Publications

@article{pmid38140387,

title = {Malnutrition Screening Tools Are Not Sensitive Enough to Identify Older Hospital Patients with Malnutrition},

author = {Carliene van Dronkelaar and Michael Tieland and Tommy Cederholm and Esmee M Reijnierse and Peter J M Weijs and Hinke Kruizenga},

doi = {10.3390/nu15245126},

issn = {2072-6643},

year  = {2023},

date = {2023-12-01},

journal = {Nutrients},

volume = {15},

number = {24},

abstract = {This study evaluates the concurrent validity of five malnutrition screening tools to identify older hospitalized patients against the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria as limited evidence is available. The screening tools Short Nutritional Assessment Questionnaire (SNAQ), Malnutrition Universal Screening Tool (MUST), Malnutrition Screening Tool (MST), Mini Nutritional Assessment-Short Form (MNA-SF), and the Patient-Generated Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs for both malnutrition (conservative) and moderate malnutrition or risk of malnutrition (liberal) were used. The concurrent validity was determined by the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the level of agreement by Cohen's kappa. In total, 356 patients were included in the analyses (median age 70 y (IQR 63-77); 54% male). The prevalence of malnutrition according to the GLIM criteria without prior screening was 42%. The conservative cut-offs showed a low-to-moderate sensitivity (32-68%) and moderate-to-high specificity (61-98%). The PPV and NPV ranged from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs displayed a moderate-to-high sensitivity (66-89%) and a low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their capacity to identify hospitalized older patients with malnutrition. The screening process in the GLIM framework requires further consideration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Walrabenstein2023-xtb,

title = {A multidisciplinary lifestyle program for metabolic 

 syndrome-associated osteoarthritis: the ``Plants for Joints'' 

 randomized controlled trial},

author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marieke Put and Marike Leeden and Martijn Gerritsen and Jos W R Twisk and Martin Esch and Henriët Middendorp and Peter J M Weijs and Leo D Roorda and Dirkjan Schaardenburg},

year  = {2023},

date = {2023-11-01},

journal = {Osteoarthritis Cartilage},

volume = {31},

number = {11},

pages = {1491–1500},

publisher = {Elsevier BV},

abstract = {OBJECTIVE: To determine the effectiveness of the ``Plants for 

 Joints'' multidisciplinary lifestyle program in patients with 

 metabolic syndrome-associated osteoarthritis (MSOA). DESIGN: 

 Patients with hip or knee MSOA were randomized to the 

 intervention or control group. The intervention group followed a 

 16-week program in addition to usual care based on a whole food 

 plant-based diet, physical activity, and stress management. The 

 control group received usual care. The patient-reported Western 

 Ontario and McMasters Universities Osteoarthritis Index (WOMAC) 

 total score (range 0-96) was the primary outcome. Secondary 

 outcomes included other patient-reported, anthropometric, and 

 metabolic measures. An intention-to-treat analysis with a 

 linear-mixed model adjusted for baseline values was used to 

 analyze between-group differences. RESULTS: Of the 66 people 

 randomized, 64 completed the study. Participants (84% female) 

 had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a 

 mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group 

 also lost more weight (-5 kg), fat mass (-4 kg), and waist 

 circumference (-6 cm) compared to the control group. 

 Patient-Reported Outcomes Measurement Information System 

 (PROMIS) fatigue, pain interference, C-reactive protein, 

 hemoglobin A1c, fasting glucose, and low-density lipoproteins 

 improved in the intervention versus the control group, while 

 other PROMIS measures, blood pressure, high-density 

 lipoproteins, and triglycerides did not differ significantly 

 between the groups. CONCLUSION: The ``Plants for Joints'' 

 lifestyle program reduced stiffness, relieved pain, and improved 

 physical function in people with hip or knee MSOA compared to 

 usual care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{De_Leeuwerk2023-lvb,

title = {The efficacy of a blended intervention to improve physical 

 activity and protein intake for optimal physical recovery after 

 oncological gastrointestinal and lung cancer surgery, the Optimal 

 Physical Recovery After Hospitalization (OPRAH) trial: study 

 protocol for a randomized controlled multicenter trial},

author = {Marijke Leeuwerk and Vincent Groot and Suzanne Ten Dam and Hinke Kruizenga and Peter J M Weijs and Edwin Geleijn and Marike Leeden and Marike Schaaf and OPRAH consortium},

year  = {2023},

date = {2023-11-01},

journal = {Trials},

volume = {24},

number = {1},

pages = {757},

abstract = {BACKGROUND: Improving physical activity, especially in 

 combination with optimizing protein intake, after surgery has a 

 potential positive effect on recovery of physical functioning in 

 patients after gastrointestinal and lung cancer surgery. The aim 

 of this randomized controlled trial is to evaluate the efficacy 

 of a blended intervention to improve physical activity and 

 protein intake after hospital discharge on recovery of physical 

 functioning in these patients. METHODS: In this multicenter 

 single-blinded randomized controlled trial, 161 adult patients 

 scheduled for elective gastrointestinal or lung cancer surgery 

 will be randomly assigned to the intervention or control group. 

 The purpose of the Optimal Physical Recovery After 

 Hospitalization (OPRAH) intervention is to encourage 

 self-management of patients in their functional recovery, by 

 using a smartphone application and corresponding accelerometer in 

 combination with coaching by a physiotherapist and dietician 

 during three months after hospital discharge. Study outcomes will 

 be measured prior to surgery (baseline) and one, four, eight, and 

 twelve weeks and six months after hospital discharge. The primary 

 outcome is recovery in physical functioning six months after 

 surgery, and the most important secondary outcome is physical 

 activity. Other outcomes include lean body mass, muscle mass, 

 protein intake, symptoms, physical performance, self-reported 

 limitations in activities and participation, self-efficacy, 

 hospital readmissions and adverse events. DISCUSSION: The results 

 of this study will demonstrate whether a blended intervention to 

 support patients increasing their level of physical activity and 

 protein intake after hospital discharge improves recovery in 

 physical functioning in patients after gastrointestinal and lung 

 cancer surgery. TRIAL REGISTRATION: The trial has been registered 

 at the International Clinical Trials Registry Platform at 

 14-10-2021 with registration number NL9793. Trial registration 

 data are presented in Table 1.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Walrabenstein2023-xt,

title = {A multidisciplinary lifestyle program for metabolic 

 syndrome-associated osteoarthritis: the ``Plants for Joints'' 

 randomized controlled trial},

author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marieke Put and Marike Leeden and Martijn Gerritsen and Jos W R Twisk and Martin Esch and Henriët Middendorp and Peter J M Weijs and Leo D Roorda and Dirkjan Schaardenburg},

year  = {2023},

date = {2023-11-01},

journal = {Osteoarthritis Cartilage},

volume = {31},

number = {11},

pages = {1491–1500},

publisher = {Elsevier BV},

abstract = {OBJECTIVE: To determine the effectiveness of the ``Plants for 

 Joints'' multidisciplinary lifestyle program in patients with 

 metabolic syndrome-associated osteoarthritis (MSOA). DESIGN: 

 Patients with hip or knee MSOA were randomized to the 

 intervention or control group. The intervention group followed a 

 16-week program in addition to usual care based on a whole food 

 plant-based diet, physical activity, and stress management. The 

 control group received usual care. The patient-reported Western 

 Ontario and McMasters Universities Osteoarthritis Index (WOMAC) 

 total score (range 0-96) was the primary outcome. Secondary 

 outcomes included other patient-reported, anthropometric, and 

 metabolic measures. An intention-to-treat analysis with a 

 linear-mixed model adjusted for baseline values was used to 

 analyze between-group differences. RESULTS: Of the 66 people 

 randomized, 64 completed the study. Participants (84% female) 

 had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a 

 mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group 

 also lost more weight (-5 kg), fat mass (-4 kg), and waist 

 circumference (-6 cm) compared to the control group. 

 Patient-Reported Outcomes Measurement Information System 

 (PROMIS) fatigue, pain interference, C-reactive protein, 

 hemoglobin A1c, fasting glucose, and low-density lipoproteins 

 improved in the intervention versus the control group, while 

 other PROMIS measures, blood pressure, high-density 

 lipoproteins, and triglycerides did not differ significantly 

 between the groups. CONCLUSION: The ``Plants for Joints'' 

 lifestyle program reduced stiffness, relieved pain, and improved 

 physical function in people with hip or knee MSOA compared to 

 usual care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{De_Leeuwerk2023-lv,

title = {The efficacy of a blended intervention to improve physical 

 activity and protein intake for optimal physical recovery after 

 oncological gastrointestinal and lung cancer surgery, the Optimal 

 Physical Recovery After Hospitalization (OPRAH) trial: study 

 protocol for a randomized controlled multicenter trial},

author = {Marijke Leeuwerk and Vincent Groot and Suzanne Ten Dam and Hinke Kruizenga and Peter J M Weijs and Edwin Geleijn and Marike Leeden and Marike Schaaf and OPRAH consortium},

year  = {2023},

date = {2023-11-01},

journal = {Trials},

volume = {24},

number = {1},

pages = {757},

abstract = {BACKGROUND: Improving physical activity, especially in 

 combination with optimizing protein intake, after surgery has a 

 potential positive effect on recovery of physical functioning in 

 patients after gastrointestinal and lung cancer surgery. The aim 

 of this randomized controlled trial is to evaluate the efficacy 

 of a blended intervention to improve physical activity and 

 protein intake after hospital discharge on recovery of physical 

 functioning in these patients. METHODS: In this multicenter 

 single-blinded randomized controlled trial, 161 adult patients 

 scheduled for elective gastrointestinal or lung cancer surgery 

 will be randomly assigned to the intervention or control group. 

 The purpose of the Optimal Physical Recovery After 

 Hospitalization (OPRAH) intervention is to encourage 

 self-management of patients in their functional recovery, by 

 using a smartphone application and corresponding accelerometer in 

 combination with coaching by a physiotherapist and dietician 

 during three months after hospital discharge. Study outcomes will 

 be measured prior to surgery (baseline) and one, four, eight, and 

 twelve weeks and six months after hospital discharge. The primary 

 outcome is recovery in physical functioning six months after 

 surgery, and the most important secondary outcome is physical 

 activity. Other outcomes include lean body mass, muscle mass, 

 protein intake, symptoms, physical performance, self-reported 

 limitations in activities and participation, self-efficacy, 

 hospital readmissions and adverse events. DISCUSSION: The results 

 of this study will demonstrate whether a blended intervention to 

 support patients increasing their level of physical activity and 

 protein intake after hospital discharge improves recovery in 

 physical functioning in patients after gastrointestinal and lung 

 cancer surgery. TRIAL REGISTRATION: The trial has been registered 

 at the International Clinical Trials Registry Platform at 

 14-10-2021 with registration number NL9793. Trial registration 

 data are presented in Table 1.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37608512b,

title = {Sarcopenia predicts 5-year mortality in older adults with intellectual disabilities},

author = {B Valentin and D Maes-Festen and J Schoufour and A Oppewal},

doi = {10.1111/jir.13078},

issn = {1365-2788},

year  = {2023},

date = {2023-11-01},

journal = {J Intellect Disabil Res},

volume = {67},

number = {11},

pages = {1161--1173},

abstract = {BACKGROUND: People with intellectual disabilities (ID) have a lower life expectancy than their peers without ID. A contributing factor to the lower life expectancy and early mortality could be sarcopenia: low muscle mass and low muscle function. In the general population, sarcopenia strongly predicts early mortality, but this association is unknown in people with ID. Therefore, this study aims to explore the association between sarcopenia and 5-year mortality in older adults with ID.nnMETHODS: In the Healthy Ageing and Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was measured at baseline among 884 older adults (≥50 years) with ID. All-cause mortality was measured over a 5-year follow-up period. Univariable and multivariable Cox proportional hazard models were applied to determine the association between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease, diabetes type 2 and metabolic syndrome).nnRESULTS: The unadjusted hazard ratio (HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48-3.42], P < 0.001), and 2.40 (95% CI 1.40-4.10, P = 0.001) for severe sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome, sarcopenia (HR = 1.72, 95% CI 1.08-2.75, P = 0.022) and severe sarcopenia (HR = 1.86, 95% CI 1.07-3.23, P = 0.028) were significantly associated with early mortality. When additionally adjusted for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02-2.59, P = 0.043) and 1.81 (95% CI 1.04-3.15, P = 0.035) for sarcopenia and severe sarcopenia, respectively.nnCONCLUSION: Sarcopenia is an independent risk factor for early mortality in older adults with ID over a 5-year follow-up period. Our results stress the need to delay the incidence and development of sarcopenia in older adults with ID.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37328047,

title = {A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial},

author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marieke van de Put and Marike van der Leeden and Martijn Gerritsen and Jos W R Twisk and Martin van der Esch and Henriët van Middendorp and Peter J M Weijs and Leo D Roorda and Dirkjan van Schaardenburg},

doi = {10.1016/j.joca.2023.05.014},

issn = {1522-9653},

year  = {2023},

date = {2023-11-01},

journal = {Osteoarthritis Cartilage},

volume = {31},

number = {11},

pages = {1491--1500},

abstract = {OBJECTIVE: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).nnDESIGN: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome. Secondary outcomes included other patient-reported, anthropometric, and metabolic measures. An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyze between-group differences.nnRESULTS: Of the 66 people randomized, 64 completed the study. Participants (84% female) had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m. After 16 weeks, the intervention group (n = 32) had a mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group also lost more weight (-5 kg), fat mass (-4 kg), and waist circumference (-6 cm) compared to the control group. Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue, pain interference, C-reactive protein, hemoglobin A1c, fasting glucose, and low-density lipoproteins improved in the intervention versus the control group, while other PROMIS measures, blood pressure, high-density lipoproteins, and triglycerides did not differ significantly between the groups.nnCONCLUSION: The "Plants for Joints" lifestyle program reduced stiffness, relieved pain, and improved physical function in people with hip or knee MSOA compared to usual care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Baggerman2023-wob,

title = {Visceral obesity measured using computed tomography scans: No 

 significant association with mortality in critically ill 

 patients},

author = {Michelle R Baggerman and Ingeborg M Dekker and Bjorn Winkens and Steven W M Olde Damink and Sandra N Stapel and Peter J M Weijs and Marcel C G Poll},

year  = {2023},

date = {2023-10-01},

journal = {J. Crit. Care},

volume = {77},

number = {154316},

pages = {154316},

publisher = {Elsevier BV},

abstract = {INTRODUCTION: The association between obesity and outcome in 

 critical illness is unclear. Since the amount of visceral 

 adipose tissue(VAT) rather than BMI mediates the health effects 

 of obesity we aimed to investigate the association between 

 visceral obesity, BMI and 90-day mortality in critically ill 

 patients. METHOD: In 555 critically ill patients (68% male), 

 the VAT Index(VATI) was measured using Computed Tomography scans 

 on the level of vertebra L3. The association between visceral 

 obesity, BMI and 90-day mortality was investigated using 

 univariable and multivariable analyses, correcting for age, sex, 

 APACHE II score, sarcopenia and muscle quality. RESULTS: 

 Visceral obesity was present in 48.1% of the patients and its 

 prevalence was similar in males and females. Mortality was 

 similar amongst patients with and without visceral obesity (27.7% vs 24.0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Baggerman2023-wo,

title = {Visceral obesity measured using computed tomography scans: No 

 significant association with mortality in critically ill 

 patients},

author = {Michelle R Baggerman and Ingeborg M Dekker and Bjorn Winkens and Steven W M Olde Damink and Sandra N Stapel and Peter J M Weijs and Marcel C G Poll},

year  = {2023},

date = {2023-10-01},

journal = {J. Crit. Care},

volume = {77},

number = {154316},

pages = {154316},

publisher = {Elsevier BV},

abstract = {INTRODUCTION: The association between obesity and outcome in 

 critical illness is unclear. Since the amount of visceral 

 adipose tissue(VAT) rather than BMI mediates the health effects 

 of obesity we aimed to investigate the association between 

 visceral obesity, BMI and 90-day mortality in critically ill 

 patients. METHOD: In 555 critically ill patients (68% male), 

 the VAT Index(VATI) was measured using Computed Tomography scans 

 on the level of vertebra L3. The association between visceral 

 obesity, BMI and 90-day mortality was investigated using 

 univariable and multivariable analyses, correcting for age, sex, 

 APACHE II score, sarcopenia and muscle quality. RESULTS: 

 Visceral obesity was present in 48.1% of the patients and its 

 prevalence was similar in males and females. Mortality was 

 similar amongst patients with and without visceral obesity (27.7% vs 24.0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37116438,

title = {Visceral obesity measured using computed tomography scans: No significant association with mortality in critically ill patients},

author = {Michelle R Baggerman and Ingeborg M Dekker and Bjorn Winkens and Steven W M Olde Damink and Sandra N Stapel and Peter J M Weijs and Marcel C G van de Poll},

doi = {10.1016/j.jcrc.2023.154316},

issn = {1557-8615},

year  = {2023},

date = {2023-10-01},

journal = {J Crit Care},

volume = {77},

pages = {154316},

abstract = {INTRODUCTION: The association between obesity and outcome in critical illness is unclear. Since the amount of visceral adipose tissue(VAT) rather than BMI mediates the health effects of obesity we aimed to investigate the association between visceral obesity, BMI and 90-day mortality in critically ill patients.nnMETHOD: In 555 critically ill patients (68% male), the VAT Index(VATI) was measured using Computed Tomography scans on the level of vertebra L3. The association between visceral obesity, BMI and 90-day mortality was investigated using univariable and multivariable analyses, correcting for age, sex, APACHE II score, sarcopenia and muscle quality.nnRESULTS: Visceral obesity was present in 48.1% of the patients and its prevalence was similar in males and females. Mortality was similar amongst patients with and without visceral obesity (27.7% vs 24.0%, p = 0.31). The corrected odds ratio of 90-day mortality for visceral obesity was 0.667 (95%CI 0.424-1.049, p = 0.080). Using normal BMI as reference, the corrected odds ratio for overweight was 0.721 (95%CI 0.447-1.164 p = 0.181) and for obesity 0.462 (95%CI 0.208-1.027, p = 0.058).nnCONCLUSION: No significant association of visceral obesity and BMI with 90-day mortality was observed in critically ill patients, although obesity and visceral obesity tended to be associated with improved 90-day mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Besseling2023-vib,

title = {Exercise and nutritional interventions in patients with advanced 

 gastroesophageal cancer: A systematic review},

author = {Joost Besseling and Merel Velzen and Nicolette Wierdsma and Kelly Silverio Alonso-Duin and Peter J M Weijs and Anne M May and Hanneke Laarhoven},

year  = {2023},

date = {2023-09-01},

journal = {J. Gastrointest. Cancer},

volume = {54},

number = {3},

pages = {1006–1009},

publisher = {Springer Science and Business Media LLC},

abstract = {PURPOSE: The quality of life and survival of patients with 

 advanced gastroesophageal cancer can be improved. Positive 

 effects of exercise and nutritional interventions on quality of 

 life and potential effects on cancer outcomes are found in 

 gastroesophageal cancer in the curative setting, as well as in 

 other cancer types. We therefore systematically reviewed the 

 current literature on the effect of exercise and nutritional 

 interventions on various outcomes in patients with advanced 

 gastroesophageal cancer. METHODS: We searched on the 11th of 

 June 2021 in Pubmed, Embase and the Cochrane library for 

 publications of randomized trials and observational studies on 

 exercise and nutritional interventions (either combined or as 

 separate intervention) in patients with advanced 

 gastroesophageal cancer. The outcomes of interest were overall 

 survival, progression free survival, quality of life, 

 chemotherapy toxicity, and chemotherapy adherence. RESULTS: We 

 screened 1,764 records for eligibility and included one study in 

 our analysis. The other 1,763 were excluded for various reasons, 

 most frequently an incorrect study population (e.g. both curable 

 and incurable patients) or an incorrect intervention. One 

 retrospective cohort study of 40 patients with advanced gastric 

 cancer who received first line chemotherapy was included. It was 

 stated that 'no significant differences in terms of overall and 

 progression free survival were reported between the two groups 

 of patients.' No absolute numbers were provided. CONCLUSION: Our 

 systematic review did not identify any high quality studies on 

 exercise and nutritional interventions in advanced 

 gastroesophageal cancer. We deem a randomized clinical trial on 

 this topic to be highly needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reiter2023-ngb,

title = {Effects of nutrition and exercise interventions on persons with 

 sarcopenic obesity: An umbrella review of meta-analyses of 

 randomised controlled trials},

author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},

year  = {2023},

date = {2023-09-01},

journal = {Curr. Obes. Rep.},

volume = {12},

number = {3},

pages = {250–263},

abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon 

 and has been linked to several negative health consequences. The 

 aim of this umbrella review is the assessment of effectiveness 

 and certainty of evidence of nutrition and exercise interventions 

 in persons with SO. METHOD: We searched for meta-analyses of RCTs 

 in PubMed, EMBASE and CENTRAL that had been conducted in the last 

 five years, focusing on studies on the treatment and prevention 

 of SO. The primary endpoints were parameters for SO, such as body 

 fat in %, skeletal muscle mass index (SMMI), gait speed, leg 

 strength and grip strength. The methodological quality was 

 evaluated using AMSTAR and the certainty of evidence was assessed 

 using GRADE. RESULTS: Four systematic reviews with between 30 to 

 225 participants were included in the umbrella review. These 

 examined four exercise interventions, two nutrition interventions 

 and four interventions that combined nutrition and exercise. 

 Resistance training was the most frequently studied intervention 

 and was found to improve gait speed by 0.14 m/s to 0.17 m/s and 

 lower leg strength by 9.97 kg. Resistance, aerobic, mixed 

 exercise and hypocaloric diet combined with protein 

 supplementation is not significantly effective on selected 

 outcomes for persons with SO compared to no intervention. The low 

 number of primary studies included in the reviews resulted in 

 moderate to very low certainty of evidence. CONCLUSION: Despite 

 the lack in certainty of evidence, resistance training may be a 

 suitable intervention for persons with SO, in particular for 

 improving muscle function. Nevertheless, further research is 

 necessary to strengthen the evidence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Besseling2023-vi,

title = {Exercise and nutritional interventions in patients with advanced 

 gastroesophageal cancer: A systematic review},

author = {Joost Besseling and Merel Velzen and Nicolette Wierdsma and Kelly Silverio Alonso-Duin and Peter J M Weijs and Anne M May and Hanneke Laarhoven},

year  = {2023},

date = {2023-09-01},

journal = {J. Gastrointest. Cancer},

volume = {54},

number = {3},

pages = {1006–1009},

publisher = {Springer Science and Business Media LLC},

abstract = {PURPOSE: The quality of life and survival of patients with 

 advanced gastroesophageal cancer can be improved. Positive 

 effects of exercise and nutritional interventions on quality of 

 life and potential effects on cancer outcomes are found in 

 gastroesophageal cancer in the curative setting, as well as in 

 other cancer types. We therefore systematically reviewed the 

 current literature on the effect of exercise and nutritional 

 interventions on various outcomes in patients with advanced 

 gastroesophageal cancer. METHODS: We searched on the 11th of 

 June 2021 in Pubmed, Embase and the Cochrane library for 

 publications of randomized trials and observational studies on 

 exercise and nutritional interventions (either combined or as 

 separate intervention) in patients with advanced 

 gastroesophageal cancer. The outcomes of interest were overall 

 survival, progression free survival, quality of life, 

 chemotherapy toxicity, and chemotherapy adherence. RESULTS: We 

 screened 1,764 records for eligibility and included one study in 

 our analysis. The other 1,763 were excluded for various reasons, 

 most frequently an incorrect study population (e.g. both curable 

 and incurable patients) or an incorrect intervention. One 

 retrospective cohort study of 40 patients with advanced gastric 

 cancer who received first line chemotherapy was included. It was 

 stated that 'no significant differences in terms of overall and 

 progression free survival were reported between the two groups 

 of patients.' No absolute numbers were provided. CONCLUSION: Our 

 systematic review did not identify any high quality studies on 

 exercise and nutritional interventions in advanced 

 gastroesophageal cancer. We deem a randomized clinical trial on 

 this topic to be highly needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reiter2023-ng,

title = {Effects of nutrition and exercise interventions on persons with 

 sarcopenic obesity: An umbrella review of meta-analyses of 

 randomised controlled trials},

author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},

year  = {2023},

date = {2023-09-01},

journal = {Curr. Obes. Rep.},

volume = {12},

number = {3},

pages = {250–263},

abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon 

 and has been linked to several negative health consequences. The 

 aim of this umbrella review is the assessment of effectiveness 

 and certainty of evidence of nutrition and exercise interventions 

 in persons with SO. METHOD: We searched for meta-analyses of RCTs 

 in PubMed, EMBASE and CENTRAL that had been conducted in the last 

 five years, focusing on studies on the treatment and prevention 

 of SO. The primary endpoints were parameters for SO, such as body 

 fat in %, skeletal muscle mass index (SMMI), gait speed, leg 

 strength and grip strength. The methodological quality was 

 evaluated using AMSTAR and the certainty of evidence was assessed 

 using GRADE. RESULTS: Four systematic reviews with between 30 to 

 225 participants were included in the umbrella review. These 

 examined four exercise interventions, two nutrition interventions 

 and four interventions that combined nutrition and exercise. 

 Resistance training was the most frequently studied intervention 

 and was found to improve gait speed by 0.14 m/s to 0.17 m/s and 

 lower leg strength by 9.97 kg. Resistance, aerobic, mixed 

 exercise and hypocaloric diet combined with protein 

 supplementation is not significantly effective on selected 

 outcomes for persons with SO compared to no intervention. The low 

 number of primary studies included in the reviews resulted in 

 moderate to very low certainty of evidence. CONCLUSION: Despite 

 the lack in certainty of evidence, resistance training may be a 

 suitable intervention for persons with SO, in particular for 

 improving muscle function. Nevertheless, further research is 

 necessary to strengthen the evidence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37249818c,

title = {Effects of Nutrition and Exercise Interventions on Persons with Sarcopenic Obesity: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials},

author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},

doi = {10.1007/s13679-023-00509-0},

issn = {2162-4968},

year  = {2023},

date = {2023-09-01},

journal = {Curr Obes Rep},

volume = {12},

number = {3},

pages = {250--263},

abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.nnMETHOD: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO. The primary endpoints were parameters for SO, such as body fat in %, skeletal muscle mass index (SMMI), gait speed, leg strength and grip strength. The methodological quality was evaluated using AMSTAR and the certainty of evidence was assessed using GRADE.nnRESULTS: Four systematic reviews with between 30 to 225 participants were included in the umbrella review. These examined four exercise interventions, two nutrition interventions and four interventions that combined nutrition and exercise. Resistance training was the most frequently studied intervention and was found to improve gait speed by 0.14 m/s to 0.17 m/s and lower leg strength by 9.97 kg. Resistance, aerobic, mixed exercise and hypocaloric diet combined with protein supplementation is not significantly effective on selected outcomes for persons with SO compared to no intervention. The low number of primary studies included in the reviews resulted in moderate to very low certainty of evidence.nnCONCLUSION: Despite the lack in certainty of evidence, resistance training may be a suitable intervention for persons with SO, in particular for improving muscle function. Nevertheless, further research is necessary to strengthen the evidence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37249818,

title = {Effects of Nutrition and Exercise Interventions on Persons with Sarcopenic Obesity: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials},

author = {Lea Reiter and Silvia Bauer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Alfonso Cruz-Jentoft and Eva Topinková and Doris Eglseer},

doi = {10.1007/s13679-023-00509-0},

issn = {2162-4968},

year  = {2023},

date = {2023-09-01},

journal = {Curr Obes Rep},

volume = {12},

number = {3},

pages = {250--263},

abstract = {BACKGROUND: Sarcopenic obesity (SO) is an increasing phenomenon and has been linked to several negative health consequences. The aim of this umbrella review is the assessment of effectiveness and certainty of evidence of nutrition and exercise interventions in persons with SO.nnMETHOD: We searched for meta-analyses of RCTs in PubMed, EMBASE and CENTRAL that had been conducted in the last five years, focusing on studies on the treatment and prevention of SO. The primary endpoints were parameters for SO, such as body fat in %, skeletal muscle mass index (SMMI), gait speed, leg strength and grip strength. The methodological quality was evaluated using AMSTAR and the certainty of evidence was assessed using GRADE.nnRESULTS: Four systematic reviews with between 30 to 225 participants were included in the umbrella review. These examined four exercise interventions, two nutrition interventions and four interventions that combined nutrition and exercise. Resistance training was the most frequently studied intervention and was found to improve gait speed by 0.14 m/s to 0.17 m/s and lower leg strength by 9.97 kg. Resistance, aerobic, mixed exercise and hypocaloric diet combined with protein supplementation is not significantly effective on selected outcomes for persons with SO compared to no intervention. The low number of primary studies included in the reviews resulted in moderate to very low certainty of evidence.nnCONCLUSION: Despite the lack in certainty of evidence, resistance training may be a suitable intervention for persons with SO, in particular for improving muscle function. Nevertheless, further research is necessary to strengthen the evidence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Walrabenstein2023-vbb,

title = {A multidisciplinary lifestyle program for rheumatoid arthritis: 

 the 'Plants for Joints' randomized controlled trial},

author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marike Leeden and Franktien Turkstra and Jos W R Twisk and Maarten Boers and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},

year  = {2023},

date = {2023-08-01},

journal = {Rheumatology (Oxford)},

volume = {62},

number = {8},

pages = {2683–2691},

publisher = {Oxford University Press (OUP)},

abstract = {OBJECTIVE: To determine the effect of a multidisciplinary 

 lifestyle program in patients with RA with low-moderate disease 

 activity. METHODS: In the 'Plants for Joints' (PFJ) 

 parallel-arm, assessor-blind randomized controlled trial, 

 patients with RA and 28-joint DAS (DAS28) $geq$2.6 and 

 $łeq$5.1 were randomized to the PFJ or control group. The PFJ 

 group followed a 16-week lifestyle program based on a whole-food 

 plant-based diet, physical activity and stress management. The 

 control group received usual care. Medication was kept stable 3 

 months before and during the trial whenever possible. We 

 hypothesized that PFJ would lower disease activity (DAS28). 

 Secondary outcomes included anthropometric, metabolic and 

 patient-reported measures. An intention-to-treat analysis with a 

 linear mixed model adjusted for baseline values was used to 

 analyse between-group differences. RESULTS: Of the 83 people 

 randomized, 77 completed the study. Participants were 92% 

 female with mean (s.d.) age of 55 (12) years, BMI of 26 (4) 

 kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group 

 had a mean 0.9-point greater improvement of DAS28 vs the control 

 group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led 

 to greater decreases in body weight (difference -3.9 kg), fat 

 mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3 

 mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas 

 patient-reported outcome measures, blood pressure, glucose and 

 other lipids did not change. CONCLUSION: The 16-week PFJ 

 multidisciplinary lifestyle program substantially decreased 

 disease activity and improved metabolic status in people with RA 

 with low-moderate disease activity. TRIAL REGISTRATION: 

 International Clinical Trials Registry Platform; 

 https://www.who.int/clinical-trials-registry-platform; NL7800.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Eglseer2023-jhb,

title = {Nutritional and exercise interventions in individuals with 

 sarcopenic obesity around retirement age: a systematic review 

 and meta-analysis},

author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and SO-NUTS Consortium},

year  = {2023},

date = {2023-08-01},

journal = {Nutr. Rev.},

volume = {81},

number = {9},

pages = {1077–1090},

publisher = {Oxford University Press (OUP)},

abstract = {CONTEXT: Retirement is an opportune time for people to establish 

 new healthy routines. Exercise and nutritional interventions are 

 promising in the prevention and treatment of sarcopenic obesity. 

 OBJECTIVE: This systematic review aimed. to assess the 

 effectiveness of nutritional and exercise interventions for the 

 treatment of sarcopenic obesity in persons of retirement age. 

 DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were 

 searched in September 2021 for randomized controlled trials; a 

 manual search was also conducted. The search yielded 261 

 studies, of which 11 were eligible for inclusion. DATA 

 EXTRACTION: Studies of community-dwelling individuals with 

 sarcopenic obesity receiving any nutritional or exercise 

 intervention $geq$ 8 weeks with the mean age $±$ standard 

 deviation between 50 and 70 years were included. Primary 

 endpoint was body composition, and secondary endpoints were body 

 mass index, muscle strength, and physical function. The 

 literature review, study selection, data extraction, and 

 risk-of-bias assessment were performed by two reviewers 

 independently. Data were pooled for meta-analysis when possible. 

 RESULTS: Meta-analysis was only possible for the exposure 

 ``resistance training'' and the exposure ``training (resistance 

 or aerobic)'' in combination with the exposure ``added protein'' 

 as compared with ``no intervention'' or ``training alone.'' 

 Resistance training led to a significant body fat reduction of 

 -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 

 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 

 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait 

 speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an 

 exercise intervention significantly reduces fat mass (-0.80 kg; 

 95%CI, -1.32 to -0.28). Some individual studies of dietary or 

 food supplement interventions for which data could not be pooled 

 showed positive effects on body composition. CONCLUSION: 

 Resistance training is an effective treatment for persons of 

 retirement age with sarcopenic obesity. Increased protein intake 

 combined with exercise may increase reductions in fat mass. 

 SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. 

 CRD42021276461.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Dronkelaar2023-hlb,

title = {Minerals and sarcopenia in older adults: An updated systematic 

 review},

author = {Carliene Dronkelaar and Maaike Fultinga and Mitchell Hummel and Hinke Kruizenga and Peter J M Weijs and Michael Tieland},

year  = {2023},

date = {2023-08-01},

journal = {J. Am. Med. Dir. Assoc.},

volume = {24},

number = {8},

pages = {1163–1172},

publisher = {Elsevier BV},

abstract = {OBJECTIVE: This systematic review aims to reevaluate the role of 

 minerals on muscle mass, muscle strength, physical performance, 

 and the prevalence of sarcopenia in community-dwelling and 

 institutionalized older adults. DESIGN: Systematic review. 

 SETTING AND PARTICIPANTS: In March 2022, a systematic search was 

 performed in PubMed, Scopus, and Web of Sciences using 

 predefined search terms. Original studies on dietary mineral 

 intake or mineral serum blood concentrations on muscle mass, 

 muscle strength, and physical performance or the prevalence of 

 sarcopenia in older adults (average age $geq$65 years) were 

 included. METHODS: Eligibility screening and data extraction was 

 performed by 2 independent reviewers. Quality assessment was 

 performed with the Effective Public Health Practice Project 

 (EPHPP) Quality Assessment Tool for Quantitative Studies. Risk 

 of bias was evaluated using the Risk Of Bias In Non-randomized 

 Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622 

 identified articles, a total of 45 studies were included in the 

 review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle 

 mass, strength, and physical performance as well as the 

 prevalence of sarcopenia. For calcium and zinc, no association 

 could be found. For potassium, iron, sodium, and phosphorus, the 

 association with sarcopenic outcomes remains unclear as not 

 enough studies could be included or were nonconclusive (low 

 quality of evidence). CONCLUSIONS AND IMPLICATIONS: This 

 systematic review shows a potential role for selenium and 

 magnesium on the prevention and treatment of sarcopenia in older 

 adults. More randomized controlled trials are warranted to 

 determine the impact of minerals on sarcopenia in older adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Walrabenstein2023-vb,

title = {A multidisciplinary lifestyle program for rheumatoid arthritis: 

 the 'Plants for Joints' randomized controlled trial},

author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marike Leeden and Franktien Turkstra and Jos W R Twisk and Maarten Boers and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},

year  = {2023},

date = {2023-08-01},

journal = {Rheumatology (Oxford)},

volume = {62},

number = {8},

pages = {2683–2691},

publisher = {Oxford University Press (OUP)},

abstract = {OBJECTIVE: To determine the effect of a multidisciplinary 

 lifestyle program in patients with RA with low-moderate disease 

 activity. METHODS: In the 'Plants for Joints' (PFJ) 

 parallel-arm, assessor-blind randomized controlled trial, 

 patients with RA and 28-joint DAS (DAS28) $geq$2.6 and 

 $łeq$5.1 were randomized to the PFJ or control group. The PFJ 

 group followed a 16-week lifestyle program based on a whole-food 

 plant-based diet, physical activity and stress management. The 

 control group received usual care. Medication was kept stable 3 

 months before and during the trial whenever possible. We 

 hypothesized that PFJ would lower disease activity (DAS28). 

 Secondary outcomes included anthropometric, metabolic and 

 patient-reported measures. An intention-to-treat analysis with a 

 linear mixed model adjusted for baseline values was used to 

 analyse between-group differences. RESULTS: Of the 83 people 

 randomized, 77 completed the study. Participants were 92% 

 female with mean (s.d.) age of 55 (12) years, BMI of 26 (4) 

 kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group 

 had a mean 0.9-point greater improvement of DAS28 vs the control 

 group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led 

 to greater decreases in body weight (difference -3.9 kg), fat 

 mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3 

 mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas 

 patient-reported outcome measures, blood pressure, glucose and 

 other lipids did not change. CONCLUSION: The 16-week PFJ 

 multidisciplinary lifestyle program substantially decreased 

 disease activity and improved metabolic status in people with RA 

 with low-moderate disease activity. TRIAL REGISTRATION: 

 International Clinical Trials Registry Platform; 

 https://www.who.int/clinical-trials-registry-platform; NL7800.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Eglseer2023-jh,

title = {Nutritional and exercise interventions in individuals with 

 sarcopenic obesity around retirement age: a systematic review 

 and meta-analysis},

author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and SO-NUTS Consortium},

year  = {2023},

date = {2023-08-01},

journal = {Nutr. Rev.},

volume = {81},

number = {9},

pages = {1077–1090},

publisher = {Oxford University Press (OUP)},

abstract = {CONTEXT: Retirement is an opportune time for people to establish 

 new healthy routines. Exercise and nutritional interventions are 

 promising in the prevention and treatment of sarcopenic obesity. 

 OBJECTIVE: This systematic review aimed. to assess the 

 effectiveness of nutritional and exercise interventions for the 

 treatment of sarcopenic obesity in persons of retirement age. 

 DATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were 

 searched in September 2021 for randomized controlled trials; a 

 manual search was also conducted. The search yielded 261 

 studies, of which 11 were eligible for inclusion. DATA 

 EXTRACTION: Studies of community-dwelling individuals with 

 sarcopenic obesity receiving any nutritional or exercise 

 intervention $geq$ 8 weeks with the mean age $±$ standard 

 deviation between 50 and 70 years were included. Primary 

 endpoint was body composition, and secondary endpoints were body 

 mass index, muscle strength, and physical function. The 

 literature review, study selection, data extraction, and 

 risk-of-bias assessment were performed by two reviewers 

 independently. Data were pooled for meta-analysis when possible. 

 RESULTS: Meta-analysis was only possible for the exposure 

 ``resistance training'' and the exposure ``training (resistance 

 or aerobic)'' in combination with the exposure ``added protein'' 

 as compared with ``no intervention'' or ``training alone.'' 

 Resistance training led to a significant body fat reduction of 

 -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 

 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 

 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait 

 speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an 

 exercise intervention significantly reduces fat mass (-0.80 kg; 

 95%CI, -1.32 to -0.28). Some individual studies of dietary or 

 food supplement interventions for which data could not be pooled 

 showed positive effects on body composition. CONCLUSION: 

 Resistance training is an effective treatment for persons of 

 retirement age with sarcopenic obesity. Increased protein intake 

 combined with exercise may increase reductions in fat mass. 

 SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. 

 CRD42021276461.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Dronkelaar2023-hl,

title = {Minerals and sarcopenia in older adults: An updated systematic 

 review},

author = {Carliene Dronkelaar and Maaike Fultinga and Mitchell Hummel and Hinke Kruizenga and Peter J M Weijs and Michael Tieland},

year  = {2023},

date = {2023-08-01},

journal = {J. Am. Med. Dir. Assoc.},

volume = {24},

number = {8},

pages = {1163–1172},

publisher = {Elsevier BV},

abstract = {OBJECTIVE: This systematic review aims to reevaluate the role of 

 minerals on muscle mass, muscle strength, physical performance, 

 and the prevalence of sarcopenia in community-dwelling and 

 institutionalized older adults. DESIGN: Systematic review. 

 SETTING AND PARTICIPANTS: In March 2022, a systematic search was 

 performed in PubMed, Scopus, and Web of Sciences using 

 predefined search terms. Original studies on dietary mineral 

 intake or mineral serum blood concentrations on muscle mass, 

 muscle strength, and physical performance or the prevalence of 

 sarcopenia in older adults (average age $geq$65 years) were 

 included. METHODS: Eligibility screening and data extraction was 

 performed by 2 independent reviewers. Quality assessment was 

 performed with the Effective Public Health Practice Project 

 (EPHPP) Quality Assessment Tool for Quantitative Studies. Risk 

 of bias was evaluated using the Risk Of Bias In Non-randomized 

 Studies-of Exposure (ROBINS-E) tool. RESULTS: From the 15,622 

 identified articles, a total of 45 studies were included in the 

 review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle 

 mass, strength, and physical performance as well as the 

 prevalence of sarcopenia. For calcium and zinc, no association 

 could be found. For potassium, iron, sodium, and phosphorus, the 

 association with sarcopenic outcomes remains unclear as not 

 enough studies could be included or were nonconclusive (low 

 quality of evidence). CONCLUSIONS AND IMPLICATIONS: This 

 systematic review shows a potential role for selenium and 

 magnesium on the prevention and treatment of sarcopenia in older 

 adults. More randomized controlled trials are warranted to 

 determine the impact of minerals on sarcopenia in older adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36882046c,

title = {Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis},

author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and },

doi = {10.1093/nutrit/nuad007},

issn = {1753-4887},

year  = {2023},

date = {2023-08-01},

journal = {Nutr Rev},

volume = {81},

number = {9},

pages = {1077--1090},

abstract = {CONTEXT: Retirement is an opportune time for people to establish new healthy routines. Exercise and nutritional interventions are promising in the prevention and treatment of sarcopenic obesity.nnOBJECTIVE: This systematic review aimed.nnto assess the effectiveness of nutritional and exercise interventions for the treatment of sarcopenic obesity in persons of retirement age.nnDATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were searched in September 2021 for randomized controlled trials; a manual search was also conducted. The search yielded 261 studies, of which 11 were eligible for inclusion.nnDATA EXTRACTION: Studies of community-dwelling individuals with sarcopenic obesity receiving any nutritional or exercise intervention ≥ 8 weeks with the mean age  ±  standard deviation between 50 and 70 years were included. Primary endpoint was body composition, and secondary endpoints were body mass index, muscle strength, and physical function. The literature review, study selection, data extraction, and risk-of-bias assessment were performed by two reviewers independently. Data were pooled for meta-analysis when possible.nnRESULTS: Meta-analysis was only possible for the exposure "resistance training" and the exposure "training (resistance or aerobic)" in combination with the exposure "added protein" as compared with "no intervention" or "training alone." Resistance training led to a significant body fat reduction of -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an exercise intervention significantly reduces fat mass (-0.80 kg; 95%CI, -1.32 to -0.28). Some individual studies of dietary or food supplement interventions for which data could not be pooled showed positive effects on body composition.nnCONCLUSION: Resistance training is an effective treatment for persons of retirement age with sarcopenic obesity. Increased protein intake combined with exercise may increase reductions in fat mass.nnSYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021276461.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36882046,

title = {Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis},

author = {Doris Eglseer and Mariella Traxler and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso J Cruz-Jentoft and Lea Reiter and Silvia Bauer and },

doi = {10.1093/nutrit/nuad007},

issn = {1753-4887},

year  = {2023},

date = {2023-08-01},

journal = {Nutr Rev},

volume = {81},

number = {9},

pages = {1077--1090},

abstract = {CONTEXT: Retirement is an opportune time for people to establish new healthy routines. Exercise and nutritional interventions are promising in the prevention and treatment of sarcopenic obesity.nnOBJECTIVE: This systematic review aimed.nnto assess the effectiveness of nutritional and exercise interventions for the treatment of sarcopenic obesity in persons of retirement age.nnDATA SOURCES: PubMed, Embase, CINAHL, and CENTRAL databases were searched in September 2021 for randomized controlled trials; a manual search was also conducted. The search yielded 261 studies, of which 11 were eligible for inclusion.nnDATA EXTRACTION: Studies of community-dwelling individuals with sarcopenic obesity receiving any nutritional or exercise intervention ≥ 8 weeks with the mean age  ±  standard deviation between 50 and 70 years were included. Primary endpoint was body composition, and secondary endpoints were body mass index, muscle strength, and physical function. The literature review, study selection, data extraction, and risk-of-bias assessment were performed by two reviewers independently. Data were pooled for meta-analysis when possible.nnRESULTS: Meta-analysis was only possible for the exposure "resistance training" and the exposure "training (resistance or aerobic)" in combination with the exposure "added protein" as compared with "no intervention" or "training alone." Resistance training led to a significant body fat reduction of -1.53% (95%CI, -2.91 to -0.15), an increase in muscle mass of 2.72% (95%CI, 1.23-4.22), an increase in muscle strength of 4.42 kg (95%CI, 2.44-6.04), and a slight improvement in gait speed of 0.17 m/s (95%CI, 0.01-0.34). Protein combined with an exercise intervention significantly reduces fat mass (-0.80 kg; 95%CI, -1.32 to -0.28). Some individual studies of dietary or food supplement interventions for which data could not be pooled showed positive effects on body composition.nnCONCLUSION: Resistance training is an effective treatment for persons of retirement age with sarcopenic obesity. Increased protein intake combined with exercise may increase reductions in fat mass.nnSYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021276461.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36617162,

title = {A multidisciplinary lifestyle program for rheumatoid arthritis: the 'Plants for Joints' randomized controlled trial},

author = {Wendy Walrabenstein and Carlijn A Wagenaar and Marike van der Leeden and Franktien Turkstra and Jos W R Twisk and Maarten Boers and Henriët van Middendorp and Peter J M Weijs and Dirkjan van Schaardenburg},

doi = {10.1093/rheumatology/keac693},

issn = {1462-0332},

year  = {2023},

date = {2023-08-01},

journal = {Rheumatology (Oxford)},

volume = {62},

number = {8},

pages = {2683--2691},

abstract = {OBJECTIVE: To determine the effect of a multidisciplinary lifestyle program in patients with RA with low-moderate disease activity.nnMETHODS: In the 'Plants for Joints' (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.1 were randomized to the PFJ or control group. The PFJ group followed a 16-week lifestyle program based on a whole-food plant-based diet, physical activity and stress management. The control group received usual care. Medication was kept stable 3 months before and during the trial whenever possible. We hypothesized that PFJ would lower disease activity (DAS28). Secondary outcomes included anthropometric, metabolic and patient-reported measures. An intention-to-treat analysis with a linear mixed model adjusted for baseline values was used to analyse between-group differences.nnRESULTS: Of the 83 people randomized, 77 completed the study. Participants were 92% female with mean (s.d.) age of 55 (12) years, BMI of 26 (4) kg/m2 and mean DAS28 of 3.8 (0.7). After 16 weeks the PFJ group had a mean 0.9-point greater improvement of DAS28 vs the control group (95% CI 0.4, 1.3; P < 0.0001). The PFJ intervention led to greater decreases in body weight (difference -3.9 kg), fat mass (-2.8 kg), waist circumference (-3 cm), HbA1c (-1.3 mmol/mol) and low-density lipoprotein (-0.32 mmol/l), whereas patient-reported outcome measures, blood pressure, glucose and other lipids did not change.nnCONCLUSION: The 16-week PFJ multidisciplinary lifestyle program substantially decreased disease activity and improved metabolic status in people with RA with low-moderate disease activity.nnTRIAL REGISTRATION: International Clinical Trials Registry Platform; https://www.who.int/clinical-trials-registry-platform; NL7800.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37355247,

title = {Minerals and Sarcopenia in Older Adults: An Updated Systematic Review},

author = {Carliene van Dronkelaar and Maaike Fultinga and Mitchell Hummel and Hinke Kruizenga and Peter J M Weijs and Michael Tieland},

doi = {10.1016/j.jamda.2023.05.017},

issn = {1538-9375},

year  = {2023},

date = {2023-08-01},

journal = {J Am Med Dir Assoc},

volume = {24},

number = {8},

pages = {1163--1172},

abstract = {OBJECTIVE: This systematic review aims to reevaluate the role of minerals on muscle mass, muscle strength, physical performance, and the prevalence of sarcopenia in community-dwelling and institutionalized older adults.nnDESIGN: Systematic review.nnSETTING AND PARTICIPANTS: In March 2022, a systematic search was performed in PubMed, Scopus, and Web of Sciences using predefined search terms. Original studies on dietary mineral intake or mineral serum blood concentrations on muscle mass, muscle strength, and physical performance or the prevalence of sarcopenia in older adults (average age ≥65 years) were included.nnMETHODS: Eligibility screening and data extraction was performed by 2 independent reviewers. Quality assessment was performed with the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for Quantitative Studies. Risk of bias was evaluated using the Risk Of Bias In Non-randomized Studies-of Exposure (ROBINS-E) tool.nnRESULTS: From the 15,622 identified articles, a total of 45 studies were included in the review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle mass, strength, and physical performance as well as the prevalence of sarcopenia. For calcium and zinc, no association could be found. For potassium, iron, sodium, and phosphorus, the association with sarcopenic outcomes remains unclear as not enough studies could be included or were nonconclusive (low quality of evidence).nnCONCLUSIONS AND IMPLICATIONS: This systematic review shows a potential role for selenium and magnesium on the prevention and treatment of sarcopenia in older adults. More randomized controlled trials are warranted to determine the impact of minerals on sarcopenia in older adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Memelink2023-hyb,

title = {Additional effects of exercise to hypocaloric diet on body 

 weight, body composition, glycaemic control and 

 cardio-respiratory fitness in adults with overweight or obesity 

 and type 2 diabetes: A systematic review and meta-analysis},

author = {Robert G Memelink and Mitchell Hummel and Aveline Hijlkema and Martinet T Streppel and Ivan Bautmans and Peter J M Weijs and Kirsten A Berk and Michael Tieland},

year  = {2023},

date = {2023-07-01},

journal = {Diabet. Med.},

volume = {40},

number = {7},

pages = {e15096},

publisher = {Wiley},

abstract = {AIMS: This systematic review and meta-analysis evaluates the 

 additional effect of exercise to hypocaloric diet on body 

 weight, body composition, glycaemic control and 

 cardio-respiratory fitness in adults with overweight or obesity 

 and type 2 diabetes. METHODS: Embase, Medline, Web of Science 

 and Cochrane Central databases were evaluated, and 11 studies 

 were included. Random-effects meta-analysis was performed on 

 body weight and measures of body composition and glycaemic 

 control, to compare the effect of hypocaloric diet plus exercise 

 with hypocaloric diet alone. RESULTS: Exercise interventions 

 consisted of walking or jogging, cycle ergometer training, 

 football training or resistance training and duration varied 

 from 2 to 52 weeks. Body weight and measures of body composition 

 and glycaemic control decreased during both the combined 

 intervention and hypocaloric diet alone. Mean difference in 

 change of body weight (-0.77 kg [95% CI: -2.03; 0.50]), BMI 

 (-0.34 kg/m2 [95% CI: -0.73; 0.05]), waist circumference (-1.42 

 cm [95% CI: -3.84; 1.00]), fat-free mass (-0.18 kg [95% CI: 

 -0.52; 0.17]), fat mass (-1.61 kg [95% CI: -4.42; 1.19]), 

 fasting glucose (+0.14 mmol/L [95% CI: -0.02; 0.30]), HbA1c (-1 

 mmol/mol [95% CI: -3; 1], -0.1% [95% CI: -0.2; 0.1]) and 

 HOMA-IR (+0.01 [95% CI: -0.40; 0.42]) was not statistically 

 different between the combined intervention and hypocaloric diet 

 alone. Two studies reported VO2max and showed significant 

 increases upon the addition of exercise to hypocaloric diet. 

 CONCLUSIONS: Based on limited data, we did not find additional 

 effects of exercise to hypocaloric diet in adults with 

 overweight or obesity and type 2 diabetes on body weight, body 

 composition or glycaemic control, while cardio-respiratory 

 fitness improved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Memelink2023-hy,

title = {Additional effects of exercise to hypocaloric diet on body 

 weight, body composition, glycaemic control and 

 cardio-respiratory fitness in adults with overweight or obesity 

 and type 2 diabetes: A systematic review and meta-analysis},

author = {Robert G Memelink and Mitchell Hummel and Aveline Hijlkema and Martinet T Streppel and Ivan Bautmans and Peter J M Weijs and Kirsten A Berk and Michael Tieland},

year  = {2023},

date = {2023-07-01},

journal = {Diabet. Med.},

volume = {40},

number = {7},

pages = {e15096},

publisher = {Wiley},

abstract = {AIMS: This systematic review and meta-analysis evaluates the 

 additional effect of exercise to hypocaloric diet on body 

 weight, body composition, glycaemic control and 

 cardio-respiratory fitness in adults with overweight or obesity 

 and type 2 diabetes. METHODS: Embase, Medline, Web of Science 

 and Cochrane Central databases were evaluated, and 11 studies 

 were included. Random-effects meta-analysis was performed on 

 body weight and measures of body composition and glycaemic 

 control, to compare the effect of hypocaloric diet plus exercise 

 with hypocaloric diet alone. RESULTS: Exercise interventions 

 consisted of walking or jogging, cycle ergometer training, 

 football training or resistance training and duration varied 

 from 2 to 52 weeks. Body weight and measures of body composition 

 and glycaemic control decreased during both the combined 

 intervention and hypocaloric diet alone. Mean difference in 

 change of body weight (-0.77 kg [95% CI: -2.03; 0.50]), BMI 

 (-0.34 kg/m2 [95% CI: -0.73; 0.05]), waist circumference (-1.42 

 cm [95% CI: -3.84; 1.00]), fat-free mass (-0.18 kg [95% CI: 

 -0.52; 0.17]), fat mass (-1.61 kg [95% CI: -4.42; 1.19]), 

 fasting glucose (+0.14 mmol/L [95% CI: -0.02; 0.30]), HbA1c (-1 

 mmol/mol [95% CI: -3; 1], -0.1% [95% CI: -0.2; 0.1]) and 

 HOMA-IR (+0.01 [95% CI: -0.40; 0.42]) was not statistically 

 different between the combined intervention and hypocaloric diet 

 alone. Two studies reported VO2max and showed significant 

 increases upon the addition of exercise to hypocaloric diet. 

 CONCLUSIONS: Based on limited data, we did not find additional 

 effects of exercise to hypocaloric diet in adults with 

 overweight or obesity and type 2 diabetes on body weight, body 

 composition or glycaemic control, while cardio-respiratory 

 fitness improved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36997475,

title = {Additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes: A systematic review and meta-analysis},

author = {Robert G Memelink and Mitchell Hummel and Aveline Hijlkema and Martinet T Streppel and Ivan Bautmans and Peter J M Weijs and Kirsten A Berk and Michael Tieland},

doi = {10.1111/dme.15096},

issn = {1464-5491},

year  = {2023},

date = {2023-07-01},

journal = {Diabet Med},

volume = {40},

number = {7},

pages = {e15096},

abstract = {AIMS: This systematic review and meta-analysis evaluates the additional effect of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes.nnMETHODS: Embase, Medline, Web of Science and Cochrane Central databases were evaluated, and 11 studies were included. Random-effects meta-analysis was performed on body weight and measures of body composition and glycaemic control, to compare the effect of hypocaloric diet plus exercise with hypocaloric diet alone.nnRESULTS: Exercise interventions consisted of walking or jogging, cycle ergometer training, football training or resistance training and duration varied from 2 to 52 weeks. Body weight and measures of body composition and glycaemic control decreased during both the combined intervention and hypocaloric diet alone. Mean difference in change of body weight (-0.77 kg [95% CI: -2.03; 0.50]), BMI (-0.34 kg/m [95% CI: -0.73; 0.05]), waist circumference (-1.42 cm [95% CI: -3.84; 1.00]), fat-free mass (-0.18 kg [95% CI: -0.52; 0.17]), fat mass (-1.61 kg [95% CI: -4.42; 1.19]), fasting glucose (+0.14 mmol/L [95% CI: -0.02; 0.30]), HbA (-1 mmol/mol [95% CI: -3; 1], -0.1% [95% CI: -0.2; 0.1]) and HOMA-IR (+0.01 [95% CI: -0.40; 0.42]) was not statistically different between the combined intervention and hypocaloric diet alone. Two studies reported VO and showed significant increases upon the addition of exercise to hypocaloric diet.nnCONCLUSIONS: Based on limited data, we did not find additional effects of exercise to hypocaloric diet in adults with overweight or obesity and type 2 diabetes on body weight, body composition or glycaemic control, while cardio-respiratory fitness improved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ma2023-fwb,

title = {Optimization of protocols using neuromuscular electrical 

 stimulation for paralyzed lower-limb muscles to increase energy 

 expenditure in people with spinal cord injury},

author = {Yiming Ma and Sonja Groot and Ad Vink and Wouter Harmsen and Christof A J Smit and Janneke M Stolwijk-Swuste and Peter J M Weijs and Thomas W J Janssen},

year  = {2023},

date = {2023-06-01},

journal = {Am. J. Phys. Med. Rehabil.},

volume = {102},

number = {6},

pages = {489–497},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {OBJECTIVE: The aim of this study was to evaluate whether using 

 surface neuromuscular electrical stimulation (NMES) for 

 paralyzed lower-limb muscles results in an increase in energy 

 expenditure and whether the number of activated muscles and duty 

 cycle affect the potential increase. DESIGN: This was a 

 cross-sectional study. RESULTS: Energy expenditure during all 

 NMES protocols was significantly higher than the condition 

 without NMES (1.2 $±$ 0.2 kcal/min), with the highest increase 

 (+51%; +0.7 kcal/min, 95% confidence interval, 0.3-1.2) for 

 the protocol with more muscles activated and the duty cycle with 

 a shorter rest period. A significant decrease in muscle 

 contraction size during NMES was found with a longer stimulation 

 time, more muscles activated, or the duty cycle with a shorter 

 rest period. CONCLUSION: Using NMES for paralyzed lower-limb 

 muscles can significantly increase energy expenditure compared 

 with sitting without NMES, with the highest increase for the 

 protocol with more muscles activated and the duty cycle with a 

 shorter rest period. Muscle fatigue occurred significantly with 

 the more intense NMES protocols, which might cause a lower 

 energy expenditure in a longer protocol. Future studies should 

 further optimize the NMES parameters and investigate the 

 long-term effects of NMES on weight management in people with 

 SCI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Gassel2023-twb,

title = {The impact of high versus standard enteral protein provision on 

 functional recovery following intensive care admission (PRECISE 

 trial): study protocol for a randomized controlled, quadruple 

 blinded, multicenter, parallel group trial in mechanically 

 ventilated patients},

author = {Rob J J Gassel and Julia L M Bels and Katrien Tartaglia and Bas C T Bussel and Sander M J Kuijk and Adam M Deane and Zudin Puthucheary and Peter J M Weijs and Lilian Vloet and Bert Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H Zanten and Dieter Mesotten and Marcel C G Poll},

year  = {2023},

date = {2023-06-01},

journal = {Trials},

volume = {24},

number = {1},

pages = {416},

abstract = {BACKGROUND: Critically ill patients are subject to severe 

 skeletal muscle wasting during intensive care unit (ICU) stay, 

 resulting in impaired short- and long-term functional outcomes 

 and health-related quality of life. Increased protein provision 

 may improve functional outcomes in ICU patients by attenuating 

 skeletal muscle breakdown. Supporting evidence is limited however 

 and results in great variety in recommended protein targets. 

 METHODS: The PRECISe trial is an investigator-initiated, 

 bi-national, multi-center, quadruple-blinded randomized 

 controlled trial with a parallel group design. In 935 patients, 

 we will compare provision of isocaloric enteral nutrition with 

 either a standard or high protein content, providing 1.3 or 2.0 g 

 of protein/kg/day, respectively, when fed on target. All 

 unplanned ICU admissions with initiation of invasive mechanical 

 ventilation within 24 h of admission and an expected stay on 

 ventilator support of at least 3 days are eligible. The study is 

 designed to assess the effect of the intervention on functional 

 recovery at 1, 3, and 6 months following ICU admission, including 

 health-related quality of life, measures of muscle strength, 

 physical function, and mental health. The primary endpoint of the 

 trial is health-related quality of life as measured by the 

 Euro-QoL-5D-5-level questionnaire Health Utility Score. Overall 

 between-group differences will be assessed over the three time 

 points using linear mixed-effects models. DISCUSSION: The PRECISe 

 trial will evaluate the effect of protein on functional recovery 

 including both patient-centered and muscle-related outcomes. 

 TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04633421 . 

 Registered on November 18, 2020. First patient in (FPI) on 

 November 19, 2020. Expected last patient last visit (LPLV) in 

 October 2023.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ma2023-fw,

title = {Optimization of protocols using neuromuscular electrical 

 stimulation for paralyzed lower-limb muscles to increase energy 

 expenditure in people with spinal cord injury},

author = {Yiming Ma and Sonja Groot and Ad Vink and Wouter Harmsen and Christof A J Smit and Janneke M Stolwijk-Swuste and Peter J M Weijs and Thomas W J Janssen},

year  = {2023},

date = {2023-06-01},

journal = {Am. J. Phys. Med. Rehabil.},

volume = {102},

number = {6},

pages = {489–497},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {OBJECTIVE: The aim of this study was to evaluate whether using 

 surface neuromuscular electrical stimulation (NMES) for 

 paralyzed lower-limb muscles results in an increase in energy 

 expenditure and whether the number of activated muscles and duty 

 cycle affect the potential increase. DESIGN: This was a 

 cross-sectional study. RESULTS: Energy expenditure during all 

 NMES protocols was significantly higher than the condition 

 without NMES (1.2 $±$ 0.2 kcal/min), with the highest increase 

 (+51%; +0.7 kcal/min, 95% confidence interval, 0.3-1.2) for 

 the protocol with more muscles activated and the duty cycle with 

 a shorter rest period. A significant decrease in muscle 

 contraction size during NMES was found with a longer stimulation 

 time, more muscles activated, or the duty cycle with a shorter 

 rest period. CONCLUSION: Using NMES for paralyzed lower-limb 

 muscles can significantly increase energy expenditure compared 

 with sitting without NMES, with the highest increase for the 

 protocol with more muscles activated and the duty cycle with a 

 shorter rest period. Muscle fatigue occurred significantly with 

 the more intense NMES protocols, which might cause a lower 

 energy expenditure in a longer protocol. Future studies should 

 further optimize the NMES parameters and investigate the 

 long-term effects of NMES on weight management in people with 

 SCI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Gassel2023-tw,

title = {The impact of high versus standard enteral protein provision on 

 functional recovery following intensive care admission (PRECISE 

 trial): study protocol for a randomized controlled, quadruple 

 blinded, multicenter, parallel group trial in mechanically 

 ventilated patients},

author = {Rob J J Gassel and Julia L M Bels and Katrien Tartaglia and Bas C T Bussel and Sander M J Kuijk and Adam M Deane and Zudin Puthucheary and Peter J M Weijs and Lilian Vloet and Bert Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H Zanten and Dieter Mesotten and Marcel C G Poll},

year  = {2023},

date = {2023-06-01},

journal = {Trials},

volume = {24},

number = {1},

pages = {416},

abstract = {BACKGROUND: Critically ill patients are subject to severe 

 skeletal muscle wasting during intensive care unit (ICU) stay, 

 resulting in impaired short- and long-term functional outcomes 

 and health-related quality of life. Increased protein provision 

 may improve functional outcomes in ICU patients by attenuating 

 skeletal muscle breakdown. Supporting evidence is limited however 

 and results in great variety in recommended protein targets. 

 METHODS: The PRECISe trial is an investigator-initiated, 

 bi-national, multi-center, quadruple-blinded randomized 

 controlled trial with a parallel group design. In 935 patients, 

 we will compare provision of isocaloric enteral nutrition with 

 either a standard or high protein content, providing 1.3 or 2.0 g 

 of protein/kg/day, respectively, when fed on target. All 

 unplanned ICU admissions with initiation of invasive mechanical 

 ventilation within 24 h of admission and an expected stay on 

 ventilator support of at least 3 days are eligible. The study is 

 designed to assess the effect of the intervention on functional 

 recovery at 1, 3, and 6 months following ICU admission, including 

 health-related quality of life, measures of muscle strength, 

 physical function, and mental health. The primary endpoint of the 

 trial is health-related quality of life as measured by the 

 Euro-QoL-5D-5-level questionnaire Health Utility Score. Overall 

 between-group differences will be assessed over the three time 

 points using linear mixed-effects models. DISCUSSION: The PRECISe 

 trial will evaluate the effect of protein on functional recovery 

 including both patient-centered and muscle-related outcomes. 

 TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04633421 . 

 Registered on November 18, 2020. First patient in (FPI) on 

 November 19, 2020. Expected last patient last visit (LPLV) in 

 October 2023.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37004674b,

title = {Exploring barriers and facilitators of behavioural changes in dietary intake and physical activity: a qualitative study in older adults undergoing transcatheter aortic valve implantation},

author = {Dennis van Erck and Christine D Dolman and José P Henriques and Josje D Schoufour and Ronak Delewi and Wilma J M Scholte Op Reimer and Marjolein Snaterse},

doi = {10.1007/s41999-023-00774-1},

issn = {1878-7649},

year  = {2023},

date = {2023-06-01},

journal = {Eur Geriatr Med},

volume = {14},

number = {3},

pages = {503--510},

abstract = {PURPOSE: The majority of older patients, scheduled for a cardiac procedure, do not adhere to international dietary intake and physical activity guidelines. The purpose of this study was to explore barriers and facilitators regarding dietary intake and physical activity behaviour change in older patients undergoing transcatheter aortic valve implantation (TAVI).nnMETHODS: We conducted a qualitative study using semi-structured interviews with patients undergoing TAVI. Interviews were analysed by two independent researchers using thematic analysis, the capability, opportunity and motivation behaviour model was used as a framework.nnRESULTS: The study included 13 patients (82 ± 6 years old, 6 females) until data saturation was reached. Six themes were identified, which were all applicable to both dietary intake and physical activity. Three following themes were identified as barriers: (1) low physical capability, (2) healthy dietary intake and physical activity are not a priority at an older age and (3) ingrained habits and preferences. Three following themes were identified as facilitators: (1) knowledge that dietary intake and physical activity are important for maintaining health, (2) norms set by family, friends and caregivers and (3) support from the social environment.nnCONCLUSION: Our study found that older patients had mixed feelings about changing their behaviour. The majority initially stated that dietary intake and physical activity were not a priority at older age. However, with knowledge that behaviour could improve health, patients also stated willingness to change, leading to a state of ambivalence. Healthcare professionals may consider motivational interviewing techniques to address this ambivalence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36228281,

title = {Optimization of Protocols Using Neuromuscular Electrical Stimulation for Paralyzed Lower-Limb Muscles to Increase Energy Expenditure in People With Spinal Cord Injury},

author = {Yiming Ma and Sonja de Groot and Ad Vink and Wouter Harmsen and Christof A J Smit and Janneke M Stolwijk-Swuste and Peter J M Weijs and Thomas W J Janssen},

doi = {10.1097/PHM.0000000000002120},

issn = {1537-7385},

year  = {2023},

date = {2023-06-01},

journal = {Am J Phys Med Rehabil},

volume = {102},

number = {6},

pages = {489--497},

abstract = {OBJECTIVE: The aim of this study was to evaluate whether using surface neuromuscular electrical stimulation (NMES) for paralyzed lower-limb muscles results in an increase in energy expenditure and whether the number of activated muscles and duty cycle affect the potential increase.nnDESIGN: This was a cross-sectional study.nnRESULTS: Energy expenditure during all NMES protocols was significantly higher than the condition without NMES (1.2 ± 0.2 kcal/min), with the highest increase (+51%; +0.7 kcal/min, 95% confidence interval, 0.3-1.2) for the protocol with more muscles activated and the duty cycle with a shorter rest period. A significant decrease in muscle contraction size during NMES was found with a longer stimulation time, more muscles activated, or the duty cycle with a shorter rest period.nnCONCLUSION: Using NMES for paralyzed lower-limb muscles can significantly increase energy expenditure compared with sitting without NMES, with the highest increase for the protocol with more muscles activated and the duty cycle with a shorter rest period. Muscle fatigue occurred significantly with the more intense NMES protocols, which might cause a lower energy expenditure in a longer protocol. Future studies should further optimize the NMES parameters and investigate the long-term effects of NMES on weight management in people with SCI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37337234,

title = {The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial): study protocol for a randomized controlled, quadruple blinded, multicenter, parallel group trial in mechanically ventilated patients},

author = {Rob J J van Gassel and Julia L M Bels and Katrien Tartaglia and Bas C T van Bussel and Sander M J van Kuijk and Adam M Deane and Zudin Puthucheary and Peter J M Weijs and Lilian Vloet and Bert Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H van Zanten and Dieter Mesotten and Marcel C G van de Poll},

doi = {10.1186/s13063-023-07380-3},

issn = {1745-6215},

year  = {2023},

date = {2023-06-01},

journal = {Trials},

volume = {24},

number = {1},

pages = {416},

abstract = {BACKGROUND: Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating skeletal muscle breakdown. Supporting evidence is limited however and results in great variety in recommended protein targets.nnMETHODS: The PRECISe trial is an investigator-initiated, bi-national, multi-center, quadruple-blinded randomized controlled trial with a parallel group design. In 935 patients, we will compare provision of isocaloric enteral nutrition with either a standard or high protein content, providing 1.3 or 2.0 g of protein/kg/day, respectively, when fed on target. All unplanned ICU admissions with initiation of invasive mechanical ventilation within 24 h of admission and an expected stay on ventilator support of at least 3 days are eligible. The study is designed to assess the effect of the intervention on functional recovery at 1, 3, and 6 months following ICU admission, including health-related quality of life, measures of muscle strength, physical function, and mental health. The primary endpoint of the trial is health-related quality of life as measured by the Euro-QoL-5D-5-level questionnaire Health Utility Score. Overall between-group differences will be assessed over the three time points using linear mixed-effects models.nnDISCUSSION: The PRECISe trial will evaluate the effect of protein on functional recovery including both patient-centered and muscle-related outcomes.nnTRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04633421 . Registered on November 18, 2020. First patient in (FPI) on November 19, 2020. Expected last patient last visit (LPLV) in October 2023.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gortan_Cappellari2023-isb,

title = {Sarcopenic obesity research perspectives outlined by the 

 sarcopenic obesity global leadership initiative (SOGLI) - 

 Proceedings from the SOGLI consortium meeting in rome November 

 2022},

author = {Gianluca Gortan Cappellari and Christelle Guillet and Eleonora Poggiogalle and Maria D Ballesteros Pomar and John A Batsis and Yves Boirie and Irene Breton and Stefano Frara and Laurence Genton and Yftach Gepner and Maria Cristina Gonzalez and Steven B Heymsfield and Eva Kiesswetter and Alessandro Laviano and Carla M Prado and Ferruccio Santini and Mireille J Serlie and Mario Siervo and Dennis T Villareal and Dorothee Volkert and Trudy Voortman and Peter J M Weijs and Mauro Zamboni and Stephan C Bischoff and Luca Busetto and Tommy Cederholm and Rocco Barazzoni and Lorenzo M Donini and SOGLI Expert Panel},

year  = {2023},

date = {2023-05-01},

journal = {Clin. Nutr.},

volume = {42},

number = {5},

pages = {687–699},

publisher = {Elsevier BV},

abstract = {The European Society for Clinical Nutrition and Metabolism 

 (ESPEN) and the European Association for the Study of Obesity 

 (EASO) launched the Sarcopenic Obesity Global Leadership 

 Initiative (SOGLI) to reach expert consensus on a definition and 

 diagnostic criteria for Sarcopenic Obesity (SO). The present 

 paper describes the proceeding of the Sarcopenic Obesity Global 

 Leadership Initiative (SOGLI) meeting that was held on November 

 25th and 26th, 2022 in Rome, Italy. This consortium involved the 

 participation of 50 researchers from different geographic 

 regions and countries. The document outlines an agenda advocated 

 by the SOGLI expert panel regarding the pathophysiology, 

 screening, diagnosis, staging and treatment of SO that needs to 

 be prioritized for future research in the field.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Eglseer2023-thb,

title = {Nutrition and exercise interventions to improve body composition 

 for persons with overweight or obesity near retirement age: A 

 systematic review and network meta-analysis of randomized 

 controlled trials},

author = {Doris Eglseer and Mariella Traxler and Stefan Embacher and Lea Reiter and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso Cruz-Jentoft and Silvia Bauer and SO-NUTS consortium},

year  = {2023},

date = {2023-05-01},

journal = {Adv. Nutr.},

volume = {14},

number = {3},

pages = {516–538},

publisher = {Elsevier BV},

abstract = {The retirement phase is an opportunity to integrate healthy 

 (nutrition/exercise) habits into daily life. We conducted this 

 systematic review to assess which nutrition and exercise 

 interventions most effectively improve body composition 

 (fat/muscle mass), body mass index (BMI), and waist 

 circumference (WC) in persons with obesity/overweight near 

 retirement age (ages 55-70 y). We conducted a systematic review 

 and network meta-analysis (NMA) of randomized controlled trials, 

 searching 4 databases from their inception up to July 12, 2022. 

 The NMA was based on a random effects model, pooled mean 

 differences, standardized mean differences, their 95% 

 confidence intervals, and correlations with multi-arm studies. 

 Subgroup and sensitivity analyses were also conducted. 

 Ninety-two studies were included, 66 of which with 4957 

 participants could be used for the NMA. Identified interventions 

 were clustered into 12 groups: no intervention, energy 

 restriction (i.e., 500-1000 kcal), energy restriction plus 

 high-protein intake (1.1-1.7 g/kg/body weight), intermittent 

 fasting, mixed exercise (aerobic and resistance), resistance 

 training, aerobic training, high protein plus resistance 

 training, energy restriction plus high protein plus exercise, 

 energy restriction plus resistance training, energy restriction 

 plus aerobic training, and energy restriction plus mixed 

 exercise. Intervention durations ranged from 8 wk to 6 mo. Body 

 fat was reduced with energy restriction plus any exercise or 

 plus high-protein intake. Energy restriction alone was less 

 effective and tended to decrease muscle mass. Muscle mass was 

 only significantly increased with mixed exercise. All other 

 interventions including exercise effectively preserved muscle 

 mass. A BMI and/or WC decrease was achieved with all 

 interventions except aerobic training/resistance training alone 

 or resistance training plus high protein. Overall, the most 

 effective strategy for nearly all outcomes was combining energy 

 restriction with resistance training or mixed exercise and high 

 protein. Health care professionals involved in the management of 

 persons with obesity need to be aware that an energy-restricted 

 diet alone may contribute to sarcopenic obesity in persons near 

 retirement age. This network meta-analysis is registered at 

 https://www.crd.york.ac.uk/prospero/ as CRD42021276465.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Erck2023-tpb,

title = {Adherence of older cardiac patients to a home-based cardiac 

 rehabilitation program},

author = {Dennis Erck and Michel Terbraak and Christine D Dolman and Peter J M Weijs and José P Henriques and Ronak Delewi and Lotte Verweij and Patricia Jepma and Wilma J M Scholte Op Reimer and Josje D Schoufour},

year  = {2023},

date = {2023-05-01},

journal = {Geriatrics (Basel)},

volume = {8},

number = {3},

abstract = {Referral to home-based cardiac rehabilitation (HBCR) is low among 

 older and frailer patients due to low expectations regarding 

 adherence by healthcare professionals. The aim of this study was 

 to determine adherence to HBCR when old and frail patients are 

 referred, and to explore any differences in baseline 

 characteristics between adherent and nonadherent patients. Data 

 of the Cardiac Care Bridge were used (Dutch trial register 

 NTR6316). The study included hospitalized cardiac patients $geq$ 

 70 years old and at high risk of functional loss. Adherence to 

 HBCR was confirmed when two-thirds of the intended nine sessions 

 were followed. Of the 153 patients included (age: 82 $±$ 6 

 years, 54% female), 29% could not be referred due to death 

 before referral, not returning home, or practical problems. Of 

 the 109 patients who were referred, 67% adhered. Characteristics 

 associated with non-adherence were older age (84 $±$ 6 vs. 82 $±$},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gortan_Cappellari2023-is,

title = {Sarcopenic obesity research perspectives outlined by the 

 sarcopenic obesity global leadership initiative (SOGLI) - 

 Proceedings from the SOGLI consortium meeting in rome November 

 2022},

author = {Gianluca Gortan Cappellari and Christelle Guillet and Eleonora Poggiogalle and Maria D Ballesteros Pomar and John A Batsis and Yves Boirie and Irene Breton and Stefano Frara and Laurence Genton and Yftach Gepner and Maria Cristina Gonzalez and Steven B Heymsfield and Eva Kiesswetter and Alessandro Laviano and Carla M Prado and Ferruccio Santini and Mireille J Serlie and Mario Siervo and Dennis T Villareal and Dorothee Volkert and Trudy Voortman and Peter J M Weijs and Mauro Zamboni and Stephan C Bischoff and Luca Busetto and Tommy Cederholm and Rocco Barazzoni and Lorenzo M Donini and SOGLI Expert Panel},

year  = {2023},

date = {2023-05-01},

journal = {Clin. Nutr.},

volume = {42},

number = {5},

pages = {687–699},

publisher = {Elsevier BV},

abstract = {The European Society for Clinical Nutrition and Metabolism 

 (ESPEN) and the European Association for the Study of Obesity 

 (EASO) launched the Sarcopenic Obesity Global Leadership 

 Initiative (SOGLI) to reach expert consensus on a definition and 

 diagnostic criteria for Sarcopenic Obesity (SO). The present 

 paper describes the proceeding of the Sarcopenic Obesity Global 

 Leadership Initiative (SOGLI) meeting that was held on November 

 25th and 26th, 2022 in Rome, Italy. This consortium involved the 

 participation of 50 researchers from different geographic 

 regions and countries. The document outlines an agenda advocated 

 by the SOGLI expert panel regarding the pathophysiology, 

 screening, diagnosis, staging and treatment of SO that needs to 

 be prioritized for future research in the field.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Eglseer2023-th,

title = {Nutrition and exercise interventions to improve body composition 

 for persons with overweight or obesity near retirement age: A 

 systematic review and network meta-analysis of randomized 

 controlled trials},

author = {Doris Eglseer and Mariella Traxler and Stefan Embacher and Lea Reiter and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso Cruz-Jentoft and Silvia Bauer and SO-NUTS consortium},

year  = {2023},

date = {2023-05-01},

journal = {Adv. Nutr.},

volume = {14},

number = {3},

pages = {516–538},

publisher = {Elsevier BV},

abstract = {The retirement phase is an opportunity to integrate healthy 

 (nutrition/exercise) habits into daily life. We conducted this 

 systematic review to assess which nutrition and exercise 

 interventions most effectively improve body composition 

 (fat/muscle mass), body mass index (BMI), and waist 

 circumference (WC) in persons with obesity/overweight near 

 retirement age (ages 55-70 y). We conducted a systematic review 

 and network meta-analysis (NMA) of randomized controlled trials, 

 searching 4 databases from their inception up to July 12, 2022. 

 The NMA was based on a random effects model, pooled mean 

 differences, standardized mean differences, their 95% 

 confidence intervals, and correlations with multi-arm studies. 

 Subgroup and sensitivity analyses were also conducted. 

 Ninety-two studies were included, 66 of which with 4957 

 participants could be used for the NMA. Identified interventions 

 were clustered into 12 groups: no intervention, energy 

 restriction (i.e., 500-1000 kcal), energy restriction plus 

 high-protein intake (1.1-1.7 g/kg/body weight), intermittent 

 fasting, mixed exercise (aerobic and resistance), resistance 

 training, aerobic training, high protein plus resistance 

 training, energy restriction plus high protein plus exercise, 

 energy restriction plus resistance training, energy restriction 

 plus aerobic training, and energy restriction plus mixed 

 exercise. Intervention durations ranged from 8 wk to 6 mo. Body 

 fat was reduced with energy restriction plus any exercise or 

 plus high-protein intake. Energy restriction alone was less 

 effective and tended to decrease muscle mass. Muscle mass was 

 only significantly increased with mixed exercise. All other 

 interventions including exercise effectively preserved muscle 

 mass. A BMI and/or WC decrease was achieved with all 

 interventions except aerobic training/resistance training alone 

 or resistance training plus high protein. Overall, the most 

 effective strategy for nearly all outcomes was combining energy 

 restriction with resistance training or mixed exercise and high 

 protein. Health care professionals involved in the management of 

 persons with obesity need to be aware that an energy-restricted 

 diet alone may contribute to sarcopenic obesity in persons near 

 retirement age. This network meta-analysis is registered at 

 https://www.crd.york.ac.uk/prospero/ as CRD42021276465.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Erck2023-tp,

title = {Adherence of older cardiac patients to a home-based cardiac 

 rehabilitation program},

author = {Dennis Erck and Michel Terbraak and Christine D Dolman and Peter J M Weijs and José P Henriques and Ronak Delewi and Lotte Verweij and Patricia Jepma and Wilma J M Scholte Op Reimer and Josje D Schoufour},

year  = {2023},

date = {2023-05-01},

journal = {Geriatrics (Basel)},

volume = {8},

number = {3},

abstract = {Referral to home-based cardiac rehabilitation (HBCR) is low among 

 older and frailer patients due to low expectations regarding 

 adherence by healthcare professionals. The aim of this study was 

 to determine adherence to HBCR when old and frail patients are 

 referred, and to explore any differences in baseline 

 characteristics between adherent and nonadherent patients. Data 

 of the Cardiac Care Bridge were used (Dutch trial register 

 NTR6316). The study included hospitalized cardiac patients $geq$ 

 70 years old and at high risk of functional loss. Adherence to 

 HBCR was confirmed when two-thirds of the intended nine sessions 

 were followed. Of the 153 patients included (age: 82 $±$ 6 

 years, 54% female), 29% could not be referred due to death 

 before referral, not returning home, or practical problems. Of 

 the 109 patients who were referred, 67% adhered. Characteristics 

 associated with non-adherence were older age (84 $±$ 6 vs. 82 $±$},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37218833c,

title = {Adherence of Older Cardiac Patients to a Home-Based Cardiac Rehabilitation Program},

author = {Dennis van Erck and Michel Terbraak and Christine D Dolman and Peter J M Weijs and José P Henriques and Ronak Delewi and Lotte Verweij and Patricia Jepma and Wilma J M Scholte Op Reimer and Josje D Schoufour},

doi = {10.3390/geriatrics8030053},

issn = {2308-3417},

year  = {2023},

date = {2023-05-01},

journal = {Geriatrics (Basel)},

volume = {8},

number = {3},

abstract = {Referral to home-based cardiac rehabilitation (HBCR) is low among older and frailer patients due to low expectations regarding adherence by healthcare professionals. The aim of this study was to determine adherence to HBCR when old and frail patients are referred, and to explore any differences in baseline characteristics between adherent and nonadherent patients. Data of the Cardiac Care Bridge were used (Dutch trial register NTR6316). The study included hospitalized cardiac patients ≥ 70 years old and at high risk of functional loss. Adherence to HBCR was confirmed when two-thirds of the intended nine sessions were followed. Of the 153 patients included (age: 82 ± 6 years, 54% female), 29% could not be referred due to death before referral, not returning home, or practical problems. Of the 109 patients who were referred, 67% adhered. Characteristics associated with non-adherence were older age (84 ± 6 vs. 82 ± 6,  = 0.05) and higher handgrip strength in men (33 ± 8 vs. 25 ± 11,  = 0.01). There was no difference in comorbidity, symptoms, or physical capacity. Based on these observations, most older cardiac patients who return home after hospital admission appear to adhere to HBCR after referral, suggesting that most older cardiac patients are motivated and capable of receiving HBCR.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37028708c,

title = {Nutrition and Exercise Interventions to Improve Body Composition for Persons with Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials},

author = {Doris Eglseer and Mariella Traxler and Stefan Embacher and Lea Reiter and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso Cruz-Jentoft and Silvia Bauer and },

doi = {10.1016/j.advnut.2023.04.001},

issn = {2156-5376},

year  = {2023},

date = {2023-05-01},

journal = {Adv Nutr},

volume = {14},

number = {3},

pages = {516--538},

abstract = {The retirement phase is an opportunity to integrate healthy (nutrition/exercise) habits into daily life. We conducted this systematic review to assess which nutrition and exercise interventions most effectively improve body composition (fat/muscle mass), body mass index (BMI), and waist circumference (WC) in persons with obesity/overweight near retirement age (ages 55-70 y). We conducted a systematic review and network meta-analysis (NMA) of randomized controlled trials, searching 4 databases from their inception up to July 12, 2022. The NMA was based on a random effects model, pooled mean differences, standardized mean differences, their 95% confidence intervals, and correlations with multi-arm studies. Subgroup and sensitivity analyses were also conducted. Ninety-two studies were included, 66 of which with 4957 participants could be used for the NMA. Identified interventions were clustered into 12 groups: no intervention, energy restriction (i.e., 500-1000 kcal), energy restriction plus high-protein intake (1.1-1.7 g/kg/body weight), intermittent fasting, mixed exercise (aerobic and resistance), resistance training, aerobic training, high protein plus resistance training, energy restriction plus high protein plus exercise, energy restriction plus resistance training, energy restriction plus aerobic training, and energy restriction plus mixed exercise. Intervention durations ranged from 8 wk to 6 mo. Body fat was reduced with energy restriction plus any exercise or plus high-protein intake. Energy restriction alone was less effective and tended to decrease muscle mass. Muscle mass was only significantly increased with mixed exercise. All other interventions including exercise effectively preserved muscle mass. A BMI and/or WC decrease was achieved with all interventions except aerobic training/resistance training alone or resistance training plus high protein. Overall, the most effective strategy for nearly all outcomes was combining energy restriction with resistance training or mixed exercise and high protein. Health care professionals involved in the management of persons with obesity need to be aware that an energy-restricted diet alone may contribute to sarcopenic obesity in persons near retirement age. This network meta-analysis is registered at https://www.crd.york.ac.uk/prospero/ as CRD42021276465.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37218833,

title = {Adherence of Older Cardiac Patients to a Home-Based Cardiac Rehabilitation Program},

author = {Dennis van Erck and Michel Terbraak and Christine D Dolman and Peter J M Weijs and José P Henriques and Ronak Delewi and Lotte Verweij and Patricia Jepma and Wilma J M Scholte Op Reimer and Josje D Schoufour},

doi = {10.3390/geriatrics8030053},

issn = {2308-3417},

year  = {2023},

date = {2023-05-01},

journal = {Geriatrics (Basel)},

volume = {8},

number = {3},

abstract = {Referral to home-based cardiac rehabilitation (HBCR) is low among older and frailer patients due to low expectations regarding adherence by healthcare professionals. The aim of this study was to determine adherence to HBCR when old and frail patients are referred, and to explore any differences in baseline characteristics between adherent and nonadherent patients. Data of the Cardiac Care Bridge were used (Dutch trial register NTR6316). The study included hospitalized cardiac patients ≥ 70 years old and at high risk of functional loss. Adherence to HBCR was confirmed when two-thirds of the intended nine sessions were followed. Of the 153 patients included (age: 82 ± 6 years, 54% female), 29% could not be referred due to death before referral, not returning home, or practical problems. Of the 109 patients who were referred, 67% adhered. Characteristics associated with non-adherence were older age (84 ± 6 vs. 82 ± 6,  = 0.05) and higher handgrip strength in men (33 ± 8 vs. 25 ± 11,  = 0.01). There was no difference in comorbidity, symptoms, or physical capacity. Based on these observations, most older cardiac patients who return home after hospital admission appear to adhere to HBCR after referral, suggesting that most older cardiac patients are motivated and capable of receiving HBCR.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37028708,

title = {Nutrition and Exercise Interventions to Improve Body Composition for Persons with Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials},

author = {Doris Eglseer and Mariella Traxler and Stefan Embacher and Lea Reiter and Josje D Schoufour and Peter J M Weijs and Trudy Voortman and Yves Boirie and Alfonso Cruz-Jentoft and Silvia Bauer and },

doi = {10.1016/j.advnut.2023.04.001},

issn = {2156-5376},

year  = {2023},

date = {2023-05-01},

journal = {Adv Nutr},

volume = {14},

number = {3},

pages = {516--538},

abstract = {The retirement phase is an opportunity to integrate healthy (nutrition/exercise) habits into daily life. We conducted this systematic review to assess which nutrition and exercise interventions most effectively improve body composition (fat/muscle mass), body mass index (BMI), and waist circumference (WC) in persons with obesity/overweight near retirement age (ages 55-70 y). We conducted a systematic review and network meta-analysis (NMA) of randomized controlled trials, searching 4 databases from their inception up to July 12, 2022. The NMA was based on a random effects model, pooled mean differences, standardized mean differences, their 95% confidence intervals, and correlations with multi-arm studies. Subgroup and sensitivity analyses were also conducted. Ninety-two studies were included, 66 of which with 4957 participants could be used for the NMA. Identified interventions were clustered into 12 groups: no intervention, energy restriction (i.e., 500-1000 kcal), energy restriction plus high-protein intake (1.1-1.7 g/kg/body weight), intermittent fasting, mixed exercise (aerobic and resistance), resistance training, aerobic training, high protein plus resistance training, energy restriction plus high protein plus exercise, energy restriction plus resistance training, energy restriction plus aerobic training, and energy restriction plus mixed exercise. Intervention durations ranged from 8 wk to 6 mo. Body fat was reduced with energy restriction plus any exercise or plus high-protein intake. Energy restriction alone was less effective and tended to decrease muscle mass. Muscle mass was only significantly increased with mixed exercise. All other interventions including exercise effectively preserved muscle mass. A BMI and/or WC decrease was achieved with all interventions except aerobic training/resistance training alone or resistance training plus high protein. Overall, the most effective strategy for nearly all outcomes was combining energy restriction with resistance training or mixed exercise and high protein. Health care professionals involved in the management of persons with obesity need to be aware that an energy-restricted diet alone may contribute to sarcopenic obesity in persons near retirement age. This network meta-analysis is registered at https://www.crd.york.ac.uk/prospero/ as CRD42021276465.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Slotegraaf2023-jfb,

title = {Nutritional problems of patients with COVID-19 receiving 

 dietetic treatment in primary care},

author = {Anne I Slotegraaf and Marian A E Schueren and Nicolette J Wierdsma and Peter J M Weijs and Hinke M Kruizenga},

year  = {2023},

date = {2023-02-01},

journal = {J. Hum. Nutr. Diet.},

volume = {36},

number = {1},

pages = {20–30},

publisher = {Wiley},

abstract = {BACKGROUND: The nutritional problems of patients who are 

 hospitalised for COVID-19 are becoming increasingly clear. 

 However, a large group of patients have never been hospitalised 

 and also appear to experience persistent nutritional problems. 

 The present study describes the nutritional status, risk of 

 sarcopaenia and nutrition-related complaints of patients 

 recovering from COVID-19 receiving dietetic treatment in primary 

 care. METHODS: In this retrospective observational study, data 

 were collected during dietetic treatment by a primary care 

 dietitian between April and December 2020. Both patients who had 

 and had not been admitted to the hospital were included at their 

 first visit to a primary care dietitian. Data on nutritional 

 status, risk of sarcopaenia and nutrition-related complaints 

 were collected longitudinally. RESULTS: Data from 246 patients 

 with COVID-19 were collected. Mean $±$ SD age was 57 $±$ 16 

 years and 61% of the patient population was female. At first 

 consultation, two thirds of patients were classified as 

 overweight or obese (body mass index >25 kg m-2 ). The majority 

 had experienced unintentional weight loss because of COVID-19. 

 Additionally, 55% of hospitalised and 34% of non-hospitalised 

 patients had a high risk of sarcopaenia. Most commonly reported 

 nutrition-related complaints were decreased appetite, shortness 

 of breath, changed or loss of taste and feeling of being full. 

 Nutrition-related complaints decreased after the first 

 consultation, but remained present over time. CONCLUSIONS: In 

 conclusion, weight changes, risk of sarcopaenia and 

 nutrition-related complaints were prevalent in patients with 

 COVID-19, treated by a primary care dietitian. Nutrition-related 

 complaints improved over time, but remained prevalent until 

 several months after infection.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Toussaint2023-nsb,

title = {Effect and process evaluation of a preschool-based intervention 

 to promote an early childhood education and care teacher-parent 

 partnership about healthy behaviours in children: Study protocol 

 for the cluster randomised controlled trial CO-HEALTHY},

author = {Nicole Toussaint and Martinette T Streppel and Sandra Mul and Meryem Gündüz and Marloes D A Verseveld and Mirka Janssen and Peter J M Weijs and Ruben G Fukkink},

year  = {2023},

date = {2023-02-01},

journal = {PLoS One},

volume = {18},

number = {2},

pages = {e0281999},

abstract = {BACKGROUND: Early Childhood Education and Care (ECEC) teachers at 

 urban preschools are potential key figures to promote healthy 

 behaviours in disadvantaged young children and to engage parents 

 in lifestyle-related topics. An ECEC teacher-parent partnership 

 regarding healthy behaviours may support parents and stimulate 

 their children's development. However, it is not an easy task to 

 establish such a collaboration and ECEC teachers need tools to 

 communicate with parents about lifestyle-related topics. This 

 paper describes the study protocol of a preschool-based 

 intervention (CO-HEALTHY) to promote an ECEC teacher-parent 

 partnership regarding healthy eating, physical (in)activity and 

 sleeping behaviours in young children. METHODS: A cluster 

 randomised controlled trial will be performed at preschools in 

 Amsterdam, the Netherlands. Preschools will be randomly allocated 

 to an intervention or control group. The intervention consists of 

 a toolkit with 10 parent-child activities and associated training 

 for ECEC teachers. The activities were composed using the 

 Intervention Mapping protocol. At intervention preschools, ECEC 

 teachers will carry out the activities during standard contact 

 moments. Parents will receive associated intervention materials 

 and will be encouraged to perform similar parent-child activities 

 at home. At control preschools, the toolkit and training will not 

 be implemented. The primary outcome will be the teacher- and 

 parent-reported partnership regarding healthy eating, physical 

 (in)activity and sleeping behaviours in young children. The 

 perceived partnership will be assessed by a questionnaire at 

 baseline and at 6 months. In addition, short interviews with ECEC 

 teachers will be held. Secondary outcomes include the knowledge, 

 attitude, food- and activity-related practices of ECEC teachers 

 and parents. Furthermore, children's eating, physical 

 (in)activity and sleeping behaviours, and weight development will 

 be assessed. A process evaluation of the intervention will be 

 made. DISCUSSION: The intervention aims to provide a practical 

 tool for ECEC teachers at urban preschools to promote an ECEC 

 teacher-parent partnership regarding a healthy lifestyle in young 

 children. TRIAL REGISTRATION: Netherlands Trial Register (NTR): 

 NL8883. Date registered: September 8, 2020.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}