Publications

@article{pmid39191118,

title = {Adherence to resistance training and hypocaloric diet among persons near retirement age - A secondary data analysis of three randomized controlled trials},

author = {S Bauer and L Reiter and P J M Weijs and J D Schoufour and Y Boirie and E Topinková and R G Memelink and A M Verreijen and A Borenich and D Eglseer and },

doi = {10.1016/j.jnha.2024.100344},

issn = {1760-4788},

year  = {2024},

date = {2024-08-01},

journal = {J Nutr Health Aging},

volume = {28},

number = {10},

pages = {100344},

abstract = {OBJECTIVES: Adherence to lifestyle interventions is crucial for the treatment of obesity. However, there is little research about adherence to lifestyle interventions in persons around retirement age. The objectives of this study are (1) to identify factors associated with the adherence to resistance training and a hypocaloric diet and (2) to describe the association between adherence and changes in body composition outcome parameters.nnDESIGN: This secondary data analysis included three randomized controlled trials.nnSETTING & PARTICIPANTS: The inclusion criteria of the participants were an age of 55-75 years, a BMI ≥ 25 kg/m and receiving both a hypocaloric diet and resistance training. All participants were residing in the community.nnMEASUREMENTS: Adherence to hypocaloric diet was measured through the mean dietary intake on the basis of a 3-day dietary record. If the participant consumed at least 600 kcal less than the individual caloric requirements, they were considered adherent. Adherence to resistance training was achieved if ≥67% of the recommended training sessions were attended over the course of the study periods.nnRESULTS: 232 participants were included, 47.0% female, mean age 64.0 (±5.5) years. 80.2% adhered to resistance training and 51.3% adhered to a hypocaloric diet. Older age (Beta 0.41; 95% CI 0.05, 0.78; p = 0.028) and male sex (Beta 7.7; 95% CI 3.6, 11; p < 0.001) were associated with higher resistance training adherence. A higher BMI at baseline (Beta 6.4; 95% CI 3.6, 9.2; p < 0.001) and male sex (Beta 65; 95% CI 41, 88; p < 0.001) were associated with higher adherence to hypocaloric diet.nnCONCLUSION: We identified several associated factors (sex, age and BMI at baseline) that should be considered to promote adherence in future lifestyle intervention studies in persons around retirement age. We recommend including behavior change techniques in lifestyle interventions and consider sex-specific interventions to improve the adherence of women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38653002,

title = {Analysis of behavioral change techniques used in exercise and nutritional interventions targeting adults around retirement age with sarcopenic obesity in a systematic review},

author = {Paula Collazo-Castiñeira and Macarena Sánchez-Izquierdo and Lea Joanne Reiter and Silvia Bauer and Alfonso J Cruz-Jentoft and Josje D Schoufour and Peter J M Weijs and Doris Eglseer},

doi = {10.1016/j.archger.2024.105437},

issn = {1872-6976},

year  = {2024},

date = {2024-08-01},

journal = {Arch Gerontol Geriatr},

volume = {123},

pages = {105437},

abstract = {BACKGROUND: Sarcopenic obesity significantly burdens health and autonomy. Strategies to intervene in or prevent sarcopenic obesity generally focus on losing body fat and building or maintaining muscle mass and function. For a lifestyle intervention, it is important to consider psychological aspects such as behavioral change techniques (BCTs) to elicit a long-lasting behavioral change.nnPURPOSE: The study was carried out to analyze BCTs used in exercise and nutritional interventions targeting community-dwelling adults around retirement age with sarcopenic obesity.nnMETHODS: We conducted an analysis of articles cited in an existing systematic review on the effectiveness of exercise and nutritional interventions on physiological outcomes in community-dwelling adults around retirement age with sarcopenic obesity. We identified BCTs used in these studies by applying a standardized taxonomy.nnRESULTS: Only nine BCTs were identified. Most BCTs were not used intentionally (82 %), and those used derived from the implementation of lifestyle components, such as exercise classes ("instructions on how to perform a behavior," "demonstration of the behavior," "behavioral practice/rehearsal," and "body changes"). Only two studies used BCTs intentionally to reinforce adherence in their interventions.nnCONCLUSIONS: Few studies integrated BCTs in lifestyle interventions for community-dwelling persons around retirement age with sarcopenic obesity. Future studies on interventions to counteract sarcopenic obesity should include well-established BCTs to foster adherence and, therefore, their effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39153816,

title = {Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands},

author = {Julia L M Bels and Steven Thiessen and Rob J J van Gassel and Albertus Beishuizen and Ashley De Bie Dekker and Vincent Fraipont and Stoffel Lamote and Didier Ledoux and Clarissa Scheeren and Elisabeth De Waele and Arthur R H van Zanten and Laura Bormans-Russell and Bas C T van Bussel and Marlies M J Dictus and Tom Fivez and Ingeborg Harks and Iwan C C van der Horst and Joop Jonckheer and Hugues Marechal and Paul B Massion and Ingrid Meex and Michelle C Paulus and Martin Rinket and Susanne van Santen and Katrien Tartaglia and Adam M Deane and Frieda Demuydt and Zudin Puthucheary and Lilian C M Vloet and Peter J M Weijs and Sander M J van Kuijk and Marcel C G van de Poll and Dieter Mesotten and },

doi = {10.1016/S0140-6736(24)01304-7},

issn = {1474-547X},

year  = {2024},

date = {2024-08-01},

journal = {Lancet},

volume = {404},

number = {10453},

pages = {659--669},

abstract = {BACKGROUND: Increased protein provision might ameliorate muscle wasting and improve long-term outcomes in critically ill patients. The aim of the PRECISe trial was to assess whether higher enteral protein provision (ie, 2·0 g/kg per day) would improve health-related quality of life and functional outcomes in critically ill patients who were mechanically ventilated compared with standard enteral protein provision (ie, 1·3 g/kg per day).nnMETHODS: The PRECISe trial was an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in five Dutch hospitals and five Belgian hospitals. Inclusion criteria were initiation of invasive mechanical ventilation within 24 h of intensive care unit (ICU) admission and an expected duration of invasive ventilation of 3 days or longer. Exclusion criteria were contraindications for enteral nutrition, moribund condition, BMI less than 18 kg/m, kidney failure with a no dialysis code, or hepatic encephalopathy. Patients were randomly assigned to one of four randomisation labels, corresponding with two study groups (ie, standard or high protein; two labels per group) in a 1:1:1:1 ratio through an interactive web-response system. Randomisation was done via random permuted-block randomisation in varying block sizes of eight and 12, stratified by centre. Participants, care providers, investigators, outcome assessors, data analysts, and the independent data safety monitoring board were all blinded to group allocation. Patients received isocaloric enteral feeds that contained 1·3 kcal/mL and 0·06 g of protein/mL (ie, standard protein) or 1·3 kcal/mL and 0·10 g of protein/mL (ie, high protein). The study-nutrition intervention was limited to the time period during the patient's ICU stay in which they required enteral feeding, with a maximum of 90 days. The primary outcome was EuroQoL 5-Dimension 5-level (EQ-5D-5L) health utility score at 30 days, 90 days, and 180 days after randomisation, adjusted for baseline EQ-5D-5L health utility score. This trial was registered with ClinicalTrials.gov (NCT04633421) and is closed to new participants.nnFINDINGS: Between Nov 19, 2020, and April 14, 2023, 935 patients were randomly assigned. 335 (35·8%) of 935 patients were female and 600 (64·2%) were male. 465 (49·7%) of 935 were assigned to the standard protein group and 470 (50·3%) were assigned to the high protein group. 430 (92·5%) of 465 patients in the standard protein group and 419 (89·1%) of 470 patients in the high protein group were assessed for the primary outcome. The primary outcome, EQ-5D-5L health utility score during 180 days after randomisation (assessed at 30 days, 90 days, and 180 days), was lower in patients allocated to the high protein group than in those allocated to the standard protein group, with a mean difference of -0·05 (95% CI -0·10 to -0·01; p=0·031). Regarding safety outcomes, the probability of mortality during the entire follow-up was 0·38 (SE 0·02) in the standard protein group and 0·42 (0·02) in the high protein group (hazard ratio 1·14, 95% CI 0·92 to 1·40; p=0·22). There was a higher incidence of symptoms of gastrointestinal intolerance in patients in the high protein group (odds ratio 1·76, 95% CI 1·06 to 2·92; p=0·030). Incidence of other adverse events did not differ between groups.nnINTERPRETATION: High enteral protein provision compared with standard enteral protein provision resulted in worse health-related quality of life in critically ill patients and did not improve functional outcomes during 180 days after ICU admission.nnFUNDING: Netherlands Organisation for Healthcare Research and Development and Belgian Health Care Knowledge Centre.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Memelink2024-rrb,

title = {The effect of a combined lifestyle intervention with and without 

 protein drink on inflammation in older adults with obesity and 

 type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J Bos Kuil and Suzan Wopereis and Johan Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

year  = {2024},

date = {2024-06-01},

journal = {Exp. Gerontol.},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one 

 of the pathways involved in type 2 diabetes (T2D). Currently, 

 there is limited evidence for ameliorating effects of combined 

 lifestyle interventions on CLIP in type 2 diabetes. We 

 investigated whether a 13-week combined lifestyle intervention, 

 using hypocaloric diet and resistance exercise plus 

 high-intensity interval training with or without consumption of a 

 protein drink, affected CLIP in older adults with T2D. METHODS: 

 In this post-hoc analysis of the PROBE study 114 adults ($geq$55 

 years) with obesity and type 2 (pre-)diabetes had measurements of 

 C-reactive protein (CRP), pro-inflammatory cytokines interleukin 

 (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte 

 chemoattractant protein (MCP)-1, anti-inflammatory cytokines 

 IL-10, IL-1 receptor antagonist (RA), and soluble 

 tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and 

 adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) 

 and soluble receptor for advanced glycation end products (sRAGE) 

 from fasting blood samples. A linear mixed model was used to 

 evaluate change in inflammatory biomarkers after lifestyle 

 intervention and effect of the protein drink. Linear regression 

 analysis was performed with parameters of body composition (by 

 dual-energy X-ray absorptiometry) and parameters of insulin 

 resistance (by oral glucose tolerance test). RESULTS: There were 

 no significant differences in CLIP responses between the protein 

 and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 

 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP 

 increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pinel2024-hkb,

title = {Identification of factors associated with sarcopenic obesity 

 development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and Peter J M Weijs and Y Boirie},

year  = {2024},

date = {2024-06-01},

journal = {Clin. Nutr.},

volume = {43},

number = {6},

pages = {1414–1424},

publisher = {Elsevier BV},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess 

 fat mass (obesity) and low skeletal muscle mass and function 

 (sarcopenia). The identification and classification of factors 

 related to SO would favor better prevention and diagnosis. The 

 present article aimed to (i) define a list of factors related 

 with SO based on literature analysis, (ii) identify clinical 

 conditions linked with SO development from literature search and 

 (iii) evaluate their relevance and the potential research gaps 

 by consulting an expert panel. From 4746 articles screened, 240 

 articles were selected for extraction of the factors associated 

 with SO. Factors were classified according to their frequency in 

 the literature. Clinical conditions were also recorded. Then, 

 they were evaluated by a panel of expert for evaluation of their 

 relevance in SO development. Experts also suggested additional 

 factors. Thirty-nine unique factors were extracted from the 

 papers and additional eleven factors suggested by a panel of 

 experts in the SO field. The frequency in the literature showed 

 insulin resistance, dyslipidemia, lack of exercise training, 

 inflammation and hypertension as the most frequent factors 

 associated with SO whereas experts ranked low spontaneous 

 physical activity, protein and energy intakes, low exercise 

 training and aging as the most important. Although literature 

 and expert panel presented some differences, this first list of 

 associated factors could help to identify patients at risk of 

 SO. Further work is needed to confirm the contribution of 

 factors associated with SO among the population overtime or in 

 randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Memelink2024-rr,

title = {The effect of a combined lifestyle intervention with and without 

 protein drink on inflammation in older adults with obesity and 

 type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J Bos Kuil and Suzan Wopereis and Johan Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

year  = {2024},

date = {2024-06-01},

journal = {Exp. Gerontol.},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one 

 of the pathways involved in type 2 diabetes (T2D). Currently, 

 there is limited evidence for ameliorating effects of combined 

 lifestyle interventions on CLIP in type 2 diabetes. We 

 investigated whether a 13-week combined lifestyle intervention, 

 using hypocaloric diet and resistance exercise plus 

 high-intensity interval training with or without consumption of a 

 protein drink, affected CLIP in older adults with T2D. METHODS: 

 In this post-hoc analysis of the PROBE study 114 adults ($geq$55 

 years) with obesity and type 2 (pre-)diabetes had measurements of 

 C-reactive protein (CRP), pro-inflammatory cytokines interleukin 

 (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte 

 chemoattractant protein (MCP)-1, anti-inflammatory cytokines 

 IL-10, IL-1 receptor antagonist (RA), and soluble 

 tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and 

 adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) 

 and soluble receptor for advanced glycation end products (sRAGE) 

 from fasting blood samples. A linear mixed model was used to 

 evaluate change in inflammatory biomarkers after lifestyle 

 intervention and effect of the protein drink. Linear regression 

 analysis was performed with parameters of body composition (by 

 dual-energy X-ray absorptiometry) and parameters of insulin 

 resistance (by oral glucose tolerance test). RESULTS: There were 

 no significant differences in CLIP responses between the protein 

 and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 

 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP 

 increased by 12 % in participants with low to average CLIP (pre 1.91 $±$ 0.39 mg/L, post 2.13 $±$ 1.16 mg/},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pinel2024-hk,

title = {Identification of factors associated with sarcopenic obesity 

 development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and Peter J M Weijs and Y Boirie},

year  = {2024},

date = {2024-06-01},

journal = {Clin. Nutr.},

volume = {43},

number = {6},

pages = {1414–1424},

publisher = {Elsevier BV},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess 

 fat mass (obesity) and low skeletal muscle mass and function 

 (sarcopenia). The identification and classification of factors 

 related to SO would favor better prevention and diagnosis. The 

 present article aimed to (i) define a list of factors related 

 with SO based on literature analysis, (ii) identify clinical 

 conditions linked with SO development from literature search and 

 (iii) evaluate their relevance and the potential research gaps 

 by consulting an expert panel. From 4746 articles screened, 240 

 articles were selected for extraction of the factors associated 

 with SO. Factors were classified according to their frequency in 

 the literature. Clinical conditions were also recorded. Then, 

 they were evaluated by a panel of expert for evaluation of their 

 relevance in SO development. Experts also suggested additional 

 factors. Thirty-nine unique factors were extracted from the 

 papers and additional eleven factors suggested by a panel of 

 experts in the SO field. The frequency in the literature showed 

 insulin resistance, dyslipidemia, lack of exercise training, 

 inflammation and hypertension as the most frequent factors 

 associated with SO whereas experts ranked low spontaneous 

 physical activity, protein and energy intakes, low exercise 

 training and aging as the most important. Although literature 

 and expert panel presented some differences, this first list of 

 associated factors could help to identify patients at risk of 

 SO. Further work is needed to confirm the contribution of 

 factors associated with SO among the population overtime or in 

 randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38527636c,

title = {The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J de Bos Kuil and Suzan Wopereis and Johan de Vogel-van den Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

doi = {10.1016/j.exger.2024.112410},

issn = {1873-6815},

year  = {2024},

date = {2024-06-01},

journal = {Exp Gerontol},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D.nnMETHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples. A linear mixed model was used to evaluate change in inflammatory biomarkers after lifestyle intervention and effect of the protein drink. Linear regression analysis was performed with parameters of body composition (by dual-energy X-ray absorptiometry) and parameters of insulin resistance (by oral glucose tolerance test).nnRESULTS: There were no significant differences in CLIP responses between the protein and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP increased by 12 % in participants with low to average CLIP (pre 1.91 ± 0.39 mg/L, post 2.13 ± 1.16 mg/L, p = 0.006) and decreased by 36 % in those with high CLIP (pre 5.14 mg/L ± 1.20, post 3.30 ± 2.29 mg/L, p < 0.001). Change in leptin and IL-1RA was positively associated with change in fat mass (β = 0.133, p < 0.001; β = 0.017, p < 0.001) and insulin resistance (β = 0.095, p = 0.024; β = 0.020, p = 0.001). Change in lean mass was not associated with any of the biomarkers.nnCONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38701709c,

title = {Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and P J M Weijs and Y Boirie},

doi = {10.1016/j.clnu.2024.04.033},

issn = {1532-1983},

year  = {2024},

date = {2024-06-01},

journal = {Clin Nutr},

volume = {43},

number = {6},

pages = {1414--1424},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38701709,

title = {Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting},

author = {A Pinel and C Guillet and F Capel and M Pouget and M De Antonio and B Pereira and E Topinkova and D Eglseer and R Barazzoni and A J Cruz-Jentoft and J D Schoufour and P J M Weijs and Y Boirie},

doi = {10.1016/j.clnu.2024.04.033},

issn = {1532-1983},

year  = {2024},

date = {2024-06-01},

journal = {Clin Nutr},

volume = {43},

number = {6},

pages = {1414--1424},

abstract = {Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38527636,

title = {The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes},

author = {Robert G Memelink and Rose Njemini and Minse J J de Bos Kuil and Suzan Wopereis and Johan de Vogel-van den Bosch and Josje D Schoufour and Michael Tieland and Peter J M Weijs and Ivan Bautmans},

doi = {10.1016/j.exger.2024.112410},

issn = {1873-6815},

year  = {2024},

date = {2024-06-01},

journal = {Exp Gerontol},

volume = {190},

pages = {112410},

abstract = {BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D.nnMETHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples. A linear mixed model was used to evaluate change in inflammatory biomarkers after lifestyle intervention and effect of the protein drink. Linear regression analysis was performed with parameters of body composition (by dual-energy X-ray absorptiometry) and parameters of insulin resistance (by oral glucose tolerance test).nnRESULTS: There were no significant differences in CLIP responses between the protein and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP increased by 12 % in participants with low to average CLIP (pre 1.91 ± 0.39 mg/L, post 2.13 ± 1.16 mg/L, p = 0.006) and decreased by 36 % in those with high CLIP (pre 5.14 mg/L ± 1.20, post 3.30 ± 2.29 mg/L, p < 0.001). Change in leptin and IL-1RA was positively associated with change in fat mass (β = 0.133, p < 0.001; β = 0.017, p < 0.001) and insulin resistance (β = 0.095, p = 0.024; β = 0.020, p = 0.001). Change in lean mass was not associated with any of the biomarkers.nnCONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hoevenaars2024-adb,

title = {Lifestyle and health changes in wheelchair users with a chronic 

 disability after 12 weeks of using the WHEELS mHealth 

 application},

author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},

year  = {2024},

date = {2024-04-01},

journal = {Disabil. Rehabil. Assist. Technol.},

volume = {19},

number = {3},

pages = {648–657},

abstract = {PURPOSE: The aim of this study was to determine changes in 

 physical activity, nutrition, sleep behaviour and body 

 composition in wheelchair users with a chronic disability after 

 12 weeks of using the WHEELS mHealth application (app). METHODS: 

 A 12-week pre-post intervention study was performed, starting 

 with a 1-week control period. Physical activity and sleep 

 behaviour were continuously measured with a Fitbit charge 3. 

 Self-reported nutritional intake, body mass and waist 

 circumference were collected. Pre-post outcomes were compared 

 with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit 

 data were analysed with a mixed model or a panel linear model. 

 Effect sizes were determined and significance was accepted at p < 

 .05. RESULTS: Thirty participants completed the study. No 

 significant changes in physical activity (+1.5 $surd$steps) and 

 sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Ruijven2024-stb,

title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as 

 beneficially high protein provision in critically ill patients},

author = {Isabel M Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},

year  = {2024},

date = {2024-04-01},

journal = {Clin. Nutr.},

volume = {43},

number = {4},

pages = {1077–1078},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hoevenaars2024-ad,

title = {Lifestyle and health changes in wheelchair users with a chronic 

 disability after 12 weeks of using the WHEELS mHealth 

 application},

author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},

year  = {2024},

date = {2024-04-01},

journal = {Disabil. Rehabil. Assist. Technol.},

volume = {19},

number = {3},

pages = {648–657},

abstract = {PURPOSE: The aim of this study was to determine changes in 

 physical activity, nutrition, sleep behaviour and body 

 composition in wheelchair users with a chronic disability after 

 12 weeks of using the WHEELS mHealth application (app). METHODS: 

 A 12-week pre-post intervention study was performed, starting 

 with a 1-week control period. Physical activity and sleep 

 behaviour were continuously measured with a Fitbit charge 3. 

 Self-reported nutritional intake, body mass and waist 

 circumference were collected. Pre-post outcomes were compared 

 with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit 

 data were analysed with a mixed model or a panel linear model. 

 Effect sizes were determined and significance was accepted at p < 

 .05. RESULTS: Thirty participants completed the study. No 

 significant changes in physical activity (+1.5 $surd$steps) and 

 sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 k},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Ruijven2024-st,

title = {Reply - Letter to the editor: Reconsidering 1.2-1.5 g/kg as 

 beneficially high protein provision in critically ill patients},

author = {Isabel M Ruijven and Anja H Brunsveld-Reinders and Sandra N Stapel and Peter J M Weijs},

year  = {2024},

date = {2024-04-01},

journal = {Clin. Nutr.},

volume = {43},

number = {4},

pages = {1077–1078},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36165036,

title = {Lifestyle and health changes in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application},

author = {Dirk Hoevenaars and Jasmijn F M Holla and Sonja de Groot and Peter J M Weijs and Wessel Kraaij and Thomas W J Janssen},

doi = {10.1080/17483107.2022.2115563},

issn = {1748-3115},

year  = {2024},

date = {2024-04-01},

journal = {Disabil Rehabil Assist Technol},

volume = {19},

number = {3},

pages = {648--657},

abstract = {PURPOSE: The aim of this study was to determine changes in physical activity, nutrition, sleep behaviour and body composition in wheelchair users with a chronic disability after 12 weeks of using the WHEELS mHealth application (app).nnMETHODS: A 12-week pre-post intervention study was performed, starting with a 1-week control period. Physical activity and sleep behaviour were continuously measured with a Fitbit charge 3. Self-reported nutritional intake, body mass and waist circumference were collected. Pre-post outcomes were compared with a paired-sample t-test or Wilcoxon signed-rank test. Fitbit data were analysed with a mixed model or a panel linear model. Effect sizes were determined and significance was accepted at  < .05.nnRESULTS: Thirty participants completed the study. No significant changes in physical activity (+1.5 √steps) and sleep quality (-9.7 sleep minutes; -1.2% sleep efficiency) were found. Significant reduction in energy (-1022 kJ,  = 0.71), protein (-8.3 g,  = 0.61) and fat (-13.1 g,  = 0.87) intake, body mass (-2.2 kg,  = 0.61) and waist circumference (-3.3 cm,  = 0.80) were found.nnCONCLUSION: Positive changes were found in nutritional behaviour and body composition, but not in physical activity and sleep quality. The WHEELS app seems to partly support healthy lifestyle behaviour.Implications for RehabilitationHealthy lifestyle promotion is crucial, especially for wheelchair users as they tend to show poorer lifestyle behaviour despite an increased risk of obesity and comorbidity.The WHEELS lifestyle app seems to be a valuable tool to support healthy nutrition choices and weight loss and to improve body satisfaction, mental health and vitality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Benz2024-onb,

title = {Sarcopenia and sarcopenic obesity and mortality among older 

 people},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw. Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {Importance: Sarcopenia and obesity are 2 global concerns 

 associated with adverse health outcomes in older people. Evidence 

 on the population-based prevalence of the combination of 

 sarcopenia with obesity (sarcopenic obesity [SO]) and its 

 association with mortality are still limited. Objective: To 

 investigate the prevalence of sarcopenia and SO and their 

 association with all-cause mortality. Design, Setting, and 

 Participants: This large-scale, population-based cohort study 

 assessed participants from the Rotterdam Study from March 1, 

 2009, to June 1, 2014. Associations of sarcopenia and SO with 

 all-cause mortality were studied using Kaplan-Meier curves, Cox 

 proportional hazards regression, and accelerated failure time 

 models fitted for sex, age, and body mass index (BMI). Data 

 analysis was performed from January 1 to April 1, 2023. 

 Exposures: The prevalence of sarcopenia and SO, measured based on 

 handgrip strength and body composition (BC) (dual-energy x-ray 

 absorptiometry) as recommended by current consensus criteria, 

 with probable sarcopenia defined as having low handgrip strength 

 and confirmed sarcopenia and SO defined as altered BC (high fat 

 percentage and/or low appendicular skeletal muscle index) in 

 addition to low handgrip strength. Main Outcome and Measure: The 

 primary outcome was all-cause mortality, collected using linked 

 mortality data from general practitioners and the central 

 municipal records, until October 2022. Results: In the total 

 population of 5888 participants (mean [SD] age, 69.5 [9.1] years; 

 mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 

 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 

 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic 

 obesity with 1 altered component of BC was present in 295 

 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered 

 components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An 

 increased risk of all-cause mortality was observed in 

 participants with probable sarcopenia (hazard ratio [HR], 1.29; 

 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 

 1.53-2.43). Participants with SO plus 1 altered component of BC 

 (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC 

 (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality 

 than those without SO. Similar results for SO were obtained for 

 participants with a BMI of 27 or greater. Conclusions and 

 Relevance: In this study, sarcopenia and SO were found to be 

 prevalent phenotypes in older people and were associated with 

 all-cause mortality. Additional alterations of BC amplified this 

 risk independently of age, sex, and BMI. The use of low muscle 

 strength as a first step of both diagnoses may allow for early 

 identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Benz2024-on,

title = {Sarcopenia and sarcopenic obesity and mortality among older 

 people},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw. Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {Importance: Sarcopenia and obesity are 2 global concerns 

 associated with adverse health outcomes in older people. Evidence 

 on the population-based prevalence of the combination of 

 sarcopenia with obesity (sarcopenic obesity [SO]) and its 

 association with mortality are still limited. Objective: To 

 investigate the prevalence of sarcopenia and SO and their 

 association with all-cause mortality. Design, Setting, and 

 Participants: This large-scale, population-based cohort study 

 assessed participants from the Rotterdam Study from March 1, 

 2009, to June 1, 2014. Associations of sarcopenia and SO with 

 all-cause mortality were studied using Kaplan-Meier curves, Cox 

 proportional hazards regression, and accelerated failure time 

 models fitted for sex, age, and body mass index (BMI). Data 

 analysis was performed from January 1 to April 1, 2023. 

 Exposures: The prevalence of sarcopenia and SO, measured based on 

 handgrip strength and body composition (BC) (dual-energy x-ray 

 absorptiometry) as recommended by current consensus criteria, 

 with probable sarcopenia defined as having low handgrip strength 

 and confirmed sarcopenia and SO defined as altered BC (high fat 

 percentage and/or low appendicular skeletal muscle index) in 

 addition to low handgrip strength. Main Outcome and Measure: The 

 primary outcome was all-cause mortality, collected using linked 

 mortality data from general practitioners and the central 

 municipal records, until October 2022. Results: In the total 

 population of 5888 participants (mean [SD] age, 69.5 [9.1] years; 

 mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 

 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 

 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic 

 obesity with 1 altered component of BC was present in 295 

 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered 

 components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An 

 increased risk of all-cause mortality was observed in 

 participants with probable sarcopenia (hazard ratio [HR], 1.29; 

 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 

 1.53-2.43). Participants with SO plus 1 altered component of BC 

 (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC 

 (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality 

 than those without SO. Similar results for SO were obtained for 

 participants with a BMI of 27 or greater. Conclusions and 

 Relevance: In this study, sarcopenia and SO were found to be 

 prevalent phenotypes in older people and were associated with 

 all-cause mortality. Additional alterations of BC amplified this 

 risk independently of age, sex, and BMI. The use of low muscle 

 strength as a first step of both diagnoses may allow for early 

 identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38526491c,

title = {Sarcopenia and Sarcopenic Obesity and Mortality Among Older People},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

doi = {10.1001/jamanetworkopen.2024.3604},

issn = {2574-3805},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38526491,

title = {Sarcopenia and Sarcopenic Obesity and Mortality Among Older People},

author = {Elizabeth Benz and Alexandre Pinel and Christelle Guillet and Frederic Capel and Bruno Pereira and Marie De Antonio and Melanie Pouget and Alfonso J Cruz-Jentoft and Doris Eglseer and Eva Topinkova and Rocco Barazzoni and Fernando Rivadeneira and M Arfan Ikram and Marinka Steur and Trudy Voortman and Josje D Schoufour and Peter J M Weijs and Yves Boirie},

doi = {10.1001/jamanetworkopen.2024.3604},

issn = {2574-3805},

year  = {2024},

date = {2024-03-01},

journal = {JAMA Netw Open},

volume = {7},

number = {3},

pages = {e243604},

abstract = {IMPORTANCE: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.nnOBJECTIVE: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.nnDESIGN, SETTING, AND PARTICIPANTS: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023.nnEXPOSURES: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength.nnMAIN OUTCOME AND MEASURE: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022.nnRESULTS: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [HR], 1.29; 95% CI, 1.14-1.47) and confirmed sarcopenia (HR, 1.93; 95% CI, 1.53-2.43). Participants with SO plus 1 altered component of BC (HR, 1.94; 95% CI, 1.60-2.33]) or 2 altered components of BC (HR, 2.84; 95% CI, 1.97-4.11) had a higher risk of mortality than those without SO. Similar results for SO were obtained for participants with a BMI of 27 or greater.nnCONCLUSIONS AND RELEVANCE: In this study, sarcopenia and SO were found to be prevalent phenotypes in older people and were associated with all-cause mortality. Additional alterations of BC amplified this risk independently of age, sex, and BMI. The use of low muscle strength as a first step of both diagnoses may allow for early identification of individuals at risk for premature mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wagenaar2024-fub,

title = {Long-term effectiveness of a lifestyle intervention for 

 rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 

 'Plants for Joints' randomised clinical trial},

author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin Esch and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

pages = {e004025},

publisher = {BMJ},

abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for 

 Joints (PFJ) multidisciplinary lifestyle intervention reduced 

 signs and symptoms of rheumatoid arthritis (RA), or metabolic 

 syndrome-associated hip or knee osteoarthritis (MSOA) compared 

 with usual care. The current study investigated long-term 

 outcomes. METHODS: After completion of two 16-week trials in 

 people with (1) RA or (2) MSOA, control groups switched to the 

 active PFJ intervention. At the end of the intervention, all 

 participants were followed up in a 1-year observational 

 extension study. Primary outcomes were 28-joint Disease Activity 

 Score (DAS28) (RA) and Western Ontario and McMaster Universities 

 Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included 

 body composition, metabolic outcomes, medication changes and 

 intervention adherence. An intention-to-treat analysis with a 

 linear mixed model was used to analyse within-group changes. 

 RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 

 MSOA participants completed the extension study. The effects of 

 the PFJ intervention were replicated in the original control 

 groups and sustained within the RA group a year after 

 intervention completion (mean DAS28 -0.9 points; p<0.001), while 

 in the MSOA group mean WOMAC increased towards but remained well 

 under the starting value (-7.8 points, p<0.001). Improvements in 

 C-reactive protein, waist circumference (RA and MSOA); 

 low-density lipoprotein cholesterol (RA); and weight, 

 haemoglobin A1c, blood pressure (MSOA) were also sustained. 

 Participants had a net decrease of medication, and intervention 

 adherence was largely sustained. CONCLUSIONS: A year after the 

 PFJ lifestyle intervention, improvements of disease activity and 

 metabolic outcomes within RA and MSOA groups were largely 

 sustained and related to sustained adherence, with a net 

 decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800, 

 NL7801.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wagenaar2024-fu,

title = {Long-term effectiveness of a lifestyle intervention for 

 rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 

 'Plants for Joints' randomised clinical trial},

author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin Esch and Henriët Middendorp and Peter J M Weijs and Dirkjan Schaardenburg},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

pages = {e004025},

publisher = {BMJ},

abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for 

 Joints (PFJ) multidisciplinary lifestyle intervention reduced 

 signs and symptoms of rheumatoid arthritis (RA), or metabolic 

 syndrome-associated hip or knee osteoarthritis (MSOA) compared 

 with usual care. The current study investigated long-term 

 outcomes. METHODS: After completion of two 16-week trials in 

 people with (1) RA or (2) MSOA, control groups switched to the 

 active PFJ intervention. At the end of the intervention, all 

 participants were followed up in a 1-year observational 

 extension study. Primary outcomes were 28-joint Disease Activity 

 Score (DAS28) (RA) and Western Ontario and McMaster Universities 

 Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included 

 body composition, metabolic outcomes, medication changes and 

 intervention adherence. An intention-to-treat analysis with a 

 linear mixed model was used to analyse within-group changes. 

 RESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 

 MSOA participants completed the extension study. The effects of 

 the PFJ intervention were replicated in the original control 

 groups and sustained within the RA group a year after 

 intervention completion (mean DAS28 -0.9 points; p<0.001), while 

 in the MSOA group mean WOMAC increased towards but remained well 

 under the starting value (-7.8 points, p<0.001). Improvements in 

 C-reactive protein, waist circumference (RA and MSOA); 

 low-density lipoprotein cholesterol (RA); and weight, 

 haemoglobin A1c, blood pressure (MSOA) were also sustained. 

 Participants had a net decrease of medication, and intervention 

 adherence was largely sustained. CONCLUSIONS: A year after the 

 PFJ lifestyle intervention, improvements of disease activity and 

 metabolic outcomes within RA and MSOA groups were largely 

 sustained and related to sustained adherence, with a net 

 decrease of medication. TRIAL REGISTRATION NUMBERS: NL7800, 

 NL7801.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38413171,

title = {Long-term effectiveness of a lifestyle intervention for rheumatoid arthritis and osteoarthritis: 1-year follow-up of the 'Plants for Joints' randomised clinical trial},

author = {Carlijn A Wagenaar and Wendy Walrabenstein and Marike van der Leeden and Franktien Turkstra and Martijn Gerritsen and Jos W R Twisk and Maarten Boers and Martin van der Esch and Henriët van Middendorp and Peter J M Weijs and Dirkjan van Schaardenburg},

doi = {10.1136/rmdopen-2023-004025},

issn = {2056-5933},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

abstract = {OBJECTIVES: In two randomised controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. The current study investigated long-term outcomes.nnMETHODS: After completion of two 16-week trials in people with (1) RA or (2) MSOA, control groups switched to the active PFJ intervention. At the end of the intervention, all participants were followed up in a 1-year observational extension study. Primary outcomes were 28-joint Disease Activity Score (DAS28) (RA) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included body composition, metabolic outcomes, medication changes and intervention adherence. An intention-to-treat analysis with a linear mixed model was used to analyse within-group changes.nnRESULTS: 65 (84%) of 77 RA participants and 49 (77%) of 64 MSOA participants completed the extension study. The effects of the PFJ intervention were replicated in the original control groups and sustained within the RA group a year after intervention completion (mean DAS28 -0.9 points; p<0.001), while in the MSOA group mean WOMAC increased towards but remained well under the starting value (-7.8 points, p<0.001). Improvements in C-reactive protein, waist circumference (RA and MSOA); low-density lipoprotein cholesterol (RA); and weight, haemoglobin A1c, blood pressure (MSOA) were also sustained. Participants had a net decrease of medication, and intervention adherence was largely sustained.nnCONCLUSIONS: A year after the PFJ lifestyle intervention, improvements of disease activity and metabolic outcomes within RA and MSOA groups were largely sustained and related to sustained adherence, with a net decrease of medication.nnTRIAL REGISTRATION NUMBERS: NL7800, NL7801.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{De_Geus2024-ilb,

title = {The impact of combined nutrition and exercise interventions in 

 patients with chronic kidney disease},

author = {Manon Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},

year  = {2024},

date = {2024-01-01},

journal = {Nutrients},

volume = {16},

number = {3},

abstract = {Combined nutrition and exercise interventions potentially improve 

 protein-energy wasting/malnutrition-related outcomes in patients 

 with chronic kidney disease (CKD). The aim was to systematically 

 review the effect of combined interventions on nutritional 

 status, muscle strength, physical performance and QoL. MEDLINE, 

 Cochrane, Embase, Web of Science and Google Scholar were searched 

 for studies up to the date of July 2023. Methodological quality 

 was appraised with the Cochrane risk-of-bias tool. Ten randomized 

 controlled trials (nine publications) were included (334 

 patients). No differences were observed in body mass index, lean 

 body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{De_Geus2024-il,

title = {The impact of combined nutrition and exercise interventions in 

 patients with chronic kidney disease},

author = {Manon Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},

year  = {2024},

date = {2024-01-01},

journal = {Nutrients},

volume = {16},

number = {3},

abstract = {Combined nutrition and exercise interventions potentially improve 

 protein-energy wasting/malnutrition-related outcomes in patients 

 with chronic kidney disease (CKD). The aim was to systematically 

 review the effect of combined interventions on nutritional 

 status, muscle strength, physical performance and QoL. MEDLINE, 

 Cochrane, Embase, Web of Science and Google Scholar were searched 

 for studies up to the date of July 2023. Methodological quality 

 was appraised with the Cochrane risk-of-bias tool. Ten randomized 

 controlled trials (nine publications) were included (334 

 patients). No differences were observed in body mass index, lean 

 body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38337689,

title = {The Impact of Combined Nutrition and Exercise Interventions in Patients with Chronic Kidney Disease},

author = {Manon de Geus and Manouk Dam and Wesley J Visser and Karin J R Ipema and Anneke M E de Mik-van Egmond and Michael Tieland and Peter J M Weijs and Hinke M Kruizenga},

doi = {10.3390/nu16030406},

issn = {2072-6643},

year  = {2024},

date = {2024-01-01},

journal = {Nutrients},

volume = {16},

number = {3},

abstract = {Combined nutrition and exercise interventions potentially improve protein-energy wasting/malnutrition-related outcomes in patients with chronic kidney disease (CKD). The aim was to systematically review the effect of combined interventions on nutritional status, muscle strength, physical performance and QoL. MEDLINE, Cochrane, Embase, Web of Science and Google Scholar were searched for studies up to the date of July 2023. Methodological quality was appraised with the Cochrane risk-of-bias tool. Ten randomized controlled trials (nine publications) were included (334 patients). No differences were observed in body mass index, lean body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) ( = 3, MD 27.2, 95%CI [7 to 48],  = 0.008), but not in the timed up-and-go test. No effect was found on QoL. A positive impact on 6-MWT was observed, but no improvements were detected in nutritional status, muscle strength or QoL. Concerns about reliability and generalizability arise due to limited statistical power and study heterogeneity of the studies included.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Ruijven2023-dsb,

title = {High protein provision of more than 1.2 g/kg improves muscle 

 mass preservation and mortality in ICU patients: A systematic 

 review and meta-analyses},

author = {Isabel M Ruijven and José Abma and Anja H Brunsveld-Reinders and Sandra N Stapel and Faridi Etten-Jamaludin and Yves Boirie and Rocco Barazzoni and Peter J M Weijs},

year  = {2023},

date = {2023-12-01},

journal = {Clin. Nutr.},

volume = {42},

number = {12},

pages = {2395–2403},

publisher = {Elsevier BV},

abstract = {BACKGROUND: ICU patients lose muscle mass rapidly and 

 maintenance of muscle mass may contribute to improved survival 

 rates and quality of life. Protein provision may be beneficial 

 for preservation of muscle mass and other clinical outcomes, 

 including survival. Current protein recommendations are 

 expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed 

 a systematic review and meta-analysis on protein provision and 

 all clinically relevant outcomes recorded in the available 

 literature. METHODS: We conducted a systematic review and 

 meta-analyses, including studies of all designs except case 

 control and case studies, with patients aged $geq$18 years with 

 an ICU stay of $geq$2 days and a mean protein provision group 

 of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of 

 $geq$0.2 g/kg between protein provision groups. All clinically 

 relevant outcomes were studied. Meta-analyses were performed for 

 all clinically relevant outcomes that were recorded in $geq$3 

 included studies. RESULTS: A total of 29 studies published 

 between 2012 and 2022 were included. Outcomes reported in the 

 included studies were ICU, hospital, 28-day, 30-day, 42-day, 

 60-day, 90-day and 6-month mortality, ICU and hospital length of 

 stay, duration of mechanical ventilation, vomiting, diarrhea, 

 gastric residual volume, pneumonia, overall infections, nitrogen 

 balance, changes in muscle mass, destination at hospital 

 discharge, physical performance and psychological status. 

 Meta-analyses showed differences between groups in favour of 

 high protein provision for 60-day mortality, nitrogen balance 

 and changes in muscle mass. CONCLUSION: High protein provision 

 of more than 1.2 g/kg in critically ill patients seemed to 

 improve nitrogen balance and changes in muscle mass on the 

 short-term and likely 60-day mortality. Data on long-term 

 effects on quality of life are urgently needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Dronkelaar2023-oab,

title = {Malnutrition screening tools are not sensitive enough to identify 

 older hospital patients with malnutrition},

author = {Carliene Dronkelaar and Michael Tieland and Tommy Cederholm and Esmee M Reijnierse and Peter J M Weijs and Hinke Kruizenga},

year  = {2023},

date = {2023-12-01},

journal = {Nutrients},

volume = {15},

number = {24},

abstract = {This study evaluates the concurrent validity of five malnutrition 

 screening tools to identify older hospitalized patients against 

 the Global Leadership Initiative on Malnutrition (GLIM) 

 diagnostic criteria as limited evidence is available. The 

 screening tools Short Nutritional Assessment Questionnaire 

 (SNAQ), Malnutrition Universal Screening Tool (MUST), 

 Malnutrition Screening Tool (MST), Mini Nutritional 

 Assessment-Short Form (MNA-SF), and the Patient-Generated 

 Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs 

 for both malnutrition (conservative) and moderate malnutrition or 

 risk of malnutrition (liberal) were used. The concurrent validity 

 was determined by the sensitivity, specificity, positive 

 predictive value (PPV), negative predictive value (NPV), and the 

 level of agreement by Cohen's kappa. In total, 356 patients were 

 included in the analyses (median age 70 y (IQR 63-77); 54% 

 male). The prevalence of malnutrition according to the GLIM 

 criteria without prior screening was 42%. The conservative 

 cut-offs showed a low-to-moderate sensitivity (32-68%) and 

 moderate-to-high specificity (61-98%). The PPV and NPV ranged 

 from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs 

 displayed a moderate-to-high sensitivity (66-89%) and a 

 low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their 

 capacity to identify hospitalized older patients with 

 malnutrition. The screening process in the GLIM framework 

 requires further consideration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Ruijven2023-ds,

title = {High protein provision of more than 1.2 g/kg improves muscle 

 mass preservation and mortality in ICU patients: A systematic 

 review and meta-analyses},

author = {Isabel M Ruijven and José Abma and Anja H Brunsveld-Reinders and Sandra N Stapel and Faridi Etten-Jamaludin and Yves Boirie and Rocco Barazzoni and Peter J M Weijs},

year  = {2023},

date = {2023-12-01},

journal = {Clin. Nutr.},

volume = {42},

number = {12},

pages = {2395–2403},

publisher = {Elsevier BV},

abstract = {BACKGROUND: ICU patients lose muscle mass rapidly and 

 maintenance of muscle mass may contribute to improved survival 

 rates and quality of life. Protein provision may be beneficial 

 for preservation of muscle mass and other clinical outcomes, 

 including survival. Current protein recommendations are 

 expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed 

 a systematic review and meta-analysis on protein provision and 

 all clinically relevant outcomes recorded in the available 

 literature. METHODS: We conducted a systematic review and 

 meta-analyses, including studies of all designs except case 

 control and case studies, with patients aged $geq$18 years with 

 an ICU stay of $geq$2 days and a mean protein provision group 

 of $geq$1.2 g/kg as compared to <1.2 g/kg with a difference of 

 $geq$0.2 g/kg between protein provision groups. All clinically 

 relevant outcomes were studied. Meta-analyses were performed for 

 all clinically relevant outcomes that were recorded in $geq$3 

 included studies. RESULTS: A total of 29 studies published 

 between 2012 and 2022 were included. Outcomes reported in the 

 included studies were ICU, hospital, 28-day, 30-day, 42-day, 

 60-day, 90-day and 6-month mortality, ICU and hospital length of 

 stay, duration of mechanical ventilation, vomiting, diarrhea, 

 gastric residual volume, pneumonia, overall infections, nitrogen 

 balance, changes in muscle mass, destination at hospital 

 discharge, physical performance and psychological status. 

 Meta-analyses showed differences between groups in favour of 

 high protein provision for 60-day mortality, nitrogen balance 

 and changes in muscle mass. CONCLUSION: High protein provision 

 of more than 1.2 g/kg in critically ill patients seemed to 

 improve nitrogen balance and changes in muscle mass on the 

 short-term and likely 60-day mortality. Data on long-term 

 effects on quality of life are urgently needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Van_Dronkelaar2023-oa,

title = {Malnutrition screening tools are not sensitive enough to identify 

 older hospital patients with malnutrition},

author = {Carliene Dronkelaar and Michael Tieland and Tommy Cederholm and Esmee M Reijnierse and Peter J M Weijs and Hinke Kruizenga},

year  = {2023},

date = {2023-12-01},

journal = {Nutrients},

volume = {15},

number = {24},

abstract = {This study evaluates the concurrent validity of five malnutrition 

 screening tools to identify older hospitalized patients against 

 the Global Leadership Initiative on Malnutrition (GLIM) 

 diagnostic criteria as limited evidence is available. The 

 screening tools Short Nutritional Assessment Questionnaire 

 (SNAQ), Malnutrition Universal Screening Tool (MUST), 

 Malnutrition Screening Tool (MST), Mini Nutritional 

 Assessment-Short Form (MNA-SF), and the Patient-Generated 

 Subjective Global Assessment-Short Form (PG-SGA-SF) with cut-offs 

 for both malnutrition (conservative) and moderate malnutrition or 

 risk of malnutrition (liberal) were used. The concurrent validity 

 was determined by the sensitivity, specificity, positive 

 predictive value (PPV), negative predictive value (NPV), and the 

 level of agreement by Cohen's kappa. In total, 356 patients were 

 included in the analyses (median age 70 y (IQR 63-77); 54% 

 male). The prevalence of malnutrition according to the GLIM 

 criteria without prior screening was 42%. The conservative 

 cut-offs showed a low-to-moderate sensitivity (32-68%) and 

 moderate-to-high specificity (61-98%). The PPV and NPV ranged 

 from 59 to 94% and 67-86%, respectively. The Cohen's kappa showed poor agreement (k = 0.21-0.59). The liberal cut-offs 

 displayed a moderate-to-high sensitivity (66-89%) and a 

 low-to-high specificity (46-95%). The agreement was fair to good (k = 0.33-0.75). The currently used screening tools vary in their 

 capacity to identify hospitalized older patients with 

 malnutrition. The screening process in the GLIM framework 

 requires further consideration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37862825,

title = {High protein provision of more than 1.2 g/kg improves muscle mass preservation and mortality in ICU patients: A systematic review and meta-analyses},

author = {Isabel M van Ruijven and José Abma and Anja H Brunsveld-Reinders and Sandra N Stapel and Faridi van Etten-Jamaludin and Yves Boirie and Rocco Barazzoni and Peter J M Weijs},

doi = {10.1016/j.clnu.2023.09.026},

issn = {1532-1983},

year  = {2023},

date = {2023-12-01},

journal = {Clin Nutr},

volume = {42},

number = {12},

pages = {2395--2403},

abstract = {BACKGROUND: ICU patients lose muscle mass rapidly and maintenance of muscle mass may contribute to improved survival rates and quality of life. Protein provision may be beneficial for preservation of muscle mass and other clinical outcomes, including survival. Current protein recommendations are expert-based and range from 1.2 to 2.0 g/kg. Thus, we performed a systematic review and meta-analysis on protein provision and all clinically relevant outcomes recorded in the available literature.nnMETHODS: We conducted a systematic review and meta-analyses, including studies of all designs except case control and case studies, with patients aged ≥18 years with an ICU stay of ≥2 days and a mean protein provision group of ≥1.2 g/kg as compared to <1.2 g/kg with a difference of ≥0.2 g/kg between protein provision groups. All clinically relevant outcomes were studied. Meta-analyses were performed for all clinically relevant outcomes that were recorded in ≥3 included studies.nnRESULTS: A total of 29 studies published between 2012 and 2022 were included. Outcomes reported in the included studies were ICU, hospital, 28-day, 30-day, 42-day, 60-day, 90-day and 6-month mortality, ICU and hospital length of stay, duration of mechanical ventilation, vomiting, diarrhea, gastric residual volume, pneumonia, overall infections, nitrogen balance, changes in muscle mass, destination at hospital discharge, physical performance and psychological status. Meta-analyses showed differences between groups in favour of high protein provision for 60-day mortality, nitrogen balance and changes in muscle mass.nnCONCLUSION: High protein provision of more than 1.2 g/kg in critically ill patients seemed to improve nitrogen balance and changes in muscle mass on the short-term and likely 60-day mortality. Data on long-term effects on quality of life are urgently needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}