BC) (dual-energy x-ray
absorptiometry) as recommended by current consensus criteria,
with probable sarcopenia defined as having low handgrip strength
and confirmed sarcopenia and SO defined as altered BC (high fat
percentage and/or low appendicular skeletal muscle index) in
addition to low handgrip strength. Main Outcome and Measure: The
primary outcome was all-cause mortality, collected using linked
mortality data from general practitioners and the central
municipal records, until October 2022. Results: In the total
population of 5888 participants (mean [SD] age, 69.5 [9.1] years;
mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%;
95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%;
95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic
obesity with 1 altered component of BC was present in 295
participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered
components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An
increased risk of all-cause mortality was observed in
participants with probable sarcopenia (hazard ratio [HR], 1.29;
95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI,
1.53-2.43). Participants with SO plus 1 altered component of BC
(HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC
(HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality
than those without SO. Similar results for SO were obtained for
participants with a BMI of 27 or greater. Conclusions and
Relevance: In this study, sarcopenia and SO were found to be
prevalent phenotypes in older people and were associated with
all-cause mortality. Additional alterations of BC amplified this
risk independently of age, sex, and BMI. The use of low muscle
strength as a first step of both diagnoses may allow for early
identification of individuals at risk for premature mortality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Importance: Sarcopenia and obesity are 2 global concerns
associated with adverse health outcomes in older people. Evidence
on the population-based prevalence of the combination of
sarcopenia with obesity (sarcopenic obesity [SO]) and its
association with mortality are still limited. Objective: To
investigate the prevalence of sarcopenia and SO and their
association with all-cause mortality. Design, Setting, and
Participants: This large-scale, population-based cohort study
assessed participants from the Rotterdam Study from March 1,
2009, to June 1, 2014. Associations of sarcopenia and SO with
all-cause mortality were studied using Kaplan-Meier curves, Cox
proportional hazards regression, and accelerated failure time
models fitted for sex, age, and body mass index (BMI). Data
analysis was performed from January 1 to April 1, 2023.
Exposures: The prevalence of sarcopenia and SO, measured based on
handgrip strength and body composition (BC) (dual-energy x-ray
absorptiometry) as recommended by current consensus criteria,
with probable sarcopenia defined as having low handgrip strength
and confirmed sarcopenia and SO defined as altered BC (high fat
percentage and/or low appendicular skeletal muscle index) in
addition to low handgrip strength. Main Outcome and Measure: The
primary outcome was all-cause mortality, collected using linked
mortality data from general practitioners and the central
municipal records, until October 2022. Results: In the total
population of 5888 participants (mean [SD] age, 69.5 [9.1] years;
mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%;
95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%;
95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic
obesity with 1 altered component of BC was present in 295
participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered
components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An
increased risk of all-cause mortality was observed in
participants with probable sarcopenia (hazard ratio [HR], 1.29;
95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI,
1.53-2.43). Participants with SO plus 1 altered component of BC
(HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC
(HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality
than those without SO. Similar results for SO were obtained for
participants with a BMI of 27 or greater. Conclusions and
Relevance: In this study, sarcopenia and SO were found to be
prevalent phenotypes in older people and were associated with
all-cause mortality. Additional alterations of BC amplified this
risk independently of age, sex, and BMI. The use of low muscle
strength as a first step of both diagnoses may allow for early
identification of individuals at risk for premature mortality.
associated with adverse health outcomes in older people. Evidence
on the population-based prevalence of the combination of
sarcopenia with obesity (sarcopenic obesity [SO]) and its
association with mortality are still limited. Objective: To
investigate the prevalence of sarcopenia and SO and their
association with all-cause mortality. Design, Setting, and
Participants: This large-scale, population-based cohort study
assessed participants from the Rotterdam Study from March 1,
2009, to June 1, 2014. Associations of sarcopenia and SO with
all-cause mortality were studied using Kaplan-Meier curves, Cox
proportional hazards regression, and accelerated failure time
models fitted for sex, age, and body mass index (BMI). Data
analysis was performed from January 1 to April 1, 2023.
Exposures: The prevalence of sarcopenia and SO, measured based on
handgrip strength and body composition (BC) (dual-energy x-ray
absorptiometry) as recommended by current consensus criteria,
with probable sarcopenia defined as having low handgrip strength
and confirmed sarcopenia and SO defined as altered BC (high fat
percentage and/or low appendicular skeletal muscle index) in
addition to low handgrip strength. Main Outcome and Measure: The
primary outcome was all-cause mortality, collected using linked
mortality data from general practitioners and the central
municipal records, until October 2022. Results: In the total
population of 5888 participants (mean [SD] age, 69.5 [9.1] years;
mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%;
95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%;
95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic
obesity with 1 altered component of BC was present in 295
participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered
components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An
increased risk of all-cause mortality was observed in
participants with probable sarcopenia (hazard ratio [HR], 1.29;
95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI,
1.53-2.43). Participants with SO plus 1 altered component of BC
(HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC
(HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality
than those without SO. Similar results for SO were obtained for
participants with a BMI of 27 or greater. Conclusions and
Relevance: In this study, sarcopenia and SO were found to be
prevalent phenotypes in older people and were associated with
all-cause mortality. Additional alterations of BC amplified this
risk independently of age, sex, and BMI. The use of low muscle
strength as a first step of both diagnoses may allow for early
identification of individuals at risk for premature mortality.
Wagenaar, Carlijn A; Walrabenstein, Wendy; van der Leeden, Marike; Turkstra, Franktien; Gerritsen, Martijn; Twisk, Jos W R; Boers, Maarten; van der Esch, Martin; van Middendorp, Henriët; Weijs, Peter J M; van Schaardenburg, Dirkjan
Long-term effectiveness of a lifestyle intervention for rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 'Plants for Joints' randomised clinical trial Tijdschriftartikel
In: RMD Open, vol. 10, nr. 1, 2024, ISSN: 2056-5933.
@article{pmid38413171,
title = {Long-term effectiveness of a lifestyle intervention for rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 'Plants for Joints' randomised clinical trial},
author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike van der Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin van der Esch and Henriët van Middendorp and Peter J M Weijs and Dirkjan van Schaardenburg},
doi = {10.1136/rmdopen-2023-004025},
issn = {2056-5933},
year = {2024},
date = {2024-02-01},
journal = {RMD Open},
volume = {10},
number = {1},
abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. The current study investigated long-term outcomes.nnMETHODS: After completion of two 16-week trials in people with (1) RA or (2) MSOA, control groups switched to the active PFJ intervention. At the end of the intervention, all participants were followed up in a 1-year observational extension study. Primary outcomes were 28-joint Disease Activity Score (DAS28) (RA) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included body composition, metabolic outcomes, medication changes and intervention adherence. An intention-to-treat analysis with a linear mixed model was used to analyse within-group changes.nnRESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 MSOA participants completed the extension study. The effects of the PFJ intervention were replicated in the original control groups and sustained within the RA group a year after intervention completion (mean DAS28 -0.9 points; p<0.001), while in the MSOA group mean WOMAC increased towards but remained well under the starting value (-7.8 points, p<0.001). Improvements in C-reactive protein, waist circumference (RA and MSOA); low-density lipoprotein cholesterol (RA); and weight, haemoglobin A1c, blood pressure (MSOA) were also sustained. Participants had a net decrease of medication, and intervention adherence was largely sustained.nnCONCLUSIONS: A year after the PFJ lifestyle intervention, improvements of disease activity and metabolic outcomes within RA and MSOA groups were largely sustained and related to sustained adherence, with a net decrease of medication.nnTRIAL REGISTRATION NUMBERS: NL7800, NL7801.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: In two randomised controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. The current study investigated long-term outcomes.nnMETHODS: After completion of two 16-week trials in people with (1) RA or (2) MSOA, control groups switched to the active PFJ intervention. At the end of the intervention, all participants were followed up in a 1-year observational extension study. Primary outcomes were 28-joint Disease Activity Score (DAS28) (RA) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included body composition, metabolic outcomes, medication changes and intervention adherence. An intention-to-treat analysis with a linear mixed model was used to analyse within-group changes.nnRESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 MSOA participants completed the extension study. The effects of the PFJ intervention were replicated in the original control groups and sustained within the RA group a year after intervention completion (mean DAS28 -0.9 points; p<0.001), while in the MSOA group mean WOMAC increased towards but remained well under the starting value (-7.8 points, p<0.001). Improvements in C-reactive protein, waist circumference (RA and MSOA); low-density lipoprotein cholesterol (RA); and weight, haemoglobin A1c, blood pressure (MSOA) were also sustained. Participants had a net decrease of medication, and intervention adherence was largely sustained.nnCONCLUSIONS: A year after the PFJ lifestyle intervention, improvements of disease activity and metabolic outcomes within RA and MSOA groups were largely sustained and related to sustained adherence, with a net decrease of medication.nnTRIAL REGISTRATION NUMBERS: NL7800, NL7801.
Wagenaar, Carlijn A; Walrabenstein, Wendy; Leeden, Marike; Turkstra, Franktien; Gerritsen, Martijn; Twisk, Jos W R; Boers, Maarten; Esch, Martin; Middendorp, Henriët; Weijs, Peter J M; Schaardenburg, Dirkjan
Long-term effectiveness of a lifestyle intervention for
rheumatoid arthritis and osteoarthritis: 1-year follow-up of the
'Plants for Joints' randomised clinical trial Tijdschriftartikel
In: RMD Open, vol. 10, nr. 1, pp. e004025, 2024.
@article{Wagenaar2024-fu,
title = {Long-term effectiveness of a lifestyle intervention for
rheumatoid arthritis and osteoarthritis: 1-year follow-up of the
'Plants for Joints' randomised clinical trial},
author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin Esch and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},
year = {2024},
date = {2024-02-01},
journal = {RMD Open},
volume = {10},
number = {1},
pages = {e004025},
publisher = {BMJ},
abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for
Joints (PFJ) multidisciplinary lifestyle intervention reduced
signs and symptoms of rheumatoid arthritis (RA), or metabolic
syndrome-associated hip or knee osteoarthritis (MSOA) compared
with usual care. The current study investigated long-term
outcomes. METHODS: After completion of two 16-week trials in
people with (1) RA or (2) MSOA, control groups switched to the
active PFJ intervention. At the end of the intervention, all
participants were followed up in a 1-year observational
extension study. Primary outcomes were 28-joint Disease Activity
Score (DAS28) (RA) and Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included
body composition, metabolic outcomes, medication changes and
intervention adherence. An intention-to-treat analysis with a
linear mixed model was used to analyse within-group changes.
RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64
MSOA participants completed the extension study. The effects of
the PFJ intervention were replicated in the original control
groups and sustained within the RA group a year after
intervention completion (mean DAS28 -0.9 points; p<0.001), while
in the MSOA group mean WOMAC increased towards but remained well
under the starting value (-7.8 points, p<0.001). Improvements in
C-reactive protein, waist circumference (RA and MSOA);
low-density lipoprotein cholesterol (RA); and weight,
haemoglobin A1c, blood pressure (MSOA) were also sustained.
Participants had a net decrease of medication, and intervention
adherence was largely sustained. CONCLUSIONS: A year after the
PFJ lifestyle intervention, improvements of disease activity and
metabolic outcomes within RA and MSOA groups were largely
sustained and related to sustained adherence, with a net
decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800,
NL7801.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: In two randomised controlled trials, the Plants for
Joints (PFJ) multidisciplinary lifestyle intervention reduced
signs and symptoms of rheumatoid arthritis (RA), or metabolic
syndrome-associated hip or knee osteoarthritis (MSOA) compared
with usual care. The current study investigated long-term
outcomes. METHODS: After completion of two 16-week trials in
people with (1) RA or (2) MSOA, control groups switched to the
active PFJ intervention. At the end of the intervention, all
participants were followed up in a 1-year observational
extension study. Primary outcomes were 28-joint Disease Activity
Score (DAS28) (RA) and Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included
body composition, metabolic outcomes, medication changes and
intervention adherence. An intention-to-treat analysis with a
linear mixed model was used to analyse within-group changes.
RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64
MSOA participants completed the extension study. The effects of
the PFJ intervention were replicated in the original control
groups and sustained within the RA group a year after
intervention completion (mean DAS28 -0.9 points; p<0.001), while
in the MSOA group mean WOMAC increased towards but remained well
under the starting value (-7.8 points, p<0.001). Improvements in
C-reactive protein, waist circumference (RA and MSOA);
low-density lipoprotein cholesterol (RA); and weight,
haemoglobin A1c, blood pressure (MSOA) were also sustained.
Participants had a net decrease of medication, and intervention
adherence was largely sustained. CONCLUSIONS: A year after the
PFJ lifestyle intervention, improvements of disease activity and
metabolic outcomes within RA and MSOA groups were largely
sustained and related to sustained adherence, with a net
decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800,
NL7801.
Joints (PFJ) multidisciplinary lifestyle intervention reduced
signs and symptoms of rheumatoid arthritis (RA), or metabolic
syndrome-associated hip or knee osteoarthritis (MSOA) compared
with usual care. The current study investigated long-term
outcomes. METHODS: After completion of two 16-week trials in
people with (1) RA or (2) MSOA, control groups switched to the
active PFJ intervention. At the end of the intervention, all
participants were followed up in a 1-year observational
extension study. Primary outcomes were 28-joint Disease Activity
Score (DAS28) (RA) and Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included
body composition, metabolic outcomes, medication changes and
intervention adherence. An intention-to-treat analysis with a
linear mixed model was used to analyse within-group changes.
RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64
MSOA participants completed the extension study. The effects of
the PFJ intervention were replicated in the original control
groups and sustained within the RA group a year after
intervention completion (mean DAS28 -0.9 points; p<0.001), while
in the MSOA group mean WOMAC increased towards but remained well
under the starting value (-7.8 points, p<0.001). Improvements in
C-reactive protein, waist circumference (RA and MSOA);
low-density lipoprotein cholesterol (RA); and weight,
haemoglobin A1c, blood pressure (MSOA) were also sustained.
Participants had a net decrease of medication, and intervention
adherence was largely sustained. CONCLUSIONS: A year after the
PFJ lifestyle intervention, improvements of disease activity and
metabolic outcomes within RA and MSOA groups were largely
sustained and related to sustained adherence, with a net
decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800,
NL7801.
Wagenaar, Carlijn A; Walrabenstein, Wendy; Leeden, Marike; Turkstra, Franktien; Gerritsen, Martijn; Twisk, Jos W R; Boers, Maarten; Esch, Martin; Middendorp, Henriët; Weijs, Peter J M; Schaardenburg, Dirkjan
Long-term effectiveness of a lifestyle intervention for
rheumatoid arthritis and osteoarthritis: 1-year follow-up of the
'Plants for Joints' randomised clinical trial Tijdschriftartikel
In: RMD Open, vol. 10, nr. 1, pp. e004025, 2024.
@article{Wagenaar2024-fub,
title = {Long-term effectiveness of a lifestyle intervention for
rheumatoid arthritis and osteoarthritis: 1-year follow-up of the
'Plants for Joints' randomised clinical trial},
author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin Esch and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},
year = {2024},
date = {2024-02-01},
journal = {RMD Open},
volume = {10},
number = {1},
pages = {e004025},
publisher = {BMJ},
abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for
Joints (PFJ) multidisciplinary lifestyle intervention reduced
signs and symptoms of rheumatoid arthritis (RA), or metabolic
syndrome-associated hip or knee osteoarthritis (MSOA) compared
with usual care. The current study investigated long-term
outcomes. METHODS: After completion of two 16-week trials in
people with (1) RA or (2) MSOA, control groups switched to the
active PFJ intervention. At the end of the intervention, all
participants were followed up in a 1-year observational
extension study. Primary outcomes were 28-joint Disease Activity
Score (DAS28) (RA) and Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included
body composition, metabolic outcomes, medication changes and
intervention adherence. An intention-to-treat analysis with a
linear mixed model was used to analyse within-group changes.
RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64
MSOA participants completed the extension study. The effects of
the PFJ intervention were replicated in the original control
groups and sustained within the RA group a year after
intervention completion (mean DAS28 -0.9 points; p<0.001), while
in the MSOA group mean WOMAC increased towards but remained well
under the starting value (-7.8 points, p<0.001). Improvements in
C-reactive protein, waist circumference (RA and MSOA);
low-density lipoprotein cholesterol (RA); and weight,
haemoglobin A1c, blood pressure (MSOA) were also sustained.
Participants had a net decrease of medication, and intervention
adherence was largely sustained. CONCLUSIONS: A year after the
PFJ lifestyle intervention, improvements of disease activity and
metabolic outcomes within RA and MSOA groups were largely
sustained and related to sustained adherence, with a net
decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800,
NL7801.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: In two randomised controlled trials, the Plants for
Joints (PFJ) multidisciplinary lifestyle intervention reduced
signs and symptoms of rheumatoid arthritis (RA), or metabolic
syndrome-associated hip or knee osteoarthritis (MSOA) compared
with usual care. The current study investigated long-term
outcomes. METHODS: After completion of two 16-week trials in
people with (1) RA or (2) MSOA, control groups switched to the
active PFJ intervention. At the end of the intervention, all
participants were followed up in a 1-year observational
extension study. Primary outcomes were 28-joint Disease Activity
Score (DAS28) (RA) and Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included
body composition, metabolic outcomes, medication changes and
intervention adherence. An intention-to-treat analysis with a
linear mixed model was used to analyse within-group changes.
RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64
MSOA participants completed the extension study. The effects of
the PFJ intervention were replicated in the original control
groups and sustained within the RA group a year after
intervention completion (mean DAS28 -0.9 points; p<0.001), while
in the MSOA group mean WOMAC increased towards but remained well
under the starting value (-7.8 points, p<0.001). Improvements in
C-reactive protein, waist circumference (RA and MSOA);
low-density lipoprotein cholesterol (RA); and weight,
haemoglobin A1c, blood pressure (MSOA) were also sustained.
Participants had a net decrease of medication, and intervention
adherence was largely sustained. CONCLUSIONS: A year after the
PFJ lifestyle intervention, improvements of disease activity and
metabolic outcomes within RA and MSOA groups were largely
sustained and related to sustained adherence, with a net
decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800,
NL7801.
Joints (PFJ) multidisciplinary lifestyle intervention reduced
signs and symptoms of rheumatoid arthritis (RA), or metabolic
syndrome-associated hip or knee osteoarthritis (MSOA) compared
with usual care. The current study investigated long-term
outcomes. METHODS: After completion of two 16-week trials in
people with (1) RA or (2) MSOA, control groups switched to the
active PFJ intervention. At the end of the intervention, all
participants were followed up in a 1-year observational
extension study. Primary outcomes were 28-joint Disease Activity
Score (DAS28) (RA) and Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included
body composition, metabolic outcomes, medication changes and
intervention adherence. An intention-to-treat analysis with a
linear mixed model was used to analyse within-group changes.
RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64
MSOA participants completed the extension study. The effects of
the PFJ intervention were replicated in the original control
groups and sustained within the RA group a year after
intervention completion (mean DAS28 -0.9 points; p<0.001), while
in the MSOA group mean WOMAC increased towards but remained well
under the starting value (-7.8 points, p<0.001). Improvements in
C-reactive protein, waist circumference (RA and MSOA);
low-density lipoprotein cholesterol (RA); and weight,
haemoglobin A1c, blood pressure (MSOA) were also sustained.
Participants had a net decrease of medication, and intervention
adherence was largely sustained. CONCLUSIONS: A year after the
PFJ lifestyle intervention, improvements of disease activity and
metabolic outcomes within RA and MSOA groups were largely
sustained and related to sustained adherence, with a net
decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800,
NL7801.
de Geus, Manon; Dam, Manouk; Visser, Wesley J; Ipema, Karin J R; de Mik-van Egmond, Anneke M E; Tieland, Michael; Weijs, Peter J M; Kruizenga, Hinke M
The Impact of Combined Nutrition and Exercise Interventions in Patients with Chronic Kidney Disease Tijdschriftartikel
In: Nutrients, vol. 16, nr. 3, 2024, ISSN: 2072-6643.
@article{pmid38337689,
title = {The Impact of Combined Nutrition and Exercise Interventions in Patients with Chronic Kidney Disease},
author = {Manon de Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E de Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},
doi = {10.3390/nu16030406},
issn = {2072-6643},
year = {2024},
date = {2024-01-01},
journal = {Nutrients},
volume = {16},
number = {3},
abstract = {Combined nutrition and exercise interventions potentially improve protein-energy wasting/malnutrition-related outcomes in patients with chronic kidney disease (CKD). The aim was to systematically review the effect of combined interventions on nutritional status, muscle strength, physical performance and QoL. MEDLINE, Cochrane, Embase, Web of Science and Google Scholar were searched for studies up to the date of July 2023. Methodological quality was appraised with the Cochrane risk-of-bias tool. Ten randomized controlled trials (nine publications) were included (334 patients). No differences were observed in body mass index, lean body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) ( = 3, MD 27.2, 95%CI [7 to 48], = 0.008), but not in the timed up-and-go test. No effect was found on QoL. A positive impact on 6-MWT was observed, but no improvements were detected in nutritional status, muscle strength or QoL. Concerns about reliability and generalizability arise due to limited statistical power and study heterogeneity of the studies included.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Combined nutrition and exercise interventions potentially improve protein-energy wasting/malnutrition-related outcomes in patients with chronic kidney disease (CKD). The aim was to systematically review the effect of combined interventions on nutritional status, muscle strength, physical performance and QoL. MEDLINE, Cochrane, Embase, Web of Science and Google Scholar were searched for studies up to the date of July 2023. Methodological quality was appraised with the Cochrane risk-of-bias tool. Ten randomized controlled trials (nine publications) were included (334 patients). No differences were observed in body mass index, lean body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) ( = 3, MD 27.2, 95%CI [7 to 48], = 0.008), but not in the timed up-and-go test. No effect was found on QoL. A positive impact on 6-MWT was observed, but no improvements were detected in nutritional status, muscle strength or QoL. Concerns about reliability and generalizability arise due to limited statistical power and study heterogeneity of the studies included.
Geus, Manon; Dam, Manouk; Visser, Wesley J; Ipema, Karin J R; Egmond, Anneke M E Mik-van; Tieland, Michael; Weijs, Peter J M; Kruizenga, Hinke M
The impact of combined nutrition and exercise interventions in
patients with chronic kidney disease Tijdschriftartikel
In: Nutrients, vol. 16, nr. 3, 2024.
@article{De_Geus2024-il,
title = {The impact of combined nutrition and exercise interventions in
patients with chronic kidney disease},
author = {Manon Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},
year = {2024},
date = {2024-01-01},
journal = {Nutrients},
volume = {16},
number = {3},
abstract = {Combined nutrition and exercise interventions potentially improve
protein-energy wasting/malnutrition-related outcomes in patients
with chronic kidney disease (CKD). The aim was to systematically
review the effect of combined interventions on nutritional
status, muscle strength, physical performance and QoL. MEDLINE,
Cochrane, Embase, Web of Science and Google Scholar were searched
for studies up to the date of July 2023. Methodological quality
was appraised with the Cochrane risk-of-bias tool. Ten randomized
controlled trials (nine publications) were included (334
patients). No differences were observed in body mass index, lean
body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Combined nutrition and exercise interventions potentially improve
protein-energy wasting/malnutrition-related outcomes in patients
with chronic kidney disease (CKD). The aim was to systematically
review the effect of combined interventions on nutritional
status, muscle strength, physical performance and QoL. MEDLINE,
Cochrane, Embase, Web of Science and Google Scholar were searched
for studies up to the date of July 2023. Methodological quality
was appraised with the Cochrane risk-of-bias tool. Ten randomized
controlled trials (nine publications) were included (334
patients). No differences were observed in body mass index, lean
body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48
protein-energy wasting/malnutrition-related outcomes in patients
with chronic kidney disease (CKD). The aim was to systematically
review the effect of combined interventions on nutritional
status, muscle strength, physical performance and QoL. MEDLINE,
Cochrane, Embase, Web of Science and Google Scholar were searched
for studies up to the date of July 2023. Methodological quality
was appraised with the Cochrane risk-of-bias tool. Ten randomized
controlled trials (nine publications) were included (334
patients). No differences were observed in body mass index, lean
body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48
Geus, Manon; Dam, Manouk; Visser, Wesley J; Ipema, Karin J R; Egmond, Anneke M E Mik-van; Tieland, Michael; Weijs, Peter J M; Kruizenga, Hinke M
The impact of combined nutrition and exercise interventions in
patients with chronic kidney disease Tijdschriftartikel
In: Nutrients, vol. 16, nr. 3, 2024.
@article{De_Geus2024-ilb,
title = {The impact of combined nutrition and exercise interventions in
patients with chronic kidney disease},
author = {Manon Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},
year = {2024},
date = {2024-01-01},
journal = {Nutrients},
volume = {16},
number = {3},
abstract = {Combined nutrition and exercise interventions potentially improve
protein-energy wasting/malnutrition-related outcomes in patients
with chronic kidney disease (CKD). The aim was to systematically
review the effect of combined interventions on nutritional
status, muscle strength, physical performance and QoL. MEDLINE,
Cochrane, Embase, Web of Science and Google Scholar were searched
for studies up to the date of July 2023. Methodological quality
was appraised with the Cochrane risk-of-bias tool. Ten randomized
controlled trials (nine publications) were included (334
patients). No differences were observed in body mass index, lean
body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Combined nutrition and exercise interventions potentially improve
protein-energy wasting/malnutrition-related outcomes in patients
with chronic kidney disease (CKD). The aim was to systematically
review the effect of combined interventions on nutritional
status, muscle strength, physical performance and QoL. MEDLINE,
Cochrane, Embase, Web of Science and Google Scholar were searched
for studies up to the date of July 2023. Methodological quality
was appraised with the Cochrane risk-of-bias tool. Ten randomized
controlled trials (nine publications) were included (334
patients). No differences were observed in body mass index, lean
body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48
protein-energy wasting/malnutrition-related outcomes in patients
with chronic kidney disease (CKD). The aim was to systematically
review the effect of combined interventions on nutritional
status, muscle strength, physical performance and QoL. MEDLINE,
Cochrane, Embase, Web of Science and Google Scholar were searched
for studies up to the date of July 2023. Methodological quality
was appraised with the Cochrane risk-of-bias tool. Ten randomized
controlled trials (nine publications) were included (334
patients). No differences were observed in body mass index, lean
body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48
2023
van Dronkelaar, Carliene; Tieland, Michael; Cederholm, Tommy; Reijnierse, Esmee M; Weijs, Peter J M; Kruizenga, Hinke
Malnutrition Screening Tools Are Not Sensitive Enough to Identify Older Hospital Patients with Malnutrition Tijdschriftartikel
In: Nutrients, vol. 15, nr. 24, 2023, ISSN: 2072-6643.
@article{pmid38140387,
title = {Malnutrition Screening Tools Are Not Sensitive Enough to Identify Older Hospital Patients with Malnutrition},
author = {Carliene van Dronkelaar and Michael Tieland and Tommy Cederholm and Esmee M Reijnierse and Peter J M Weijs and Hinke Kruizenga},
doi = {10.3390/nu15245126},
issn = {2072-6643},
year = {2023},
date = {2023-12-01},
journal = {Nutrients},
volume = {15},
number = {24},
abstract = {This study evaluates the concurrent validity of five malnutrition screening tools to identify older hospitalized patients against the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria as limited evidence is available. The screening tools Short Nutritional Assessment Questionnaire (SNAQ), Malnutrition Universal Screening Tool (MUST), Malnutrition Screening Tool (MST), Mini Nutritional Assessment-Short Form (MNA-SF), and the Patient-Generated Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs for both malnutrition (conservative) and moderate malnutrition or risk of malnutrition (liberal) were used. The concurrent validity was determined by the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the level of agreement by Cohen's kappa. In total, 356 patients were included in the analyses (median age 70 y (IQR 63-77); 54% male). The prevalence of malnutrition according to the GLIM criteria without prior screening was 42%. The conservative cut-offs showed a low-to-moderate sensitivity (32-68%) and moderate-to-high specificity (61-98%). The PPV and NPV ranged from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs displayed a moderate-to-high sensitivity (66-89%) and a low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their capacity to identify hospitalized older patients with malnutrition. The screening process in the GLIM framework requires further consideration.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
This study evaluates the concurrent validity of five malnutrition screening tools to identify older hospitalized patients against the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria as limited evidence is available. The screening tools Short Nutritional Assessment Questionnaire (SNAQ), Malnutrition Universal Screening Tool (MUST), Malnutrition Screening Tool (MST), Mini Nutritional Assessment-Short Form (MNA-SF), and the Patient-Generated Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs for both malnutrition (conservative) and moderate malnutrition or risk of malnutrition (liberal) were used. The concurrent validity was determined by the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the level of agreement by Cohen's kappa. In total, 356 patients were included in the analyses (median age 70 y (IQR 63-77); 54% male). The prevalence of malnutrition according to the GLIM criteria without prior screening was 42%. The conservative cut-offs showed a low-to-moderate sensitivity (32-68%) and moderate-to-high specificity (61-98%). The PPV and NPV ranged from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs displayed a moderate-to-high sensitivity (66-89%) and a low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their capacity to identify hospitalized older patients with malnutrition. The screening process in the GLIM framework requires further consideration.
van Ruijven, Isabel M; Abma, José; Brunsveld-Reinders, Anja H; Stapel, Sandra N; van Etten-Jamaludin, Faridi; Boirie, Yves; Barazzoni, Rocco; Weijs, Peter J M
High protein provision of more than 1.2 g/kg improves muscle mass preservation and mortality in ICU patients: A systematic review and meta-analyses Tijdschriftartikel
In: Clin Nutr, vol. 42, nr. 12, pp. 2395–2403, 2023, ISSN: 1532-1983.
@article{pmid37862825,
title = {High protein provision of more than 1.2 g/kg improves muscle mass preservation and mortality in ICU patients: A systematic review and meta-analyses},
author = {Isabel M van Ruijven and José Abma and Anja H Brunsveld-Reinders and Sandra N Stapel and Faridi van Etten-Jamaludin and Yves Boirie and Rocco Barazzoni and Peter J M Weijs},
doi = {10.1016/j.clnu.2023.09.026},
issn = {1532-1983},
year = {2023},
date = {2023-12-01},
journal = {Clin Nutr},
volume = {42},
number = {12},
pages = {2395--2403},
abstract = {BACKGROUND: ICU patients lose muscle mass rapidly and maintenance of muscle mass may contribute to improved survival rates and quality of life. Protein provision may be beneficial for preservation of muscle mass and other clinical outcomes, including survival. Current protein recommendations are expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed a systematic review and meta-analysis on protein provision and all clinically relevant outcomes recorded in the available literature.nnMETHODS: We conducted a systematic review and meta-analyses, including studies of all designs except case control and case studies, with patients aged ≥18 years with an ICU stay of ≥2 days and a mean protein provision group of ≥1.2 g/kg as compared to <1.2 g/kg with a difference of ≥0.2 g/kg between protein provision groups. All clinically relevant outcomes were studied. Meta-analyses were performed for all clinically relevant outcomes that were recorded in ≥3 included studies.nnRESULTS: A total of 29 studies published between 2012 and 2022 were included. Outcomes reported in the included studies were ICU, hospital, 28-day, 30-day, 42-day, 60-day, 90-day and 6-month mortality, ICU and hospital length of stay, duration of mechanical ventilation, vomiting, diarrhea, gastric residual volume, pneumonia, overall infections, nitrogen balance, changes in muscle mass, destination at hospital discharge, physical performance and psychological status. Meta-analyses showed differences between groups in favour of high protein provision for 60-day mortality, nitrogen balance and changes in muscle mass.nnCONCLUSION: High protein provision of more than 1.2 g/kg in critically ill patients seemed to improve nitrogen balance and changes in muscle mass on the short-term and likely 60-day mortality. Data on long-term effects on quality of life are urgently needed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: ICU patients lose muscle mass rapidly and maintenance of muscle mass may contribute to improved survival rates and quality of life. Protein provision may be beneficial for preservation of muscle mass and other clinical outcomes, including survival. Current protein recommendations are expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed a systematic review and meta-analysis on protein provision and all clinically relevant outcomes recorded in the available literature.nnMETHODS: We conducted a systematic review and meta-analyses, including studies of all designs except case control and case studies, with patients aged ≥18 years with an ICU stay of ≥2 days and a mean protein provision group of ≥1.2 g/kg as compared to <1.2 g/kg with a difference of ≥0.2 g/kg between protein provision groups. All clinically relevant outcomes were studied. Meta-analyses were performed for all clinically relevant outcomes that were recorded in ≥3 included studies.nnRESULTS: A total of 29 studies published between 2012 and 2022 were included. Outcomes reported in the included studies were ICU, hospital, 28-day, 30-day, 42-day, 60-day, 90-day and 6-month mortality, ICU and hospital length of stay, duration of mechanical ventilation, vomiting, diarrhea, gastric residual volume, pneumonia, overall infections, nitrogen balance, changes in muscle mass, destination at hospital discharge, physical performance and psychological status. Meta-analyses showed differences between groups in favour of high protein provision for 60-day mortality, nitrogen balance and changes in muscle mass.nnCONCLUSION: High protein provision of more than 1.2 g/kg in critically ill patients seemed to improve nitrogen balance and changes in muscle mass on the short-term and likely 60-day mortality. Data on long-term effects on quality of life are urgently needed.
Dronkelaar, Carliene; Tieland, Michael; Cederholm, Tommy; Reijnierse, Esmee M; Weijs, Peter J M; Kruizenga, Hinke
Malnutrition screening tools are not sensitive enough to identify
older hospital patients with malnutrition Tijdschriftartikel
In: Nutrients, vol. 15, nr. 24, 2023.
@article{Van_Dronkelaar2023-oa,
title = {Malnutrition screening tools are not sensitive enough to identify
older hospital patients with malnutrition},
author = {Carliene Dronkelaar and Michael Tieland and Tommy Cederholm and Esmee M Reijnierse and Peter J M Weijs and Hinke Kruizenga},
year = {2023},
date = {2023-12-01},
journal = {Nutrients},
volume = {15},
number = {24},
abstract = {This study evaluates the concurrent validity of five malnutrition
screening tools to identify older hospitalized patients against
the Global Leadership Initiative on Malnutrition (GLIM)
diagnostic criteria as limited evidence is available. The
screening tools Short Nutritional Assessment Questionnaire
(SNAQ), Malnutrition Universal Screening Tool (MUST),
Malnutrition Screening Tool (MST), Mini Nutritional
Assessment-Short Form (MNA-SF), and the Patient-Generated
Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs
for both malnutrition (conservative) and moderate malnutrition or
risk of malnutrition (liberal) were used. The concurrent validity
was determined by the sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), and the
level of agreement by Cohen's kappa. In total, 356 patients were
included in the analyses (median age 70 y (IQR 63-77); 54%
male). The prevalence of malnutrition according to the GLIM
criteria without prior screening was 42%. The conservative
cut-offs showed a low-to-moderate sensitivity (32-68%) and
moderate-to-high specificity (61-98%). The PPV and NPV ranged
from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs
displayed a moderate-to-high sensitivity (66-89%) and a
low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their
capacity to identify hospitalized older patients with
malnutrition. The screening process in the GLIM framework
requires further consideration.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
This study evaluates the concurrent validity of five malnutrition
screening tools to identify older hospitalized patients against
the Global Leadership Initiative on Malnutrition (GLIM)
diagnostic criteria as limited evidence is available. The
screening tools Short Nutritional Assessment Questionnaire
(SNAQ), Malnutrition Universal Screening Tool (MUST),
Malnutrition Screening Tool (MST), Mini Nutritional
Assessment-Short Form (MNA-SF), and the Patient-Generated
Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs
for both malnutrition (conservative) and moderate malnutrition or
risk of malnutrition (liberal) were used. The concurrent validity
was determined by the sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), and the
level of agreement by Cohen's kappa. In total, 356 patients were
included in the analyses (median age 70 y (IQR 63-77); 54%
male). The prevalence of malnutrition according to the GLIM
criteria without prior screening was 42%. The conservative
cut-offs showed a low-to-moderate sensitivity (32-68%) and
moderate-to-high specificity (61-98%). The PPV and NPV ranged
from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs
displayed a moderate-to-high sensitivity (66-89%) and a
low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their
capacity to identify hospitalized older patients with
malnutrition. The screening process in the GLIM framework
requires further consideration.
screening tools to identify older hospitalized patients against
the Global Leadership Initiative on Malnutrition (GLIM)
diagnostic criteria as limited evidence is available. The
screening tools Short Nutritional Assessment Questionnaire
(SNAQ), Malnutrition Universal Screening Tool (MUST),
Malnutrition Screening Tool (MST), Mini Nutritional
Assessment-Short Form (MNA-SF), and the Patient-Generated
Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs
for both malnutrition (conservative) and moderate malnutrition or
risk of malnutrition (liberal) were used. The concurrent validity
was determined by the sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), and the
level of agreement by Cohen's kappa. In total, 356 patients were
included in the analyses (median age 70 y (IQR 63-77); 54%
male). The prevalence of malnutrition according to the GLIM
criteria without prior screening was 42%. The conservative
cut-offs showed a low-to-moderate sensitivity (32-68%) and
moderate-to-high specificity (61-98%). The PPV and NPV ranged
from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs
displayed a moderate-to-high sensitivity (66-89%) and a
low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their
capacity to identify hospitalized older patients with
malnutrition. The screening process in the GLIM framework
requires further consideration.
Ruijven, Isabel M; Abma, José; Brunsveld-Reinders, Anja H; Stapel, Sandra N; Etten-Jamaludin, Faridi; Boirie, Yves; Barazzoni, Rocco; Weijs, Peter J M
High protein provision of more than 1.2 g/kg improves muscle
mass preservation and mortality in ICU patients: A systematic
review and meta-analyses Tijdschriftartikel
In: Clin. Nutr., vol. 42, nr. 12, pp. 2395–2403, 2023.
@article{Van_Ruijven2023-ds,
title = {High protein provision of more than 1.2 g/kg improves muscle
mass preservation and mortality in ICU patients: A systematic
review and meta-analyses},
author = {Isabel M Ruijven and José Abma and Anja H Brunsveld-Reinders and Sandra N Stapel and Faridi Etten-Jamaludin and Yves Boirie and Rocco Barazzoni and Peter J M Weijs},
year = {2023},
date = {2023-12-01},
journal = {Clin. Nutr.},
volume = {42},
number = {12},
pages = {2395–2403},
publisher = {Elsevier BV},
abstract = {BACKGROUND: ICU patients lose muscle mass rapidly and
maintenance of muscle mass may contribute to improved survival
rates and quality of life. Protein provision may be beneficial
for preservation of muscle mass and other clinical outcomes,
including survival. Current protein recommendations are
expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed
a systematic review and meta-analysis on protein provision and
all clinically relevant outcomes recorded in the available
literature. METHODS: We conducted a systematic review and
meta-analyses, including studies of all designs except case
control and case studies, with patients aged $geq$18 years with
an ICU stay of $geq$2 days and a mean protein provision group
of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of
$geq$0.2 g/kg between protein provision groups. All clinically
relevant outcomes were studied. Meta-analyses were performed for
all clinically relevant outcomes that were recorded in $geq$3
included studies. RESULTS: A total of 29 studies published
between 2012 and 2022 were included. Outcomes reported in the
included studies were ICU, hospital, 28-day, 30-day, 42-day,
60-day, 90-day and 6-month mortality, ICU and hospital length of
stay, duration of mechanical ventilation, vomiting, diarrhea,
gastric residual volume, pneumonia, overall infections, nitrogen
balance, changes in muscle mass, destination at hospital
discharge, physical performance and psychological status.
Meta-analyses showed differences between groups in favour of
high protein provision for 60-day mortality, nitrogen balance
and changes in muscle mass. CONCLUSION: High protein provision
of more than 1.2 g/kg in critically ill patients seemed to
improve nitrogen balance and changes in muscle mass on the
short-term and likely 60-day mortality. Data on long-term
effects on quality of life are urgently needed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: ICU patients lose muscle mass rapidly and
maintenance of muscle mass may contribute to improved survival
rates and quality of life. Protein provision may be beneficial
for preservation of muscle mass and other clinical outcomes,
including survival. Current protein recommendations are
expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed
a systematic review and meta-analysis on protein provision and
all clinically relevant outcomes recorded in the available
literature. METHODS: We conducted a systematic review and
meta-analyses, including studies of all designs except case
control and case studies, with patients aged $geq$18 years with
an ICU stay of $geq$2 days and a mean protein provision group
of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of
$geq$0.2 g/kg between protein provision groups. All clinically
relevant outcomes were studied. Meta-analyses were performed for
all clinically relevant outcomes that were recorded in $geq$3
included studies. RESULTS: A total of 29 studies published
between 2012 and 2022 were included. Outcomes reported in the
included studies were ICU, hospital, 28-day, 30-day, 42-day,
60-day, 90-day and 6-month mortality, ICU and hospital length of
stay, duration of mechanical ventilation, vomiting, diarrhea,
gastric residual volume, pneumonia, overall infections, nitrogen
balance, changes in muscle mass, destination at hospital
discharge, physical performance and psychological status.
Meta-analyses showed differences between groups in favour of
high protein provision for 60-day mortality, nitrogen balance
and changes in muscle mass. CONCLUSION: High protein provision
of more than 1.2 g/kg in critically ill patients seemed to
improve nitrogen balance and changes in muscle mass on the
short-term and likely 60-day mortality. Data on long-term
effects on quality of life are urgently needed.
maintenance of muscle mass may contribute to improved survival
rates and quality of life. Protein provision may be beneficial
for preservation of muscle mass and other clinical outcomes,
including survival. Current protein recommendations are
expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed
a systematic review and meta-analysis on protein provision and
all clinically relevant outcomes recorded in the available
literature. METHODS: We conducted a systematic review and
meta-analyses, including studies of all designs except case
control and case studies, with patients aged $geq$18 years with
an ICU stay of $geq$2 days and a mean protein provision group
of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of
$geq$0.2 g/kg between protein provision groups. All clinically
relevant outcomes were studied. Meta-analyses were performed for
all clinically relevant outcomes that were recorded in $geq$3
included studies. RESULTS: A total of 29 studies published
between 2012 and 2022 were included. Outcomes reported in the
included studies were ICU, hospital, 28-day, 30-day, 42-day,
60-day, 90-day and 6-month mortality, ICU and hospital length of
stay, duration of mechanical ventilation, vomiting, diarrhea,
gastric residual volume, pneumonia, overall infections, nitrogen
balance, changes in muscle mass, destination at hospital
discharge, physical performance and psychological status.
Meta-analyses showed differences between groups in favour of
high protein provision for 60-day mortality, nitrogen balance
and changes in muscle mass. CONCLUSION: High protein provision
of more than 1.2 g/kg in critically ill patients seemed to
improve nitrogen balance and changes in muscle mass on the
short-term and likely 60-day mortality. Data on long-term
effects on quality of life are urgently needed.
Dronkelaar, Carliene; Tieland, Michael; Cederholm, Tommy; Reijnierse, Esmee M; Weijs, Peter J M; Kruizenga, Hinke
Malnutrition screening tools are not sensitive enough to identify
older hospital patients with malnutrition Tijdschriftartikel
In: Nutrients, vol. 15, nr. 24, 2023.
@article{Van_Dronkelaar2023-oab,
title = {Malnutrition screening tools are not sensitive enough to identify
older hospital patients with malnutrition},
author = {Carliene Dronkelaar and Michael Tieland and Tommy Cederholm and Esmee M Reijnierse and Peter J M Weijs and Hinke Kruizenga},
year = {2023},
date = {2023-12-01},
journal = {Nutrients},
volume = {15},
number = {24},
abstract = {This study evaluates the concurrent validity of five malnutrition
screening tools to identify older hospitalized patients against
the Global Leadership Initiative on Malnutrition (GLIM)
diagnostic criteria as limited evidence is available. The
screening tools Short Nutritional Assessment Questionnaire
(SNAQ), Malnutrition Universal Screening Tool (MUST),
Malnutrition Screening Tool (MST), Mini Nutritional
Assessment-Short Form (MNA-SF), and the Patient-Generated
Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs
for both malnutrition (conservative) and moderate malnutrition or
risk of malnutrition (liberal) were used. The concurrent validity
was determined by the sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), and the
level of agreement by Cohen's kappa. In total, 356 patients were
included in the analyses (median age 70 y (IQR 63-77); 54%
male). The prevalence of malnutrition according to the GLIM
criteria without prior screening was 42%. The conservative
cut-offs showed a low-to-moderate sensitivity (32-68%) and
moderate-to-high specificity (61-98%). The PPV and NPV ranged
from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs
displayed a moderate-to-high sensitivity (66-89%) and a
low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their
capacity to identify hospitalized older patients with
malnutrition. The screening process in the GLIM framework
requires further consideration.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
This study evaluates the concurrent validity of five malnutrition
screening tools to identify older hospitalized patients against
the Global Leadership Initiative on Malnutrition (GLIM)
diagnostic criteria as limited evidence is available. The
screening tools Short Nutritional Assessment Questionnaire
(SNAQ), Malnutrition Universal Screening Tool (MUST),
Malnutrition Screening Tool (MST), Mini Nutritional
Assessment-Short Form (MNA-SF), and the Patient-Generated
Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs
for both malnutrition (conservative) and moderate malnutrition or
risk of malnutrition (liberal) were used. The concurrent validity
was determined by the sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), and the
level of agreement by Cohen's kappa. In total, 356 patients were
included in the analyses (median age 70 y (IQR 63-77); 54%
male). The prevalence of malnutrition according to the GLIM
criteria without prior screening was 42%. The conservative
cut-offs showed a low-to-moderate sensitivity (32-68%) and
moderate-to-high specificity (61-98%). The PPV and NPV ranged
from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs
displayed a moderate-to-high sensitivity (66-89%) and a
low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their
capacity to identify hospitalized older patients with
malnutrition. The screening process in the GLIM framework
requires further consideration.
screening tools to identify older hospitalized patients against
the Global Leadership Initiative on Malnutrition (GLIM)
diagnostic criteria as limited evidence is available. The
screening tools Short Nutritional Assessment Questionnaire
(SNAQ), Malnutrition Universal Screening Tool (MUST),
Malnutrition Screening Tool (MST), Mini Nutritional
Assessment-Short Form (MNA-SF), and the Patient-Generated
Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs
for both malnutrition (conservative) and moderate malnutrition or
risk of malnutrition (liberal) were used. The concurrent validity
was determined by the sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), and the
level of agreement by Cohen's kappa. In total, 356 patients were
included in the analyses (median age 70 y (IQR 63-77); 54%
male). The prevalence of malnutrition according to the GLIM
criteria without prior screening was 42%. The conservative
cut-offs showed a low-to-moderate sensitivity (32-68%) and
moderate-to-high specificity (61-98%). The PPV and NPV ranged
from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs
displayed a moderate-to-high sensitivity (66-89%) and a
low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their
capacity to identify hospitalized older patients with
malnutrition. The screening process in the GLIM framework
requires further consideration.
Ruijven, Isabel M; Abma, José; Brunsveld-Reinders, Anja H; Stapel, Sandra N; Etten-Jamaludin, Faridi; Boirie, Yves; Barazzoni, Rocco; Weijs, Peter J M
High protein provision of more than 1.2 g/kg improves muscle
mass preservation and mortality in ICU patients: A systematic
review and meta-analyses Tijdschriftartikel
In: Clin. Nutr., vol. 42, nr. 12, pp. 2395–2403, 2023.
@article{Van_Ruijven2023-dsb,
title = {High protein provision of more than 1.2 g/kg improves muscle
mass preservation and mortality in ICU patients: A systematic
review and meta-analyses},
author = {Isabel M Ruijven and José Abma and Anja H Brunsveld-Reinders and Sandra N Stapel and Faridi Etten-Jamaludin and Yves Boirie and Rocco Barazzoni and Peter J M Weijs},
year = {2023},
date = {2023-12-01},
journal = {Clin. Nutr.},
volume = {42},
number = {12},
pages = {2395–2403},
publisher = {Elsevier BV},
abstract = {BACKGROUND: ICU patients lose muscle mass rapidly and
maintenance of muscle mass may contribute to improved survival
rates and quality of life. Protein provision may be beneficial
for preservation of muscle mass and other clinical outcomes,
including survival. Current protein recommendations are
expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed
a systematic review and meta-analysis on protein provision and
all clinically relevant outcomes recorded in the available
literature. METHODS: We conducted a systematic review and
meta-analyses, including studies of all designs except case
control and case studies, with patients aged $geq$18 years with
an ICU stay of $geq$2 days and a mean protein provision group
of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of
$geq$0.2 g/kg between protein provision groups. All clinically
relevant outcomes were studied. Meta-analyses were performed for
all clinically relevant outcomes that were recorded in $geq$3
included studies. RESULTS: A total of 29 studies published
between 2012 and 2022 were included. Outcomes reported in the
included studies were ICU, hospital, 28-day, 30-day, 42-day,
60-day, 90-day and 6-month mortality, ICU and hospital length of
stay, duration of mechanical ventilation, vomiting, diarrhea,
gastric residual volume, pneumonia, overall infections, nitrogen
balance, changes in muscle mass, destination at hospital
discharge, physical performance and psychological status.
Meta-analyses showed differences between groups in favour of
high protein provision for 60-day mortality, nitrogen balance
and changes in muscle mass. CONCLUSION: High protein provision
of more than 1.2 g/kg in critically ill patients seemed to
improve nitrogen balance and changes in muscle mass on the
short-term and likely 60-day mortality. Data on long-term
effects on quality of life are urgently needed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: ICU patients lose muscle mass rapidly and
maintenance of muscle mass may contribute to improved survival
rates and quality of life. Protein provision may be beneficial
for preservation of muscle mass and other clinical outcomes,
including survival. Current protein recommendations are
expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed
a systematic review and meta-analysis on protein provision and
all clinically relevant outcomes recorded in the available
literature. METHODS: We conducted a systematic review and
meta-analyses, including studies of all designs except case
control and case studies, with patients aged $geq$18 years with
an ICU stay of $geq$2 days and a mean protein provision group
of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of
$geq$0.2 g/kg between protein provision groups. All clinically
relevant outcomes were studied. Meta-analyses were performed for
all clinically relevant outcomes that were recorded in $geq$3
included studies. RESULTS: A total of 29 studies published
between 2012 and 2022 were included. Outcomes reported in the
included studies were ICU, hospital, 28-day, 30-day, 42-day,
60-day, 90-day and 6-month mortality, ICU and hospital length of
stay, duration of mechanical ventilation, vomiting, diarrhea,
gastric residual volume, pneumonia, overall infections, nitrogen
balance, changes in muscle mass, destination at hospital
discharge, physical performance and psychological status.
Meta-analyses showed differences between groups in favour of
high protein provision for 60-day mortality, nitrogen balance
and changes in muscle mass. CONCLUSION: High protein provision
of more than 1.2 g/kg in critically ill patients seemed to
improve nitrogen balance and changes in muscle mass on the
short-term and likely 60-day mortality. Data on long-term
effects on quality of life are urgently needed.
maintenance of muscle mass may contribute to improved survival
rates and quality of life. Protein provision may be beneficial
for preservation of muscle mass and other clinical outcomes,
including survival. Current protein recommendations are
expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed
a systematic review and meta-analysis on protein provision and
all clinically relevant outcomes recorded in the available
literature. METHODS: We conducted a systematic review and
meta-analyses, including studies of all designs except case
control and case studies, with patients aged $geq$18 years with
an ICU stay of $geq$2 days and a mean protein provision group
of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of
$geq$0.2 g/kg between protein provision groups. All clinically
relevant outcomes were studied. Meta-analyses were performed for
all clinically relevant outcomes that were recorded in $geq$3
included studies. RESULTS: A total of 29 studies published
between 2012 and 2022 were included. Outcomes reported in the
included studies were ICU, hospital, 28-day, 30-day, 42-day,
60-day, 90-day and 6-month mortality, ICU and hospital length of
stay, duration of mechanical ventilation, vomiting, diarrhea,
gastric residual volume, pneumonia, overall infections, nitrogen
balance, changes in muscle mass, destination at hospital
discharge, physical performance and psychological status.
Meta-analyses showed differences between groups in favour of
high protein provision for 60-day mortality, nitrogen balance
and changes in muscle mass. CONCLUSION: High protein provision
of more than 1.2 g/kg in critically ill patients seemed to
improve nitrogen balance and changes in muscle mass on the
short-term and likely 60-day mortality. Data on long-term
effects on quality of life are urgently needed.
Walrabenstein, Wendy; Wagenaar, Carlijn A; van de Put, Marieke; van der Leeden, Marike; Gerritsen, Martijn; Twisk, Jos W R; van der Esch, Martin; van Middendorp, Henriët; Weijs, Peter J M; Roorda, Leo D; van Schaardenburg, Dirkjan
A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial Tijdschriftartikel
In: Osteoarthritis Cartilage, vol. 31, nr. 11, pp. 1491–1500, 2023, ISSN: 1522-9653.
@article{pmid37328047,
title = {A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial},
author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marieke van de Put and Marike van der Leeden and Martijn Gerritsen and Jos W R Twisk and Martin van der Esch and Henriët van Middendorp and Peter J M Weijs and Leo D Roorda and Dirkjan van Schaardenburg},
doi = {10.1016/j.joca.2023.05.014},
issn = {1522-9653},
year = {2023},
date = {2023-11-01},
journal = {Osteoarthritis Cartilage},
volume = {31},
number = {11},
pages = {1491--1500},
abstract = {OBJECTIVE: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).nnDESIGN: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome. Secondary outcomes included other patient-reported, anthropometric, and metabolic measures. An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyze between-group differences.nnRESULTS: Of the 66 people randomized, 64 completed the study. Participants (84% female) had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m. After 16 weeks, the intervention group (n = 32) had a mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group also lost more weight (-5 kg), fat mass (-4 kg), and waist circumference (-6 cm) compared to the control group. Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue, pain interference, C-reactive protein, hemoglobin A1c, fasting glucose, and low-density lipoproteins improved in the intervention versus the control group, while other PROMIS measures, blood pressure, high-density lipoproteins, and triglycerides did not differ significantly between the groups.nnCONCLUSION: The "Plants for Joints" lifestyle program reduced stiffness, relieved pain, and improved physical function in people with hip or knee MSOA compared to usual care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).nnDESIGN: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome. Secondary outcomes included other patient-reported, anthropometric, and metabolic measures. An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyze between-group differences.nnRESULTS: Of the 66 people randomized, 64 completed the study. Participants (84% female) had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m. After 16 weeks, the intervention group (n = 32) had a mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group also lost more weight (-5 kg), fat mass (-4 kg), and waist circumference (-6 cm) compared to the control group. Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue, pain interference, C-reactive protein, hemoglobin A1c, fasting glucose, and low-density lipoproteins improved in the intervention versus the control group, while other PROMIS measures, blood pressure, high-density lipoproteins, and triglycerides did not differ significantly between the groups.nnCONCLUSION: The "Plants for Joints" lifestyle program reduced stiffness, relieved pain, and improved physical function in people with hip or knee MSOA compared to usual care.
Leeuwerk, Marijke; Groot, Vincent; Dam, Suzanne Ten; Kruizenga, Hinke; Weijs, Peter J M; Geleijn, Edwin; Leeden, Marike; Schaaf, Marike; consortium, OPRAH
The efficacy of a blended intervention to improve physical
activity and protein intake for optimal physical recovery after
oncological gastrointestinal and lung cancer surgery, the Optimal
Physical Recovery After Hospitalization (OPRAH) trial: study
protocol for a randomized controlled multicenter trial Tijdschriftartikel
In: Trials, vol. 24, nr. 1, pp. 757, 2023.
@article{De_Leeuwerk2023-lv,
title = {The efficacy of a blended intervention to improve physical
activity and protein intake for optimal physical recovery after
oncological gastrointestinal and lung cancer surgery, the Optimal
Physical Recovery After Hospitalization (OPRAH) trial: study
protocol for a randomized controlled multicenter trial},
author = {Marijke Leeuwerk and Vincent Groot and Suzanne Ten Dam and Hinke Kruizenga and Peter J M Weijs and Edwin Geleijn and Marike Leeden and Marike Schaaf and OPRAH consortium},
year = {2023},
date = {2023-11-01},
journal = {Trials},
volume = {24},
number = {1},
pages = {757},
abstract = {BACKGROUND: Improving physical activity, especially in
combination with optimizing protein intake, after surgery has a
potential positive effect on recovery of physical functioning in
patients after gastrointestinal and lung cancer surgery. The aim
of this randomized controlled trial is to evaluate the efficacy
of a blended intervention to improve physical activity and
protein intake after hospital discharge on recovery of physical
functioning in these patients. METHODS: In this multicenter
single-blinded randomized controlled trial, 161 adult patients
scheduled for elective gastrointestinal or lung cancer surgery
will be randomly assigned to the intervention or control group.
The purpose of the Optimal Physical Recovery After
Hospitalization (OPRAH) intervention is to encourage
self-management of patients in their functional recovery, by
using a smartphone application and corresponding accelerometer in
combination with coaching by a physiotherapist and dietician
during three months after hospital discharge. Study outcomes will
be measured prior to surgery (baseline) and one, four, eight, and
twelve weeks and six months after hospital discharge. The primary
outcome is recovery in physical functioning six months after
surgery, and the most important secondary outcome is physical
activity. Other outcomes include lean body mass, muscle mass,
protein intake, symptoms, physical performance, self-reported
limitations in activities and participation, self-efficacy,
hospital readmissions and adverse events. DISCUSSION: The results
of this study will demonstrate whether a blended intervention to
support patients increasing their level of physical activity and
protein intake after hospital discharge improves recovery in
physical functioning in patients after gastrointestinal and lung
cancer surgery. TRIAL REGISTRATION: The trial has been registered
at the International Clinical Trials Registry Platform at
14-10-2021 with registration number NL9793. Trial registration
data are presented in Table 1.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Improving physical activity, especially in
combination with optimizing protein intake, after surgery has a
potential positive effect on recovery of physical functioning in
patients after gastrointestinal and lung cancer surgery. The aim
of this randomized controlled trial is to evaluate the efficacy
of a blended intervention to improve physical activity and
protein intake after hospital discharge on recovery of physical
functioning in these patients. METHODS: In this multicenter
single-blinded randomized controlled trial, 161 adult patients
scheduled for elective gastrointestinal or lung cancer surgery
will be randomly assigned to the intervention or control group.
The purpose of the Optimal Physical Recovery After
Hospitalization (OPRAH) intervention is to encourage
self-management of patients in their functional recovery, by
using a smartphone application and corresponding accelerometer in
combination with coaching by a physiotherapist and dietician
during three months after hospital discharge. Study outcomes will
be measured prior to surgery (baseline) and one, four, eight, and
twelve weeks and six months after hospital discharge. The primary
outcome is recovery in physical functioning six months after
surgery, and the most important secondary outcome is physical
activity. Other outcomes include lean body mass, muscle mass,
protein intake, symptoms, physical performance, self-reported
limitations in activities and participation, self-efficacy,
hospital readmissions and adverse events. DISCUSSION: The results
of this study will demonstrate whether a blended intervention to
support patients increasing their level of physical activity and
protein intake after hospital discharge improves recovery in
physical functioning in patients after gastrointestinal and lung
cancer surgery. TRIAL REGISTRATION: The trial has been registered
at the International Clinical Trials Registry Platform at
14-10-2021 with registration number NL9793. Trial registration
data are presented in Table 1.
combination with optimizing protein intake, after surgery has a
potential positive effect on recovery of physical functioning in
patients after gastrointestinal and lung cancer surgery. The aim
of this randomized controlled trial is to evaluate the efficacy
of a blended intervention to improve physical activity and
protein intake after hospital discharge on recovery of physical
functioning in these patients. METHODS: In this multicenter
single-blinded randomized controlled trial, 161 adult patients
scheduled for elective gastrointestinal or lung cancer surgery
will be randomly assigned to the intervention or control group.
The purpose of the Optimal Physical Recovery After
Hospitalization (OPRAH) intervention is to encourage
self-management of patients in their functional recovery, by
using a smartphone application and corresponding accelerometer in
combination with coaching by a physiotherapist and dietician
during three months after hospital discharge. Study outcomes will
be measured prior to surgery (baseline) and one, four, eight, and
twelve weeks and six months after hospital discharge. The primary
outcome is recovery in physical functioning six months after
surgery, and the most important secondary outcome is physical
activity. Other outcomes include lean body mass, muscle mass,
protein intake, symptoms, physical performance, self-reported
limitations in activities and participation, self-efficacy,
hospital readmissions and adverse events. DISCUSSION: The results
of this study will demonstrate whether a blended intervention to
support patients increasing their level of physical activity and
protein intake after hospital discharge improves recovery in
physical functioning in patients after gastrointestinal and lung
cancer surgery. TRIAL REGISTRATION: The trial has been registered
at the International Clinical Trials Registry Platform at
14-10-2021 with registration number NL9793. Trial registration
data are presented in Table 1.
Walrabenstein, Wendy; Wagenaar, Carlijn A; Put, Marieke; Leeden, Marike; Gerritsen, Martijn; Twisk, Jos W R; Esch, Martin; Middendorp, Henriët; Weijs, Peter J M; Roorda, Leo D; Schaardenburg, Dirkjan
A multidisciplinary lifestyle program for metabolic
syndrome-associated osteoarthritis: the ``Plants for Joints''
randomized controlled trial Tijdschriftartikel
In: Osteoarthritis Cartilage, vol. 31, nr. 11, pp. 1491–1500, 2023.
@article{Walrabenstein2023-xt,
title = {A multidisciplinary lifestyle program for metabolic
syndrome-associated osteoarthritis: the ``Plants for Joints''
randomized controlled trial},
author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marieke Put and Marike Leeden and Martijn Gerritsen and Jos W R Twisk and Martin Esch and Henriët Middendorp and Peter J M Weijs and Leo D Roorda and Dirkjan Schaardenburg},
year = {2023},
date = {2023-11-01},
journal = {Osteoarthritis Cartilage},
volume = {31},
number = {11},
pages = {1491–1500},
publisher = {Elsevier BV},
abstract = {OBJECTIVE: To determine the effectiveness of the ``Plants for
Joints'' multidisciplinary lifestyle program in patients with
metabolic syndrome-associated osteoarthritis (MSOA). DESIGN:
Patients with hip or knee MSOA were randomized to the
intervention or control group. The intervention group followed a
16-week program in addition to usual care based on a whole food
plant-based diet, physical activity, and stress management. The
control group received usual care. The patient-reported Western
Ontario and McMasters Universities Osteoarthritis Index (WOMAC)
total score (range 0-96) was the primary outcome. Secondary
outcomes included other patient-reported, anthropometric, and
metabolic measures. An intention-to-treat analysis with a
linear-mixed model adjusted for baseline values was used to
analyze between-group differences. RESULTS: Of the 66 people
randomized, 64 completed the study. Participants (84% female)
had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a
mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group
also lost more weight (-5 kg), fat mass (-4 kg), and waist
circumference (-6 cm) compared to the control group.
Patient-Reported Outcomes Measurement Information System
(PROMIS) fatigue, pain interference, C-reactive protein,
hemoglobin A1c, fasting glucose, and low-density lipoproteins
improved in the intervention versus the control group, while
other PROMIS measures, blood pressure, high-density
lipoproteins, and triglycerides did not differ significantly
between the groups. CONCLUSION: The ``Plants for Joints''
lifestyle program reduced stiffness, relieved pain, and improved
physical function in people with hip or knee MSOA compared to
usual care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: To determine the effectiveness of the ``Plants for
Joints'' multidisciplinary lifestyle program in patients with
metabolic syndrome-associated osteoarthritis (MSOA). DESIGN:
Patients with hip or knee MSOA were randomized to the
intervention or control group. The intervention group followed a
16-week program in addition to usual care based on a whole food
plant-based diet, physical activity, and stress management. The
control group received usual care. The patient-reported Western
Ontario and McMasters Universities Osteoarthritis Index (WOMAC)
total score (range 0-96) was the primary outcome. Secondary
outcomes included other patient-reported, anthropometric, and
metabolic measures. An intention-to-treat analysis with a
linear-mixed model adjusted for baseline values was used to
analyze between-group differences. RESULTS: Of the 66 people
randomized, 64 completed the study. Participants (84% female)
had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a
mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group
also lost more weight (-5 kg), fat mass (-4 kg), and waist
circumference (-6 cm) compared to the control group.
Patient-Reported Outcomes Measurement Information System
(PROMIS) fatigue, pain interference, C-reactive protein,
hemoglobin A1c, fasting glucose, and low-density lipoproteins
improved in the intervention versus the control group, while
other PROMIS measures, blood pressure, high-density
lipoproteins, and triglycerides did not differ significantly
between the groups. CONCLUSION: The ``Plants for Joints''
lifestyle program reduced stiffness, relieved pain, and improved
physical function in people with hip or knee MSOA compared to
usual care.
Joints'' multidisciplinary lifestyle program in patients with
metabolic syndrome-associated osteoarthritis (MSOA). DESIGN:
Patients with hip or knee MSOA were randomized to the
intervention or control group. The intervention group followed a
16-week program in addition to usual care based on a whole food
plant-based diet, physical activity, and stress management. The
control group received usual care. The patient-reported Western
Ontario and McMasters Universities Osteoarthritis Index (WOMAC)
total score (range 0-96) was the primary outcome. Secondary
outcomes included other patient-reported, anthropometric, and
metabolic measures. An intention-to-treat analysis with a
linear-mixed model adjusted for baseline values was used to
analyze between-group differences. RESULTS: Of the 66 people
randomized, 64 completed the study. Participants (84% female)
had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a
mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group
also lost more weight (-5 kg), fat mass (-4 kg), and waist
circumference (-6 cm) compared to the control group.
Patient-Reported Outcomes Measurement Information System
(PROMIS) fatigue, pain interference, C-reactive protein,
hemoglobin A1c, fasting glucose, and low-density lipoproteins
improved in the intervention versus the control group, while
other PROMIS measures, blood pressure, high-density
lipoproteins, and triglycerides did not differ significantly
between the groups. CONCLUSION: The ``Plants for Joints''
lifestyle program reduced stiffness, relieved pain, and improved
physical function in people with hip or knee MSOA compared to
usual care.
Leeuwerk, Marijke; Groot, Vincent; Dam, Suzanne Ten; Kruizenga, Hinke; Weijs, Peter J M; Geleijn, Edwin; Leeden, Marike; Schaaf, Marike; consortium, OPRAH
The efficacy of a blended intervention to improve physical
activity and protein intake for optimal physical recovery after
oncological gastrointestinal and lung cancer surgery, the Optimal
Physical Recovery After Hospitalization (OPRAH) trial: study
protocol for a randomized controlled multicenter trial Tijdschriftartikel
In: Trials, vol. 24, nr. 1, pp. 757, 2023.
@article{De_Leeuwerk2023-lvb,
title = {The efficacy of a blended intervention to improve physical
activity and protein intake for optimal physical recovery after
oncological gastrointestinal and lung cancer surgery, the Optimal
Physical Recovery After Hospitalization (OPRAH) trial: study
protocol for a randomized controlled multicenter trial},
author = {Marijke Leeuwerk and Vincent Groot and Suzanne Ten Dam and Hinke Kruizenga and Peter J M Weijs and Edwin Geleijn and Marike Leeden and Marike Schaaf and OPRAH consortium},
year = {2023},
date = {2023-11-01},
journal = {Trials},
volume = {24},
number = {1},
pages = {757},
abstract = {BACKGROUND: Improving physical activity, especially in
combination with optimizing protein intake, after surgery has a
potential positive effect on recovery of physical functioning in
patients after gastrointestinal and lung cancer surgery. The aim
of this randomized controlled trial is to evaluate the efficacy
of a blended intervention to improve physical activity and
protein intake after hospital discharge on recovery of physical
functioning in these patients. METHODS: In this multicenter
single-blinded randomized controlled trial, 161 adult patients
scheduled for elective gastrointestinal or lung cancer surgery
will be randomly assigned to the intervention or control group.
The purpose of the Optimal Physical Recovery After
Hospitalization (OPRAH) intervention is to encourage
self-management of patients in their functional recovery, by
using a smartphone application and corresponding accelerometer in
combination with coaching by a physiotherapist and dietician
during three months after hospital discharge. Study outcomes will
be measured prior to surgery (baseline) and one, four, eight, and
twelve weeks and six months after hospital discharge. The primary
outcome is recovery in physical functioning six months after
surgery, and the most important secondary outcome is physical
activity. Other outcomes include lean body mass, muscle mass,
protein intake, symptoms, physical performance, self-reported
limitations in activities and participation, self-efficacy,
hospital readmissions and adverse events. DISCUSSION: The results
of this study will demonstrate whether a blended intervention to
support patients increasing their level of physical activity and
protein intake after hospital discharge improves recovery in
physical functioning in patients after gastrointestinal and lung
cancer surgery. TRIAL REGISTRATION: The trial has been registered
at the International Clinical Trials Registry Platform at
14-10-2021 with registration number NL9793. Trial registration
data are presented in Table 1.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Improving physical activity, especially in
combination with optimizing protein intake, after surgery has a
potential positive effect on recovery of physical functioning in
patients after gastrointestinal and lung cancer surgery. The aim
of this randomized controlled trial is to evaluate the efficacy
of a blended intervention to improve physical activity and
protein intake after hospital discharge on recovery of physical
functioning in these patients. METHODS: In this multicenter
single-blinded randomized controlled trial, 161 adult patients
scheduled for elective gastrointestinal or lung cancer surgery
will be randomly assigned to the intervention or control group.
The purpose of the Optimal Physical Recovery After
Hospitalization (OPRAH) intervention is to encourage
self-management of patients in their functional recovery, by
using a smartphone application and corresponding accelerometer in
combination with coaching by a physiotherapist and dietician
during three months after hospital discharge. Study outcomes will
be measured prior to surgery (baseline) and one, four, eight, and
twelve weeks and six months after hospital discharge. The primary
outcome is recovery in physical functioning six months after
surgery, and the most important secondary outcome is physical
activity. Other outcomes include lean body mass, muscle mass,
protein intake, symptoms, physical performance, self-reported
limitations in activities and participation, self-efficacy,
hospital readmissions and adverse events. DISCUSSION: The results
of this study will demonstrate whether a blended intervention to
support patients increasing their level of physical activity and
protein intake after hospital discharge improves recovery in
physical functioning in patients after gastrointestinal and lung
cancer surgery. TRIAL REGISTRATION: The trial has been registered
at the International Clinical Trials Registry Platform at
14-10-2021 with registration number NL9793. Trial registration
data are presented in Table 1.
combination with optimizing protein intake, after surgery has a
potential positive effect on recovery of physical functioning in
patients after gastrointestinal and lung cancer surgery. The aim
of this randomized controlled trial is to evaluate the efficacy
of a blended intervention to improve physical activity and
protein intake after hospital discharge on recovery of physical
functioning in these patients. METHODS: In this multicenter
single-blinded randomized controlled trial, 161 adult patients
scheduled for elective gastrointestinal or lung cancer surgery
will be randomly assigned to the intervention or control group.
The purpose of the Optimal Physical Recovery After
Hospitalization (OPRAH) intervention is to encourage
self-management of patients in their functional recovery, by
using a smartphone application and corresponding accelerometer in
combination with coaching by a physiotherapist and dietician
during three months after hospital discharge. Study outcomes will
be measured prior to surgery (baseline) and one, four, eight, and
twelve weeks and six months after hospital discharge. The primary
outcome is recovery in physical functioning six months after
surgery, and the most important secondary outcome is physical
activity. Other outcomes include lean body mass, muscle mass,
protein intake, symptoms, physical performance, self-reported
limitations in activities and participation, self-efficacy,
hospital readmissions and adverse events. DISCUSSION: The results
of this study will demonstrate whether a blended intervention to
support patients increasing their level of physical activity and
protein intake after hospital discharge improves recovery in
physical functioning in patients after gastrointestinal and lung
cancer surgery. TRIAL REGISTRATION: The trial has been registered
at the International Clinical Trials Registry Platform at
14-10-2021 with registration number NL9793. Trial registration
data are presented in Table 1.
Walrabenstein, Wendy; Wagenaar, Carlijn A; Put, Marieke; Leeden, Marike; Gerritsen, Martijn; Twisk, Jos W R; Esch, Martin; Middendorp, Henriët; Weijs, Peter J M; Roorda, Leo D; Schaardenburg, Dirkjan
A multidisciplinary lifestyle program for metabolic
syndrome-associated osteoarthritis: the ``Plants for Joints''
randomized controlled trial Tijdschriftartikel
In: Osteoarthritis Cartilage, vol. 31, nr. 11, pp. 1491–1500, 2023.
@article{Walrabenstein2023-xtb,
title = {A multidisciplinary lifestyle program for metabolic
syndrome-associated osteoarthritis: the ``Plants for Joints''
randomized controlled trial},
author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marieke Put and Marike Leeden and Martijn Gerritsen and Jos W R Twisk and Martin Esch and Henriët Middendorp and Peter J M Weijs and Leo D Roorda and Dirkjan Schaardenburg},
year = {2023},
date = {2023-11-01},
journal = {Osteoarthritis Cartilage},
volume = {31},
number = {11},
pages = {1491–1500},
publisher = {Elsevier BV},
abstract = {OBJECTIVE: To determine the effectiveness of the ``Plants for
Joints'' multidisciplinary lifestyle program in patients with
metabolic syndrome-associated osteoarthritis (MSOA). DESIGN:
Patients with hip or knee MSOA were randomized to the
intervention or control group. The intervention group followed a
16-week program in addition to usual care based on a whole food
plant-based diet, physical activity, and stress management. The
control group received usual care. The patient-reported Western
Ontario and McMasters Universities Osteoarthritis Index (WOMAC)
total score (range 0-96) was the primary outcome. Secondary
outcomes included other patient-reported, anthropometric, and
metabolic measures. An intention-to-treat analysis with a
linear-mixed model adjusted for baseline values was used to
analyze between-group differences. RESULTS: Of the 66 people
randomized, 64 completed the study. Participants (84% female)
had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a
mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group
also lost more weight (-5 kg), fat mass (-4 kg), and waist
circumference (-6 cm) compared to the control group.
Patient-Reported Outcomes Measurement Information System
(PROMIS) fatigue, pain interference, C-reactive protein,
hemoglobin A1c, fasting glucose, and low-density lipoproteins
improved in the intervention versus the control group, while
other PROMIS measures, blood pressure, high-density
lipoproteins, and triglycerides did not differ significantly
between the groups. CONCLUSION: The ``Plants for Joints''
lifestyle program reduced stiffness, relieved pain, and improved
physical function in people with hip or knee MSOA compared to
usual care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: To determine the effectiveness of the ``Plants for
Joints'' multidisciplinary lifestyle program in patients with
metabolic syndrome-associated osteoarthritis (MSOA). DESIGN:
Patients with hip or knee MSOA were randomized to the
intervention or control group. The intervention group followed a
16-week program in addition to usual care based on a whole food
plant-based diet, physical activity, and stress management. The
control group received usual care. The patient-reported Western
Ontario and McMasters Universities Osteoarthritis Index (WOMAC)
total score (range 0-96) was the primary outcome. Secondary
outcomes included other patient-reported, anthropometric, and
metabolic measures. An intention-to-treat analysis with a
linear-mixed model adjusted for baseline values was used to
analyze between-group differences. RESULTS: Of the 66 people
randomized, 64 completed the study. Participants (84% female)
had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a
mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group
also lost more weight (-5 kg), fat mass (-4 kg), and waist
circumference (-6 cm) compared to the control group.
Patient-Reported Outcomes Measurement Information System
(PROMIS) fatigue, pain interference, C-reactive protein,
hemoglobin A1c, fasting glucose, and low-density lipoproteins
improved in the intervention versus the control group, while
other PROMIS measures, blood pressure, high-density
lipoproteins, and triglycerides did not differ significantly
between the groups. CONCLUSION: The ``Plants for Joints''
lifestyle program reduced stiffness, relieved pain, and improved
physical function in people with hip or knee MSOA compared to
usual care.
Joints'' multidisciplinary lifestyle program in patients with
metabolic syndrome-associated osteoarthritis (MSOA). DESIGN:
Patients with hip or knee MSOA were randomized to the
intervention or control group. The intervention group followed a
16-week program in addition to usual care based on a whole food
plant-based diet, physical activity, and stress management. The
control group received usual care. The patient-reported Western
Ontario and McMasters Universities Osteoarthritis Index (WOMAC)
total score (range 0-96) was the primary outcome. Secondary
outcomes included other patient-reported, anthropometric, and
metabolic measures. An intention-to-treat analysis with a
linear-mixed model adjusted for baseline values was used to
analyze between-group differences. RESULTS: Of the 66 people
randomized, 64 completed the study. Participants (84% female)
had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a
mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group
also lost more weight (-5 kg), fat mass (-4 kg), and waist
circumference (-6 cm) compared to the control group.
Patient-Reported Outcomes Measurement Information System
(PROMIS) fatigue, pain interference, C-reactive protein,
hemoglobin A1c, fasting glucose, and low-density lipoproteins
improved in the intervention versus the control group, while
other PROMIS measures, blood pressure, high-density
lipoproteins, and triglycerides did not differ significantly
between the groups. CONCLUSION: The ``Plants for Joints''
lifestyle program reduced stiffness, relieved pain, and improved
physical function in people with hip or knee MSOA compared to
usual care.
Baggerman, Michelle R; Dekker, Ingeborg M; Winkens, Bjorn; Damink, Steven W M Olde; Stapel, Sandra N; Weijs, Peter J M; van de Poll, Marcel C G
Visceral obesity measured using computed tomography scans: No significant association with mortality in critically ill patients Tijdschriftartikel
In: J Crit Care, vol. 77, pp. 154316, 2023, ISSN: 1557-8615.
@article{pmid37116438,
title = {Visceral obesity measured using computed tomography scans: No significant association with mortality in critically ill patients},
author = {Michelle R Baggerman and Ingeborg M Dekker and Bjorn Winkens and Steven W M Olde Damink and Sandra N Stapel and Peter J M Weijs and Marcel C G van de Poll},
doi = {10.1016/j.jcrc.2023.154316},
issn = {1557-8615},
year = {2023},
date = {2023-10-01},
journal = {J Crit Care},
volume = {77},
pages = {154316},
abstract = {INTRODUCTION: The association between obesity and outcome in critical illness is unclear. Since the amount of visceral adipose tissue(VAT) rather than BMI mediates the health effects of obesity we aimed to investigate the association between visceral obesity, BMI and 90-day mortality in critically ill patients.nnMETHOD: In 555 critically ill patients (68% male), the VAT Index(VATI) was measured using Computed Tomography scans on the level of vertebra L3. The association between visceral obesity, BMI and 90-day mortality was investigated using univariable and multivariable analyses, correcting for age, sex, APACHE II score, sarcopenia and muscle quality.nnRESULTS: Visceral obesity was present in 48.1% of the patients and its prevalence was similar in males and females. Mortality was similar amongst patients with and without visceral obesity (27.7% vs 24.0%, p = 0.31). The corrected odds ratio of 90-day mortality for visceral obesity was 0.667 (95%CI 0.424-1.049, p = 0.080). Using normal BMI as reference, the corrected odds ratio for overweight was 0.721 (95%CI 0.447-1.164 p = 0.181) and for obesity 0.462 (95%CI 0.208-1.027, p = 0.058).nnCONCLUSION: No significant association of visceral obesity and BMI with 90-day mortality was observed in critically ill patients, although obesity and visceral obesity tended to be associated with improved 90-day mortality.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: The association between obesity and outcome in critical illness is unclear. Since the amount of visceral adipose tissue(VAT) rather than BMI mediates the health effects of obesity we aimed to investigate the association between visceral obesity, BMI and 90-day mortality in critically ill patients.nnMETHOD: In 555 critically ill patients (68% male), the VAT Index(VATI) was measured using Computed Tomography scans on the level of vertebra L3. The association between visceral obesity, BMI and 90-day mortality was investigated using univariable and multivariable analyses, correcting for age, sex, APACHE II score, sarcopenia and muscle quality.nnRESULTS: Visceral obesity was present in 48.1% of the patients and its prevalence was similar in males and females. Mortality was similar amongst patients with and without visceral obesity (27.7% vs 24.0%, p = 0.31). The corrected odds ratio of 90-day mortality for visceral obesity was 0.667 (95%CI 0.424-1.049, p = 0.080). Using normal BMI as reference, the corrected odds ratio for overweight was 0.721 (95%CI 0.447-1.164 p = 0.181) and for obesity 0.462 (95%CI 0.208-1.027, p = 0.058).nnCONCLUSION: No significant association of visceral obesity and BMI with 90-day mortality was observed in critically ill patients, although obesity and visceral obesity tended to be associated with improved 90-day mortality.
Baggerman, Michelle R; Dekker, Ingeborg M; Winkens, Bjorn; Damink, Steven W M Olde; Stapel, Sandra N; Weijs, Peter J M; Poll, Marcel C G
Visceral obesity measured using computed tomography scans: No
significant association with mortality in critically ill
patients Tijdschriftartikel
In: J. Crit. Care, vol. 77, nr. 154316, pp. 154316, 2023.
@article{Baggerman2023-wo,
title = {Visceral obesity measured using computed tomography scans: No
significant association with mortality in critically ill
patients},
author = {Michelle R Baggerman and Ingeborg M Dekker and Bjorn Winkens and Steven W M Olde Damink and Sandra N Stapel and Peter J M Weijs and Marcel C G Poll},
year = {2023},
date = {2023-10-01},
journal = {J. Crit. Care},
volume = {77},
number = {154316},
pages = {154316},
publisher = {Elsevier BV},
abstract = {INTRODUCTION: The association between obesity and outcome in
critical illness is unclear. Since the amount of visceral
adipose tissue(VAT) rather than BMI mediates the health effects
of obesity we aimed to investigate the association between
visceral obesity, BMI and 90-day mortality in critically ill
patients. METHOD: In 555 critically ill patients (68% male),
the VAT Index(VATI) was measured using Computed Tomography scans
on the level of vertebra L3. The association between visceral
obesity, BMI and 90-day mortality was investigated using
univariable and multivariable analyses, correcting for age, sex,
APACHE II score, sarcopenia and muscle quality. RESULTS:
Visceral obesity was present in 48.1% of the patients and its
prevalence was similar in males and females. Mortality was
similar amongst patients with and without visceral obesity (27.7% vs 24.0},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: The association between obesity and outcome in
critical illness is unclear. Since the amount of visceral
adipose tissue(VAT) rather than BMI mediates the health effects
of obesity we aimed to investigate the association between
visceral obesity, BMI and 90-day mortality in critically ill
patients. METHOD: In 555 critically ill patients (68% male),
the VAT Index(VATI) was measured using Computed Tomography scans
on the level of vertebra L3. The association between visceral
obesity, BMI and 90-day mortality was investigated using
univariable and multivariable analyses, correcting for age, sex,
APACHE II score, sarcopenia and muscle quality. RESULTS:
Visceral obesity was present in 48.1% of the patients and its
prevalence was similar in males and females. Mortality was
similar amongst patients with and without visceral obesity (27.7% vs 24.0
critical illness is unclear. Since the amount of visceral
adipose tissue(VAT) rather than BMI mediates the health effects
of obesity we aimed to investigate the association between
visceral obesity, BMI and 90-day mortality in critically ill
patients. METHOD: In 555 critically ill patients (68% male),
the VAT Index(VATI) was measured using Computed Tomography scans
on the level of vertebra L3. The association between visceral
obesity, BMI and 90-day mortality was investigated using
univariable and multivariable analyses, correcting for age, sex,
APACHE II score, sarcopenia and muscle quality. RESULTS:
Visceral obesity was present in 48.1% of the patients and its
prevalence was similar in males and females. Mortality was
similar amongst patients with and without visceral obesity (27.7% vs 24.0
Baggerman, Michelle R; Dekker, Ingeborg M; Winkens, Bjorn; Damink, Steven W M Olde; Stapel, Sandra N; Weijs, Peter J M; Poll, Marcel C G
Visceral obesity measured using computed tomography scans: No
significant association with mortality in critically ill
patients Tijdschriftartikel
In: J. Crit. Care, vol. 77, nr. 154316, pp. 154316, 2023.
@article{Baggerman2023-wob,
title = {Visceral obesity measured using computed tomography scans: No
significant association with mortality in critically ill
patients},
author = {Michelle R Baggerman and Ingeborg M Dekker and Bjorn Winkens and Steven W M Olde Damink and Sandra N Stapel and Peter J M Weijs and Marcel C G Poll},
year = {2023},
date = {2023-10-01},
journal = {J. Crit. Care},
volume = {77},
number = {154316},
pages = {154316},
publisher = {Elsevier BV},
abstract = {INTRODUCTION: The association between obesity and outcome in
critical illness is unclear. Since the amount of visceral
adipose tissue(VAT) rather than BMI mediates the health effects
of obesity we aimed to investigate the association between
visceral obesity, BMI and 90-day mortality in critically ill
patients. METHOD: In 555 critically ill patients (68% male),
the VAT Index(VATI) was measured using Computed Tomography scans
on the level of vertebra L3. The association between visceral
obesity, BMI and 90-day mortality was investigated using
univariable and multivariable analyses, correcting for age, sex,
APACHE II score, sarcopenia and muscle quality. RESULTS:
Visceral obesity was present in 48.1% of the patients and its
prevalence was similar in males and females. Mortality was
similar amongst patients with and without visceral obesity (27.7% vs 24.0},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: The association between obesity and outcome in
critical illness is unclear. Since the amount of visceral
adipose tissue(VAT) rather than BMI mediates the health effects
of obesity we aimed to investigate the association between
visceral obesity, BMI and 90-day mortality in critically ill
patients. METHOD: In 555 critically ill patients (68% male),
the VAT Index(VATI) was measured using Computed Tomography scans
on the level of vertebra L3. The association between visceral
obesity, BMI and 90-day mortality was investigated using
univariable and multivariable analyses, correcting for age, sex,
APACHE II score, sarcopenia and muscle quality. RESULTS:
Visceral obesity was present in 48.1% of the patients and its
prevalence was similar in males and females. Mortality was
similar amongst patients with and without visceral obesity (27.7% vs 24.0
critical illness is unclear. Since the amount of visceral
adipose tissue(VAT) rather than BMI mediates the health effects
of obesity we aimed to investigate the association between
visceral obesity, BMI and 90-day mortality in critically ill
patients. METHOD: In 555 critically ill patients (68% male),
the VAT Index(VATI) was measured using Computed Tomography scans
on the level of vertebra L3. The association between visceral
obesity, BMI and 90-day mortality was investigated using
univariable and multivariable analyses, correcting for age, sex,
APACHE II score, sarcopenia and muscle quality. RESULTS:
Visceral obesity was present in 48.1% of the patients and its
prevalence was similar in males and females. Mortality was
similar amongst patients with and without visceral obesity (27.7% vs 24.0
Reiter, Lea; Bauer, Silvia; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Cruz-Jentoft, Alfonso; Topinková, Eva; Eglseer, Doris
Effects of Nutrition and Exercise Interventions on Persons with Sarcopenic Obesity: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials Tijdschriftartikel
In: Curr Obes Rep, vol. 12, nr. 3, pp. 250–263, 2023, ISSN: 2162-4968.
@article{pmid37249818,
title = {Effects of Nutrition and Exercise Interventions on Persons with Sarcopenic Obesity: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials},
author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},
doi = {10.1007/s13679-023-00509-0},
issn = {2162-4968},
year = {2023},
date = {2023-09-01},
journal = {Curr Obes Rep},
volume = {12},
number = {3},
pages = {250--263},
abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.nnMETHOD: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO. The primary endpoints were parameters for SO, such as body fat in %, skeletal muscle mass index (SMMI), gait speed, leg strength and grip strength. The methodological quality was evaluated using AMSTAR and the certainty of evidence was assessed using GRADE.nnRESULTS: Four systematic reviews with between 30 to 225 participants were included in the umbrella review. These examined four exercise interventions, two nutrition interventions and four interventions that combined nutrition and exercise. Resistance training was the most frequently studied intervention and was found to improve gait speed by 0.14 m/s to 0.17 m/s and lower leg strength by 9.97 kg. Resistance, aerobic, mixed exercise and hypocaloric diet combined with protein supplementation is not significantly effective on selected outcomes for persons with SO compared to no intervention. The low number of primary studies included in the reviews resulted in moderate to very low certainty of evidence.nnCONCLUSION: Despite the lack in certainty of evidence, resistance training may be a suitable intervention for persons with SO, in particular for improving muscle function. Nevertheless, further research is necessary to strengthen the evidence.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.nnMETHOD: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO. The primary endpoints were parameters for SO, such as body fat in %, skeletal muscle mass index (SMMI), gait speed, leg strength and grip strength. The methodological quality was evaluated using AMSTAR and the certainty of evidence was assessed using GRADE.nnRESULTS: Four systematic reviews with between 30 to 225 participants were included in the umbrella review. These examined four exercise interventions, two nutrition interventions and four interventions that combined nutrition and exercise. Resistance training was the most frequently studied intervention and was found to improve gait speed by 0.14 m/s to 0.17 m/s and lower leg strength by 9.97 kg. Resistance, aerobic, mixed exercise and hypocaloric diet combined with protein supplementation is not significantly effective on selected outcomes for persons with SO compared to no intervention. The low number of primary studies included in the reviews resulted in moderate to very low certainty of evidence.nnCONCLUSION: Despite the lack in certainty of evidence, resistance training may be a suitable intervention for persons with SO, in particular for improving muscle function. Nevertheless, further research is necessary to strengthen the evidence.
Reiter, Lea; Bauer, Silvia; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Cruz-Jentoft, Alfonso; Topinková, Eva; Eglseer, Doris
Effects of Nutrition and Exercise Interventions on Persons with Sarcopenic Obesity: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials Tijdschriftartikel
In: Curr Obes Rep, vol. 12, nr. 3, pp. 250–263, 2023, ISSN: 2162-4968.
@article{pmid37249818c,
title = {Effects of Nutrition and Exercise Interventions on Persons with Sarcopenic Obesity: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials},
author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},
doi = {10.1007/s13679-023-00509-0},
issn = {2162-4968},
year = {2023},
date = {2023-09-01},
journal = {Curr Obes Rep},
volume = {12},
number = {3},
pages = {250--263},
abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.nnMETHOD: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO. The primary endpoints were parameters for SO, such as body fat in %, skeletal muscle mass index (SMMI), gait speed, leg strength and grip strength. The methodological quality was evaluated using AMSTAR and the certainty of evidence was assessed using GRADE.nnRESULTS: Four systematic reviews with between 30 to 225 participants were included in the umbrella review. These examined four exercise interventions, two nutrition interventions and four interventions that combined nutrition and exercise. Resistance training was the most frequently studied intervention and was found to improve gait speed by 0.14 m/s to 0.17 m/s and lower leg strength by 9.97 kg. Resistance, aerobic, mixed exercise and hypocaloric diet combined with protein supplementation is not significantly effective on selected outcomes for persons with SO compared to no intervention. The low number of primary studies included in the reviews resulted in moderate to very low certainty of evidence.nnCONCLUSION: Despite the lack in certainty of evidence, resistance training may be a suitable intervention for persons with SO, in particular for improving muscle function. Nevertheless, further research is necessary to strengthen the evidence.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.nnMETHOD: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO. The primary endpoints were parameters for SO, such as body fat in %, skeletal muscle mass index (SMMI), gait speed, leg strength and grip strength. The methodological quality was evaluated using AMSTAR and the certainty of evidence was assessed using GRADE.nnRESULTS: Four systematic reviews with between 30 to 225 participants were included in the umbrella review. These examined four exercise interventions, two nutrition interventions and four interventions that combined nutrition and exercise. Resistance training was the most frequently studied intervention and was found to improve gait speed by 0.14 m/s to 0.17 m/s and lower leg strength by 9.97 kg. Resistance, aerobic, mixed exercise and hypocaloric diet combined with protein supplementation is not significantly effective on selected outcomes for persons with SO compared to no intervention. The low number of primary studies included in the reviews resulted in moderate to very low certainty of evidence.nnCONCLUSION: Despite the lack in certainty of evidence, resistance training may be a suitable intervention for persons with SO, in particular for improving muscle function. Nevertheless, further research is necessary to strengthen the evidence.
Reiter, Lea; Bauer, Silvia; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Cruz-Jentoft, Alfonso; Topinková, Eva; Eglseer, Doris
Effects of nutrition and exercise interventions on persons with
sarcopenic obesity: An umbrella review of meta-analyses of
randomised controlled trials Tijdschriftartikel
In: Curr. Obes. Rep., vol. 12, nr. 3, pp. 250–263, 2023.
@article{Reiter2023-ng,
title = {Effects of nutrition and exercise interventions on persons with
sarcopenic obesity: An umbrella review of meta-analyses of
randomised controlled trials},
author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},
year = {2023},
date = {2023-09-01},
journal = {Curr. Obes. Rep.},
volume = {12},
number = {3},
pages = {250–263},
abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon
and has been linked to several negative health consequences. The
aim of this umbrella review is the assessment of effectiveness
and certainty of evidence of nutrition and exercise interventions
in persons with SO. METHOD: We searched for meta-analyses of RCTs
in PubMed, EMBASE and CENTRAL that had been conducted in the last
five years, focusing on studies on the treatment and prevention
of SO. The primary endpoints were parameters for SO, such as body
fat in %, skeletal muscle mass index (SMMI), gait speed, leg
strength and grip strength. The methodological quality was
evaluated using AMSTAR and the certainty of evidence was assessed
using GRADE. RESULTS: Four systematic reviews with between 30 to
225 participants were included in the umbrella review. These
examined four exercise interventions, two nutrition interventions
and four interventions that combined nutrition and exercise.
Resistance training was the most frequently studied intervention
and was found to improve gait speed by 0.14 m/s to 0.17 m/s and
lower leg strength by 9.97 kg. Resistance, aerobic, mixed
exercise and hypocaloric diet combined with protein
supplementation is not significantly effective on selected
outcomes for persons with SO compared to no intervention. The low
number of primary studies included in the reviews resulted in
moderate to very low certainty of evidence. CONCLUSION: Despite
the lack in certainty of evidence, resistance training may be a
suitable intervention for persons with SO, in particular for
improving muscle function. Nevertheless, further research is
necessary to strengthen the evidence.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon
and has been linked to several negative health consequences. The
aim of this umbrella review is the assessment of effectiveness
and certainty of evidence of nutrition and exercise interventions
in persons with SO. METHOD: We searched for meta-analyses of RCTs
in PubMed, EMBASE and CENTRAL that had been conducted in the last
five years, focusing on studies on the treatment and prevention
of SO. The primary endpoints were parameters for SO, such as body
fat in %, skeletal muscle mass index (SMMI), gait speed, leg
strength and grip strength. The methodological quality was
evaluated using AMSTAR and the certainty of evidence was assessed
using GRADE. RESULTS: Four systematic reviews with between 30 to
225 participants were included in the umbrella review. These
examined four exercise interventions, two nutrition interventions
and four interventions that combined nutrition and exercise.
Resistance training was the most frequently studied intervention
and was found to improve gait speed by 0.14 m/s to 0.17 m/s and
lower leg strength by 9.97 kg. Resistance, aerobic, mixed
exercise and hypocaloric diet combined with protein
supplementation is not significantly effective on selected
outcomes for persons with SO compared to no intervention. The low
number of primary studies included in the reviews resulted in
moderate to very low certainty of evidence. CONCLUSION: Despite
the lack in certainty of evidence, resistance training may be a
suitable intervention for persons with SO, in particular for
improving muscle function. Nevertheless, further research is
necessary to strengthen the evidence.
and has been linked to several negative health consequences. The
aim of this umbrella review is the assessment of effectiveness
and certainty of evidence of nutrition and exercise interventions
in persons with SO. METHOD: We searched for meta-analyses of RCTs
in PubMed, EMBASE and CENTRAL that had been conducted in the last
five years, focusing on studies on the treatment and prevention
of SO. The primary endpoints were parameters for SO, such as body
fat in %, skeletal muscle mass index (SMMI), gait speed, leg
strength and grip strength. The methodological quality was
evaluated using AMSTAR and the certainty of evidence was assessed
using GRADE. RESULTS: Four systematic reviews with between 30 to
225 participants were included in the umbrella review. These
examined four exercise interventions, two nutrition interventions
and four interventions that combined nutrition and exercise.
Resistance training was the most frequently studied intervention
and was found to improve gait speed by 0.14 m/s to 0.17 m/s and
lower leg strength by 9.97 kg. Resistance, aerobic, mixed
exercise and hypocaloric diet combined with protein
supplementation is not significantly effective on selected
outcomes for persons with SO compared to no intervention. The low
number of primary studies included in the reviews resulted in
moderate to very low certainty of evidence. CONCLUSION: Despite
the lack in certainty of evidence, resistance training may be a
suitable intervention for persons with SO, in particular for
improving muscle function. Nevertheless, further research is
necessary to strengthen the evidence.
Besseling, Joost; Velzen, Merel; Wierdsma, Nicolette; Alonso-Duin, Kelly Silverio; Weijs, Peter J M; May, Anne M; Laarhoven, Hanneke
Exercise and nutritional interventions in patients with advanced
gastroesophageal cancer: A systematic review Tijdschriftartikel
In: J. Gastrointest. Cancer, vol. 54, nr. 3, pp. 1006–1009, 2023.
@article{Besseling2023-vi,
title = {Exercise and nutritional interventions in patients with advanced
gastroesophageal cancer: A systematic review},
author = {Joost Besseling and Merel Velzen and Nicolette Wierdsma and Kelly Silverio Alonso-Duin and Peter J M Weijs and Anne M May and Hanneke Laarhoven},
year = {2023},
date = {2023-09-01},
journal = {J. Gastrointest. Cancer},
volume = {54},
number = {3},
pages = {1006–1009},
publisher = {Springer Science and Business Media LLC},
abstract = {PURPOSE: The quality of life and survival of patients with
advanced gastroesophageal cancer can be improved. Positive
effects of exercise and nutritional interventions on quality of
life and potential effects on cancer outcomes are found in
gastroesophageal cancer in the curative setting, as well as in
other cancer types. We therefore systematically reviewed the
current literature on the effect of exercise and nutritional
interventions on various outcomes in patients with advanced
gastroesophageal cancer. METHODS: We searched on the 11th of
June 2021 in Pubmed, Embase and the Cochrane library for
publications of randomized trials and observational studies on
exercise and nutritional interventions (either combined or as
separate intervention) in patients with advanced
gastroesophageal cancer. The outcomes of interest were overall
survival, progression free survival, quality of life,
chemotherapy toxicity, and chemotherapy adherence. RESULTS: We
screened 1,764 records for eligibility and included one study in
our analysis. The other 1,763 were excluded for various reasons,
most frequently an incorrect study population (e.g. both curable
and incurable patients) or an incorrect intervention. One
retrospective cohort study of 40 patients with advanced gastric
cancer who received first line chemotherapy was included. It was
stated that 'no significant differences in terms of overall and
progression free survival were reported between the two groups
of patients.' No absolute numbers were provided. CONCLUSION: Our
systematic review did not identify any high quality studies on
exercise and nutritional interventions in advanced
gastroesophageal cancer. We deem a randomized clinical trial on
this topic to be highly needed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE: The quality of life and survival of patients with
advanced gastroesophageal cancer can be improved. Positive
effects of exercise and nutritional interventions on quality of
life and potential effects on cancer outcomes are found in
gastroesophageal cancer in the curative setting, as well as in
other cancer types. We therefore systematically reviewed the
current literature on the effect of exercise and nutritional
interventions on various outcomes in patients with advanced
gastroesophageal cancer. METHODS: We searched on the 11th of
June 2021 in Pubmed, Embase and the Cochrane library for
publications of randomized trials and observational studies on
exercise and nutritional interventions (either combined or as
separate intervention) in patients with advanced
gastroesophageal cancer. The outcomes of interest were overall
survival, progression free survival, quality of life,
chemotherapy toxicity, and chemotherapy adherence. RESULTS: We
screened 1,764 records for eligibility and included one study in
our analysis. The other 1,763 were excluded for various reasons,
most frequently an incorrect study population (e.g. both curable
and incurable patients) or an incorrect intervention. One
retrospective cohort study of 40 patients with advanced gastric
cancer who received first line chemotherapy was included. It was
stated that 'no significant differences in terms of overall and
progression free survival were reported between the two groups
of patients.' No absolute numbers were provided. CONCLUSION: Our
systematic review did not identify any high quality studies on
exercise and nutritional interventions in advanced
gastroesophageal cancer. We deem a randomized clinical trial on
this topic to be highly needed.
advanced gastroesophageal cancer can be improved. Positive
effects of exercise and nutritional interventions on quality of
life and potential effects on cancer outcomes are found in
gastroesophageal cancer in the curative setting, as well as in
other cancer types. We therefore systematically reviewed the
current literature on the effect of exercise and nutritional
interventions on various outcomes in patients with advanced
gastroesophageal cancer. METHODS: We searched on the 11th of
June 2021 in Pubmed, Embase and the Cochrane library for
publications of randomized trials and observational studies on
exercise and nutritional interventions (either combined or as
separate intervention) in patients with advanced
gastroesophageal cancer. The outcomes of interest were overall
survival, progression free survival, quality of life,
chemotherapy toxicity, and chemotherapy adherence. RESULTS: We
screened 1,764 records for eligibility and included one study in
our analysis. The other 1,763 were excluded for various reasons,
most frequently an incorrect study population (e.g. both curable
and incurable patients) or an incorrect intervention. One
retrospective cohort study of 40 patients with advanced gastric
cancer who received first line chemotherapy was included. It was
stated that 'no significant differences in terms of overall and
progression free survival were reported between the two groups
of patients.' No absolute numbers were provided. CONCLUSION: Our
systematic review did not identify any high quality studies on
exercise and nutritional interventions in advanced
gastroesophageal cancer. We deem a randomized clinical trial on
this topic to be highly needed.
Reiter, Lea; Bauer, Silvia; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Cruz-Jentoft, Alfonso; Topinková, Eva; Eglseer, Doris
Effects of nutrition and exercise interventions on persons with
sarcopenic obesity: An umbrella review of meta-analyses of
randomised controlled trials Tijdschriftartikel
In: Curr. Obes. Rep., vol. 12, nr. 3, pp. 250–263, 2023.
@article{Reiter2023-ngb,
title = {Effects of nutrition and exercise interventions on persons with
sarcopenic obesity: An umbrella review of meta-analyses of
randomised controlled trials},
author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},
year = {2023},
date = {2023-09-01},
journal = {Curr. Obes. Rep.},
volume = {12},
number = {3},
pages = {250–263},
abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon
and has been linked to several negative health consequences. The
aim of this umbrella review is the assessment of effectiveness
and certainty of evidence of nutrition and exercise interventions
in persons with SO. METHOD: We searched for meta-analyses of RCTs
in PubMed, EMBASE and CENTRAL that had been conducted in the last
five years, focusing on studies on the treatment and prevention
of SO. The primary endpoints were parameters for SO, such as body
fat in %, skeletal muscle mass index (SMMI), gait speed, leg
strength and grip strength. The methodological quality was
evaluated using AMSTAR and the certainty of evidence was assessed
using GRADE. RESULTS: Four systematic reviews with between 30 to
225 participants were included in the umbrella review. These
examined four exercise interventions, two nutrition interventions
and four interventions that combined nutrition and exercise.
Resistance training was the most frequently studied intervention
and was found to improve gait speed by 0.14 m/s to 0.17 m/s and
lower leg strength by 9.97 kg. Resistance, aerobic, mixed
exercise and hypocaloric diet combined with protein
supplementation is not significantly effective on selected
outcomes for persons with SO compared to no intervention. The low
number of primary studies included in the reviews resulted in
moderate to very low certainty of evidence. CONCLUSION: Despite
the lack in certainty of evidence, resistance training may be a
suitable intervention for persons with SO, in particular for
improving muscle function. Nevertheless, further research is
necessary to strengthen the evidence.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon
and has been linked to several negative health consequences. The
aim of this umbrella review is the assessment of effectiveness
and certainty of evidence of nutrition and exercise interventions
in persons with SO. METHOD: We searched for meta-analyses of RCTs
in PubMed, EMBASE and CENTRAL that had been conducted in the last
five years, focusing on studies on the treatment and prevention
of SO. The primary endpoints were parameters for SO, such as body
fat in %, skeletal muscle mass index (SMMI), gait speed, leg
strength and grip strength. The methodological quality was
evaluated using AMSTAR and the certainty of evidence was assessed
using GRADE. RESULTS: Four systematic reviews with between 30 to
225 participants were included in the umbrella review. These
examined four exercise interventions, two nutrition interventions
and four interventions that combined nutrition and exercise.
Resistance training was the most frequently studied intervention
and was found to improve gait speed by 0.14 m/s to 0.17 m/s and
lower leg strength by 9.97 kg. Resistance, aerobic, mixed
exercise and hypocaloric diet combined with protein
supplementation is not significantly effective on selected
outcomes for persons with SO compared to no intervention. The low
number of primary studies included in the reviews resulted in
moderate to very low certainty of evidence. CONCLUSION: Despite
the lack in certainty of evidence, resistance training may be a
suitable intervention for persons with SO, in particular for
improving muscle function. Nevertheless, further research is
necessary to strengthen the evidence.
and has been linked to several negative health consequences. The
aim of this umbrella review is the assessment of effectiveness
and certainty of evidence of nutrition and exercise interventions
in persons with SO. METHOD: We searched for meta-analyses of RCTs
in PubMed, EMBASE and CENTRAL that had been conducted in the last
five years, focusing on studies on the treatment and prevention
of SO. The primary endpoints were parameters for SO, such as body
fat in %, skeletal muscle mass index (SMMI), gait speed, leg
strength and grip strength. The methodological quality was
evaluated using AMSTAR and the certainty of evidence was assessed
using GRADE. RESULTS: Four systematic reviews with between 30 to
225 participants were included in the umbrella review. These
examined four exercise interventions, two nutrition interventions
and four interventions that combined nutrition and exercise.
Resistance training was the most frequently studied intervention
and was found to improve gait speed by 0.14 m/s to 0.17 m/s and
lower leg strength by 9.97 kg. Resistance, aerobic, mixed
exercise and hypocaloric diet combined with protein
supplementation is not significantly effective on selected
outcomes for persons with SO compared to no intervention. The low
number of primary studies included in the reviews resulted in
moderate to very low certainty of evidence. CONCLUSION: Despite
the lack in certainty of evidence, resistance training may be a
suitable intervention for persons with SO, in particular for
improving muscle function. Nevertheless, further research is
necessary to strengthen the evidence.
Besseling, Joost; Velzen, Merel; Wierdsma, Nicolette; Alonso-Duin, Kelly Silverio; Weijs, Peter J M; May, Anne M; Laarhoven, Hanneke
Exercise and nutritional interventions in patients with advanced
gastroesophageal cancer: A systematic review Tijdschriftartikel
In: J. Gastrointest. Cancer, vol. 54, nr. 3, pp. 1006–1009, 2023.
@article{Besseling2023-vib,
title = {Exercise and nutritional interventions in patients with advanced
gastroesophageal cancer: A systematic review},
author = {Joost Besseling and Merel Velzen and Nicolette Wierdsma and Kelly Silverio Alonso-Duin and Peter J M Weijs and Anne M May and Hanneke Laarhoven},
year = {2023},
date = {2023-09-01},
journal = {J. Gastrointest. Cancer},
volume = {54},
number = {3},
pages = {1006–1009},
publisher = {Springer Science and Business Media LLC},
abstract = {PURPOSE: The quality of life and survival of patients with
advanced gastroesophageal cancer can be improved. Positive
effects of exercise and nutritional interventions on quality of
life and potential effects on cancer outcomes are found in
gastroesophageal cancer in the curative setting, as well as in
other cancer types. We therefore systematically reviewed the
current literature on the effect of exercise and nutritional
interventions on various outcomes in patients with advanced
gastroesophageal cancer. METHODS: We searched on the 11th of
June 2021 in Pubmed, Embase and the Cochrane library for
publications of randomized trials and observational studies on
exercise and nutritional interventions (either combined or as
separate intervention) in patients with advanced
gastroesophageal cancer. The outcomes of interest were overall
survival, progression free survival, quality of life,
chemotherapy toxicity, and chemotherapy adherence. RESULTS: We
screened 1,764 records for eligibility and included one study in
our analysis. The other 1,763 were excluded for various reasons,
most frequently an incorrect study population (e.g. both curable
and incurable patients) or an incorrect intervention. One
retrospective cohort study of 40 patients with advanced gastric
cancer who received first line chemotherapy was included. It was
stated that 'no significant differences in terms of overall and
progression free survival were reported between the two groups
of patients.' No absolute numbers were provided. CONCLUSION: Our
systematic review did not identify any high quality studies on
exercise and nutritional interventions in advanced
gastroesophageal cancer. We deem a randomized clinical trial on
this topic to be highly needed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE: The quality of life and survival of patients with
advanced gastroesophageal cancer can be improved. Positive
effects of exercise and nutritional interventions on quality of
life and potential effects on cancer outcomes are found in
gastroesophageal cancer in the curative setting, as well as in
other cancer types. We therefore systematically reviewed the
current literature on the effect of exercise and nutritional
interventions on various outcomes in patients with advanced
gastroesophageal cancer. METHODS: We searched on the 11th of
June 2021 in Pubmed, Embase and the Cochrane library for
publications of randomized trials and observational studies on
exercise and nutritional interventions (either combined or as
separate intervention) in patients with advanced
gastroesophageal cancer. The outcomes of interest were overall
survival, progression free survival, quality of life,
chemotherapy toxicity, and chemotherapy adherence. RESULTS: We
screened 1,764 records for eligibility and included one study in
our analysis. The other 1,763 were excluded for various reasons,
most frequently an incorrect study population (e.g. both curable
and incurable patients) or an incorrect intervention. One
retrospective cohort study of 40 patients with advanced gastric
cancer who received first line chemotherapy was included. It was
stated that 'no significant differences in terms of overall and
progression free survival were reported between the two groups
of patients.' No absolute numbers were provided. CONCLUSION: Our
systematic review did not identify any high quality studies on
exercise and nutritional interventions in advanced
gastroesophageal cancer. We deem a randomized clinical trial on
this topic to be highly needed.
advanced gastroesophageal cancer can be improved. Positive
effects of exercise and nutritional interventions on quality of
life and potential effects on cancer outcomes are found in
gastroesophageal cancer in the curative setting, as well as in
other cancer types. We therefore systematically reviewed the
current literature on the effect of exercise and nutritional
interventions on various outcomes in patients with advanced
gastroesophageal cancer. METHODS: We searched on the 11th of
June 2021 in Pubmed, Embase and the Cochrane library for
publications of randomized trials and observational studies on
exercise and nutritional interventions (either combined or as
separate intervention) in patients with advanced
gastroesophageal cancer. The outcomes of interest were overall
survival, progression free survival, quality of life,
chemotherapy toxicity, and chemotherapy adherence. RESULTS: We
screened 1,764 records for eligibility and included one study in
our analysis. The other 1,763 were excluded for various reasons,
most frequently an incorrect study population (e.g. both curable
and incurable patients) or an incorrect intervention. One
retrospective cohort study of 40 patients with advanced gastric
cancer who received first line chemotherapy was included. It was
stated that 'no significant differences in terms of overall and
progression free survival were reported between the two groups
of patients.' No absolute numbers were provided. CONCLUSION: Our
systematic review did not identify any high quality studies on
exercise and nutritional interventions in advanced
gastroesophageal cancer. We deem a randomized clinical trial on
this topic to be highly needed.
van Dronkelaar, Carliene; Fultinga, Maaike; Hummel, Mitchell; Kruizenga, Hinke; Weijs, Peter J M; Tieland, Michael
Minerals and Sarcopenia in Older Adults: An Updated Systematic Review Tijdschriftartikel
In: J Am Med Dir Assoc, vol. 24, nr. 8, pp. 1163–1172, 2023, ISSN: 1538-9375.
@article{pmid37355247,
title = {Minerals and Sarcopenia in Older Adults: An Updated Systematic Review},
author = {Carliene van Dronkelaar and Maaike Fultinga and Mitchell Hummel and Hinke Kruizenga and Peter J M Weijs and Michael Tieland},
doi = {10.1016/j.jamda.2023.05.017},
issn = {1538-9375},
year = {2023},
date = {2023-08-01},
journal = {J Am Med Dir Assoc},
volume = {24},
number = {8},
pages = {1163--1172},
abstract = {OBJECTIVE: This systematic review aims to reevaluate the role of minerals on muscle mass, muscle strength, physical performance, and the prevalence of sarcopenia in community-dwelling and institutionalized older adults.nnDESIGN: Systematic review.nnSETTING AND PARTICIPANTS: In March 2022, a systematic search was performed in PubMed, Scopus, and Web of Sciences using predefined search terms. Original studies on dietary mineral intake or mineral serum blood concentrations on muscle mass, muscle strength, and physical performance or the prevalence of sarcopenia in older adults (average age ≥65 years) were included.nnMETHODS: Eligibility screening and data extraction was performed by 2 independent reviewers. Quality assessment was performed with the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for Quantitative Studies. Risk of bias was evaluated using the Risk Of Bias In Non-randomized Studies-of Exposure (ROBINS-E) tool.nnRESULTS: From the 15,622 identified articles, a total of 45 studies were included in the review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle mass, strength, and physical performance as well as the prevalence of sarcopenia. For calcium and zinc, no association could be found. For potassium, iron, sodium, and phosphorus, the association with sarcopenic outcomes remains unclear as not enough studies could be included or were nonconclusive (low quality of evidence).nnCONCLUSIONS AND IMPLICATIONS: This systematic review shows a potential role for selenium and magnesium on the prevention and treatment of sarcopenia in older adults. More randomized controlled trials are warranted to determine the impact of minerals on sarcopenia in older adults.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: This systematic review aims to reevaluate the role of minerals on muscle mass, muscle strength, physical performance, and the prevalence of sarcopenia in community-dwelling and institutionalized older adults.nnDESIGN: Systematic review.nnSETTING AND PARTICIPANTS: In March 2022, a systematic search was performed in PubMed, Scopus, and Web of Sciences using predefined search terms. Original studies on dietary mineral intake or mineral serum blood concentrations on muscle mass, muscle strength, and physical performance or the prevalence of sarcopenia in older adults (average age ≥65 years) were included.nnMETHODS: Eligibility screening and data extraction was performed by 2 independent reviewers. Quality assessment was performed with the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for Quantitative Studies. Risk of bias was evaluated using the Risk Of Bias In Non-randomized Studies-of Exposure (ROBINS-E) tool.nnRESULTS: From the 15,622 identified articles, a total of 45 studies were included in the review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle mass, strength, and physical performance as well as the prevalence of sarcopenia. For calcium and zinc, no association could be found. For potassium, iron, sodium, and phosphorus, the association with sarcopenic outcomes remains unclear as not enough studies could be included or were nonconclusive (low quality of evidence).nnCONCLUSIONS AND IMPLICATIONS: This systematic review shows a potential role for selenium and magnesium on the prevention and treatment of sarcopenia in older adults. More randomized controlled trials are warranted to determine the impact of minerals on sarcopenia in older adults.
Walrabenstein, Wendy; Wagenaar, Carlijn A; van der Leeden, Marike; Turkstra, Franktien; Twisk, Jos W R; Boers, Maarten; van Middendorp, Henriët; Weijs, Peter J M; van Schaardenburg, Dirkjan
A multidisciplinary lifestyle program for rheumatoid arthritis: the 'Plants for Joints' randomized controlled trial Tijdschriftartikel
In: Rheumatology (Oxford), vol. 62, nr. 8, pp. 2683–2691, 2023, ISSN: 1462-0332.
@article{pmid36617162,
title = {A multidisciplinary lifestyle program for rheumatoid arthritis: the 'Plants for Joints' randomized controlled trial},
author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marike van der Leeden and Franktien Turkstra and Jos W R Twisk and Maarten Boers and Henriët van Middendorp and Peter J M Weijs and Dirkjan van Schaardenburg},
doi = {10.1093/rheumatology/keac693},
issn = {1462-0332},
year = {2023},
date = {2023-08-01},
journal = {Rheumatology (Oxford)},
volume = {62},
number = {8},
pages = {2683--2691},
abstract = {OBJECTIVE: To determine the effect of a multidisciplinary lifestyle program in patients with RA with low-moderate disease activity.nnMETHODS: In the 'Plants for Joints' (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.1 were randomized to the PFJ or control group. The PFJ group followed a 16-week lifestyle program based on a whole-food plant-based diet, physical activity and stress management. The control group received usual care. Medication was kept stable 3 months before and during the trial whenever possible. We hypothesized that PFJ would lower disease activity (DAS28). Secondary outcomes included anthropometric, metabolic and patient-reported measures. An intention-to-treat analysis with a linear mixed model adjusted for baseline values was used to analyse between-group differences.nnRESULTS: Of the 83 people randomized, 77 completed the study. Participants were 92% female with mean (s.d.) age of 55 (12) years, BMI of 26 (4) kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group had a mean 0.9-point greater improvement of DAS28 vs the control group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led to greater decreases in body weight (difference -3.9 kg), fat mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3 mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas patient-reported outcome measures, blood pressure, glucose and other lipids did not change.nnCONCLUSION: The 16-week PFJ multidisciplinary lifestyle program substantially decreased disease activity and improved metabolic status in people with RA with low-moderate disease activity.nnTRIAL REGISTRATION: International Clinical Trials Registry Platform; https://www.who.int/clinical-trials-registry-platform; NL7800.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: To determine the effect of a multidisciplinary lifestyle program in patients with RA with low-moderate disease activity.nnMETHODS: In the 'Plants for Joints' (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.1 were randomized to the PFJ or control group. The PFJ group followed a 16-week lifestyle program based on a whole-food plant-based diet, physical activity and stress management. The control group received usual care. Medication was kept stable 3 months before and during the trial whenever possible. We hypothesized that PFJ would lower disease activity (DAS28). Secondary outcomes included anthropometric, metabolic and patient-reported measures. An intention-to-treat analysis with a linear mixed model adjusted for baseline values was used to analyse between-group differences.nnRESULTS: Of the 83 people randomized, 77 completed the study. Participants were 92% female with mean (s.d.) age of 55 (12) years, BMI of 26 (4) kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group had a mean 0.9-point greater improvement of DAS28 vs the control group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led to greater decreases in body weight (difference -3.9 kg), fat mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3 mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas patient-reported outcome measures, blood pressure, glucose and other lipids did not change.nnCONCLUSION: The 16-week PFJ multidisciplinary lifestyle program substantially decreased disease activity and improved metabolic status in people with RA with low-moderate disease activity.nnTRIAL REGISTRATION: International Clinical Trials Registry Platform; https://www.who.int/clinical-trials-registry-platform; NL7800.
Eglseer, Doris; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Voortman, Trudy; Boirie, Yves; Cruz-Jentoft, Alfonso J; Reiter, Lea; and, Silvia Bauer
Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis Tijdschriftartikel
In: Nutr Rev, vol. 81, nr. 9, pp. 1077–1090, 2023, ISSN: 1753-4887.
@article{pmid36882046,
title = {Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis},
author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and },
doi = {10.1093/nutrit/nuad007},
issn = {1753-4887},
year = {2023},
date = {2023-08-01},
journal = {Nutr Rev},
volume = {81},
number = {9},
pages = {1077--1090},
abstract = {CONTEXT: Retirement is an opportune time for people to establish new healthy routines. Exercise and nutritional interventions are promising in the prevention and treatment of sarcopenic obesity.nnOBJECTIVE: This systematic review aimed.nnto assess the effectiveness of nutritional and exercise interventions for the treatment of sarcopenic obesity in persons of retirement age.nnDATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were searched in September 2021 for randomized controlled trials; a manual search was also conducted. The search yielded 261 studies, of which 11 were eligible for inclusion.nnDATA EXTRACTION: Studies of community-dwelling individuals with sarcopenic obesity receiving any nutritional or exercise intervention ≥ 8 weeks with the mean age ± standard deviation between 50 and 70 years were included. Primary endpoint was body composition, and secondary endpoints were body mass index, muscle strength, and physical function. The literature review, study selection, data extraction, and risk-of-bias assessment were performed by two reviewers independently. Data were pooled for meta-analysis when possible.nnRESULTS: Meta-analysis was only possible for the exposure "resistance training" and the exposure "training (resistance or aerobic)" in combination with the exposure "added protein" as compared with "no intervention" or "training alone." Resistance training led to a significant body fat reduction of -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an exercise intervention significantly reduces fat mass (-0.80 kg; 95%CI, -1.32 to -0.28). Some individual studies of dietary or food supplement interventions for which data could not be pooled showed positive effects on body composition.nnCONCLUSION: Resistance training is an effective treatment for persons of retirement age with sarcopenic obesity. Increased protein intake combined with exercise may increase reductions in fat mass.nnSYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021276461.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
CONTEXT: Retirement is an opportune time for people to establish new healthy routines. Exercise and nutritional interventions are promising in the prevention and treatment of sarcopenic obesity.nnOBJECTIVE: This systematic review aimed.nnto assess the effectiveness of nutritional and exercise interventions for the treatment of sarcopenic obesity in persons of retirement age.nnDATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were searched in September 2021 for randomized controlled trials; a manual search was also conducted. The search yielded 261 studies, of which 11 were eligible for inclusion.nnDATA EXTRACTION: Studies of community-dwelling individuals with sarcopenic obesity receiving any nutritional or exercise intervention ≥ 8 weeks with the mean age ± standard deviation between 50 and 70 years were included. Primary endpoint was body composition, and secondary endpoints were body mass index, muscle strength, and physical function. The literature review, study selection, data extraction, and risk-of-bias assessment were performed by two reviewers independently. Data were pooled for meta-analysis when possible.nnRESULTS: Meta-analysis was only possible for the exposure "resistance training" and the exposure "training (resistance or aerobic)" in combination with the exposure "added protein" as compared with "no intervention" or "training alone." Resistance training led to a significant body fat reduction of -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an exercise intervention significantly reduces fat mass (-0.80 kg; 95%CI, -1.32 to -0.28). Some individual studies of dietary or food supplement interventions for which data could not be pooled showed positive effects on body composition.nnCONCLUSION: Resistance training is an effective treatment for persons of retirement age with sarcopenic obesity. Increased protein intake combined with exercise may increase reductions in fat mass.nnSYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021276461.
Eglseer, Doris; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Voortman, Trudy; Boirie, Yves; Cruz-Jentoft, Alfonso J; Reiter, Lea; and, Silvia Bauer
Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis Tijdschriftartikel
In: Nutr Rev, vol. 81, nr. 9, pp. 1077–1090, 2023, ISSN: 1753-4887.
@article{pmid36882046c,
title = {Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis},
author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and },
doi = {10.1093/nutrit/nuad007},
issn = {1753-4887},
year = {2023},
date = {2023-08-01},
journal = {Nutr Rev},
volume = {81},
number = {9},
pages = {1077--1090},
abstract = {CONTEXT: Retirement is an opportune time for people to establish new healthy routines. Exercise and nutritional interventions are promising in the prevention and treatment of sarcopenic obesity.nnOBJECTIVE: This systematic review aimed.nnto assess the effectiveness of nutritional and exercise interventions for the treatment of sarcopenic obesity in persons of retirement age.nnDATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were searched in September 2021 for randomized controlled trials; a manual search was also conducted. The search yielded 261 studies, of which 11 were eligible for inclusion.nnDATA EXTRACTION: Studies of community-dwelling individuals with sarcopenic obesity receiving any nutritional or exercise intervention ≥ 8 weeks with the mean age ± standard deviation between 50 and 70 years were included. Primary endpoint was body composition, and secondary endpoints were body mass index, muscle strength, and physical function. The literature review, study selection, data extraction, and risk-of-bias assessment were performed by two reviewers independently. Data were pooled for meta-analysis when possible.nnRESULTS: Meta-analysis was only possible for the exposure "resistance training" and the exposure "training (resistance or aerobic)" in combination with the exposure "added protein" as compared with "no intervention" or "training alone." Resistance training led to a significant body fat reduction of -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an exercise intervention significantly reduces fat mass (-0.80 kg; 95%CI, -1.32 to -0.28). Some individual studies of dietary or food supplement interventions for which data could not be pooled showed positive effects on body composition.nnCONCLUSION: Resistance training is an effective treatment for persons of retirement age with sarcopenic obesity. Increased protein intake combined with exercise may increase reductions in fat mass.nnSYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021276461.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
CONTEXT: Retirement is an opportune time for people to establish new healthy routines. Exercise and nutritional interventions are promising in the prevention and treatment of sarcopenic obesity.nnOBJECTIVE: This systematic review aimed.nnto assess the effectiveness of nutritional and exercise interventions for the treatment of sarcopenic obesity in persons of retirement age.nnDATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were searched in September 2021 for randomized controlled trials; a manual search was also conducted. The search yielded 261 studies, of which 11 were eligible for inclusion.nnDATA EXTRACTION: Studies of community-dwelling individuals with sarcopenic obesity receiving any nutritional or exercise intervention ≥ 8 weeks with the mean age ± standard deviation between 50 and 70 years were included. Primary endpoint was body composition, and secondary endpoints were body mass index, muscle strength, and physical function. The literature review, study selection, data extraction, and risk-of-bias assessment were performed by two reviewers independently. Data were pooled for meta-analysis when possible.nnRESULTS: Meta-analysis was only possible for the exposure "resistance training" and the exposure "training (resistance or aerobic)" in combination with the exposure "added protein" as compared with "no intervention" or "training alone." Resistance training led to a significant body fat reduction of -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an exercise intervention significantly reduces fat mass (-0.80 kg; 95%CI, -1.32 to -0.28). Some individual studies of dietary or food supplement interventions for which data could not be pooled showed positive effects on body composition.nnCONCLUSION: Resistance training is an effective treatment for persons of retirement age with sarcopenic obesity. Increased protein intake combined with exercise may increase reductions in fat mass.nnSYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021276461.
Dronkelaar, Carliene; Fultinga, Maaike; Hummel, Mitchell; Kruizenga, Hinke; Weijs, Peter J M; Tieland, Michael
Minerals and sarcopenia in older adults: An updated systematic
review Tijdschriftartikel
In: J. Am. Med. Dir. Assoc., vol. 24, nr. 8, pp. 1163–1172, 2023.
@article{Van_Dronkelaar2023-hl,
title = {Minerals and sarcopenia in older adults: An updated systematic
review},
author = {Carliene Dronkelaar and Maaike Fultinga and Mitchell Hummel and Hinke Kruizenga and Peter J M Weijs and Michael Tieland},
year = {2023},
date = {2023-08-01},
journal = {J. Am. Med. Dir. Assoc.},
volume = {24},
number = {8},
pages = {1163–1172},
publisher = {Elsevier BV},
abstract = {OBJECTIVE: This systematic review aims to reevaluate the role of
minerals on muscle mass, muscle strength, physical performance,
and the prevalence of sarcopenia in community-dwelling and
institutionalized older adults. DESIGN: Systematic review.
SETTING AND PARTICIPANTS: In March 2022, a systematic search was
performed in PubMed, Scopus, and Web of Sciences using
predefined search terms. Original studies on dietary mineral
intake or mineral serum blood concentrations on muscle mass,
muscle strength, and physical performance or the prevalence of
sarcopenia in older adults (average age $geq$65 years) were
included. METHODS: Eligibility screening and data extraction was
performed by 2 independent reviewers. Quality assessment was
performed with the Effective Public Health Practice Project
(EPHPP) Quality Assessment Tool for Quantitative Studies. Risk
of bias was evaluated using the Risk Of Bias In Non-randomized
Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622
identified articles, a total of 45 studies were included in the
review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle
mass, strength, and physical performance as well as the
prevalence of sarcopenia. For calcium and zinc, no association
could be found. For potassium, iron, sodium, and phosphorus, the
association with sarcopenic outcomes remains unclear as not
enough studies could be included or were nonconclusive (low
quality of evidence). CONCLUSIONS AND IMPLICATIONS: This
systematic review shows a potential role for selenium and
magnesium on the prevention and treatment of sarcopenia in older
adults. More randomized controlled trials are warranted to
determine the impact of minerals on sarcopenia in older adults.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: This systematic review aims to reevaluate the role of
minerals on muscle mass, muscle strength, physical performance,
and the prevalence of sarcopenia in community-dwelling and
institutionalized older adults. DESIGN: Systematic review.
SETTING AND PARTICIPANTS: In March 2022, a systematic search was
performed in PubMed, Scopus, and Web of Sciences using
predefined search terms. Original studies on dietary mineral
intake or mineral serum blood concentrations on muscle mass,
muscle strength, and physical performance or the prevalence of
sarcopenia in older adults (average age $geq$65 years) were
included. METHODS: Eligibility screening and data extraction was
performed by 2 independent reviewers. Quality assessment was
performed with the Effective Public Health Practice Project
(EPHPP) Quality Assessment Tool for Quantitative Studies. Risk
of bias was evaluated using the Risk Of Bias In Non-randomized
Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622
identified articles, a total of 45 studies were included in the
review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle
mass, strength, and physical performance as well as the
prevalence of sarcopenia. For calcium and zinc, no association
could be found. For potassium, iron, sodium, and phosphorus, the
association with sarcopenic outcomes remains unclear as not
enough studies could be included or were nonconclusive (low
quality of evidence). CONCLUSIONS AND IMPLICATIONS: This
systematic review shows a potential role for selenium and
magnesium on the prevention and treatment of sarcopenia in older
adults. More randomized controlled trials are warranted to
determine the impact of minerals on sarcopenia in older adults.
minerals on muscle mass, muscle strength, physical performance,
and the prevalence of sarcopenia in community-dwelling and
institutionalized older adults. DESIGN: Systematic review.
SETTING AND PARTICIPANTS: In March 2022, a systematic search was
performed in PubMed, Scopus, and Web of Sciences using
predefined search terms. Original studies on dietary mineral
intake or mineral serum blood concentrations on muscle mass,
muscle strength, and physical performance or the prevalence of
sarcopenia in older adults (average age $geq$65 years) were
included. METHODS: Eligibility screening and data extraction was
performed by 2 independent reviewers. Quality assessment was
performed with the Effective Public Health Practice Project
(EPHPP) Quality Assessment Tool for Quantitative Studies. Risk
of bias was evaluated using the Risk Of Bias In Non-randomized
Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622
identified articles, a total of 45 studies were included in the
review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle
mass, strength, and physical performance as well as the
prevalence of sarcopenia. For calcium and zinc, no association
could be found. For potassium, iron, sodium, and phosphorus, the
association with sarcopenic outcomes remains unclear as not
enough studies could be included or were nonconclusive (low
quality of evidence). CONCLUSIONS AND IMPLICATIONS: This
systematic review shows a potential role for selenium and
magnesium on the prevention and treatment of sarcopenia in older
adults. More randomized controlled trials are warranted to
determine the impact of minerals on sarcopenia in older adults.
Eglseer, Doris; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Voortman, Trudy; Boirie, Yves; Cruz-Jentoft, Alfonso J; Reiter, Lea; Bauer, Silvia; Consortium, SO-NUTS
Nutritional and exercise interventions in individuals with
sarcopenic obesity around retirement age: a systematic review
and meta-analysis Tijdschriftartikel
In: Nutr. Rev., vol. 81, nr. 9, pp. 1077–1090, 2023.
@article{Eglseer2023-jh,
title = {Nutritional and exercise interventions in individuals with
sarcopenic obesity around retirement age: a systematic review
and meta-analysis},
author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and SO-NUTS Consortium},
year = {2023},
date = {2023-08-01},
journal = {Nutr. Rev.},
volume = {81},
number = {9},
pages = {1077–1090},
publisher = {Oxford University Press (OUP)},
abstract = {CONTEXT: Retirement is an opportune time for people to establish
new healthy routines. Exercise and nutritional interventions are
promising in the prevention and treatment of sarcopenic obesity.
OBJECTIVE: This systematic review aimed. to assess the
effectiveness of nutritional and exercise interventions for the
treatment of sarcopenic obesity in persons of retirement age.
DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were
searched in September 2021 for randomized controlled trials; a
manual search was also conducted. The search yielded 261
studies, of which 11 were eligible for inclusion. DATA
EXTRACTION: Studies of community-dwelling individuals with
sarcopenic obesity receiving any nutritional or exercise
intervention $geq$ 8 weeks with the mean age $±$ standard
deviation between 50 and 70 years were included. Primary
endpoint was body composition, and secondary endpoints were body
mass index, muscle strength, and physical function. The
literature review, study selection, data extraction, and
risk-of-bias assessment were performed by two reviewers
independently. Data were pooled for meta-analysis when possible.
RESULTS: Meta-analysis was only possible for the exposure
``resistance training'' and the exposure ``training (resistance
or aerobic)'' in combination with the exposure ``added protein''
as compared with ``no intervention'' or ``training alone.''
Resistance training led to a significant body fat reduction of
-1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of
2.72% (95%CI, 1.23-4.22), an increase in muscle strength of
4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait
speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an
exercise intervention significantly reduces fat mass (-0.80 kg;
95%CI, -1.32 to -0.28). Some individual studies of dietary or
food supplement interventions for which data could not be pooled
showed positive effects on body composition. CONCLUSION:
Resistance training is an effective treatment for persons of
retirement age with sarcopenic obesity. Increased protein intake
combined with exercise may increase reductions in fat mass.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.
CRD42021276461.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
CONTEXT: Retirement is an opportune time for people to establish
new healthy routines. Exercise and nutritional interventions are
promising in the prevention and treatment of sarcopenic obesity.
OBJECTIVE: This systematic review aimed. to assess the
effectiveness of nutritional and exercise interventions for the
treatment of sarcopenic obesity in persons of retirement age.
DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were
searched in September 2021 for randomized controlled trials; a
manual search was also conducted. The search yielded 261
studies, of which 11 were eligible for inclusion. DATA
EXTRACTION: Studies of community-dwelling individuals with
sarcopenic obesity receiving any nutritional or exercise
intervention $geq$ 8 weeks with the mean age $±$ standard
deviation between 50 and 70 years were included. Primary
endpoint was body composition, and secondary endpoints were body
mass index, muscle strength, and physical function. The
literature review, study selection, data extraction, and
risk-of-bias assessment were performed by two reviewers
independently. Data were pooled for meta-analysis when possible.
RESULTS: Meta-analysis was only possible for the exposure
``resistance training'' and the exposure ``training (resistance
or aerobic)'' in combination with the exposure ``added protein''
as compared with ``no intervention'' or ``training alone.''
Resistance training led to a significant body fat reduction of
-1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of
2.72% (95%CI, 1.23-4.22), an increase in muscle strength of
4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait
speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an
exercise intervention significantly reduces fat mass (-0.80 kg;
95%CI, -1.32 to -0.28). Some individual studies of dietary or
food supplement interventions for which data could not be pooled
showed positive effects on body composition. CONCLUSION:
Resistance training is an effective treatment for persons of
retirement age with sarcopenic obesity. Increased protein intake
combined with exercise may increase reductions in fat mass.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.
CRD42021276461.
new healthy routines. Exercise and nutritional interventions are
promising in the prevention and treatment of sarcopenic obesity.
OBJECTIVE: This systematic review aimed. to assess the
effectiveness of nutritional and exercise interventions for the
treatment of sarcopenic obesity in persons of retirement age.
DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were
searched in September 2021 for randomized controlled trials; a
manual search was also conducted. The search yielded 261
studies, of which 11 were eligible for inclusion. DATA
EXTRACTION: Studies of community-dwelling individuals with
sarcopenic obesity receiving any nutritional or exercise
intervention $geq$ 8 weeks with the mean age $±$ standard
deviation between 50 and 70 years were included. Primary
endpoint was body composition, and secondary endpoints were body
mass index, muscle strength, and physical function. The
literature review, study selection, data extraction, and
risk-of-bias assessment were performed by two reviewers
independently. Data were pooled for meta-analysis when possible.
RESULTS: Meta-analysis was only possible for the exposure
``resistance training'' and the exposure ``training (resistance
or aerobic)'' in combination with the exposure ``added protein''
as compared with ``no intervention'' or ``training alone.''
Resistance training led to a significant body fat reduction of
-1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of
2.72% (95%CI, 1.23-4.22), an increase in muscle strength of
4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait
speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an
exercise intervention significantly reduces fat mass (-0.80 kg;
95%CI, -1.32 to -0.28). Some individual studies of dietary or
food supplement interventions for which data could not be pooled
showed positive effects on body composition. CONCLUSION:
Resistance training is an effective treatment for persons of
retirement age with sarcopenic obesity. Increased protein intake
combined with exercise may increase reductions in fat mass.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.
CRD42021276461.
Walrabenstein, Wendy; Wagenaar, Carlijn A; Leeden, Marike; Turkstra, Franktien; Twisk, Jos W R; Boers, Maarten; Middendorp, Henriët; Weijs, Peter J M; Schaardenburg, Dirkjan
A multidisciplinary lifestyle program for rheumatoid arthritis:
the 'Plants for Joints' randomized controlled trial Tijdschriftartikel
In: Rheumatology (Oxford), vol. 62, nr. 8, pp. 2683–2691, 2023.
@article{Walrabenstein2023-vb,
title = {A multidisciplinary lifestyle program for rheumatoid arthritis:
the 'Plants for Joints' randomized controlled trial},
author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marike Leeden and Franktien Turkstra and Jos W R Twisk and Maarten Boers and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},
year = {2023},
date = {2023-08-01},
journal = {Rheumatology (Oxford)},
volume = {62},
number = {8},
pages = {2683–2691},
publisher = {Oxford University Press (OUP)},
abstract = {OBJECTIVE: To determine the effect of a multidisciplinary
lifestyle program in patients with RA with low-moderate disease
activity. METHODS: In the 'Plants for Joints' (PFJ)
parallel-arm, assessor-blind randomized controlled trial,
patients with RA and 28-joint DAS (DAS28) $geq$2.6 and
$łeq$5.1 were randomized to the PFJ or control group. The PFJ
group followed a 16-week lifestyle program based on a whole-food
plant-based diet, physical activity and stress management. The
control group received usual care. Medication was kept stable 3
months before and during the trial whenever possible. We
hypothesized that PFJ would lower disease activity (DAS28).
Secondary outcomes included anthropometric, metabolic and
patient-reported measures. An intention-to-treat analysis with a
linear mixed model adjusted for baseline values was used to
analyse between-group differences. RESULTS: Of the 83 people
randomized, 77 completed the study. Participants were 92%
female with mean (s.d.) age of 55 (12) years, BMI of 26 (4)
kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group
had a mean 0.9-point greater improvement of DAS28 vs the control
group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led
to greater decreases in body weight (difference -3.9 kg), fat
mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3
mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas
patient-reported outcome measures, blood pressure, glucose and
other lipids did not change. CONCLUSION: The 16-week PFJ
multidisciplinary lifestyle program substantially decreased
disease activity and improved metabolic status in people with RA
with low-moderate disease activity. TRIAL REGISTRATION:
International Clinical Trials Registry Platform;
https://www.who.int/clinical-trials-registry-platform; NL7800.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: To determine the effect of a multidisciplinary
lifestyle program in patients with RA with low-moderate disease
activity. METHODS: In the 'Plants for Joints' (PFJ)
parallel-arm, assessor-blind randomized controlled trial,
patients with RA and 28-joint DAS (DAS28) $geq$2.6 and
$łeq$5.1 were randomized to the PFJ or control group. The PFJ
group followed a 16-week lifestyle program based on a whole-food
plant-based diet, physical activity and stress management. The
control group received usual care. Medication was kept stable 3
months before and during the trial whenever possible. We
hypothesized that PFJ would lower disease activity (DAS28).
Secondary outcomes included anthropometric, metabolic and
patient-reported measures. An intention-to-treat analysis with a
linear mixed model adjusted for baseline values was used to
analyse between-group differences. RESULTS: Of the 83 people
randomized, 77 completed the study. Participants were 92%
female with mean (s.d.) age of 55 (12) years, BMI of 26 (4)
kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group
had a mean 0.9-point greater improvement of DAS28 vs the control
group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led
to greater decreases in body weight (difference -3.9 kg), fat
mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3
mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas
patient-reported outcome measures, blood pressure, glucose and
other lipids did not change. CONCLUSION: The 16-week PFJ
multidisciplinary lifestyle program substantially decreased
disease activity and improved metabolic status in people with RA
with low-moderate disease activity. TRIAL REGISTRATION:
International Clinical Trials Registry Platform;
https://www.who.int/clinical-trials-registry-platform; NL7800.
lifestyle program in patients with RA with low-moderate disease
activity. METHODS: In the 'Plants for Joints' (PFJ)
parallel-arm, assessor-blind randomized controlled trial,
patients with RA and 28-joint DAS (DAS28) $geq$2.6 and
$łeq$5.1 were randomized to the PFJ or control group. The PFJ
group followed a 16-week lifestyle program based on a whole-food
plant-based diet, physical activity and stress management. The
control group received usual care. Medication was kept stable 3
months before and during the trial whenever possible. We
hypothesized that PFJ would lower disease activity (DAS28).
Secondary outcomes included anthropometric, metabolic and
patient-reported measures. An intention-to-treat analysis with a
linear mixed model adjusted for baseline values was used to
analyse between-group differences. RESULTS: Of the 83 people
randomized, 77 completed the study. Participants were 92%
female with mean (s.d.) age of 55 (12) years, BMI of 26 (4)
kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group
had a mean 0.9-point greater improvement of DAS28 vs the control
group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led
to greater decreases in body weight (difference -3.9 kg), fat
mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3
mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas
patient-reported outcome measures, blood pressure, glucose and
other lipids did not change. CONCLUSION: The 16-week PFJ
multidisciplinary lifestyle program substantially decreased
disease activity and improved metabolic status in people with RA
with low-moderate disease activity. TRIAL REGISTRATION:
International Clinical Trials Registry Platform;
https://www.who.int/clinical-trials-registry-platform; NL7800.
Dronkelaar, Carliene; Fultinga, Maaike; Hummel, Mitchell; Kruizenga, Hinke; Weijs, Peter J M; Tieland, Michael
Minerals and sarcopenia in older adults: An updated systematic
review Tijdschriftartikel
In: J. Am. Med. Dir. Assoc., vol. 24, nr. 8, pp. 1163–1172, 2023.
@article{Van_Dronkelaar2023-hlb,
title = {Minerals and sarcopenia in older adults: An updated systematic
review},
author = {Carliene Dronkelaar and Maaike Fultinga and Mitchell Hummel and Hinke Kruizenga and Peter J M Weijs and Michael Tieland},
year = {2023},
date = {2023-08-01},
journal = {J. Am. Med. Dir. Assoc.},
volume = {24},
number = {8},
pages = {1163–1172},
publisher = {Elsevier BV},
abstract = {OBJECTIVE: This systematic review aims to reevaluate the role of
minerals on muscle mass, muscle strength, physical performance,
and the prevalence of sarcopenia in community-dwelling and
institutionalized older adults. DESIGN: Systematic review.
SETTING AND PARTICIPANTS: In March 2022, a systematic search was
performed in PubMed, Scopus, and Web of Sciences using
predefined search terms. Original studies on dietary mineral
intake or mineral serum blood concentrations on muscle mass,
muscle strength, and physical performance or the prevalence of
sarcopenia in older adults (average age $geq$65 years) were
included. METHODS: Eligibility screening and data extraction was
performed by 2 independent reviewers. Quality assessment was
performed with the Effective Public Health Practice Project
(EPHPP) Quality Assessment Tool for Quantitative Studies. Risk
of bias was evaluated using the Risk Of Bias In Non-randomized
Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622
identified articles, a total of 45 studies were included in the
review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle
mass, strength, and physical performance as well as the
prevalence of sarcopenia. For calcium and zinc, no association
could be found. For potassium, iron, sodium, and phosphorus, the
association with sarcopenic outcomes remains unclear as not
enough studies could be included or were nonconclusive (low
quality of evidence). CONCLUSIONS AND IMPLICATIONS: This
systematic review shows a potential role for selenium and
magnesium on the prevention and treatment of sarcopenia in older
adults. More randomized controlled trials are warranted to
determine the impact of minerals on sarcopenia in older adults.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: This systematic review aims to reevaluate the role of
minerals on muscle mass, muscle strength, physical performance,
and the prevalence of sarcopenia in community-dwelling and
institutionalized older adults. DESIGN: Systematic review.
SETTING AND PARTICIPANTS: In March 2022, a systematic search was
performed in PubMed, Scopus, and Web of Sciences using
predefined search terms. Original studies on dietary mineral
intake or mineral serum blood concentrations on muscle mass,
muscle strength, and physical performance or the prevalence of
sarcopenia in older adults (average age $geq$65 years) were
included. METHODS: Eligibility screening and data extraction was
performed by 2 independent reviewers. Quality assessment was
performed with the Effective Public Health Practice Project
(EPHPP) Quality Assessment Tool for Quantitative Studies. Risk
of bias was evaluated using the Risk Of Bias In Non-randomized
Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622
identified articles, a total of 45 studies were included in the
review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle
mass, strength, and physical performance as well as the
prevalence of sarcopenia. For calcium and zinc, no association
could be found. For potassium, iron, sodium, and phosphorus, the
association with sarcopenic outcomes remains unclear as not
enough studies could be included or were nonconclusive (low
quality of evidence). CONCLUSIONS AND IMPLICATIONS: This
systematic review shows a potential role for selenium and
magnesium on the prevention and treatment of sarcopenia in older
adults. More randomized controlled trials are warranted to
determine the impact of minerals on sarcopenia in older adults.
minerals on muscle mass, muscle strength, physical performance,
and the prevalence of sarcopenia in community-dwelling and
institutionalized older adults. DESIGN: Systematic review.
SETTING AND PARTICIPANTS: In March 2022, a systematic search was
performed in PubMed, Scopus, and Web of Sciences using
predefined search terms. Original studies on dietary mineral
intake or mineral serum blood concentrations on muscle mass,
muscle strength, and physical performance or the prevalence of
sarcopenia in older adults (average age $geq$65 years) were
included. METHODS: Eligibility screening and data extraction was
performed by 2 independent reviewers. Quality assessment was
performed with the Effective Public Health Practice Project
(EPHPP) Quality Assessment Tool for Quantitative Studies. Risk
of bias was evaluated using the Risk Of Bias In Non-randomized
Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622
identified articles, a total of 45 studies were included in the
review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle
mass, strength, and physical performance as well as the
prevalence of sarcopenia. For calcium and zinc, no association
could be found. For potassium, iron, sodium, and phosphorus, the
association with sarcopenic outcomes remains unclear as not
enough studies could be included or were nonconclusive (low
quality of evidence). CONCLUSIONS AND IMPLICATIONS: This
systematic review shows a potential role for selenium and
magnesium on the prevention and treatment of sarcopenia in older
adults. More randomized controlled trials are warranted to
determine the impact of minerals on sarcopenia in older adults.
Eglseer, Doris; Traxler, Mariella; Schoufour, Josje D; Weijs, Peter J M; Voortman, Trudy; Boirie, Yves; Cruz-Jentoft, Alfonso J; Reiter, Lea; Bauer, Silvia; Consortium, SO-NUTS
Nutritional and exercise interventions in individuals with
sarcopenic obesity around retirement age: a systematic review
and meta-analysis Tijdschriftartikel
In: Nutr. Rev., vol. 81, nr. 9, pp. 1077–1090, 2023.
@article{Eglseer2023-jhb,
title = {Nutritional and exercise interventions in individuals with
sarcopenic obesity around retirement age: a systematic review
and meta-analysis},
author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and SO-NUTS Consortium},
year = {2023},
date = {2023-08-01},
journal = {Nutr. Rev.},
volume = {81},
number = {9},
pages = {1077–1090},
publisher = {Oxford University Press (OUP)},
abstract = {CONTEXT: Retirement is an opportune time for people to establish
new healthy routines. Exercise and nutritional interventions are
promising in the prevention and treatment of sarcopenic obesity.
OBJECTIVE: This systematic review aimed. to assess the
effectiveness of nutritional and exercise interventions for the
treatment of sarcopenic obesity in persons of retirement age.
DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were
searched in September 2021 for randomized controlled trials; a
manual search was also conducted. The search yielded 261
studies, of which 11 were eligible for inclusion. DATA
EXTRACTION: Studies of community-dwelling individuals with
sarcopenic obesity receiving any nutritional or exercise
intervention $geq$ 8 weeks with the mean age $±$ standard
deviation between 50 and 70 years were included. Primary
endpoint was body composition, and secondary endpoints were body
mass index, muscle strength, and physical function. The
literature review, study selection, data extraction, and
risk-of-bias assessment were performed by two reviewers
independently. Data were pooled for meta-analysis when possible.
RESULTS: Meta-analysis was only possible for the exposure
``resistance training'' and the exposure ``training (resistance
or aerobic)'' in combination with the exposure ``added protein''
as compared with ``no intervention'' or ``training alone.''
Resistance training led to a significant body fat reduction of
-1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of
2.72% (95%CI, 1.23-4.22), an increase in muscle strength of
4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait
speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an
exercise intervention significantly reduces fat mass (-0.80 kg;
95%CI, -1.32 to -0.28). Some individual studies of dietary or
food supplement interventions for which data could not be pooled
showed positive effects on body composition. CONCLUSION:
Resistance training is an effective treatment for persons of
retirement age with sarcopenic obesity. Increased protein intake
combined with exercise may increase reductions in fat mass.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.
CRD42021276461.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
CONTEXT: Retirement is an opportune time for people to establish
new healthy routines. Exercise and nutritional interventions are
promising in the prevention and treatment of sarcopenic obesity.
OBJECTIVE: This systematic review aimed. to assess the
effectiveness of nutritional and exercise interventions for the
treatment of sarcopenic obesity in persons of retirement age.
DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were
searched in September 2021 for randomized controlled trials; a
manual search was also conducted. The search yielded 261
studies, of which 11 were eligible for inclusion. DATA
EXTRACTION: Studies of community-dwelling individuals with
sarcopenic obesity receiving any nutritional or exercise
intervention $geq$ 8 weeks with the mean age $±$ standard
deviation between 50 and 70 years were included. Primary
endpoint was body composition, and secondary endpoints were body
mass index, muscle strength, and physical function. The
literature review, study selection, data extraction, and
risk-of-bias assessment were performed by two reviewers
independently. Data were pooled for meta-analysis when possible.
RESULTS: Meta-analysis was only possible for the exposure
``resistance training'' and the exposure ``training (resistance
or aerobic)'' in combination with the exposure ``added protein''
as compared with ``no intervention'' or ``training alone.''
Resistance training led to a significant body fat reduction of
-1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of
2.72% (95%CI, 1.23-4.22), an increase in muscle strength of
4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait
speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an
exercise intervention significantly reduces fat mass (-0.80 kg;
95%CI, -1.32 to -0.28). Some individual studies of dietary or
food supplement interventions for which data could not be pooled
showed positive effects on body composition. CONCLUSION:
Resistance training is an effective treatment for persons of
retirement age with sarcopenic obesity. Increased protein intake
combined with exercise may increase reductions in fat mass.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.
CRD42021276461.
new healthy routines. Exercise and nutritional interventions are
promising in the prevention and treatment of sarcopenic obesity.
OBJECTIVE: This systematic review aimed. to assess the
effectiveness of nutritional and exercise interventions for the
treatment of sarcopenic obesity in persons of retirement age.
DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were
searched in September 2021 for randomized controlled trials; a
manual search was also conducted. The search yielded 261
studies, of which 11 were eligible for inclusion. DATA
EXTRACTION: Studies of community-dwelling individuals with
sarcopenic obesity receiving any nutritional or exercise
intervention $geq$ 8 weeks with the mean age $±$ standard
deviation between 50 and 70 years were included. Primary
endpoint was body composition, and secondary endpoints were body
mass index, muscle strength, and physical function. The
literature review, study selection, data extraction, and
risk-of-bias assessment were performed by two reviewers
independently. Data were pooled for meta-analysis when possible.
RESULTS: Meta-analysis was only possible for the exposure
``resistance training'' and the exposure ``training (resistance
or aerobic)'' in combination with the exposure ``added protein''
as compared with ``no intervention'' or ``training alone.''
Resistance training led to a significant body fat reduction of
-1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of
2.72% (95%CI, 1.23-4.22), an increase in muscle strength of
4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait
speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an
exercise intervention significantly reduces fat mass (-0.80 kg;
95%CI, -1.32 to -0.28). Some individual studies of dietary or
food supplement interventions for which data could not be pooled
showed positive effects on body composition. CONCLUSION:
Resistance training is an effective treatment for persons of
retirement age with sarcopenic obesity. Increased protein intake
combined with exercise may increase reductions in fat mass.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.
CRD42021276461.
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